https://m2.mtmt.hu/ hun 2026-04-30 05:38 JournalArticle 3399716 VALIDATED true 0 2018-09-24T22:20:08.000+0000 false 3399716 2026-03-25T07:54:35.711+0000 2024-01-29T11:54:39.739+0000 2018-07-27T13:14:02.000+0000 true 10019782 Csámer Iván /api/admin/10019782 Admin true 10019782 2026-02-09T11:37:48.267+0000 2024-01-29T11:54:12.012+0000 true 10065569 Pécsi Éva /api/admin/10065569 Admin true 2024-01-29T11:54:40.222+0000 true 10065569 Pécsi Éva /api/admin/10065569 Admin true Admin 10003134 /api/admin/10003134 Wolf György true 10003134 true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true 2024-10-17T16:56:06.377+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Billes, Viktor András Developmentally regulated autophagy is required for eye formation in Drosophila. true true /api/journal/10004714 REVIEWED true false 10004714 false 10004714 true 1554-8627 1554-8635 Journal FOREIGN 14 9 1499 1519 1499 21 2018 The compound eye of the fruit fly Drosophila melanogaster is one of the most intensively studied and best understood model organs in the field of developmental genetics. Herein we demonstrate that autophagy, an evolutionarily conserved selfdegradation process of eukaryotic cells, is essential for eye development in this organism. Autophagic structures accumulate in a specific pattern in the developing eye disc, predominantly in the morphogenetic furrow (MF) and differentiation zone. Silencing of several autophagy genes (Atg) in the eye primordium severely affects the morphology of the adult eye through triggering ectopic cell death. In Atg mutant genetic backgrounds however genetic compensatory mechanisms largely rescue autophagic activity in, and thereby normal morphogenesis of, this organ. We also show that in the eye disc the expression of a key autophagy gene, Atg8a, is controlled in a complex manner by the anterior Hox paralog lab (labial), a master regulator of early development. Atg8a transcription is repressed in front of, while activated along, the MF by lab. The amount of autophagic structures then remains elevated behind the moving MF. These results indicate that eye development in Drosophila depends on the cell death-suppressing and differentiating effects of the autophagic process. This novel, developmentally regulated function of autophagy in the morphogenesis of the compound eye may shed light on a more fundamental role for cellular self-digestion in differentiation and organ formation than previously thought. 2018 335987 true true true false true false GREEN GREEN 2026-03-25 true http://real.mtak.hu/82452 22 0 22 14 5 22 22 21 22 22 22 14 14 14 8 0 22 14 22 14 0 22 22 Folyóiratcikk Journal Article 24 22 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2020 0 2 2 2 2 2021 0 5 4 5 4 2022 0 4 1 4 1 2023 0 7 4 7 4 2024 0 3 3 3 3 2025 0 1 0 1 0 D1 false 10028210,10020906,10010619,10020914,10038471,10087266 false false false 2018-09-24T08:37:29.000+0000 2018-07-27T13:17:41.000+0000 Anatómiai, Sejt- és Fejlődésbiológiai Tanszék (ELTE / TTK / Bio_I); Embertani Tanszék (ELTE / TTK / Bio_I); Genetikai Intézet (HRN SZBK); Genetikai Tanszék (ELTE / TTK / Bio_I); Genetikai és Molekuláris Biológiai Tanszék (PTE / TTK / BI) 14 49 5 15 0 true 10003134 10067876 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 10314937 /api/authorship/10314937 1 0.067 true false Author 10020906 /api/author/10020906 Billes Viktor András true 10020906 true Billes Viktor András true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28838635 true PersonAuthorship 10314938 /api/authorship/10314938 2 0.067 true false Author 10028210 /api/author/10028210 Kovács Tibor true 10028210 true Kovács Tibor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28838634 true PersonAuthorship 10314939 /api/authorship/10314939 3 0.067 false false Author 10055151 /api/author/10055151 Manzéger Anna true 10055151 true Manzeger Anna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28838633 true PersonAuthorship 10314940 /api/authorship/10314940 4 0.06666667 false false Author 10020615 /api/author/10020615 Lőrincz Péter true 10020615 true Lorincz P true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28838632 true PersonAuthorship 10314941 /api/authorship/10314941 5 0.06666667 false false Author 10087266 /api/author/10087266 Vágó-Szincsák Sára true true Szincsak S true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28838631 true PersonAuthorship 10314942 /api/authorship/10314942 6 0.067 false false Author 10020916 /api/author/10020916 Regős Ágnes true 10020916 true Regős Ágnes true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28838630 true PersonAuthorship 10314943 /api/authorship/10314943 7 0.067 false false Author 10038471 /api/author/10038471 Kulcsár Péter István true 10038471 true Kulcsár Péter István true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28838629 true PersonAuthorship 10314944 /api/authorship/10314944 8 0.067 false false Author 10020914 /api/author/10020914 Korcsmáros Tamás true 10020914 true Korcsmáros Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28838628 true PersonAuthorship 10314945 /api/authorship/10314945 