https://m2.mtmt.hu/ hun 2026-09-20 23:42 JournalArticle 34056508 VALIDATED true Department of Cardiovascular and Thoracic Surgery, West Virginia University, 1 Medical Center Drive, Morgantown, WV 26506, United States University of Chicago Medicine, Chicago, United States Medical College of Wisconsin, Milwaukee, United States Franciscan Health Indianapolis, Indianapolis, United States CytoSorbents Europe, Berlin, Germany Semmelweis University, Budapest, Hungary CytoSorbents Corporation, Princeton, United States New York University School of Medicine, New York, United States Cited By :13 Export Date: 19 December 2024 CODEN: CRCAF Correspondence Address: Hayanga, J.W.A.; Department of Cardiovascular and Thoracic Surgery, 1 Medical Center Drive, United States; email: jeremiah.hayanga@wvumedicine.org Tradenames: CytoSorb, CytoSorbents, United States Manufacturers: CytoSorbents; CytoSorbents, United States Funding text 1: The study was sponsored by CytoSorbents Inc. US Monmouth Junction NJ, USA. 0 false 2026-09-13T22:48:09.595+0000 2024-12-06T18:04:50.346+0000 2023-07-11T07:59:49.500+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin Molnár-Taga Márta (SE 4-es admin) true 10062250 2026-02-19T12:17:00.110+0000 2026-02-19T12:17:00.110+0000 2024-12-06T18:04:50.525+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin Milánkovics Róbert (PTE ÁOK admin 4) true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Hayanga, J.W.A. true true /api/journal/33611 REVIEWED CRITICAL CARE 1364-8535 1466-609X true false 33611 false 33611 true 1364-8535 1466-609X Journal FOREIGN 27 1 243 243 9 2023 Objectives: The CytoSorb therapy in COVID-19 (CTC) registry evaluated the clinical performance and treatment parameters of extracorporeal hemoadsorption integrated with veno-venous extracorporeal membrane oxygenation (VV ECMO) in critically ill COVID-19 patients with acute respiratory distress syndrome (ARDS) and respiratory failure under US FDA Emergency Use Authorization. Design: Multicenter, observational, registry (NCT04391920). Setting: Intensive care units (ICUs) in five major US academic centers between April 2020 and January 2022. Patients: A total of 100 critically ill adults with COVID-19-related ARDS requiring VV ECMO support, who were treated with extracorporeal hemoadsorption. Interventions: None. Measurements and main results: Baseline demographics, clinical characteristics, laboratory values and outcomes were recorded following individual ethics committee approval at each center. Detailed data on organ support utilization parameters and hemoadsorption treatments were also collected. Biomarker data were collected according to the standard practice at each participating site, and available values were compared before and after hemoadsorption. The primary outcome of mortality was evaluated using a time-to-event analysis. A total of 100 patients (63% male; age 44 ± 11 years) were included. Survival rates were 86% at 30 days and 74% at 90 days. Median time from ICU admission to the initiation of hemoadsorption was 87 h and was used to define two post hoc groups: ≤ 87 h (group-early start, G E) and > 87 h (group-late start, G L). After the start of hemoadsorption, patients in the G E versus G L had significantly shorter median duration of mechanical ventilation (7 [2–26] vs. 17 [7–37] days, p = 0.02), ECMO support (13 [8–24] vs. 29 [14–38] days, p = 0.021) and ICU stay (17 [10–40] vs 36 [19–55] days, p = 0.002). Survival at 90 days in G E was 82% compared to 66% in GL (p = 0.14). No device-related adverse events were reported. Conclusions: In critically ill patients with severe COVID-19-related ARDS treated with the combination of VV-ECMO and hemoadsorption, 90-day survival was 74% and earlier intervention was associated with shorter need for organ support and ICU stay. These results lend support to the concept of “enhanced lung rest” with the combined use of VV-ECMO plus hemoadsorption in patients with ARDS. © 2023, The Author(s). true true 2023 true true true false true false GOLD 2026-09-14 true https://doi.org/10.1186/s13054-023-04517-3 23 0 23 18 2 23 23 19 23 23 23 18 18 18 5 0 23 18 23 18 0 2 2 Folyóiratcikk Journal Article 24 23 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 6 4 6 4 2024 0 8 6 8 6 2025 0 7 6 7 6 2026 0 2 2 2 2 D1 false 10001298 false false false 2023-07-10T08:03:10.634+0000 Transzlációs Medicina Központ (SE / KSZE) 1 20 1 9 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 109233185 /api/authorship/109233185 Hayanga, J.W.A. ✉ 1 0.11111111 true false true Hayanga J.W.A. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109233186 /api/authorship/109233186 Song, T. 2 0.11111111 false false false Song T. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109233187 /api/authorship/109233187 Durham, L. 3 0.11111111 false false false Durham L. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109233188 /api/authorship/109233188 Garrison, L. 4 0.11111111 false false false Garrison L. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109233189 /api/authorship/109233189 Smith, D. 5 0.11111111 false false false Smith D. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109233190 /api/authorship/109233190 Molnar, Z. [Molnár, Zsolt (Klinikai orvostud...), szerző] Transzlációs Medicina Központ (SE / KSZE) 6 0.111 false false false Author 10001298 /api/author/10001298 Molnár Zsolt (Klinikai orvostudományok - aneszteziológia és intenzív terápia) Molnár Zsolt true 10001298 true Molnar Z. