https://m2.mtmt.hu/ eng 2026-10-23 03:48 JournalArticle 3397026 ADMIN_APPROVED true 0 2018-07-25T22:20:08.000+0000 false 3397026 2026-10-18T20:22:53.594+0000 2024-09-19T08:11:19.983+0000 2018-07-19T01:59:13.000+0000 true 220 Hangya Balázs /api/author/220 Author true 220 2026-06-29T06:29:54.401+0000 2024-09-19T08:11:20.364+0000 true 10003133 Boros Annamária /api/admin/10003133 Admin true 10003133 Admin 10003133 /api/admin/10003133 Boros Annamária true 10003133 true 2024-09-13T11:56:08.998+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Solari, N Open Source Tools for Temporally Controlled Rodent Behavior Suitable for Electrophysiology and Optogenetic Manipulations true true /api/journal/10019826 REVIEWED true false 10019826 false 10019826 true 1662-5137 Journal FOREIGN 12 18 18 14 2018 Understanding how the brain controls behavior requires observing and manipulating neural activity in awake behaving animals. Neuronal firing is timed at millisecond precision. Therefore, to decipher temporal coding, it is necessary to monitor and control animal behavior at the same level of temporal accuracy. However, it is technically challenging to deliver sensory stimuli and reinforcers as well as to read the behavioral responses they elicit with millisecond precision. Presently available commercial systems often excel in specific aspects of behavior control, but they do not provide a customizable environment allowing flexible experimental design while maintaining high standards for temporal control necessary for interpreting neuronal activity. Moreover, delay measurements of stimulus and reinforcement delivery are largely unavailable. We combined microcontroller-based behavior control with a sound delivery system for playing complex acoustic stimuli, fast solenoid valves for precisely timed reinforcement delivery and a custom-built sound attenuated chamber using high-end industrial insulation materials. Together this setup provides a physical environment to train head-fixed animals, enables calibrated sound stimuli and precisely timed fluid and air puff presentation as reinforcers. We provide latency measurements for stimulus and reinforcement delivery and an algorithm to perform such measurements on other behavior control systems. Combined with electrophysiology and optogenetic manipulations, the millisecond timing accuracy will help interpret temporally precise neural signals and behavioral changes. Additionally, since software and hardware provided here can be readily customized to achieve a large variety of paradigms, these solutions enable an unusually flexible design of rodent behavioral experiments. Funding 1991332 /api/funding/1991332 false true Funding 1991333 /api/funding/1991333 false true true true 2018 722114 true true true false true false GOLD 2026-10-18 true https://doi.org/10.3389/fnsys.2018.00018 18 0 18 9 10 18 18 17 18 18 18 9 9 9 9 0 18 9 18 9 0 5 5 Folyóiratcikk Journal Article 24 18 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2018 0 1 0 1 0 2019 0 2 2 2 2 2020 0 5 1 5 1 2021 0 4 2 4 2 2022 0 1 1 1 1 2023 0 2 1 2 1 2024 0 3 2 3 2 Q1 false 10064504 false false false 2018-07-19T02:14:26.000+0000 2018-07-19T02:09:14.000+0000 Doktori Iskola (SE); Doktori Iskola (SE); Lendület Rendszer-Neurobiológia Kutatócsoport (KOKI) 5 22 3 5 0 true 10003133 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 10300008 /api/authorship/10300008 1 0.2 true false Author 10059091 /api/author/10059091 Solari Nicola true 10059091 true Solari N true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28683726 true PersonAuthorship 10300009 /api/authorship/10300009 2 0.2 true false Author 10055930 /api/author/10055930 Tóthné Sviatkó Katalin true 10055930 true Sviatko K true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28683725 true PersonAuthorship 10300010 /api/authorship/10300010 3 0.2 true false Author 10052392 /api/author/10052392 Laszlovszky Tamás Kristóf true 10052392 true Laszlovszky T true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28683724 true PersonAuthorship 10300011 /api/authorship/10300011 4 0.2 true false Author 10064504 /api/author/10064504 Hegedüs Panna true 10064504 true Hegedus P true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28683723 true PersonAuthorship 10300012 /api/authorship/10300012 5 0.2 false true true Author 220 /api/author/220 Hangya Balázs true 220 true Hangya B true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28683722 true PublicationIdentifier 1312350 /api/publicationidentifier/1312350 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3389/fnsys.2018.00018 https://doi.org/10.3389/fnsys.2018.00018 false 1803388 true PublicationIdentifier 1312348 /api/publicationidentifier/1312348 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000432309000003 https://www.webofscience.com/wos/woscc/full-record/000432309000003 false 1806434 true PublicationIdentifier 1312349 /api/publicationidentifier/1312349 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 85049500321 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85049500321 