https://m2.mtmt.hu/ hun 2026-09-23 03:35 JournalArticle 34049652 VALIDATED true 0 false 2026-07-27T13:23:20.111+0000 2026-06-01T06:52:10.033+0000 2023-07-06T22:03:49.028+0000 true 10019974 xSzűts xFerencné /api/admin/10019974 Admin xSzűts xFerencné (xSE_AOK_2Gyerek_Admin5_SzFné, admin) true 10019974 2026-06-01T06:52:01.480+0000 2026-06-01T06:52:01.480+0000 2026-06-01T06:52:10.041+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin Molnár-Taga Márta (SE 4-es admin) true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Müller, Judit true true /api/journal/10071196 REVIEWED CHILDREN (BASEL) 2227-9067 true false 10071196 false 10071196 true 2227-9067 Journal FOREIGN 10 7 1160 1160 7 2023 Background: Asparaginase is a key component of chemotherapy protocols for the treatment of lymphoblastic malignancies among children. Adequate asparagine depletion is an important factor to achieve optimal therapeutic outcomes. Methods: Over a 3.5 year period, 106 patients were monitored for asparaginase activity (329 samples) in a single center of the Hungarian Pediatric Oncology–Hematology Group. In Hungary, three asparaginase products are available: native E. coli ASNase (Kidrolase), a pegylated form of this enzyme (Pegaspargase) and another native product from Erwinia chrysanthemi (Erwinase). A retrospective data analysis was performed. Results: In 81% (268/329) of our patients, AEA levels were in the optimal therapeutic range of over 100 IU/L. Of 106 patients, 13 (12%) were diagnosed with ‘silent inactivation’. Conclusions: Monitoring of AEA can help to identify patients with ‘silent inactivation’ and their asparaginase therapy can thus be optimized. true 2023 true true true false true false GOLD 2026-07-27 true https://doi.org/10.3390/children10071160 5 0 5 5 0 5 5 5 5 5 5 5 5 5 0 0 5 5 5 5 0 0 0 Folyóiratcikk Journal Article 24 5 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 3 3 3 3 2025 0 2 2 2 2 Q2 false false false false 2023-08-09T07:37:31.576+0000 Gyermekgyógyászati Klinika (SE / AOK / K); II. Sz. Gyermekgyógyászati Klinika (SE / AOK / K); Laboratóriumi Medicina Intézet (SE / AOK / I) 7 16 3 8 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 109173314 /api/authorship/109173314 Müller, Judit ✉ [Müller, Judit (Csecsemő- és gyer...), szerző] II. Sz. Gyermekgyógyászati Klinika (SE / AOK / K); Gyermekgyógyászati Klinika (SE / AOK / K) 1 0.125 true false true Author 10023438 /api/author/10023438 Müller Judit (Csecsemő- és gyermekgyógyászat, Gyermek hemato-onkológia) Müller Judit DUPLUM true 10023438 true Müller Judit true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109173315 /api/authorship/109173315 Egyed, Petra 2 0.125 false false false Egyed Petra true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109173316 /api/authorship/109173316 Erdelyi, Daniel [Erdélyi, Dániel (Gyermekgyógyászat), szerző] Gyermekgyógyászati Klinika (SE / AOK / K) 3 0.125 false false false Author 10023613 /api/author/10023613 Erdélyi Dániel (Gyermekgyógyászat) Erdélyi Dániel true 10023613 true Erdelyi Daniel true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109173317 /api/authorship/109173317 Kovacs, Krisztian [Kovács, Krisztián (Molekuláris biológia), szerző] Laboratóriumi Medicina Intézet (SE / AOK / I) 4 0.125 false false false Author 10033055 /api/author/10033055 Kovács Krisztián (Molekuláris biológia) Kovács Krisztián true 10033055 true Kovacs Krisztian true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109173318 /api/authorship/109173318 Mudra, Katalin [Mudra, Katalin (Gyermekgyógyászat), szerző] II. Sz. Gyermekgyógyászati Klinika (SE / AOK / K); Gyermekgyógyászati Klinika (SE / AOK / K) 5 0.125 false false false Author 10081122 /api/author/10081122 Mudra Katalin (Gyermekgyógyászat) Mudra Katalin true true Mudra Katalin true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109173319 /api/authorship/109173319 Szabo, Sandor [Szabó, Sándor (Gyermekgyógyászat...), szerző] II. Sz. Gyermekgyógyászati Klinika (SE / AOK / K); Gyermekgyógyászati Klinika (SE / AOK / K) 6 0.125 false false false Author 10088020 /api/author/10088020 Szabó Sándor (Gyermekgyógyászat, Gyermek Hemato-Onkológia) Szabó Sándor true true Szabo Sandor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109173320 /api/authorship/109173320 Egyed, Balint [Egyed, Bálint (Gyermekgyógyászat...), szerző] II. Sz. Gyermekgyógyászati Klinika (SE / AOK / K); Gyermekgyógyászati Klinika (SE / AOK / K) 7 0.125 false false false Author 10072921 /api/author/10072921 Egyed Bálint (Gyermekgyógyászat, hematológia, onkogenetika) Egyed Bálint true true Egyed Balint true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109173321 /api/authorship/109173321 Gabor, Kovacs [Kovács, Gábor (Gyermekgyógyászat...), szerző] II. Sz. Gyermekgyógyászati Klinika (SE / AOK / K) 8 0.125 false true false Author 10022153 /api/author/10022153 Kovács Gábor (Gyermekgyógyászat; hematológia) Kovács Gábor true 10022153 true Gabor Kovacs true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 24122738 /api/publicationidentifier/24122738 DOI: 10.3390/children10071160 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/children10071160 https://doi.org/10.3390/children10071160 false true PublicationIdentifier 24246307 /api/publicationidentifier/24246307 WoS: 001035204600001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001035204600001 