https://m2.mtmt.hu/ hun 2026-05-26 10:55 JournalArticle 34069454 VALIDATED true 0 false 2026-05-23T02:34:45.930+0000 2023-08-25T08:39:38.138+0000 2023-07-20T07:48:37.858+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin Csajbók Edit (SE_KK_Admin5_CSE, admin) true 10015544 2025-07-29T09:07:56.428+0000 2025-07-29T09:07:56.428+0000 2023-08-21T13:38:14.177+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin Molnár-Taga Márta (SE 4-es admin) true 10062250 Admin 10003134 /api/admin/10003134 Wolf György (MTMT Központi admin) Wolf György true 10003134 true 2025-12-18T14:33:13.723+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Tran, Minh Ngoc true true /api/journal/10024487 REVIEWED LIFE-BASEL 2075-1729 true false 10024487 false 10024487 true 2075-1729 Journal FOREIGN 13 7 1581 1581 13 2023 The trabecular meshwork (TM) route is the principal outflow egress of the aqueous humor. Actin cytoskeletal remodeling in the TM and extracellular matrix (ECM) deposition increase TM stiffness, outflow resistance, and elevate intraocular pressure (IOP). These alterations are strongly linked to transforming growth factor-β2 (TGFβ2), a known profibrotic cytokine that is markedly elevated in the aqueous humor of glaucomatous eyes. Sigma-1 receptor (S1R) has been shown to have neuroprotective effects in the retina, but data are lacking about its role in the TM. In this study, we identified the presence of S1R in mouse TM tissue and investigated the effect of an S1R agonist fluvoxamine (FLU) on TGFβ2-induced human TM cells regarding cell proliferation; ECM-related functions, including F-actin reorganization; and the accumulation of ECM elements. TGFβ2 increased the proliferation, cytoskeletal remodeling, and protein levels of fibronectin, collagen type IV, and connective tissue growth factor, and decreased the level of matrix metalloproteinase-2. Most importantly, FLU reversed all these effects of TGFβ2, suggesting that S1R agonists could be potential candidates for preserving TM function and thus maintaining normal IOP. Funding 2029090 /api/funding/2029090 OTKA(K135398) false true Funding 2029091 /api/funding/2029091 (LP2021-3/2021) false true Funding 2029092 /api/funding/2029092 Thematic Institutional Excellence Programme(TKP2021-EGA-24) Támogató: Emberi Erőforrások Minisztériuma false true true 2023 true true true false true false GOLD 2026-05-23 true https://doi.org/10.3390/life13071581 7 0 7 4 4 7 7 7 6 7 7 4 4 4 3 0 7 4 7 4 0 0 0 Folyóiratcikk Journal Article 24 7 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 2 1 2 1 2025 0 2 2 2 2 2026 0 3 1 3 1 Q1 false 10011883,10032759 false false false 2023-07-19T07:48:45.753+0000 Biofizikai és Sugárbiológiai Intézet (SE / AOK / I); Gyermekgyógyászati Klinika (SE / AOK / K); MTA-SE Lendület Diabétesz Kutatócsoport (SE / AOK / K / GYGYK); Szemészeti Klinika (SE / AOK / K); Transzlációs Medicina Intézet (SE / AOK / I) 8 43 5 9 0 true 10003134 Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 109337450 /api/authorship/109337450 Tran, Minh Ngoc [Tran, Ngoc Minh (clinical medicine), szerző] MTA-SE Lendület Diabétesz Kutatócsoport (SE / AOK / K / GYGYK); Gyermekgyógyászati Klinika (SE / AOK / K) 1 0.111 true false false Author 10071676 /api/author/10071676 Tran Ngoc Minh (clinical medicine) Tran Ngoc Minh true true Tran Minh Ngoc true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109337451 /api/authorship/109337451 Medveczki, Timea [Medveczki, Tímea (molekuláris bioló...), szerző] MTA-SE Lendület Diabétesz Kutatócsoport (SE / AOK / K / GYGYK); Gyermekgyógyászati Klinika (SE / AOK / K) 2 0.111 false false false Author 10080260 /api/author/10080260 Medveczki Tímea (molekuláris biológia, szemészet) Medveczki Tímea true true Medveczki Timea true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109337452 /api/authorship/109337452 Besztercei, Balazs [Besztercei, Balázs (Élettan), szerző] Transzlációs Medicina Intézet (SE / AOK / I) 3 0.111 false false false Author 10068063 /api/author/10068063 Besztercei Balázs (Élettan) Besztercei Balázs true true Besztercei Balazs true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109337453 /api/authorship/109337453 Torok, Gyorgy [Török, György (Biofizika, Sejt- ...), szerző] Biofizikai és Sugárbiológiai Intézet (SE / AOK / I) 4 0.111 false false false Author 10035824 /api/author/10035824 Török György (Biofizika, Sejt- és fejlődésbiológia,) Török György true 10035824 true Torok Gyorgy true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109337454 /api/authorship/109337454 Szabo, Attila J. [Szabó, Attila (Gyermekgyógyászat...), szerző] Gyermekgyógyászati Klinika (SE / AOK / K) 5 0.111 false false false Author 10015517 /api/author/10015517 Szabó Attila (Gyermekgyógyászat, nephrologia) Szabó Attila true 10015517 true Szabo Attila J. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109337455 /api/authorship/109337455 Gasull, Xavier 6 0.11111111 false false false Gasull Xavier true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109337456 /api/authorship/109337456 Kovacs, Illes [Kovács, Illés (Szemészet), szerző] Szemészeti Klinika (SE / AOK / K) 7 0.111 false false false Author 10025486 /api/author/10025486 Kovács Illés (Szemészet) Kovács Illés true 10025486 true Kovacs Illes true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109337457 /api/authorship/109337457 Fekete, Andrea ✉ [Fekete, Andrea (nefrológia, gyerm...), szerző] MTA-SE Lendület Diabétesz Kutatócsoport (SE / AOK / K / GYGYK); Gyermekgyógyászati Klinika (SE / AOK / K) 8 0.111 false false true Author 10011883 /api/author/10011883 Fekete Andrea (nefrológia, gyermekgyógyászat) Fekete Andrea true 10011883 true Fekete Andrea true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109337458 /api/authorship/109337458 Hodrea, Judit [Hodrea, Judit (szemészet, diabet...), szerző] MTA-SE Lendület Diabétesz Kutatócsoport (SE / AOK / K / GYGYK); Gyermekgyógyászati Klinika (SE / AOK / K) 9 0.111 false true false Author 10032759 /api/author/10032759 Hodrea Judit (szemészet, diabetológia, nephrologia) Hodrea Judit true 10032759 true Hodrea Judit true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 24184667 /api/publicationidentifier/24184667 DOI: 10.3390/life13071581 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/life13071581 https://doi.org/10.3390/life13071581 false true PublicationIdentifier 24298624 /api/publicationidentifier/24298624 WoS: 001037346600001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001037346600001 https://www.webofscience.com/wos/woscc/full-record/001037346600001 true true PublicationIdentifier 24284883 /api/publicationidentifier/24284883 Scopus: 85166358577 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85166358577 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85166358577 true true PublicationIdentifier 24298626 /api/publicationidentifier/24298626 PubMed: 37511956 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37511956 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37511956&dopt=Abstract true true SjrRating 11405124 /api/sjrrating/11405124 sjr:Q1 (2023) Scopus - Paleontology LIFE-BASEL 2075-1729 23 