https://m2.mtmt.hu/ hun 2026-09-22 04:40 JournalArticle 34060763 VALIDATED true 0 false 2026-05-23T02:16:57.078+0000 2024-04-17T14:11:14.050+0000 2023-07-13T08:51:16.045+0000 true 221 Polony Gábor /api/author/221 Author Polony Gábor (Fül-orr-gégészet) true 221 2026-05-21T09:12:55.257+0000 2026-05-21T09:12:55.257+0000 2024-04-17T14:11:14.302+0000 true 10025544 Lévayné Deseő Katalin /api/admin/10025544 Admin Lévayné Deseő Katalin (MTMT Központi admin) true 10025544 Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin (MTMT Központi admin) Lévayné Deseő Katalin true 10025544 true 2024-04-17T14:11:18.377+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Moysan, Louise true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 24 13 11095 11095 21 2023 ATP, as a paracrine signalling molecule, induces intracellular Ca2+ elevation via the activation of purinergic receptors on the surface of glia-like cochlear supporting cells. These cells, including the Deiters’ cells (DCs), are also coupled by gap junctions that allow the propagation of intercellular Ca2+ waves via diffusion of Ca2+ mobilising second messenger IP3 between neighbouring cells. We have compared the ATP-evoked Ca2+ transients and the effect of two different gap junction (GJ) blockers (octanol and carbenoxolone, CBX) on the Ca2+ transients in DCs located in the apical and middle turns of the hemicochlea preparation of BALB/c mice (P14–19). Octanol had no effect on Ca2+ signalling, while CBX inhibited the ATP response, more prominently in the middle turn. Based on astrocyte models and using our experimental results, we successfully simulated the Ca2+ dynamics in DCs in different cochlear regions. The mathematical model reliably described the Ca2+ transients in the DCs and suggested that the tonotopical differences could originate from differences in purinoceptor and Ca2+ pump expressions and in IP3–Ca2+ release mechanisms. The cochlear turn-dependent effect of CBX might be the result of the differing connexin isoform composition of GJs along the tonotopic axis. The contribution of IP3-mediated Ca2+ signalling inhibition by CBX cannot be excluded. Funding 2029223 /api/funding/2029223 Országos Tudományos Kutatási Alapprogramok(K128875) false true Funding 2039147 /api/funding/2039147 Hungarian Scientific Research Fund(NKFI K128875) false true Funding 2029224 /api/funding/2029224 (TKP2021-EGA-23) Támogató: Innovációs és Technológiai Minisztérium false true Funding 2029225 /api/funding/2029225 (TKP2021-EGA-25) false true true true 2023 true true true false true false GOLD 2026-05-23 true https://doi.org/10.3390/ijms241311095 3 0 3 3 0 3 3 2 3 3 3 3 3 3 0 0 3 3 3 3 0 4 4 Folyóiratcikk Journal Article 24 3 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 2 2 2 2 2025 0 1 1 1 1 D1 false false false false 2023-07-24T10:37:47.012+0000 Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I); Molekuláris Farmakológia Kutatócsoport (HRN KOKI); Orálbiológiai Tanszék (SE / FOK); Ökológiai Tanszék (ÁTE / BI) 3 23 4 6 0 true 10025544 Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 109264002 /api/authorship/109264002 Moysan, Louise 1 0.167 true false false Moysan Louise true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109264003 /api/authorship/109264003 Fazekas, Fruzsina 2 0.16666667 false false false Fazekas Fruzsina true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109264004 /api/authorship/109264004 Fekete, Adam 3 0.16666667 false false false Fekete Adam true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109264005 /api/authorship/109264005 Köles, László [Köles, László (Farmakológia), szerző] Orálbiológiai Tanszék (SE / FOK); Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I) 4 0.167 false false false Author 10015482 /api/author/10015482 Köles László (Farmakológia) Köles László true 10015482 true Köles László true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109264006 /api/authorship/109264006 Zelles, Tibor** [Zelles, Tibor (Idegtudományok), szerző] Orálbiológiai Tanszék (SE / FOK); Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I); Molekuláris Farmakológia Kutatócsoport (HRN KOKI) 5 0.167 false true false Author 10000028 /api/author/10000028 Zelles Tibor (Idegtudományok) Zelles Tibor true 10000028 true Zelles Tibor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109264007 /api/authorship/109264007 Berekméri, Eszter ✉ [Berekméri, Eszter, szerző] Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I); Ökológiai Tanszék (ÁTE / BI) 6 0.167 false true true Author 10052116 /api/author/10052116 Berekméri Eszter Berekméri Eszter true 10052116 true Berekméri Eszter true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 24156190 /api/publicationidentifier/24156190 DOI: 10.3390/ijms241311095 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms241311095 https://doi.org/10.3390/ijms241311095 false true PublicationIdentifier 24217862 /api/publicationidentifier/24217862 REAL: 170696 SwordSource 36 /api/publicationsource/36 REAL PublicationSourceType 10007 /api/publicationsourcetype/10007 Repozitórium