https://m2.mtmt.hu/ hun 2026-09-22 12:49 JournalArticle 34024285 VALIDATED true Funding Agency and Grant Number: Hungarian National Research, Development, and Innovation Office [KH130356, 2020-1.1.6-JOVO, TKP2021-EGA-33, FK-143751]; Austrian Science Fund [T 1062-B33, FWF I4677, 2020]; New National Excellence Program of the Ministry for Innovation and Technology of Hungary [UNKP-20-3, UNKP-21-3]; Hungarian Respiratory Society; International Association for the Study of Lung Cancer/International Lung Cancer Foundation Young Investigator Grant; City of Vienna Fund for Innovative Interdisciplinary Cancer Research; International Association for the Study of Lung Cancer Early Career Education Award; American Society of Clinical Oncology Young Investigator Award; Cancer Research Prevention Institute of Texas Early Clinical Investigator Award; LUNGevity Foundation Career Development Award; [FWF I3522]; [FWF I3977] 0 false 2026-09-21T10:26:51.228+0000 2023-11-07T08:08:18.699+0000 2023-06-19T12:45:34.531+0000 true 10070075 Nádas Orsolya /api/admin/10070075 Admin true 2026-08-06T12:47:32.785+0000 2026-08-06T12:47:32.785+0000 2023-11-07T08:08:18.997+0000 true 10003134 Wolf György /api/admin/10003134 Admin true 10003134 Admin 10073918 /api/admin/10073918 Kovács Marcell true true 2023-10-04T07:54:51.165+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Megyesfalvi, Zsolt Clinical insights into small cell lung cancer Tumor heterogeneity, diagnosis, therapy, and future directions. true true /api/journal/846 REVIEWED true false 846 false 846 true 0007-9235 1542-4863 Journal FOREIGN 73 6 620 652 620 33 2023 Small cell lung cancer (SCLC) is characterized by rapid growth and high metastatic capacity. It has strong epidemiologic and biologic links to tobacco carcinogens. Although the majority of SCLCs exhibit neuroendocrine features, an important subset of tumors lacks these properties. Genomic profiling of SCLC reveals genetic instability, almost universal inactivation of the tumor suppressor genes TP53 and RB1, and a high mutation burden. Because of early metastasis, only a small fraction of patients are amenable to curative-intent lung resection, and these individuals require adjuvant platinum-etoposide chemotherapy. Therefore, the vast majority of patients are currently being treated with chemoradiation with or without immunotherapy. In patients with disease confined to the chest, standard therapy includes thoracic radiotherapy and concurrent platinum-etoposide chemotherapy. Patients with metastatic (extensive-stage) disease are treated with a combination of platinum-etoposide chemotherapy plus immunotherapy with an anti-programmed death-ligand 1 monoclonal antibody. Although SCLC is initially very responsive to platinum-based chemotherapy, these responses are transient because of the development of drug resistance. In recent years, the authors have witnessed an accelerating pace of biologic insights into the disease, leading to the redefinition of the SCLC classification scheme. This emerging knowledge of SCLC molecular subtypes has the potential to define unique therapeutic vulnerabilities. Synthesizing these new discoveries with the current knowledge of SCLC biology and clinical management may lead to unprecedented advances in SCLC patient care. Here, the authors present an overview of multimodal clinical approaches in SCLC, with a special focus on illuminating how recent advancements in SCLC research could accelerate clinical development. 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/api/keyword/5322 true 5322 true Keyword 14256 /api/keyword/14256 true 14256 true Keyword 1227880 /api/keyword/1227880 true 1227880 true Keyword 1556184 /api/keyword/1556184 true true SjrRating 11384212 /api/sjrrating/11384212 1 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2720 /api/classificationexternal/2720 true 2720 true D1 DIRECT true true /api/publication/34024285 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10071898"><a href="/gui2/?type=authors&mode=browse&sel=10071898" target="_blank">Megyesfalvi Zsolt (<span class="authorship-author-name">Megyesfalvi Zsolt</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Mellkassebészeti Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gay Carl M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Popper Helmut </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pirker Robert </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10029172"><a href="/gui2/?type=authors&mode=browse&sel=10029172" target="_blank">Ostoros Gyula (<span class="authorship-author-name">Ostoros Gyula</span> <span class="authorAux-mtmt"> Pulmonológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Heeke Simon </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lang Christian </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hoetzenecker Konrad </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schwendenwein Anna </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Boettiger Kristiina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bunn Paul A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10034324"><a href="/gui2/?type=authors&mode=browse&sel=10034324" target="_blank">Renyi-Vamos Ferenc (<span class="authorship-author-name">Rényi-Vámos Ferenc István</span> <span class="authorAux-mtmt"> Mellkassebész</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Mellkassebészeti Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schelch Karin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Prosch Helmut </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Byers Lauren A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hirsch Fred R<sup>**</sup> ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000046"><a href="/gui2/?type=authors&mode=browse&sel=10000046" target="_blank">Dome Balazs ✉ (<span class="authorship-author-name">Döme Balázs</span> <span class="authorAux-mtmt"> Tumor indukált angiogenezis</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Mellkassebészeti Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34024285" target="_blank">Clinical insights into small cell lung cancer : Tumor heterogeneity, diagnosis, therapy, and future directions..</a></div> <div> <span class="journal-title">CA-A CANCER JOURNAL FOR CLINICIANS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0007-9235">0007-9235</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1542-4863">1542-4863</a>)</span>: <span class="journal-volume">73</span> <span 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href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37329269&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85161960246&doi=10.3322%2Fcaac.21785&partnerID=40&md5=da68f57e41a1a8efdb40bc8c529468d3" target="_blank" href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85161960246&doi=10.3322%2Fcaac.21785&partnerID=40&md5=da68f57e41a1a8efdb40bc8c529468d3"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Hematology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 447</span> | Független: 426 | Függő: 21 | Nem jelölt: 0 | WoS jelölt: 410 | Scopus jelölt:&nbsp;388 | WoS/Scopus jelölt:&nbsp;447 | DOI jelölt:&nbsp;445 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34024285&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 14 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34024285</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (2020-1.1.6-JOVO), (FK-143751), (TKP2021-EGA-33), (KH130356), (ÚNKP-20-3), (UNKP-21-3) </div> <div class="lastModified">Utolsó módosítás: 2023.11.07. 09:08 Wolf György (MTMT Központi admin) </div> <div class="lockedBy">Központi kezelésű 2023.10.04. 09:54 Kovács Marcell (MTMT Közp., admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: Hungarian National Research, Development, and Innovation Office [KH130356, 2020-1.1.6-JOVO, TKP2021-EGA-33, FK-143751]; Austrian Science Fund [T 1062-B33, FWF I4677, 2020]; New National Excellence Program of the Ministry for Innovation and Technology of Hungary [UNKP-20-3, UNKP-21-3]; Hungarian Respiratory Society; International Association for the Study of Lung...</pre> </div></div>