false 1805058 true PublicationIdentifier 1312351 /api/publicationidentifier/1312351 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 29867383 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=29867383&dopt=Abstract false 1803390 true PublicationIdentifier 1312352 /api/publicationidentifier/1312352 PlainSource 137 /api/publicationsource/137 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true Pubmed Central http://www.ncbi.nlm.nih.gov/pmc/articles/@@@ true true 137 true false IDENTICAL PMC5962774 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962774 false 1803389 true Classification 12125 /api/classification/12125 true true SjrRating 10760951 /api/sjrrating/10760951 18 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2804 /api/classificationexternal/2804 true 2804 true Q1 DIRECT true true /api/publication/3397026 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10059091"><a href="/gui2/?type=authors&mode=browse&sel=10059091" target="_blank">Solari N (<span class="authorship-author-name">Solari Nicola</span> <span class="authorAux-mtmt"> Idegtudomány</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Lendület Laboratory of System-Neurobiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055930"><a href="/gui2/?type=authors&mode=browse&sel=10055930" target="_blank">Sviatko K<sup>*</sup> (<span class="authorship-author-name">Tóthné Sviatkó Katalin</span> <span class="authorAux-mtmt"> idegtudományok, rendszer neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/School of Ph. D. Studies; <span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Lendület Laboratory of System-Neurobiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052392"><a href="/gui2/?type=authors&mode=browse&sel=10052392" target="_blank">Laszlovszky T<sup>*</sup> (<span class="authorship-author-name">Laszlovszky Tamás Kristóf</span> <span class="authorAux-mtmt"> Idegtudományok</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Lendület Laboratory of System-Neurobiology; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064504"><a href="/gui2/?type=authors&mode=browse&sel=10064504" target="_blank">Hegedus P<sup>*</sup> (<span class="authorship-author-name">Hegedüs Panna</span> <span class="authorAux-mtmt"> Idegtudomány</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Lendület Laboratory of System-Neurobiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="220"><a href="/gui2/?type=authors&mode=browse&sel=220" target="_blank">Hangya B ✉ (<span class="authorship-author-name">Hangya Balázs</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Lendület Laboratory of System-Neurobiology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3397026" target="_blank">Open Source Tools for Temporally Controlled Rodent Behavior Suitable for Electrophysiology and Optogenetic Manipulations</a></div> <div> <span class="journal-title">FRONTIERS IN SYSTEMS NEUROSCIENCE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1662-5137">1662-5137</a>)</span>: <span class="journal-volume">12</span> <span class="page"> Paper 18. 14 p. </span> <span class="year">(2018)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3389/fnsys.2018.00018" target="_blank" href="https://doi.org/10.3389/fnsys.2018.00018"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000432309000003" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000432309000003"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85049500321" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85049500321"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="29867383" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=29867383&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="PMC5962774" target="_blank" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962774"> Pubmed Central </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Cellular and Molecular Neuroscience&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Cognitive Neuroscience&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Developmental Neuroscience&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 18</span> | Independent citation: 9 | Self citation: 9 | Unknown citation: 0 | Number of citations in WoS: 17 | Number of citations in Scopus:&nbsp;18 | WoS/Scopus assigned:&nbsp;18 | Number of citations with DOI:&nbsp;18 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3397026&sort=publishedYear,desc&sort=title"> Number of cited publications: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 3397026</span> | <span class="status-data status-ADMIN_APPROVED"> Admin approved </span> <span class="oldId">Old id: 3397026</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="funder"> ‘Lendület’ Program of the Hungarian Academy of Sciences(Grant No. LP2015-2/2015), European Research Council(Grant No. StG 715043) </div> <div class="lastModified">Last Modified: 2024.09.19. 10:11 Annamária Boros (MTMT Központi admin) </div> <div class="lockedBy">Centrally managed 2024.09.13. 13:56 Annamária Boros (MTMT Központi admin) </div> </div></div>