https://m2.mtmt.hu/ hun 2026-05-01 02:10 JournalArticle 3399467 VALIDATED true Cited By :11 Export Date: 16 June 2022 CODEN: ARPMA 0 2018-07-26T22:20:10.000+0000 false 3399467 2026-04-16T14:11:26.889+0000 2023-09-19T17:47:55.333+0000 2018-07-26T13:51:59.000+0000 true 10045852 Patkósné Hanesz Andrea /api/admin/10045852 Admin true 10045852 2023-09-19T17:47:55.744+0000 2023-09-19T17:47:55.744+0000 2019-01-28T12:43:49.325+0000 true 10018677 Berkes Kata /api/admin/10018677 Admin true 10018677 2019-03-18T08:16:45.060+0000 true 10018677 Berkes Kata /api/admin/10018677 Admin true 10018677 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Demjen, A Synthesis, cytotoxic characterization, and SAR study of imidazo[1,2-b]pyrazole-7-carboxamides true true /api/journal/521 REVIEWED true false 521 false 521 true 0365-6233 1521-4184 Journal FOREIGN 351 7 e1800062 e1800062 21 2018 The synthesis and in vitro cytotoxic characteristics of new imidazo[1,2-b]pyrazole-7-carboxamides were investigated. Following a hit-to-lead optimization exploiting 2D and 3D cultures of MCF-7 human breast, 4T1 mammary gland, and HL-60 human promyelocytic leukemia cancer cell lines, a 67-membered library was constructed and the structure-activity relationship (SAR) was determined. Seven synthesized analogues exhibited sub-micromolar activities, from which compound 63 exerted the most significant potency with a remarkable HL-60 sensitivity (IC50=0.183M). 2018 435545 true true true false true false RESTRICTED 2026-04-16 false 18 0 18 10 6 18 18 18 13 18 18 10 10 10 8 0 18 10 18 10 0 6 6 Folyóiratcikk Journal Article 24 18 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research 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Reference 2342699 /api/reference/2342699 69 10.1007/s10549-009-0502-2 false true Reference 2342700 /api/reference/2342700 70 10.1016/j.ejmech.2012.08.007 false true Reference 2342701 /api/reference/2342701 71 10.1016/j.bmcl.2010.04.039 false true Reference 2342702 /api/reference/2342702 72 false true Reference 2342703 /api/reference/2342703 73 10.1016/j.bmcl.2013.04.039 false true /api/publication/3399467 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Demjen A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10038284"><a href="/gui2/?type=authors&mode=browse&sel=10038284" target="_blank">Alfoldi R (<span class="authorship-author-name">Alföldi Róbert</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048220"><a href="/gui2/?type=authors&mode=browse&sel=10048220" target="_blank">Angyal A (<span class="authorship-author-name">Angyal Anikó</span> <span class="authorAux-mtmt"> szerves kémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Természettudományi és Informatikai Kar">TTIK</span>/<span title="Kémiai Intézet">KI</span>/Szerves Kémiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gyuris M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hackler L </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025339"><a href="/gui2/?type=authors&mode=browse&sel=10025339" target="_blank">Szebeni GJ (<span class="authorship-author-name">Szebeni Gábor</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Genetikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000356"><a href="/gui2/?type=authors&mode=browse&sel=10000356" target="_blank">Wolfling J (<span class="authorship-author-name">Wölfling János</span> <span class="authorAux-mtmt"> Szerves kémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Természettudományi és Informatikai Kar">TTIK</span>/<span title="Kémiai Intézet">KI</span>/Szerves Kémiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010041"><a href="/gui2/?type=authors&mode=browse&sel=10010041" target="_blank">Puskas LG (<span class="authorship-author-name">Puskás László</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Genetikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064926"><a href="/gui2/?type=authors&mode=browse&sel=10064926" target="_blank">Kanizsai I (<span class="authorship-author-name">Kanizsai Iván</span> <span class="authorAux-mtmt"> Szerves kémia</span>) </a> </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3399467" target="_blank">Synthesis, cytotoxic characterization, and SAR study of imidazo[1,2-b]pyrazole-7-carboxamides</a></div> <div> <span class="journal-title">ARCHIV DER PHARMAZIE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0365-6233">0365-6233</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1521-4184">1521-4184</a>)</span>: <span class="journal-volume">351</span> <span class="journal-issue">7</span> <span class="page"> Paper e1800062. 21 p. </span> <span class="year">(2018)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span 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<span class="id identifier oa_CLOSED" title=" Zárt "> <a style="color:blue" title="14531" target="_blank" href="http://publicatio.bibl.u-szeged.hu/14531"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmaceutical Science&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Drug Discovery&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 18</span> | Független: 10 | Függő: 8 | Nem jelölt: 0 | WoS jelölt: 18 | Scopus jelölt:&nbsp;13 | WoS/Scopus jelölt:&nbsp;18 | DOI jelölt:&nbsp;18 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3399467&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 3399467</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 3399467</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS</span> </div> <div class="lastModified">Utolsó módosítás: 2023.09.19. 19:47 Ladányi Gusztáv (MTMT API user, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Cited By :11 Export Date: 16 June 2022 CODEN: ARPMA</pre> </div></div>