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1911 /api/classificationexternal/1911 Scopus - Paleontology true 1911 true Q1 DIRECT true true Reference 43672244 /api/reference/43672244 1. Last 2011: Elastic Modulus Determination of Normal and Glaucomatous Human Trabecular Meshwork., Investig. Opthalmol. Vis. Sci., 52, p. 2147, DOI: 10.1167/iovs.10-6342 1 10.1167/iovs.10-6342 false true Reference 43672245 /api/reference/43672245 2. Grant 1963: Experimental aqueous perfusion in enucleated human eyes., Arch. Ophthalmol., 69, p. 783, DOI: 10.1001/archopht.1963.00960040789022 2 10.1001/archopht.1963.00960040789022 false true Reference 43672246 /api/reference/43672246 3. Vranka 2015: Extracellular matrix in the trabecular meshwork: Intraocular pressure regulation and dysregulation in glaucoma., Exp. Eye Res., 133, p. 112, DOI: 10.1016/j.exer.2014.07.014 3 10.1016/j.exer.2014.07.014 false true Reference 43672247 /api/reference/43672247 4. Knepper 1996: Glycosaminoglycan stratification of the juxtacanalicular tissue in normal and primary open-angle glaucoma., Investig. Ophthalmol. Vis. Sci., 37, p. 2414 4 false true Reference 43672248 /api/reference/43672248 5. Rohen 1983: Why is Intraocular Pressure Elevated in Chronic Simple Glaucoma?: Anatomical Considerations., Ophthalmology, 90, p. 758, DOI: 10.1016/S0161-6420(83)34492-4 5 10.1016/S0161-6420(83)34492-4 false true Reference 43672249 /api/reference/43672249 6. Boland 2007: Risk factors and open-angle glaucoma: Classification and application., J. Glaucoma, 16, p. 406, DOI: 10.1097/IJG.0b013e31806540a1 6 10.1097/IJG.0b013e31806540a1 false true Reference 43672250 /api/reference/43672250 7. Hoffman 2004: Predictive factors for glaucomatous visual field progression in the Advanced Glaucoma Intervention Study., Ophthalmology, 111, p. 1627, DOI: 10.1016/j.ophtha.2004.02.017 7 10.1016/j.ophtha.2004.02.017 false true Reference 43672251 /api/reference/43672251 8. Hirsch 2015: TGF-β2 secretion from RPE decreases with polarization and becomes apically oriented., Cytokine, 71, p. 394, DOI: 10.1016/j.cyto.2014.11.014 8 10.1016/j.cyto.2014.11.014 false true Reference 43672252 /api/reference/43672252 9. Tanihara 1993: Identification of transforming growth factor-beta expressed in cultured human retinal pigment epithelial cells., Investig. Ophthalmol. Vis. Sci., 34, p. 413 9 false true Reference 43672253 /api/reference/43672253 10. Fleenor 2006: TGFβ2-Induced Changes in Human Trabecular Meshwork: Implications for Intraocular Pressure., Investig. Ophthalmol. Vis. Sci., 47, p. 226, DOI: 10.1167/iovs.05-1060 10 10.1167/iovs.05-1060 false true Reference 43672254 /api/reference/43672254 11. Kasetti 2018: Transforming growth factor β2 (TGFβ2) signaling plays a key role in glucocorticoid-induced ocular hypertension., J. Biol. Chem., 293, p. 9854, DOI: 10.1074/jbc.RA118.002540 11 10.1074/jbc.RA118.002540 false true Reference 43672255 /api/reference/43672255 12. Gottanka 2004: Effects of TGF-β2 in Perfused Human Eyes., Investig. Ophthalmol. Vis. Sci., 45, p. 153, DOI: 10.1167/iovs.03-0796 12 10.1167/iovs.03-0796 false true Reference 43672256 /api/reference/43672256 13. Sethi 2011: Role of TGFbeta/Smad signaling in gremlin induction of human trabecular meshwork extracellular matrix proteins., Investig. Ophthalmol. Vis. Sci., 52, p. 5251, DOI: 10.1167/iovs.11-7587 13 10.1167/iovs.11-7587 false true Reference 43672257 /api/reference/43672257 14. Igarashi 2021: mTOR inhibitors potentially reduce TGF-β2-induced fibrogenic changes in trabecular meshwork cells., Sci. Rep., 11, p. 14111, DOI: 10.1038/s41598-021-93580-3 14 