https://m2.mtmt.hu/ hun 2026-05-02 09:06 JournalArticle 34007459 APPROVED true MTA Bolyai János Kutatási Ösztöndíj 0 false 2025-12-28T14:22:49.942+0000 2025-06-04T07:24:51.573+0000 2023-06-09T14:58:28.248+0000 true 10077906 Gantsetseg Garmaa /api/author/10077906 Author true 2025-06-04T07:24:52.562+0000 2025-06-04T07:24:52.562+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000071 Abstract true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000071 Absztrakt / Kivonat SubType 114 true 10000071 true 1 /api/category/1 Category true 1 Miklos, Mozes PIOGLITAZONE REVERSES MIR-130A AND MIR-199 DYSREGULATION INDUCED BY TGF-BETA DURING KIDNEY FIBROSIS true true /api/journal/3323 REVIEWED true false 3323 false 3323 true 0931-0509 1460-2385 Journal FOREIGN 38 S1 I477 5503 5503 2 2023 2023 true 301867 /api/conference/301867 true 10569 true 10020 /api/country/10020 Country true 16 /api/city/10569 City true 1094179 Conference true Background and Aims: The peroxisome proliferator-activated receptor-γ (PPARγ ) agonists have been shown to dampen TGF-β signaling and suppress miR-130a in VSMCs and also profibrotic miR-21-5p in the kidney. We have recently demonstrated that pioglitazone ameliorates established renal fibrosis by suppressing STAT3 and EGR1 [1], but its effect on renal miR-130a has not been investigated. Thus, we aimed to study how chronic oral pioglitazone treatment would affect TGF-β–driven renal miRNA dysregulation in mice. Method: Ten week old male C57Bl6 control (CTL, n = 6) and TGF-β transgenic mice (TGFb, n = 12, having elevated plasma TGF-β1 level) were used. CTL mice and half of TGFb mice received regular chow. The second half of transgenic mice received pioglitazone containing chow (dose: 20mg/kg/day) for 5 weeks (TGFb+Pio, n = 6), when the kidneys were evaluated. Results: Untreated TGFb mice had a 4.7-fold and 2.8-fold type I and type III collagen mRNA overexpression as compared to controls, respectively. This was accompanied by 3.8-fold pro-fibrotic Egr2 mRNA, 2.9-fold miR-130a, 3.9- fold miR-199 and 3.3-fold miR-21 overexpression. Chronic treatment with the PPARγ agonist pioglitazone reduced the expression of both collagen mRNAs and miRNAs miR-199 and miR-21 to control levels, but miR-130a reached even lower values than in control kidneys. Interestingly, the expression of miR-200a (regulated by TGF-beta and known to ameliorate fibrosis) was similar in all CTL and TGFb groups, regardless of treatment. Conclusion: Our data indicate that PPARγ agonist pioglitazone not only attenuates the TGF-β induced miR-21 overexpression, but also the renal dysregulation of miR-130a and miR-199, supporting its anti-fibrotic effects. true true 2023 true true false true true false NONE 2025-12-28 false 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 false false false false 2023-09-13T08:28:02.601+0000 Transzlációs Medicina Intézet (SE / AOK / I) 4 18 1 4 0 false Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 108939309 /api/authorship/108939309 1 0.25 true false Author 10015693 /api/author/10015693 Mózes Miklós true 10015693 true Miklos Mozes true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108939310 /api/authorship/108939310 2 0.25 false false Author 10077906 /api/author/10077906 Gantsetseg Garmaa true true Garmaa Gantsetseg true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108939311 /api/authorship/108939311 3 0.25 false false Author 10055151 /api/author/10055151 Manzéger Anna true 10055151 true Anna Manzéger true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108939312 /api/authorship/108939312 4 0.25 false true Author 10014641 /api/author/10014641 Kökény Gábor true 10014641 true Gabor Kokeny true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 24371171 /api/publicationidentifier/24371171 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1093/ndt/gfad063c_5503 https://doi.org/10.1093/ndt/gfad063c_5503 false true PublicationIdentifier 24848369 /api/publicationidentifier/24848369 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001022961101277 https://www.webofscience.com/wos/woscc/full-record/001022961101277 false true Classification 12215 /api/classification/12215 true true Keyword 1500129 /api/keyword/1500129 true true /api/publication/34007459 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10015693"><a href="/gui2/?type=authors&mode=browse&sel=10015693" target="_blank">Miklos Mozes (<span class="authorship-author-name">Mózes Miklós</span> <span class="authorAux-mtmt"> Nephrologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10077906"><a href="/gui2/?type=authors&mode=browse&sel=10077906" target="_blank">Garmaa Gantsetseg (<span class="authorship-author-name">Gantsetseg Garmaa</span> <span class="authorAux-mtmt"> miRNA in kidney disease, proximal tubular cell ...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055151"><a href="/gui2/?type=authors&mode=browse&sel=10055151" target="_blank">Anna Manzéger (<span class="authorship-author-name">Manzéger Anna</span> <span class="authorAux-mtmt"> molekuláris genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014641"><a href="/gui2/?type=authors&mode=browse&sel=10014641" target="_blank">Gabor Kokeny (<span class="authorship-author-name">Kökény Gábor</span> <span class="authorAux-mtmt"> Nefrológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34007459" target="_blank">PIOGLITAZONE REVERSES MIR-130A AND MIR-199 DYSREGULATION INDUCED BY TGF-BETA DURING KIDNEY FIBROSIS</a></div> <div> <span class="journal-title">NEPHROLOGY DIALYSIS TRANSPLANTATION</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0931-0509">0931-0509</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1460-2385">1460-2385</a>)</span>: <span class="journal-volume">38</span> <span class="journal-issue">S1</span> <span class="page"> Paper 5503. 2 p. </span> <span class="year">(2023)</span> <div class="conference"> 60th ERA Congress. Konferencia helye, ideje: <span class="location">Milano, Olaszország <span class="conference-date">2023.06.15. - 2023.06.18.</span> </div> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1093/ndt/gfad063c_5503" target="_blank" href="https://doi.org/10.1093/ndt/gfad063c_5503"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001022961101277" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001022961101277"> WoS </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34007459&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34007459</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Absztrakt / Kivonat ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2025.06.04. 09:24 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: MTA Bolyai János Kutatási Ösztöndíj</pre> </div></div>