9 0.06666667 false false Lukacsovich T true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28838627 true PersonAuthorship 10314946 /api/authorship/10314946 10 0.067 false false Author 10010619 /api/author/10010619 Hoffmann Gyula true 10010619 true Hoffmann Gyula true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28838626 true PersonAuthorship 10314947 /api/authorship/10314947 11 0.067 false false Author 10009410 /api/author/10009410 Erdélyi Miklós true 10009410 true Erdélyi Miklós true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28838625 true PersonAuthorship 10314948 /api/authorship/10314948 12 0.067 false false Author 10010519 /api/author/10010519 Mihály József true 10010519 true Mihály József true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28838624 true PersonAuthorship 10314949 /api/authorship/10314949 13 0.067 false false Author 10013108 /api/author/10013108 Vellainé Takács Krisztina true 10013108 true Takacs-Vellai Krisztina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28838623 true PersonAuthorship 10314950 /api/authorship/10314950 14 0.067 false false true Author 10009420 /api/author/10009420 Sass Miklós true 10009420 true Sass Miklós true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28838622 true PersonAuthorship 10314951 /api/authorship/10314951 15 0.067 false true true Author 10003103 /api/author/10003103 Vellai Tibor true 10003103 true Vellai Tibor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28838621 true PublicationIdentifier 1314200 /api/publicationidentifier/1314200 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1080/15548627.2018.1454569 https://doi.org/10.1080/15548627.2018.1454569 false 1807753 true PublicationIdentifier 1314202 /api/publicationidentifier/1314202 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL http://real.mtak.hu/@@@ true true 36 true GREEN true NO 82452 http://real.mtak.hu/82452 false 1807757 true PublicationIdentifier 1314198 /api/publicationidentifier/1314198 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000443966700003 https://www.webofscience.com/wos/woscc/full-record/000443966700003 false 1838494 true PublicationIdentifier 1314199 /api/publicationidentifier/1314199 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 85052068745 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85052068745 false 1822063 true PublicationIdentifier 1314201 /api/publicationidentifier/1314201 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 29940806 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=29940806&dopt=Abstract false 1807754 true PublicationIdentifier 15191863 /api/publicationidentifier/15191863 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true NONE IDENTICAL https://doi.org/10.1080/15548627.2018.1454569 https://doi.org/10.1080/15548627.2018.1454569 false true PublicationIdentifier 31160850 /api/publicationidentifier/31160850 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true NONE IDENTICAL https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052068745&doi=10.1080%2F15548627.2018.1454569&partnerID=40&md5=70acb69e2bd5e12ebe8bd19af0cdb80b https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052068745&doi=10.1080%2F15548627.2018.1454569&partnerID=40&md5=70acb69e2bd5e12ebe8bd19af0cdb80b false true Classification 10545 /api/classification/10545 true true SjrRating 10985211 /api/sjrrating/10985211 25 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1307 /api/classificationexternal/1307 true 1307 true D1 DIRECT true true /api/publication/3399716 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10020906"><a href="/gui2/?type=authors&mode=browse&sel=10020906" target="_blank">Billes Viktor András (<span class="authorship-author-name">Billes Viktor András</span> <span class="authorAux-mtmt"> Biológia, genetika</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Genetikai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028210"><a href="/gui2/?type=authors&mode=browse&sel=10028210" target="_blank">Kovács Tibor<sup>*</sup> (<span class="authorship-author-name">Kovács Tibor</span> <span class="authorAux-mtmt"> Fejlődés genetika</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Genetikai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055151"><a href="/gui2/?type=authors&mode=browse&sel=10055151" target="_blank">Manzeger Anna (<span class="authorship-author-name">Manzéger Anna</span> <span class="authorAux-mtmt"> molekuláris genetika</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020615"><a href="/gui2/?type=authors&mode=browse&sel=10020615" target="_blank">Lorincz P (<span class="authorship-author-name">Lőrincz Péter</span> <span class="authorAux-mtmt"> Sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Anatómiai, Sejt- és Fejlődésbiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10087266"><a href="/gui2/?type=authors&mode=browse&sel=10087266" target="_blank">Szincsak S (<span class="authorship-author-name">Vágó-Szincsák Sára</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Genetikai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020916"><a