Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009)
Támogató: EFOP-VEKOP
(ÚNKP-22-4-II-SE-13)
(ÚNKP-21-2-I-SE-41)
(ÚNKP-22-2-III-SE- 18)
Background: Each brain hemisphere plays a specialized role in cognitive and behavioral
processes, known as hemispheric lateralization. In chronic skin diseases, such as
plaque psoriasis (Pso) and atopic dermatitis (AD), the degree of lateralization between
the frontal hemispheres may provide insight into specific connections between skin
diseases and the psyche. This study aims to analyze the hemispherical lateralization,
neurovegetative responses, and psychometric characteristics of patients with Pso and
AD. Methods: The study included 46 patients with Pso, 56 patients with AD, and 29
healthy control (Ctrl) subjects. The participants underwent frontal electroencephalogram
(EEG) measurement, heart rate variability (HRV) assessment, and psychological tests.
Statistical analyses were performed using ANOVA, with Bonferroni correction applied
for multiple comparisons. Results: This study shows a significant right-lateralized
prefrontal activity in both AD patients (p < 0.001) and Pso patients (p = 0.045) compared
with Ctrl, with no significant difference between the AD and Pso groups (p = 0.633).
AD patients with right-hemispheric dominant prefrontal activation exhibited increased
inhibition and avoidance markers, while Pso patients showed elevated sympathetic nervous
system activity. Conclusion: Psychophysiological and psychometric data suggest a shared
prevalence of right-hemispheric dominance in both AD and Pso patient groups. However,
the findings indicate distinct psychodermatological mechanisms in AD and Pso.