10.1038/s41598-021-93580-3 false true Reference 43672258 /api/reference/43672258 15. Yu 2013: Vitamin E reduces TGF-beta2-induced changes in human trabecular meshwork cells., Curr. Eye Res., 38, p. 952, DOI: 10.3109/02713683.2013.793360 15 10.3109/02713683.2013.793360 false true Reference 43672259 /api/reference/43672259 16. Junglas 2012: Connective tissue growth factor causes glaucoma by modifying the actin cytoskeleton of the trabecular meshwork., Am. J. Pathol., 180, p. 2386, DOI: 10.1016/j.ajpath.2012.02.030 16 10.1016/j.ajpath.2012.02.030 false true Reference 43672260 /api/reference/43672260 17. Lipson 2012: CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis., Fibrogenesis Tissue Repair, 5, p. S24, DOI: 10.1186/1755-1536-5-S1-S24 17 10.1186/1755-1536-5-S1-S24 false true Reference 43672261 /api/reference/43672261 18. Junglas 2009: Connective tissue growth factor induces extracellular matrix deposition in human trabecular meshwork cells., Exp. Eye Res., 88, p. 1065, DOI: 10.1016/j.exer.2009.01.008 18 10.1016/j.exer.2009.01.008 false true Reference 43672262 /api/reference/43672262 19. Li 2022: TGFβ2 Regulates Human Trabecular Meshwork Cell Contractility via ERK and ROCK Pathways with Distinct Signaling Crosstalk Dependent on the Culture Substrate., Curr. Eye Res., 47, p. 1165, DOI: 10.1080/02713683.2022.2071943 19 10.1080/02713683.2022.2071943 false true Reference 43672263 /api/reference/43672263 20. Buffault, J., Brignole-Baudouin, F., Reboussin, É., Kessal, K., Labbé, A., Mélik Parsadaniantz, S., and Baudouin, C. (2022). The Dual Effect of Rho-Kinase Inhibition on Trabecular Meshwork Cells Cytoskeleton and Extracellular Matrix in an In Vitro Model of Glaucoma. J. Clin. Med., 11., DOI: 10.3390/jcm11041001 20 10.3390/jcm11041001 false true Reference 43672264 /api/reference/43672264 21. Keller 2022: Pathogenesis of glaucoma: Extracellular matrix dysfunction in the trabecular meshwork-A review., Clin. Exp. Ophthalmol., 50, p. 163, DOI: 10.1111/ceo.14027 21 10.1111/ceo.14027 false true Reference 43672265 /api/reference/43672265 22. Kasetti 2017: Increased synthesis and deposition of extracellular matrix proteins leads to endoplasmic reticulum stress in the trabecular meshwork., Sci. Rep., 7, p. 65, DOI: 10.1038/s41598-017-14938-0 22 10.1038/s41598-017-14938-0 false true Reference 43672266 /api/reference/43672266 23. Overby 2014: Ultrastructural changes associated with dexamethasone-induced ocular hypertension in mice., Investig. Ophthalmol. Vis. Sci., 55, p. 4922, DOI: 10.1167/iovs.14-14429 23 10.1167/iovs.14-14429 false true Reference 43672267 /api/reference/43672267 24. Albayrak 2017: Sigma-1 Receptor Agonists and Their Clinical Implications in Neuropsychiatric Disorders., Adv. Exp. Med. Biol., 964, p. 153, DOI: 10.1007/978-3-319-50174-1_11 24 10.1007/978-3-319-50174-1_11 false true Reference 43672268 /api/reference/43672268 25. Ren 2023: Sigma-1 receptor agonist properties that mediate the fast-onset antidepressant effect of hypidone hydrochloride (YL-0919)., Eur. J. Pharmacol., 946, p. 175647, DOI: 10.1016/j.ejphar.2023.175647 25 10.1016/j.ejphar.2023.175647 false true Reference 43672269 /api/reference/43672269 26. Ryskamp 2019: Neuronal Sigma-1 Receptors: Signaling Functions and Protective Roles in Neurodegenerative Diseases., Front. Neurosci., 13, p. 862, DOI: 10.3389/fnins.2019.00862 26 10.3389/fnins.2019.00862 false true Reference 43672270 /api/reference/43672270 27. Hayashi 2011: Targeting ligand-operated chaperone sigma-1 receptors in the treatment of neuropsychiatric disorders., Expert Opin. Ther. Targets, 