Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009)
Támogató: EFOP-VEKOP
Diagnosing interstitial lung disease (ILD) can be a challenging process. New biomarkers
may support diagnostic decisions. Elevated serum progranulin (PGRN) levels have been
reported in liver fibrosis and dermatomyositis-associated acute interstitial pneumonia.
Our aim was to assess the role of PGRN in the differential diagnosis of idiopathic
pulmonary fibrosis (IPF) and other ILDs. Serum levels of PGRN were measured by enzyme-linked
immunosorbent assay in stable IPF (n = 40), non-IPF ILD (n = 48) and healthy controls
(n = 17). Patient characteristics, lung function, CO diffusion (DLCO), arterial blood
gases, 6-min walk test, laboratory parameters and high-resolution (HR)CT pattern were
assessed. In stable IPF, PGRN levels did not differ from healthy controls; however,
serum PGRN levels were significantly higher in non-IPF ILD patients compared to healthy
subjects and IPF (53.47 ± 15.38 vs. 40.99 ± 5.33 vs. 44.66 ± 7.77 ng/mL respectively;
p < 0.01). The HRCT pattern of usual interstitial pneumonia (UIP) was associated with
normal PGRN level, while for non-UIP patterns, significantly elevated PGRN level was
measured. Elevated serum PGRN levels may be associated with non-IPF ILD, especially
non-UIP patterns and might be helpful in cases of unclear radiological patterns in
the differentiation between IPF and other ILDs.