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109233191 /api/authorship/109233191 Scheier, J. 7 0.11111111 false false false Scheier J. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109233192 /api/authorship/109233192 Deliargyris, E.N. 8 0.11111111 false false false Deliargyris E.N. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109233193 /api/authorship/109233193 Moazami, N. 9 0.11111111 false true false Moazami N. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 24143104 /api/publicationidentifier/24143104 DOI: 10.1186/s13054-023-04517-3 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1186/s13054-023-04517-3 https://doi.org/10.1186/s13054-023-04517-3 false true PublicationIdentifier 24208907 /api/publicationidentifier/24208907 WoS: 001015040700002 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001015040700002 https://www.webofscience.com/wos/woscc/full-record/001015040700002 true true PublicationIdentifier 24143103 /api/publicationidentifier/24143103 Scopus: 85162631716 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85162631716 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85162631716 false true PublicationIdentifier 24208912 /api/publicationidentifier/24208912 PubMed: 37337243 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37337243 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37337243&dopt=Abstract true true Keyword 64 /api/keyword/64 Inflammation true 64 true Keyword 2591 /api/keyword/2591 MORTALITY true 2591 true Keyword 1837371 /api/keyword/1837371 Hemoadsorption true true Keyword 1844005 /api/keyword/1844005 Cytosorb true true Keyword 1848134 /api/keyword/1848134 hemoperfusion true true Keyword 2296541 /api/keyword/2296541 ARDS—acute respiratory distress syndrome true true Keyword 2643410 /api/keyword/2643410 Coronavirus-COVID-19 true true Keyword 3133496 /api/keyword/3133496 ECMO—Extracorporeal membrane oxygenation true true Keyword 3133497 /api/keyword/3133497 ICU—Intensive care unit true true SjrRating 11367721 /api/sjrrating/11367721 sjr:D1 (2023) Scopus - Critical Care and Intensive Care Medicine CRITICAL CARE 1364-8535 1466-609X 3 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2706 /api/classificationexternal/2706 Scopus - Critical Care and Intensive Care Medicine true 2706 true D1 DIRECT true true Reference 43264555 /api/reference/43264555 1. 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(2023) CRITICAL CARE 1364-8535 1466-609X 27 1<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Hayanga J.W.A. ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Song T. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Durham L. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Garrison L. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Smith D. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001298"><a href="/gui2/?type=authors&mode=browse&sel=10001298" target="_blank">Molnar Z. (<span class="authorship-author-name">Molnár Zsolt</span> <span class="authorAux-mtmt"> Klinikai orvostudományok - aneszteziológia és i...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Transzlációs Medicina Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Scheier J. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Deliargyris E.N. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Moazami N. </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34056508" target="_blank">Extracorporeal hemoadsorption in critically ill COVID-19 patients on VV ECMO: the CytoSorb therapy in COVID-19 (CTC) registry</a></div> <div> <span class="journal-title">CRITICAL CARE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1364-8535">1364-8535</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1466-609X">1466-609X</a>)</span>: <span class="journal-volume">27</span> <span class="journal-issue">1</span> <span class="page"> Paper 243. 9 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1186/s13054-023-04517-3" target="_blank" href="https://doi.org/10.1186/s13054-023-04517-3"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001015040700002" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001015040700002"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85162631716" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85162631716"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37337243" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37337243&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Critical Care and Intensive Care Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 23</span> | Független: 18 | Függő: 5 | Nem jelölt: 0 | WoS jelölt: 19 | Scopus jelölt:&nbsp;23 | WoS/Scopus jelölt:&nbsp;23 | DOI jelölt:&nbsp;23 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34056508&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34056508</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="lastModified">Utolsó módosítás: 2024.12.06. 19:04 Milánkovics Róbert (PTE ÁOK admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Cardiovascular and Thoracic Surgery, West Virginia University, 1 Medical Center Drive, Morgantown, WV 26506, United States University of Chicago Medicine, Chicago, United States Medical College of Wisconsin, Milwaukee, United States Franciscan Health Indianapolis, Indianapolis, United States ...</pre> </div></div>