15, p. 557, DOI: 10.1517/14728222.2011.560837 27 10.1517/14728222.2011.560837 false true Reference 43672271 /api/reference/43672271 28. Omi 2014: Fluvoxamine alleviates ER stress via induction of Sigma-1 receptor., Cell Death Dis., 5, p. e1332, DOI: 10.1038/cddis.2014.301 28 10.1038/cddis.2014.301 false true Reference 43672272 /api/reference/43672272 29. Meng 2017: σ-1 receptor stimulation protects against pressure-induced damage through InsR-MAPK signaling in human trabecular meshwork cells., Mol. Med. Rep., 16, p. 617, DOI: 10.3892/mmr.2017.6647 29 10.3892/mmr.2017.6647 false true Reference 43672273 /api/reference/43672273 30. Ola 2001: Expression pattern of sigma receptor 1 mRNA and protein in mammalian retina., Brain Res. Mol. Brain Res., 95, p. 86, DOI: 10.1016/S0169-328X(01)00249-2 30 10.1016/S0169-328X(01)00249-2 false true Reference 43672274 /api/reference/43672274 31. Bucolo 1999: Sigma Recognition Sites in Rabbit Iris-Ciliary Body: Topical sigmal1-Site Agonists Lower Intraocular Pressure., J. Pharmacol. Exp. Ther., 289, p. 1362 31 false true Reference 43672275 /api/reference/43672275 32. Wang 2006: Silencing of sigma-1 receptor induces cell death in human lens cells., Exp. Cell Res., 312, p. 1439, DOI: 10.1016/j.yexcr.2006.01.004 32 10.1016/j.yexcr.2006.01.004 false true Reference 43672276 /api/reference/43672276 33. Schoenwald 1993: The presence of sigma-receptors in the lacrimal gland., J. Ocul. Pharmacol., 9, p. 125, DOI: 10.1089/jop.1993.9.125 33 10.1089/jop.1993.9.125 false true Reference 43672277 /api/reference/43672277 34. Zhao 2022: Sigma 1 Receptor Contributes to Astrocyte-Mediated Retinal Ganglion Cell Protection., Investig. Ophthalmol. Vis. Sci., 63, p. 1, DOI: 10.1167/iovs.63.2.1 34 10.1167/iovs.63.2.1 false true Reference 43672278 /api/reference/43672278 35. Martin 2004: The sigma receptor ligand (+)−pentazocine prevents apoptotic retinal ganglion cell death induced in vitro by homocysteine and glutamate., Mol. Brain Res., 123, p. 66, DOI: 10.1016/j.molbrainres.2003.12.019 35 10.1016/j.molbrainres.2003.12.019 false true Reference 43672279 /api/reference/43672279 36. Sun 2012: Pregnenolone sulfate decreases intraocular pressure and changes expression of sigma receptor in a model of chronic ocular hypertension., Mol. Biol. Rep., 39, p. 6607, DOI: 10.1007/s11033-012-1491-5 36 10.1007/s11033-012-1491-5 false true Reference 43672280 /api/reference/43672280 37. Zhao 2016: (+)-Pentazocine Reduces NMDA-Induced Murine Retinal Ganglion Cell Death Through a σR1-Dependent Mechanism., Investig. Ophthalmol. Vis. Sci., 57, p. 453, DOI: 10.1167/iovs.15-18565 37 10.1167/iovs.15-18565 false true Reference 43672281 /api/reference/43672281 38. Pang 1994: Preliminary characterization of a transformed cell strain derived from human trabecular meshwork., Curr. Eye Res., 13, p. 51, DOI: 10.3109/02713689409042398 38 10.3109/02713689409042398 false true Reference 43672282 /api/reference/43672282 39. (2023, July 05). Huygens Deconvolution: Restore Microscopy Images. Available online: https://svi.nl/Huygens-Deconvolution. 39 false true Reference 43672283 /api/reference/43672283 40. Tripathi 1994: Aqueous humor in glaucomatous eyes contains an increased level of TGF-beta 2., Exp. Eye Res., 59, p. 723, DOI: 10.1006/exer.1994.1158 40 10.1006/exer.1994.1158 false true Reference 43672284 /api/reference/43672284 41. Keller 2018: Consensus recommendations for trabecular meshwork cell isolation, characterization and culture., Exp. Eye Res., 171, p. 164, DOI: 10.1016/j.exer.2018.03.001 41 10.1016/j.exer.2018.03.001 false true Reference 43672285 /api/reference/43672285 42. Pollard 2009: Actin, a Central Player in Cell Shape and Movement., Science, 326, p. 1208, DOI: 10.1126/science.1175862 42 10.1126/science.1175862 false true Reference 43672286 /api/reference/43672286 43. Cooper, G.M. (2000). The Cell: A Molecular Approach, Sinauer Associates. 