https://www.webofscience.com/wos/woscc/full-record/001035204600001 true true PublicationIdentifier 24568264 /api/publicationidentifier/24568264 SE Repozitórium: 9584 SwordSource 84 /api/publicationsource/84 SE Repozitórium PublicationSourceType 10007 /api/publicationsourcetype/10007 Repozitórium true true true SE Repozitórium SE Repozitórium https://repo.lib.semmelweis.hu/handle/123456789/@@@ true true 84 true GREEN true IDENTICAL 9584 https://repo.lib.semmelweis.hu/handle/123456789/9584 false true PublicationIdentifier 24246311 /api/publicationidentifier/24246311 Scopus: 85166302874 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85166302874 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85166302874 true true PublicationIdentifier 24246312 /api/publicationidentifier/24246312 PubMed: 37508657 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37508657 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37508657&dopt=Abstract true true Classification 12220 /api/classification/12220 Gyermekorvoslás true true SjrRating 11405710 /api/sjrrating/11405710 sjr:Q2 (2023) Scopus - Pediatrics, Perinatology and Child Health CHILDREN (BASEL) 2227-9067 129 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2735 /api/classificationexternal/2735 Scopus - Pediatrics, Perinatology and Child Health true 2735 true Q2 DIRECT true true Reference 43177848 /api/reference/43177848 1. 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(2023) CHILDREN (BASEL) 2227-9067 10 7<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10023438"><a href="/gui2/?type=authors&mode=browse&sel=10023438" target="_blank">Müller Judit ✉ (<span class="authorship-author-name">Müller Judit</span> <span class="authorAux-mtmt"> Csecsemő- és gyermekgyógyászat, Gyermek hemato-...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/II. Sz. Gyermekgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Egyed Petra </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023613"><a href="/gui2/?type=authors&mode=browse&sel=10023613" target="_blank">Erdelyi Daniel (<span class="authorship-author-name">Erdélyi Dániel</span> <span class="authorAux-mtmt"> Gyermekgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10033055"><a href="/gui2/?type=authors&mode=browse&sel=10033055" target="_blank">Kovacs Krisztian (<span class="authorship-author-name">Kovács Krisztián</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Laboratóriumi Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10081122"><a href="/gui2/?type=authors&mode=browse&sel=10081122" target="_blank">Mudra Katalin (<span class="authorship-author-name">Mudra Katalin</span> <span class="authorAux-mtmt"> Gyermekgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/II. Sz. Gyermekgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10088020"><a href="/gui2/?type=authors&mode=browse&sel=10088020" target="_blank">Szabo Sandor (<span class="authorship-author-name">Szabó Sándor</span> <span class="authorAux-mtmt"> Gyermekgyógyászat, Gyermek Hemato-Onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/II. Sz. Gyermekgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10072921"><a href="/gui2/?type=authors&mode=browse&sel=10072921" target="_blank">Egyed Balint (<span class="authorship-author-name">Egyed Bálint</span> <span class="authorAux-mtmt"> Gyermekgyógyászat, hematológia, onkogenetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/II. Sz. Gyermekgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10022153"><a href="/gui2/?type=authors&mode=browse&sel=10022153" target="_blank">Gabor Kovacs (<span class="authorship-author-name">Kovács Gábor</span> <span class="authorAux-mtmt"> Gyermekgyógyászat; hematológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/II. Sz. Gyermekgyógyászati Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34049652" target="_blank">Our Experiences with Asparaginase Activity Measurements in Children with Lymphoblastic Diseases</a></div> <div> <span class="journal-title">CHILDREN (BASEL)</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2227-9067">2227-9067</a>)</span>: <span class="journal-volume">10</span> <span class="journal-issue">7</span> <span class="page"> Paper 1160. 7 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/children10071160" target="_blank" href="https://doi.org/10.3390/children10071160"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001035204600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001035204600001"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="9584" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/9584"> SE Repozitórium </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85166302874" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85166302874"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37508657" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37508657&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pediatrics, Perinatology and Child Health&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 5</span> | Független: 5 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 5 | Scopus jelölt:&nbsp;5 | WoS/Scopus jelölt:&nbsp;5 | DOI jelölt:&nbsp;5 </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34049652</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2026.06.01. 08:52 Molnár-Taga Márta (SE 4-es admin) </div> </div></div>