The pulmonary endothelium is a highly regulated organ that performs a wide range of
functions under physiological and pathological conditions. Since endothelial dysfunction
has been demonstrated to play a direct role in sepsis and acute respiratory distress
syndrome, its role in COVID-19 has also been extensively investigated. Indeed, apart
from the COVID-19-associated coagulopathy biomarkers, new biomarkers were recognised
early during the pandemic, including markers of endothelial cell activation or injury.
We systematically searched the literature up to 10 March 2023 for studies examining
the association between acute and long COVID-19 severity and outcomes and endothelial
biomarkers.