43 false true Reference 43672287 /api/reference/43672287 44. Fuchshofer 2014: The Prostaglandin F2α Analog Fluprostenol Attenuates the Fibrotic Effects of Connective Tissue Growth Factor on Human Trabecular Meshwork Cells., J. Ocul. Pharmacol. Ther., 30, p. 237, DOI: 10.1089/jop.2013.0205 44 10.1089/jop.2013.0205 false true Reference 43672288 /api/reference/43672288 45. Aishwarya 2021: Sigmar1’s Molecular, Cellular, and Biological Functions in Regulating Cellular Pathophysiology., Front. Physiol., 12, p. 705575, DOI: 10.3389/fphys.2021.705575 45 10.3389/fphys.2021.705575 false true Reference 43672289 /api/reference/43672289 46. Xu, Z., Lei, Y., Qin, H., Zhang, S., Li, P., and Yao, K. (2022). Sigma-1 Receptor in Retina: Neuroprotective Effects and Potential Mechanisms. Int. J. Mol. Sci., 23., DOI: 10.3390/ijms23147572 46 10.3390/ijms23147572 false true Reference 43672290 /api/reference/43672290 47. Vogler 2016: Sigma-1 receptor activation inhibits osmotic swelling of rat retinal glial (Müller) cells by transactivation of glutamatergic and purinergic receptors., Neurosci. Lett., 610, p. 13, DOI: 10.1016/j.neulet.2015.10.042 47 10.1016/j.neulet.2015.10.042 false true Reference 43672291 /api/reference/43672291 48. Wang 2016: Activation of the molecular chaperone, sigma 1 receptor, preserves cone function in a murine model of inherited retinal degeneration., Proc. Natl. Acad. Sci. USA, 113, p. E3764 48 false true Reference 43672292 /api/reference/43672292 49. Mueller 2014: Sigma-1 receptor stimulation protects retinal ganglion cells from ischemia-like insult through the activation of extracellular-signal-regulated kinases 1/2., Exp. Eye Res., 128, p. 156, DOI: 10.1016/j.exer.2014.10.007 49 10.1016/j.exer.2014.10.007 false true Reference 43672293 /api/reference/43672293 50. Fuchshofer 2003: The effect of TGF-beta2 on human trabecular meshwork extracellular proteolytic system., Exp. Eye Res., 77, p. 757, DOI: 10.1016/S0014-4835(03)00220-3 50 10.1016/S0014-4835(03)00220-3 false true /api/publication/34069454 Tran Minh Ngoc et al. Sigma-1 Receptor Activation Is Protective against TGFβ2-Induced Extracellular Matrix Changes in Human Trabecular Meshwork Cells. (2023) LIFE-BASEL 2075-1729 13 7<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10071676"><a href="/gui2/?type=authors&mode=browse&sel=10071676" target="_blank">Tran Minh Ngoc (<span class="authorship-author-name">Tran Ngoc Minh</span> <span class="authorAux-mtmt"> clinical medicine</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Gyermekgyógyászati Klinika">GYGYK</span>/MTA-SE Lendület Diabétesz Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10080260"><a href="/gui2/?type=authors&mode=browse&sel=10080260" target="_blank">Medveczki Timea (<span class="authorship-author-name">Medveczki Tímea</span> <span class="authorAux-mtmt"> molekuláris biológia, szemészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Gyermekgyógyászati Klinika">GYGYK</span>/MTA-SE Lendület Diabétesz Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10068063"><a href="/gui2/?type=authors&mode=browse&sel=10068063" target="_blank">Besztercei Balazs (<span class="authorship-author-name">Besztercei Balázs</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10035824"><a