true true true REAL REAL http://real.mtak.hu/@@@ true true 36 true GOLD true IDENTICAL 170696 http://real.mtak.hu/170696 false true PublicationIdentifier 24247137 /api/publicationidentifier/24247137 WoS: 001030099500001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001030099500001 https://www.webofscience.com/wos/woscc/full-record/001030099500001 true true PublicationIdentifier 24200538 /api/publicationidentifier/24200538 Scopus: 85164845618 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85164845618 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85164845618 true true PublicationIdentifier 24156191 /api/publicationidentifier/24156191 PubMed: 37446272 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37446272 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37446272&dopt=Abstract false true Keyword 1004101 /api/keyword/1004101 computational model true 1004101 true Keyword 1013042 /api/keyword/1013042 octanol true 1013042 true Keyword 1019357 /api/keyword/1019357 Ca2+ imaging true 1019357 true Keyword 1159333 /api/keyword/1159333 Calcium signalling true 1159333 true Keyword 1454470 /api/keyword/1454470 GAP-JUNCTION true 1454470 true Keyword 1510558 /api/keyword/1510558 single-cell electroporation true true Keyword 1675052 /api/keyword/1675052 tonotopy true true Keyword 1762436 /api/keyword/1762436 DCs true true Keyword 2110975 /api/keyword/2110975 CBX true true SjrRating 11388415 /api/sjrrating/11388415 sjr:D1 (2023) Scopus - Inorganic Chemistry INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 7 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1604 /api/classificationexternal/1604 Scopus - Inorganic Chemistry true 1604 true D1 DIRECT true true Reference 43366787 /api/reference/43366787 1. 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Ca2+ Dynamics of Gap Junction Coupled and Uncoupled Deiters’ Cells in the Organ of Corti in Hearing BALB/c Mice. (2023) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 24 13<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Moysan Louise </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Fazekas Fruzsina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Fekete Adam </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015482"><a href="/gui2/?type=authors&mode=browse&sel=10015482" target="_blank">Köles László (<span class="authorship-author-name">Köles László</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Orálbiológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000028"><a href="/gui2/?type=authors&mode=browse&sel=10000028" target="_blank">Zelles Tibor^** (<span class="authorship-author-name">Zelles Tibor</span> <span class="authorAux-mtmt"> Idegtudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Orálbiológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet; <span title="Kísérleti Orvostudományi Kutatóintézet">KOKI</span>/Molekuláris Farmakológia Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052116"><a href="/gui2/?type=authors&mode=browse&sel=10052116" target="_blank">Berekméri Eszter ✉ (<span class="authorship-author-name">Berekméri Eszter</span> <span class="authorAux-mtmt"> </span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet; <span title="Állatorvostudományi Egyetem">ÁTE</span>/<span title="Biológiai Intézet">BI</span>/Ökológiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34060763" target="_blank">Ca2+ Dynamics of Gap Junction Coupled and Uncoupled Deiters’ Cells in the Organ of Corti in Hearing BALB/c Mice</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">24</span> <span class="journal-issue">13</span> <span class="page"> Paper 11095. 21 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms241311095" target="_blank" href="https://doi.org/10.3390/ijms241311095"> DOI </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="170696" target="_blank" href="http://real.mtak.hu/170696"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001030099500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001030099500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85164845618" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85164845618"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37446272" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37446272&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 3</span> | Független: 3 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 2 | Scopus jelölt:&nbsp;3 | WoS/Scopus jelölt:&nbsp;3 | DOI jelölt:&nbsp;3 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34060763&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34060763</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Országos Tudományos Kutatási Alapprogramok(K128875), Hungarian Scientific Research Fund(NKFI K128875), (TKP2021-EGA-23) Támogató: Innovációs és Technológiai Minisztérium, (TKP2021-EGA-25) </div> <div class="lastModified">Utolsó módosítás: 2024.04.17. 16:11 Lévayné Deseő Katalin (MTMT Központi admin) </div> <div class="lockedBy">Központi kezelésű 2024.04.17. 16:11 Lévayné Deseő Katalin (MTMT Központi admin) </div> </div></div>