(TKP2021-EGA-23) Támogató: Innovációs és Technológiai Minisztérium
(K143321)
Knowledge of the physical and chemical properties of phospholipids, such as phase
transition temperatures (Tc), is of great importance in order to reveal the functionalities
of biological and artificial membranes. Our research group developed an oscillatory
rheological method for the simple and rapid determination of phase transition temperatures
(Tc). The phospholipids constructing the membranes undergo conformational changes
at their Tc, which cause alterations of viscoelastic properties of the molecules.
The oscillatory technique recommended by us proved to be appropriate to reveal the
altered molecular properties of phospholipids as tracking the slightest changes in
the viscoelasticity. Our study demonstrates the abrupt changes in rheological properties
at Tc for the following phospholipids: 1,2-Dimyristoyl-sn-glycero-3-Phosphocholine
(DMPC), 1,2-Dipalmitoyl-sn-glycero-3-Phosphatidylcholine (DPPC), and 1,2-Distearoyl-sn-glycero-3-Phosphocholine
(DSPC), proving that the applied methodology is adequate for determining the Tc of
phospholipids.