href="/gui2/?type=authors&mode=browse&sel=10035824" target="_blank">Torok Gyorgy (<span class="authorship-author-name">Török György</span> <span class="authorAux-mtmt"> Biofizika, Sejt- és fejlődésbiológia,</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Biofizikai és Sugárbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015517"><a href="/gui2/?type=authors&mode=browse&sel=10015517" target="_blank">Szabo Attila J. (<span class="authorship-author-name">Szabó Attila</span> <span class="authorAux-mtmt"> Gyermekgyógyászat, nephrologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gasull Xavier </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025486"><a href="/gui2/?type=authors&mode=browse&sel=10025486" target="_blank">Kovacs Illes (<span class="authorship-author-name">Kovács Illés</span> <span class="authorAux-mtmt"> Szemészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Szemészeti Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011883"><a href="/gui2/?type=authors&mode=browse&sel=10011883" target="_blank">Fekete Andrea ✉ (<span class="authorship-author-name">Fekete Andrea</span> <span class="authorAux-mtmt"> nefrológia, gyermekgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Gyermekgyógyászati Klinika">GYGYK</span>/MTA-SE Lendület Diabétesz Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032759"><a href="/gui2/?type=authors&mode=browse&sel=10032759" target="_blank">Hodrea Judit (<span class="authorship-author-name">Hodrea Judit</span> <span class="authorAux-mtmt"> szemészet, diabetológia, nephrologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Gyermekgyógyászati Klinika">GYGYK</span>/MTA-SE Lendület Diabétesz Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34069454" target="_blank">Sigma-1 Receptor Activation Is Protective against TGFβ2-Induced Extracellular Matrix Changes in Human Trabecular Meshwork Cells</a></div> <div> <span class="journal-title">LIFE-BASEL</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2075-1729">2075-1729</a>)</span>: <span class="journal-volume">13</span> <span class="journal-issue">7</span> <span class="page"> Paper 1581. 13 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/life13071581" target="_blank" href="https://doi.org/10.3390/life13071581"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001037346600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001037346600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85166358577" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85166358577"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37511956" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37511956&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Paleontology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Ecology, Evolution, Behavior and Systematics&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Space and Planetary Science&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 7</span> | Független: 4 | Függő: 3 | Nem jelölt: 0 | WoS jelölt: 7 | Scopus jelölt:&nbsp;6 | WoS/Scopus jelölt:&nbsp;7 | DOI jelölt:&nbsp;7 </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34069454</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> OTKA(K135398), (LP2021-3/2021), Thematic Institutional Excellence Programme(TKP2021-EGA-24) Támogató: Emberi Erőforrások Minisztériuma </div> <div class="lastModified">Utolsó módosítás: 2023.08.25. 10:39 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> <div class="lockedBy">Központi kezelésű 2025.12.18. 15:33 Wolf György (MTMT Központi admin) </div> </div></div>