https://m2.mtmt.hu/ eng 2026-10-24 05:26 JournalArticle 34072773 VALIDATED true Second Department of Neurology, 'Attikon' University Hospital, National and Kapodistrian University of Athens, Athens, Greece Department of Neurology, University Hospitals Cleveland Medical Center, Cleveland, OH, United States Stroke Unit, Metropolitan Hospital, Piraeus, Greece National Institute of Mental Health, Neurology and Neurosurgery, Department Section of Neurointervention, Semmelweis University, Budapest, Hungary Neuroradiology Department, Metropolitan Hospital, Piraeus, Greece Interventional Radiology Department, 'Attikon' University Hospital, National and Kapodistrian, University of Athens, Athens, Greece Neurology, University Hospitals Leuven, Leuven, Belgium Department of Neurosciences, Division of Experimental Neurology, KU Leuven, Leuven, Belgium Department of Neurology, Oslo University Hospital, Oslo, Norway Norwegian Air Ambulance Foundation, Bodo, Norway Department of Neurology, GHU Paris Psychiatrie et Neurosciences, Paris, France Department of Neurology, Université Paris Cité, Paris, France Institute of Psychiatry and Neuroscience of Paris, INSERM U1266, Paris, France Department of Neurology, FHU NeuroVasc, Paris, France Department of Neuroradiology, Clinic of Radiology & Nuclear Medicine, Universität Basel, Basel, Switzerland Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, United States Cited By :16 Export Date: 4 July 2024 CODEN: JNNPA Correspondence Address: Tsivgoulis, G.; Department of Neurology, Greece; email: tsivgoulisgiorg@yahoo.gr 0 false 2026-10-23T16:49:55.323+0000 2026-05-08T07:10:15.211+0000 2023-07-24T07:14:15.696+0000 true 10078148 Havas Petra /api/admin/10078148 Admin true 2026-05-08T07:10:04.951+0000 2026-05-08T07:10:04.951+0000 2026-05-08T07:10:15.554+0000 true 10095366 Havas Petra Gabriella /api/admin/10095366 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Palaiodimou, Lina Endovascular treatment for large-core ischaemic stroke a meta-analysis of randomised controlled clinical trials true true /api/journal/2701 REVIEWED true false 2701 false 2701 true 0022-3050 1468-330X Journal FOREIGN 94 10 781 785 781 5 2023 Current guidelines recommend endovascular treatment (EVT) for acute ischaemic stroke (AIS), due to large-vessel occlusion and an Alberta Stroke Program Early CT Score (ASPECTS) of ≥6. High-quality evidence resulting from randomised controlled clinical trials (RCTs) regarding EVT among large-core AIS has recently become available, justifying an updated meta-analysis aiming to evaluate efficacy and safety of EVT in this clinical setting.We conducted a systematic review and meta-analysis including all available RCTs that compared EVT in addition to best medical treatment (BMT) versus BMT alone for large-core AIS (defined by ASPECTS 2-5 or volumetric methods). The primary outcome was reduced disability at 3 months (≥1-point reduction across all Modified Rankin Scale (mRS) grades). Secondary outcomes included independent ambulation at 3 months (mRS score 0-3), good functional outcome at 3 months (mRS score 0-2), excellent functional outcome at 3 months (mRS score 0-1), symptomatic intracranial haemorrhage (sICH) and any intracranial haemorrhage (ICH) and mortality at 3 months. The random-effects model was used.Four RCTs were included comprising a total of 662 patients treated with EVT vs 649 patients treated with BMT. Compared with BMT, EVT was significantly associated with reduced disability (common OR 1.70, 95% CI 1.39 to 2.07; I2=0%), independent ambulation (risk ratio (RR) 1.69, 95% CI 1.33 to 2.14; I2=39%) and good functional outcome (RR 2.33, 95% CI 1.76 to 3.10; I2=0%), but not with excellent functional outcome (RR 1.46, 95% CI 0.91 to 2.33; I2=39%) at 3 months. Although rates of sICH (RR 1.98, 95% CI 1.07 to 3.68; I2=0%) and any ICH (RR 2.13, 95% CI 1.70 to 2.66; I2=37%) were higher in the EVT group, 3-month mortality (RR 0.98, 95% CI 0.83 to 1.15; I2=0%) did not differ between the two groups.EVT appears to be effective and safe and may be considered for the treatment of large-core AIS, as assessed by ASPECTS of 2-5 or volumetric methods.CRD42022334417. true true 2023 true true true false true false NONE 2026-10-23 false 53 0 53 46 0 53 53 51 50 53 53 46 46 46 7 0 53 46 53 46 0 1 1 Folyóiratcikk Journal Article 24 53 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 2 2 2 2 2024 0 28 22 28 22 2025 0 18 18 18 18 2026 0 5 4 5 4 D1 false false false false 2023-09-18T12:27:42.047+0000 Amerikai úti Ideggyógyászati és Idegsebészeti I... (OMIII); Idegsebészeti Tanszék (SE / AOK / K / INK); Neurointervenciós Tanszéki Csoport (SE / AOK / K / INK / IT) 1 11 3 9 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 109355859 /api/authorship/109355859 1 0.11111111 true false false Palaiodimou Lina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109355860 /api/authorship/109355860 2 0.11111111 false false false Sarraj Amrou true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109355861 /api/authorship/109355861 3 0.111 false false false Author 10087626 /api/author/10087626 Safouris Apostolos true true Safouris Apostolos true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109355862 /api/authorship/109355862 4 0.11111111 false false false Magoufis Georgios true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109355863 /api/authorship/109355863 5 0.11111111 false false false Lemmens Robin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109355864 /api/authorship/109355864 6 0.11111111 false false false Sandset Else Charlotte true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109355865 /api/authorship/109355865 7 0.11111111 false false false Turc Guillaume true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109355866 /api/authorship/109355866 8 0.11111111 false false false Psychogios Marios true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109355867 /api/authorship/109355867 9 0.111 false true true Tsivgoulis Georgios true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 24193363 /api/publicationidentifier/24193363 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1136/jnnp-2023-331513 https://doi.org/10.1136/jnnp-2023-331513 false true PublicationIdentifier 24228090 /api/publicationidentifier/24228090 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001033126700001 https://www.webofscience.com/wos/woscc/full-record/001033126700001 true true PublicationIdentifier 24283162 /api/publicationidentifier/24283162 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85166412364 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85166412364 true true PublicationIdentifier 24193362 /api/publicationidentifier/24193362 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37451694 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37451694&dopt=Abstract false true SjrRating 11419092 /api/sjrrating/11419092 2 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2746 /api/classificationexternal/2746 true 2746 true D1 DIRECT true true /api/publication/34072773 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Palaiodimou Lina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sarraj Amrou </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10087626"><a href="/gui2/?type=authors&mode=browse&sel=10087626" target="_blank">Safouris Apostolos (<span class="authorship-author-name">Safouris Apostolos</span> <span class="authorAux-mtmt"> Neurológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Neurosurgery; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Neurosurgery">DN</span>/Section of Neurointerventions; <span title="Országos Mentális, Ideggyógyászati és Idegsebészeti Intézet">OMIII</span>/Institute of Neurology and Neurosurgery (Amerikai street)</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Magoufis Georgios </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lemmens Robin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sandset Else Charlotte </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Turc Guillaume </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Psychogios Marios </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tsivgoulis Georgios ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34072773" target="_blank">Endovascular treatment for large-core ischaemic stroke : a meta-analysis of randomised controlled clinical trials.</a></div> <div> <span class="journal-title">JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0022-3050">0022-3050</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1468-330X">1468-330X</a>)</span>: <span class="journal-volume">94</span> <span class="journal-issue">10</span> <span class="page"> pp 781-785 </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1136/jnnp-2023-331513" target="_blank" href="https://doi.org/10.1136/jnnp-2023-331513"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001033126700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001033126700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85166412364" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85166412364"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37451694" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37451694&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Neurology (clinical)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Psychiatry and Mental Health&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Surgery&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 53</span> | Independent citation: 46 | Self citation: 7 | Unknown citation: 0 | Number of citations in WoS: 51 | Number of citations in Scopus:&nbsp;50 | WoS/Scopus assigned:&nbsp;53 | Number of citations with DOI:&nbsp;53 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34072773&sort=publishedYear,desc&sort=title"> Number of cited publications: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 34072773</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Last Modified: 2026.05.08. 09:10 Petra Gabriella Havas (SE_KK_Idegsebeszet_Admin5_HP, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Second Department of Neurology, 'Attikon' University Hospital, National and Kapodistrian University of Athens, Athens, Greece Department of Neurology, University Hospitals Cleveland Medical Center, Cleveland, OH, United States Stroke Unit, Metropolitan Hospital, Piraeus, Greece National Institute of Mental Health, Neurology...</pre> </div></div>