https://m2.mtmt.hu/ hun 2026-10-26 08:04 JournalArticle 34069251 VALIDATED true 0 false 2026-10-23T16:41:42.822+0000 2024-06-12T08:26:53.877+0000 2023-07-20T06:33:03.049+0000 true 10015206 Áncsán Gizella /api/admin/10015206 Admin Áncsán Gizella (SE admin) true 10015206 2025-07-29T08:46:08.813+0000 2025-07-29T08:46:08.813+0000 2024-06-12T08:26:53.890+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) true Admin 10003134 /api/admin/10003134 Wolf György (MTMT Központi admin) Wolf György true 10003134 true 2025-12-18T14:33:13.723+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Hodrea, Judit true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 24 14 11646 11646 15 2023 Primary open-angle glaucoma remains a global issue, lacking a definitive treatment. Increased intraocular pressure (IOP) is considered the primary risk factor of the disease and it can be caused by fibrotic-like changes in the trabecular meshwork (TM) such as increased tissue stiffness and outflow resistance. Previously, we demonstrated that the sigma-1 receptor (S1R) agonist fluvoxamine (FLU) has anti-fibrotic properties in the kidney and lung. In this study, the localization of the S1R in TM cells was determined, and the anti-fibrotic efficacy of FLU was examined in both mouse and human TM cells. Treatment with FLU reduced the F-actin rearrangement, inhibited cell proliferation and migration induced by the platelet-derived growth factor and decreased the levels of fibrotic proteins. The protective role of the S1R in fibrosis was confirmed by a more pronounced increase in alpha smooth muscle actin and F-actin bundle and clump formation in primary mouse S1R knockout TM cells. Furthermore, FLU demonstrated its protective effects by increasing the production of nitric oxide and facilitating the degradation of the extracellular matrix through the elevation of cathepsin K. These findings suggest that the S1R could be a novel target for the development of anti-fibrotic drugs and offer a new therapeutic approach for glaucoma. Funding 2029094 /api/funding/2029094 OTKA(K135398) false true Funding 2029095 /api/funding/2029095 (LP2021-3/2021) false true Funding 2029096 /api/funding/2029096 Thematic Institutional Excellence Programme(TKP2021-EGA-24) Támogató: Emberi Erőforrások Minisztériuma false true true 2023 true true true false true false GOLD 2026-10-23 false http://www.mdpi.com/journal/ijms 10 0 9 5 4 9 9 8 8 8 8 4 4 5 5 0 10 5 9 5 0 0 0 Folyóiratcikk Journal Article 24 9 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 1 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 1 0 1 0 2024 0 2 1 2 1 2025 0 4 3 4 3 2026 0 3 1 3 1 D1 false 10003054,10011883,10032759 false false false 2023-07-19T08:03:57.479+0000 Gyermekgyógyászati Klinika (SE / AOK / K); Gyógyszerészi Kémiai Intézet (SE / GYTK); MTA-SE Lendület Diabétesz Kutatócsoport (SE / AOK / K / GYGYK); Szemészeti Klinika (SE / AOK / K); Szemészeti Klinikai Ismeretek Tanszék (SE / ETK2007); Transzlációs Medicina Intézet (SE / AOK / I) 8 31 6 8 0 true 10003134 Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 109331122 /api/authorship/109331122 Hodrea, Judit [Hodrea, Judit (szemészet, diabet...), szerző] MTA-SE Lendület Diabétesz Kutatócsoport (SE / AOK / K / GYGYK); Gyermekgyógyászati Klinika (SE / AOK / K) 1 0.125 true false false Author 10032759 /api/author/10032759 Hodrea Judit (szemészet, diabetológia, nephrologia) Hodrea Judit true 10032759 true Hodrea Judit true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109331123 /api/authorship/109331123 Tran, Minh Ngoc ✉ [Tran, Ngoc Minh (clinical medicine), szerző] MTA-SE Lendület Diabétesz Kutatócsoport (SE / AOK / K / GYGYK); Gyermekgyógyászati Klinika (SE / AOK / K) 2 0.125 false false true Author 10071676 /api/author/10071676 Tran Ngoc Minh (clinical medicine) Tran Ngoc Minh true true Tran Minh Ngoc true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109331124 /api/authorship/109331124 Besztercei, Balazs [Besztercei, Balázs (Élettan), szerző] Transzlációs Medicina Intézet (SE / AOK / I) 3 0.125 false false false Author 10068063 /api/author/10068063 Besztercei Balázs (Élettan) Besztercei Balázs true true Besztercei Balazs true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109331125 /api/authorship/109331125 Medveczki, Timea [Medveczki, Tímea (molekuláris bioló...), szerző] MTA-SE Lendület Diabétesz Kutatócsoport (SE / AOK / K / GYGYK); Gyermekgyógyászati Klinika (SE / AOK / K) 4 0.125 false false false Author 10080260 /api/author/10080260 Medveczki Tímea (molekuláris biológia, szemészet) Medveczki Tímea true true Medveczki Timea true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109331126 /api/authorship/109331126 Szabo, Attila J. [Szabó, Attila (Gyermekgyógyászat...), szerző] Gyermekgyógyászati Klinika (SE / AOK / K) 5 0.125 false false false Author 10015517 /api/author/10015517 Szabó Attila (Gyermekgyógyászat, nephrologia) Szabó Attila true 10015517 true Szabo Attila J. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109331127 /api/authorship/109331127 Őrfi, Laszlo [Őrfi, László (Szerves- és Gyógy...), szerző] Gyógyszerészi Kémiai Intézet (SE / GYTK) 6 0.125 false false false Author 10003054 /api/author/10003054 Őrfi László (Szerves- és Gyógyszerkémia) Őrfi László true 10003054 true Őrfi Laszlo true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109331128 /api/authorship/109331128 Kovacs, Illes [Kovács, Illés (Szemészet), szerző] Szemészeti Klinika (SE / AOK / K); Szemészeti Klinikai Ismeretek Tanszék (SE / ETK2007) 7 0.125 false false false Author 10025486 /api/author/10025486 Kovács Illés (Szemészet) Kovács Illés true 10025486 true Kovacs Illes true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109331129 /api/authorship/109331129 Fekete, Andrea ✉ [Fekete, Andrea (nefrológia, gyerm...), szerző] MTA-SE Lendület Diabétesz Kutatócsoport (SE / AOK / K / GYGYK); Gyermekgyógyászati Klinika (SE / AOK / K) 8 0.125 false true true Author 10011883 /api/author/10011883 Fekete Andrea (nefrológia, gyermekgyógyászat) Fekete Andrea true 10011883 true Fekete Andrea true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 24183845 /api/publicationidentifier/24183845 DOI: 10.3390/ijms241411646 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3390/ijms241411646 https://doi.org/10.3390/ijms241411646 false true PublicationIdentifier 24246597 /api/publicationidentifier/24246597 WoS: 001036205200001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001036205200001 https://www.webofscience.com/wos/woscc/full-record/001036205200001 true true PublicationIdentifier 24246598 /api/publicationidentifier/24246598 Scopus: 85166231208 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85166231208 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85166231208 true true PublicationIdentifier 24246596 /api/publicationidentifier/24246596 PubMed: 37511406 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37511406 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37511406&dopt=Abstract true true SjrRating 11388415 /api/sjrrating/11388415 sjr:D1 (2023) Scopus - Inorganic Chemistry INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 7 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1604 /api/classificationexternal/1604 Scopus - Inorganic Chemistry true 1604 true D1 DIRECT true true Reference 43668723 /api/reference/43668723 1. 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(2023) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 24 14<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10032759"><a href="/gui2/?type=authors&mode=browse&sel=10032759" target="_blank">Hodrea Judit (<span class="authorship-author-name">Hodrea Judit</span> <span class="authorAux-mtmt"> szemészet, diabetológia, nephrologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Gyermekgyógyászati Klinika">GYGYK</span>/MTA-SE Lendület Diabétesz Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071676"><a href="/gui2/?type=authors&mode=browse&sel=10071676" target="_blank">Tran Minh Ngoc ✉ (<span class="authorship-author-name">Tran Ngoc Minh</span> <span class="authorAux-mtmt"> clinical medicine</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Gyermekgyógyászati Klinika">GYGYK</span>/MTA-SE Lendület Diabétesz Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10068063"><a href="/gui2/?type=authors&mode=browse&sel=10068063" target="_blank">Besztercei Balazs (<span class="authorship-author-name">Besztercei Balázs</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10080260"><a href="/gui2/?type=authors&mode=browse&sel=10080260" target="_blank">Medveczki Timea (<span class="authorship-author-name">Medveczki Tímea</span> <span class="authorAux-mtmt"> molekuláris biológia, szemészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Gyermekgyógyászati Klinika">GYGYK</span>/MTA-SE Lendület Diabétesz Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015517"><a href="/gui2/?type=authors&mode=browse&sel=10015517" target="_blank">Szabo Attila J. (<span class="authorship-author-name">Szabó Attila</span> <span class="authorAux-mtmt"> Gyermekgyógyászat, nephrologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003054"><a href="/gui2/?type=authors&mode=browse&sel=10003054" target="_blank">Őrfi Laszlo (<span class="authorship-author-name">Őrfi László</span> <span class="authorAux-mtmt"> Szerves- és Gyógyszerkémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészi Kémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025486"><a href="/gui2/?type=authors&mode=browse&sel=10025486" target="_blank">Kovacs Illes (<span class="authorship-author-name">Kovács Illés</span> <span class="authorAux-mtmt"> Szemészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Szemészeti Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Egészségtudományi Kar">ETK2007</span>/Szemészeti Klinikai Ismeretek Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011883"><a href="/gui2/?type=authors&mode=browse&sel=10011883" target="_blank">Fekete Andrea ✉ (<span class="authorship-author-name">Fekete Andrea</span> <span class="authorAux-mtmt"> nefrológia, gyermekgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Gyermekgyógyászati Klinika">GYGYK</span>/MTA-SE Lendület Diabétesz Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34069251" target="_blank">Sigma-1 Receptor Agonist Fluvoxamine Ameliorates Fibrotic Response of Trabecular Meshwork Cells</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">24</span> <span class="journal-issue">14</span> <span class="page"> Paper 11646. 15 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/ijms241411646" target="_blank" href="https://doi.org/10.3390/ijms241411646"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001036205200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001036205200001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85166231208" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85166231208"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37511406" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37511406&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 10</span> | Független: 5 | Függő: 5 | Nem jelölt: 0 | WoS jelölt: 8 | Scopus jelölt:&nbsp;8 | WoS/Scopus jelölt:&nbsp;8 | DOI jelölt:&nbsp;9 </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34069251</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> OTKA(K135398), (LP2021-3/2021), Thematic Institutional Excellence Programme(TKP2021-EGA-24) Támogató: Emberi Erőforrások Minisztériuma </div> <div class="lastModified">Utolsó módosítás: 2024.06.12. 10:26 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> <div class="lockedBy">Központi kezelésű 2025.12.18. 15:33 Wolf György (MTMT Központi admin) </div> </div></div>