https://m2.mtmt.hu/ hun 2026-05-25 13:49 JournalArticle 34023632 APPROVED true Department of Internal Medicine and Haematology, Semmelweis University, Budapest, 1085, Hungary Research Group for Immunology and Haematology, Semmelweis University, Eötvös Loránd Research Network (Office for Supported Research Groups), Budapest, 1052, Hungary Institute of Enzymology, Research Centre for Natural Sciences, Budapest, 1117, Hungary Export Date: 11 March 2024 Correspondence Address: Cervenak, L.; Department of Internal Medicine and Haematology, Hungary; email: cervenak.laszlo@med.semmelweis-univ.hu 0 false 2026-05-23T01:05:02.832+0000 2025-02-26T14:19:04.088+0000 2023-06-19T09:40:19.428+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-05-15T08:35:29.466+0000 Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2024-04-04T10:41:30.324+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Németh, Z. Cooperation of Complement MASP-1 with Other Proinflammatory Factors to Enhance the Activation of Endothelial Cells true true /api/journal/10003252 REVIEWED true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 24 11 9181 9181 15 2023 Endothelial cells play an important role in sensing danger signals and regulating inflammation. Several factors are capable of inducing a proinflammatory response (e.g., LPS, histamine, IFNγ, and bradykinin), and these factors act simultaneously during the natural course of the inflammatory reaction. We have previously shown that the complement protein mannan-binding lectin-associated serine protease-1 (MASP-1) also induces a proinflammatory activation of the endothelial cells. Our aim was to investigate the possible cooperation between MASP-1 and other proinflammatory mediators when they are present in low doses. We used HUVECs and measured Ca2+ mobilization, IL-8, E-selectin, VCAM-1 expression, endothelial permeability, and mRNA levels of specific receptors. LPS pretreatment increased the expression of PAR2, a MASP-1 receptor, and furthermore, MASP-1 and LPS enhanced each other’s effects in regulating IL-8, E-selectin, Ca2+ mobilization, and changes in permeability in a variety of ways. Cotreatment of MASP-1 and IFNγ increased the IL-8 expression of HUVECs. MASP-1 induced bradykinin and histamine receptor expression, and consequently, increased Ca2+ mobilization was found. Pretreatment with IFNγ enhanced MASP-1-induced Ca2+ mobilization. Our findings highlight that well-known proinflammatory mediators and MASP-1, even at low effective doses, can strongly synergize to enhance the inflammatory response of endothelial cells. Funding 2027930 /api/funding/2027930 false true Funding 2027931 /api/funding/2027931 false true Funding 2027932 /api/funding/2027932 false true true true 2023 true true true false true false GOLD 2026-05-23 true https://doi.org/10.3390/ijms24119181 11 0 11 7 4 11 11 10 10 11 11 7 7 7 4 0 11 7 11 7 0 14 14 Folyóiratcikk Journal Article 24 11 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 4 1 4 1 2025 0 4 3 4 3 2026 0 3 3 3 3 D1 false 10057478,10040542,10000203 false false false 2023-06-18T09:48:11.255+0000 Belgyógyászati és Hematológiai Klinika (SE / AOK / K); Enzimológiai Intézet (TTK); Szerkezeti Biofizika Kutatócsoport (HRN TTK / MÉI) 6 21 3 6 0 true 10014568 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 109026490 /api/authorship/109026490 1 0.167 true false false Author 10065724 /api/author/10065724 Németh Zsuzsanna true true Németh Z. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109026491 /api/authorship/109026491 2 0.167 false false false Author 10057478 /api/author/10057478 Nagy-Debreczeni Márta Lídia true 10057478 true Debreczeni M.L. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109026492 /api/authorship/109026492 3 0.167 false false false Author 10040542 /api/author/10040542 Kajdácsi Erika true 10040542 true Kajdácsi E. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109026493 /api/authorship/109026493 4 0.16666667 false false false Author 10015069 /api/author/10015069 Dobó József true 10015069 true Dobó J. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109026494 /api/authorship/109026494 5 0.16666667 false false false Author 10010445 /api/author/10010445 Gál Péter true 10010445 true Gál P. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109026495 /api/authorship/109026495 6 0.167 false true true Author 10000203 /api/author/10000203 Cervenak László true 10000203 true Cervenak L. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 24053135 /api/publicationidentifier/24053135 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms24119181 https://doi.org/10.3390/ijms24119181 false true PublicationIdentifier 24096289 /api/publicationidentifier/24096289 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001006293300001 https://www.webofscience.com/wos/woscc/full-record/001006293300001 true true PublicationIdentifier 24053134 /api/publicationidentifier/24053134 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85161521213 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85161521213 false true PublicationIdentifier 24053157 /api/publicationidentifier/24053157 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37298134 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37298134&dopt=Abstract false true PublicationIdentifier 31904725 /api/publicationidentifier/31904725 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true NONE IDENTICAL https://www.scopus.com/pages/publications/85161521213?origin=resultslist https://www.scopus.com/pages/publications/85161521213?origin=resultslist false true Classification 12324 /api/classification/12324 true true SjrRating 11388415 /api/sjrrating/11388415 7 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1604 /api/classificationexternal/1604 true 1604 true D1 DIRECT true true /api/publication/34023632 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10065724"><a href="/gui2/?type=authors&mode=browse&sel=10065724" target="_blank">Németh Z. (<span class="authorship-author-name">Németh Zsuzsanna</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Hematológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10057478"><a href="/gui2/?type=authors&mode=browse&sel=10057478" target="_blank">Debreczeni M.L. (<span class="authorship-author-name">Nagy-Debreczeni Márta Lídia</span> <span class="authorAux-mtmt"> Immunológia, Sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Hematológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040542"><a href="/gui2/?type=authors&mode=browse&sel=10040542" target="_blank">Kajdácsi E. (<span class="authorship-author-name">Kajdácsi Erika</span> <span class="authorAux-mtmt"> immunológia, sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Hematológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015069"><a href="/gui2/?type=authors&mode=browse&sel=10015069" target="_blank">Dobó J. (<span class="authorship-author-name">Dobó József</span> <span class="authorAux-mtmt"> biokémia és immunológia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet; <span title="Természettudományi Kutatóközpont">TTK</span>/<span title="Molekuláris Élettudományi Intézet">MÉI</span>/Szerkezeti Biofizika Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010445"><a href="/gui2/?type=authors&mode=browse&sel=10010445" target="_blank">Gál P. (<span class="authorship-author-name">Gál Péter</span> <span class="authorAux-mtmt"> Szerkezeti biokémia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000203"><a href="/gui2/?type=authors&mode=browse&sel=10000203" target="_blank">Cervenak L. ✉ (<span class="authorship-author-name">Cervenak László</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Hematológiai Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34023632" target="_blank">Cooperation of Complement MASP-1 with Other Proinflammatory Factors to Enhance the Activation of Endothelial Cells</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">24</span> <span class="journal-issue">11</span> <span class="page"> Paper 9181. 15 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms24119181" target="_blank" href="https://doi.org/10.3390/ijms24119181"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001006293300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001006293300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85161521213" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85161521213"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37298134" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37298134&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://www.scopus.com/pages/publications/85161521213?origin=resultslist" target="_blank" href="https://www.scopus.com/pages/publications/85161521213?origin=resultslist"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 11</span> | Független: 7 | Függő: 4 | Nem jelölt: 0 | WoS jelölt: 10 | Scopus jelölt:&nbsp;10 | WoS/Scopus jelölt:&nbsp;11 | DOI jelölt:&nbsp;11 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34023632&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 14 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34023632</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (K115623), (TKP2021-EGA-24), (Molecular Biology Thematic Programme of Semmelweis University) </div> <div class="lastModified">Utolsó módosítás: 2025.02.26. 15:19 Ladányi Gusztáv (MTMT API user, admin) </div> <div class="lockedBy">Központi kezelésű 2024.04.04. 12:41 Vándor Andrea (VA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Internal Medicine and Haematology, Semmelweis University, Budapest, 1085, Hungary Research Group for Immunology and Haematology, Semmelweis University, Eötvös Loránd Research Network (Office for Supported Research Groups), Budapest, 1052, Hungary Institute of Enzymology, Research Centre for Natural Sciences, Budapest, 1117, Hungary ...</pre> </div></div>