href="/gui2/?type=authors&mode=browse&sel=10020916" target="_blank">Regős Ágnes (<span class="authorship-author-name">Regős Ágnes</span> <span class="authorAux-mtmt"> Fejlődés genetika</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Genetikai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10038471"><a href="/gui2/?type=authors&mode=browse&sel=10038471" target="_blank">Kulcsár Péter István (<span class="authorship-author-name">Kulcsár Péter István</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020914"><a href="/gui2/?type=authors&mode=browse&sel=10020914" target="_blank">Korcsmáros Tamás (<span class="authorship-author-name">Korcsmáros Tamás</span> <span class="authorAux-mtmt"> Rendszerbiológia, bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Genetikai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lukacsovich T </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010619"><a href="/gui2/?type=authors&mode=browse&sel=10010619" target="_blank">Hoffmann Gyula (<span class="authorship-author-name">Hoffmann Gyula</span> <span class="authorAux-mtmt"> Genetika</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">BI</span>/Genetikai és Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009410"><a href="/gui2/?type=authors&mode=browse&sel=10009410" target="_blank">Erdélyi Miklós (<span class="authorship-author-name">Erdélyi Miklós</span> <span class="authorAux-mtmt"> genetika</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Genetikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010519"><a href="/gui2/?type=authors&mode=browse&sel=10010519" target="_blank">Mihály József (<span class="authorship-author-name">Mihály József</span> <span class="authorAux-mtmt"> genetika</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Genetikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013108"><a href="/gui2/?type=authors&mode=browse&sel=10013108" target="_blank">Takacs-Vellai Krisztina (<span class="authorship-author-name">Vellainé Takács Krisztina</span> <span class="authorAux-mtmt"> Genetika</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Embertani Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009420"><a href="/gui2/?type=authors&mode=browse&sel=10009420" target="_blank">Sass Miklós ✉ (<span class="authorship-author-name">Sass Miklós</span> <span class="authorAux-mtmt"> Biológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Anatómiai, Sejt- és Fejlődésbiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003103"><a href="/gui2/?type=authors&mode=browse&sel=10003103" target="_blank">Vellai Tibor ✉ (<span class="authorship-author-name">Vellai Tibor</span> <span class="authorAux-mtmt"> Genetika</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Genetikai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3399716" target="_blank">Developmentally regulated autophagy is required for eye formation in Drosophila.</a></div> <div> <span class="journal-title">AUTOPHAGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1554-8627">1554-8627</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1554-8635">1554-8635</a>)</span>: <span class="journal-volume">14</span> <span class="journal-issue">9</span> <span class="page"> pp 1499-1519 </span> <span class="year">(2018)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1080/15548627.2018.1454569" target="_blank" href="https://doi.org/10.1080/15548627.2018.1454569"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="82452" target="_blank" href="http://real.mtak.hu/82452"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000443966700003" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000443966700003"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85052068745" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85052068745"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="29940806" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=29940806&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://doi.org/10.1080/15548627.2018.1454569" target="_blank" href="https://doi.org/10.1080/15548627.2018.1454569"> Egyéb URL </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052068745&doi=10.1080%2F15548627.2018.1454569&partnerID=40&md5=70acb69e2bd5e12ebe8bd19af0cdb80b" target="_blank" href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052068745&doi=10.1080%2F15548627.2018.1454569&partnerID=40&md5=70acb69e2bd5e12ebe8bd19af0cdb80b"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 22</span> | Független: 14 | Függő: 8 | Nem jelölt: 0 | WoS jelölt: 21 | Scopus jelölt:&nbsp;22 | WoS/Scopus jelölt:&nbsp;22 | DOI jelölt:&nbsp;22 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3399716&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 22 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 3399716</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 3399716</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Utolsó módosítás: 2024.01.29. 12:54 Pécsi Éva (MTMT Közp 2,3, admin) </div> <div class="lockedBy">Központi kezelésű 2024.10.17. 18:56 Wolf György (MTMT Központi admin) Ladányi Gusztáv (MTMT API user, admin) </div> </div></div>