https://m2.mtmt.hu/ eng 2026-10-23 20:38 JournalArticle 34010700 VALIDATED true 0 false 2026-10-23T14:54:05.624+0000 2026-05-05T12:12:46.212+0000 2023-06-12T09:20:47.190+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-05-21T09:12:50.165+0000 2026-05-21T09:12:50.165+0000 2026-04-01T19:22:05.122+0000 true 10003141 Aggod Zsuzsa /api/admin/10003141 Admin true 10003141 Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2024-02-01T13:22:05.795+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Biro, L. Post-weaning social isolation in male mice leads to abnormal aggression and disrupted network organization in the prefrontal cortex: Contribution of parvalbumin interneurons with or without perineuronal nets true true /api/journal/10045166 REVIEWED true false 10045166 false 10045166 true 2352-2895 Journal FOREIGN 25 100546 100546 21 2023 Adverse social experiences during childhood increase the risk of developing aggression-related psychopathol- ogies. The prefrontal cortex (PFC) is a key regulator of social behavior, where experience-dependent network development is tied to the maturation of parvalbumin-positive (PV+) interneurons. Maltreatment in childhood could impact PFC development and lead to disturbances in social behavior during later life. However, our knowledge regarding the impact of early-life social stress on PFC operation and PV+ cell function is still scarce. Here, we used post-weaning social isolation (PWSI) to model early-life social neglect in mice and to study the associated neuronal changes in the PFC, additionally distinguishing between the two main subpopulations of PV+ interneurons, i.e. those without or those enwrapped by perineuronal nets (PNN). For the first time to such detailed extent in mice, we show that PWSI induced disturbances in social behavior, including abnormal aggression, excessive vigilance and fragmented behavioral organization. PWSI mice showed altered resting-state and fighting-induced co-activation patterns between orbitofrontal and medial PFC (mPFC) subregions, with a particularly highly elevated activity in the mPFC. Surprisingly, aggressive interaction was associated with a higher recruitment of mPFC PV+ neurons that were surrounded by PNN in PWSI mice that seemed to mediate the emergence of social deficits. PWSI did not affect the number of PV+ neurons and PNN density, but enhanced PV and PNN intensity as well as cortical and subcortical glutamatergic drive onto mPFC PV+ neurons. Our results suggest that the increased excitatory input of PV+ cells could emerge as a compensatory mechanism for the PV+ neuron-mediated impaired inhibition of mPFC layer 5 pyramidal neurons, since we found lower numbers of GABAergic PV+ puncta on the perisomatic region of these cells. In conclusion, PWSI leads to altered PV-PNN activity and impaired excitatory/inhibitory balance in the mPFC, which possibly contributes to social behav- ioral disruptions seen in PWSI mice. Our data advances our understanding on how early-life social stress can impact the maturing PFC and lead to the development of social abnormalities in adulthood. Funding 2028788 /api/funding/2028788 false true Funding 2027648 /api/funding/2027648 false true Funding 2027647 /api/funding/2027647 false true true 2023 true true true false true false GOLD 2026-10-23 true https://real.mtak.hu/168217 24 0 24 22 3 23 24 24 24 24 24 22 22 22 2 0 24 22 24 22 0 12 12 Folyóiratcikk Journal Article 24 23 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 1 1 1 1 2024 0 3 3 3 3 2025 0 13 11 13 11 2026 0 7 7 7 7 Q1 false 177,10030200,10012353,10012928 false false false 2023-06-11T09:29:06.858+0000 Doktori Iskola (SE); Kísérleti Orvostudományi Kutatóintézet; Természettudományi és Szoftvertechnológiai Intézet (ÓE / AMK); Transzlációs Magatartás Idegtudomány Kutatócsoport (HRN KOKI) 9 21 4 9 0 true 10014568 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 108961382 /api/authorship/108961382 1 0.111 true false true Author 10030200 /api/author/10030200 Bíró László true 10030200 true Biro L. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108961383 /api/authorship/108961383 2 0.111 true false false Author 10062707 /api/author/10062707 Miskolczi Christina true 10062707 true Miskolczi C. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108961384 /api/authorship/108961384 3 0.111 false false false Author 10076338 /api/author/10076338 Szebik Huba true true Szebik H. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108961385 /api/authorship/108961385 4 0.111 false false false Author 10054890 /api/author/10054890 Bruzsik Bíborka true 10054890 true Bruzsik B. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108961386 /api/authorship/108961386 5 0.111 false false false Author 10060719 /api/author/10060719 Varga Zoltán Kristóf true 10060719 true Varga Z.K. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108961387 /api/authorship/108961387 6 0.111 false false false Author 10065769 /api/author/10065769 Szente László true true Szente L. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108961388 /api/authorship/108961388 7 0.111 false false false Author 177 /api/author/177 Tóth Máté true 177 true Toth M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108961389 /api/authorship/108961389 8 0.11111111 false false false Author 10012353 /api/author/10012353 Halász József true 10012353 true Halasz J. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108961390 /api/authorship/108961390 9 0.111 false true true Author 10012928 /api/author/10012928 Mikics Éva true 10012928 true Mikics E. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 24020604 /api/publicationidentifier/24020604 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1016/j.ynstr.2023.100546 https://doi.org/10.1016/j.ynstr.2023.100546 false true PublicationIdentifier 24061722 /api/publicationidentifier/24061722 SwordSource 36 /api/publicationsource/36 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/api/publicationidentifier/24142583 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37323648 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37323648&dopt=Abstract true true SjrRating 11357748 /api/sjrrating/11357748 54 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1303 /api/classificationexternal/1303 true 1303 true Q1 DIRECT true true /api/publication/34010700 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10030200"><a href="/gui2/?type=authors&mode=browse&sel=10030200" target="_blank">Biro L. ✉ (<span class="authorship-author-name">Bíró László</span> <span class="authorAux-mtmt"> Magatartásélettan</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Translational Behavioural Neuroscience Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10062707"><a href="/gui2/?type=authors&mode=browse&sel=10062707" target="_blank">Miskolczi C.<sup>*</sup> (<span class="authorship-author-name">Miskolczi Christina</span> <span class="authorAux-mtmt"> idegtudományok</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Translational Behavioural Neuroscience Group; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10076338"><a href="/gui2/?type=authors&mode=browse&sel=10076338" target="_blank">Szebik H. (<span class="authorship-author-name">Szebik Huba</span> <span class="authorAux-mtmt"> idegtudományok</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Translational Behavioural Neuroscience Group; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10054890"><a href="/gui2/?type=authors&mode=browse&sel=10054890" target="_blank">Bruzsik B. (<span class="authorship-author-name">Bruzsik Bíborka</span> <span class="authorAux-mtmt"> neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Translational Behavioural Neuroscience Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060719"><a href="/gui2/?type=authors&mode=browse&sel=10060719" target="_blank">Varga Z.K. (<span class="authorship-author-name">Varga Zoltán Kristóf</span> <span class="authorAux-mtmt"> Biológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Translational Behavioural Neuroscience Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10065769"><a href="/gui2/?type=authors&mode=browse&sel=10065769" target="_blank">Szente L. (<span class="authorship-author-name">Szente László</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Translational Behavioural Neuroscience Group; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="177"><a href="/gui2/?type=authors&mode=browse&sel=177" target="_blank">Toth M. (<span class="authorship-author-name">Tóth Máté</span> <span class="authorAux-mtmt"> Magatartástudomány</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Translational Behavioural Neuroscience Group; Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012353"><a href="/gui2/?type=authors&mode=browse&sel=10012353" target="_blank">Halasz J. (<span class="authorship-author-name">Halász József</span> <span class="authorAux-mtmt"> Szociális viselkedés modellezése</span>) </a> </span> <span class="author-affil"><span title="Óbuda University">ÓU</span>/<span title="Alba Regia Műszaki Kar">ARMK</span>/Természettudományi és Szoftvertechnológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012928"><a href="/gui2/?type=authors&mode=browse&sel=10012928" target="_blank">Mikics E. ✉ (<span class="authorship-author-name">Mikics Éva</span> <span class="authorAux-mtmt"> Neuroendokrinológia, viselkedésbiológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Translational Behavioural Neuroscience Group; Institute of Experimental Medicine</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34010700" target="_blank">Post-weaning social isolation in male mice leads to abnormal aggression and disrupted network organization in the prefrontal cortex: Contribution of parvalbumin interneurons with or without perineuronal nets</a></div> <div> <span class="journal-title">NEUROBIOLOGY OF STRESS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2352-2895">2352-2895</a>)</span>: <span class="journal-volume">25</span> <span class="page"> Paper 100546. 21 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.ynstr.2023.100546" target="_blank" href="https://doi.org/10.1016/j.ynstr.2023.100546"> DOI </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="168217" target="_blank" href="https://real.mtak.hu/168217"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001021817200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001021817200001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85160863553" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85160863553"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37323648" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37323648&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Biochemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Cellular and Molecular Neuroscience&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Endocrine and Autonomic Systems&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Endocrinology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Physiology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 24</span> | Independent citation: 22 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 24 | Number of citations in Scopus:&nbsp;24 | WoS/Scopus assigned:&nbsp;24 | Number of citations with DOI:&nbsp;24 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34010700&sort=publishedYear,desc&sort=title"> Number of cited publications: 12 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 34010700</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> National Laboratory of Translational Neuroscience (TINL)(RRF-2.3.1-21-2022-00011), Hungarian Scientific Research Fund(K125390), Hungarian National Brain Research Program(2017-1.2.1-NKP-2017-00002) </div> <div class="lastModified">Last Modified: 2026.05.05. 14:12 András Balázs (MTMT Központ, admin) </div> <div class="lockedBy">Centrally managed 2024.02.01. 14:22 Andrea Vándor (VA, admin) </div> </div></div>