Rivaroxaban for Stroke Prevention after Embolic Stroke of Undetermined Source
NAVIGATE ESUS Investigators [Collaborative Organization]; Hart, RG ✉; Sharma, M; Mundl, H; Kasner, SE; Bangdiwala, SI; Berkowitz, SD; Swaminathan, B; Lavados, P; Wang, Y; Wang, Y; Davalos, A; Shamalov, N; Mikulik, R; Cunha, L; Lindgren, A; Arauz, A; Lang, W; Czlonkowska, A; Eckstein, J; Gagliardi, RJ; Amarenco, P; Ameriso, SF; Tatlisumak, T; Veltkamp, R; Hankey, GJ; Toni, D; Bereczki, D [Bereczki, Dániel (Stroke), author] Department of Neurology (SU / FM /
C); Uchiyama, S; Ntaios, G; Yoon, BW; Brouns, R; Endres, M; Muir, KW; Bornstein, N; Ozturk, S; O'Donnell, MJ; Basson, MMD; Pare, G; Pater, C; Kirsch, B; Sheridan, P; Peters, G; Weitz, JI; Peacock, WF; Shoamanesh, A; Benavente, OR; Joyner, C; Themeles, E**; Anderson, DC [Collaborator]; DeMets, DL [Collaborator]; Kaste, M [Collaborator]; Norrving, B [Collaborator]; Wyse, DG [Collaborator]; Alet, M [Collaborator]; Allende, G [Collaborator]; Beinlich, A [Collaborator]; Berrios, W [Collaborator]; Bruera, G [Collaborator]; Castro, D [Collaborator]; Chialvo, L [Collaborator]; Claverie, S [Collaborator]; Contardo, L [Collaborator]; Couto, J [Collaborator]; Deganutto, R [Collaborator]; Diaz, R [Collaborator]; Dossi, D [Collaborator]; Esnaola, M [Collaborator]; Falco, M [Collaborator]; Fernandez, Pirrone P [Collaborator]; Ferrari, J [Collaborator]; Firstenfeld, A [Collaborator]; Galli, Giqueauk E [Collaborator]; Gilli, M [Collaborator]; Gonzalez, L [Collaborator]; Gonzalez, Toledo M [Collaborator]; Grecco, M [Collaborator]; Halac, B [Collaborator]; Hawkes, M [Collaborator]; Ioli, P [Collaborator]; Jure, L [Collaborator]; Klein, F [Collaborator]; Lepera, S [Collaborator]; Lujan, S [Collaborator]; Mackinnon, F [Collaborator]; Marroquin, M [Collaborator]; Martin, J [Collaborator]; Parisi, V [Collaborator]; Perez, Leguizamon P [Collaborator]; Persi, G [Collaborator]; Povedano, P [Collaborator]; Povedano, G [Collaborator]; Pujol, Lereis V [Collaborator]; Radrizzani, L [Collaborator]; Reich, E [Collaborator]; Repetto, M [Collaborator]; Rodriguez, Lucci F [Collaborator]; Romano, M [Collaborator]; Saredo, G [Collaborator]; Schneider, M [Collaborator]; Simonsini, C [Collaborator]; Sumay, G [Collaborator]; Thomson, A [Collaborator]; Toledo, W [Collaborator]; Torres, C [Collaborator]; Vila, A [Collaborator]; Abdul, Rasheed N [Collaborator]; Anderson, C [Collaborator]; Bailey, P [Collaborator]; Blacker, D [Collaborator]; Carcel, C [Collaborator]; Clissold, B [Collaborator]; Delcourt, C [Collaborator]; Field, D [Collaborator]; Gangadharan, S [Collaborator]; Ghia, D [Collaborator]; Kleinig, T [Collaborator]; Leyden, J [Collaborator]; Ly, J [Collaborator]; Ma, H [Collaborator]; Mackey, E [Collaborator]; Mishra, S [Collaborator]; Moey, A [Collaborator]; Musuka, T [Collaborator]; Pepper, E [Collaborator]; Phan, T [Collaborator]; Sabet, A [Collaborator]; Saw, J [Collaborator]; Singh, B [Collaborator]; Tryambake, D [Collaborator]; Tu, H [Collaborator]; Wijeratne, T [Collaborator]; Wong, A [Collaborator]; Augustin, S [Collaborator]; Esterbauer, M [Collaborator]; Ferrari, J [Collaborator]; Garnauf, M [Collaborator]; Gasiorek, K [Collaborator]; Gasser, S [Collaborator]; Gaugg, M [Collaborator]; Greisenegger, S [Collaborator]; Harrasser, M [Collaborator]; Heine, M [Collaborator]; Huber, B [Collaborator]; Joachim, B [Collaborator]; Kapeller, P [Collaborator]; Krebs, S [Collaborator]; Kreuzpointer, R [Collaborator]; Kunzmann, J [Collaborator]; Lechner, H [Collaborator]; Lohninger, B [Collaborator]; Luschin, G [Collaborator]; Macher, S [Collaborator]; Marko, M [Collaborator]; Matosevic, B [Collaborator]; Mayr, A [Collaborator]; Mismas, A [Collaborator]; Mitrovic, N [Collaborator]; Mutzenbach, J [Collaborator]; Oberndorfer, S [Collaborator]; Obmann, S [Collaborator]; Raffelsberger, T [Collaborator]; Roesler, C [Collaborator]; Salletmayr, T [Collaborator]; Serles, W [Collaborator]; Stadler, K [Collaborator]; Tinchon, A [Collaborator]; Tolino, M [Collaborator]; Verocai, V [Collaborator]; Vigl, M [Collaborator]; Voglsperger, B [Collaborator]; Weber, J [Collaborator]; Werner, P [Collaborator]; Windt, J [Collaborator]; Winkler, A [Collaborator]; Wurzinger, H [Collaborator]; Zelenka, I [Collaborator]; Cras, P [Collaborator]; Crols, R [Collaborator]; De Keyser, J [Collaborator]; De Klippel, N [Collaborator]; De Pauw, A [Collaborator]; De Smedt, A [Collaborator]; Dhollander, I [Collaborator]; Hermans, S [Collaborator]; Ligot, N [Collaborator]; Maqueda, V [Collaborator]; Maqueda, Maqueda V [Collaborator]; Naeije, G [Collaborator]; Seynaeve, L [Collaborator]; Soors, P [Collaborator]; Van, Daele W [Collaborator]; Vanacker, P [Collaborator]; Vanderschueren, G [Collaborator]; Willems, C [Collaborator]; Yperzeele, L [Collaborator]; Avelar, W [Collaborator]; Bacellar, A [Collaborator]; Batista, C [Collaborator]; Bazan, R [Collaborator]; Braga, G [Collaborator]; Cardoso, F [Collaborator]; Dagnino, M [Collaborator]; Fabio, S [Collaborator]; Ferreira, Junior G [Collaborator]; Freitas, G [Collaborator]; Friedrich, M [Collaborator]; Gomes, Neto A [Collaborator]; Guarda, S [Collaborator]; Katsurayama, M [Collaborator]; Machado, M [Collaborator]; Martins, S [Collaborator]; Meira, F [Collaborator]; Minelli, C [Collaborator]; Morais, R [Collaborator]; Moro, C [Collaborator]; Neto, O [Collaborator]; Polin, M [Collaborator]; Silva, D [Collaborator]; Weiss, G [Collaborator]; Basile, V [Collaborator]; Beaudry, M [Collaborator]; Berlingieri, J [Collaborator]; Blacquiere, D [Collaborator]; Buck, B [Collaborator]; Chan, R [Collaborator]; Coutts, S [Collaborator]; Das, S [Collaborator]; Desai, J [Collaborator]; Ehrensperger, E [Collaborator]; Field, T [Collaborator]; Gladstone, D [Collaborator]; Hachinski, V [Collaborator]; Hassan, A [Collaborator]; Hegedus, J [Collaborator]; Hill, M [Collaborator]; Jin, A [Collaborator]; Khaw, A [Collaborator]; Mackey, A [Collaborator]; Maclean, G [Collaborator]; Mandzia, J [Collaborator]; Mann, S [Collaborator]; Mehdiratta, M [Collaborator]; Murphy, C [Collaborator]; Ng, K [Collaborator]; Oczkowski, W [Collaborator]; Penn, A [Collaborator]; Perera, K [Collaborator]; Perez, Y [Collaborator]; Pesant, Y [Collaborator]; Phillips, S [Collaborator]; Poppe, A [Collaborator]; Sahlas, J [Collaborator]; Shuaib, A [Collaborator]; Spence, D [Collaborator]; Sposato, L [Collaborator]; Stotts, G [Collaborator]; Tamayo, A [Collaborator]; Teal, P [Collaborator]; Wilson, L [Collaborator]; Winder, T [Collaborator]; Yegappan, C [Collaborator]; Yip, S [Collaborator]; Andreu, D [Collaborator]; Araya, P [Collaborator]; Bustamante, G [Collaborator]; Figueroa, C [Collaborator]; Gasic, K [Collaborator]; Herrero, D [Collaborator]; Matamala, G [Collaborator]; Munoz, S [Collaborator]; Olavarria, V [Collaborator]; Pasten, J [Collaborator]; Polanco, J [Collaborator]; Reyes, P [Collaborator]; Roldan, A [Collaborator]; Salamanca, P [Collaborator]; Silva, P [Collaborator]; Toloza, C [Collaborator]; Verdugo, M [Collaborator]; Cai, K [Collaborator]; Che, C [Collaborator]; Chen, J [Collaborator]; Chen, Z [Collaborator]; Chen, T [Collaborator]; Chen, H [Collaborator]; Chen, X [Collaborator]; Chen, H [Collaborator]; Chen, B [Collaborator]; Chen, G [Collaborator]; Chen, J [Collaborator]; Chen, J [Collaborator]; Chen, L [Collaborator]; Chu, F [Collaborator]; Cui, L [Collaborator]; Dai, C [Collaborator]; Ding, N [Collaborator]; Ding, J [Collaborator]; Ding, J [Collaborator]; Du, P [Collaborator]; Du, J [Collaborator]; Fang, L [Collaborator]; Feng, J [Collaborator]; Gao, Y [Collaborator]; Geng, J [Collaborator]; Guan, J [Collaborator]; Hao, L [Collaborator]; Huang, D [Collaborator]; Huang, H [Collaborator]; Jin, X [Collaborator]; Jing, P [Collaborator]; Ke, K [Collaborator]; Li, G [Collaborator]; Li, G [Collaborator]; Li, M [Collaborator]; Li, S [Collaborator]; Li, J [Collaborator]; Liang, Z [Collaborator]; Lin, H [Collaborator]; Liu, K [Collaborator]; Liu, X [Collaborator]; Lu, Z [Collaborator]; Ma, C [Collaborator]; Pei, H [Collaborator]; Qiu, J [Collaborator]; Qu, X [Collaborator]; Shen, W [Collaborator]; Sun, X [Collaborator]; Tian, J [Collaborator]; Tong, L [Collaborator]; Tong, Z [Collaborator]; Wang, J [Collaborator]; Wang, L [Collaborator]; Wang, X [Collaborator]; Wang, W [Collaborator]; Wang, N [Collaborator]; Wang, D [Collaborator]; Wang, H [Collaborator]; Wang, X [Collaborator]; Wen, G [Collaborator]; Weng, G [Collaborator]; Wu, W [Collaborator]; Wu, S [Collaborator]; Xiao, B [Collaborator]; Xiaopeng, W [Collaborator]; Xiong, L [Collaborator]; Xiong, Y [Collaborator]; Xu, Y [Collaborator]; Xu, J [Collaborator]; Xu, Z [Collaborator]; Yang, L [Collaborator]; Yang, Y [Collaborator]; Yang, X [Collaborator]; Yang, J [Collaborator]; Yang, Q [Collaborator]; Yang, B [Collaborator]; Yang, Y [Collaborator]; Zhang, C [Collaborator]; Zhang, B [Collaborator]; Zhang, B [Collaborator]; Zhang, Y [Collaborator]; Zhang, S [Collaborator]; Zhang, C [Collaborator]; Zhang, M [Collaborator]; Zhang, X [Collaborator]; Zhang, J [Collaborator]; Zhang, J [Collaborator]; Zhao, L [Collaborator]; Zhou, L [Collaborator]; Bar, M [Collaborator]; Barteys, M [Collaborator]; Bartolottiova, T [Collaborator]; Carek, M [Collaborator]; Ferencova, K [Collaborator]; Fiksa, J [Collaborator]; Gallo, J [Collaborator]; Goldemund, D [Collaborator]; Hanouskova, L [Collaborator]; Herzig, R [Collaborator]; Hon, P [Collaborator]; Jankovych, J [Collaborator]; Jura, R [Collaborator]; Kadlcikova, J [Collaborator]; Kemlink, D [Collaborator]; Kopecky, S [Collaborator]; Krajickova, D [Collaborator]; Kral, M [Collaborator]; Krejci, V [Collaborator]; Pavlik, O [Collaborator]; Peisker, T [Collaborator]; Pernicka, M [Collaborator]; Peska, S [Collaborator]; Rapantova, P [Collaborator]; Reif, M [Collaborator]; Rekova, P [Collaborator]; Sanak, D [Collaborator]; Sebejova, M [Collaborator]; Skoda, O [Collaborator]; Slonkova, J [Collaborator]; Stetkarova, I [Collaborator]; Tenora, D [Collaborator]; Tumova, R [Collaborator]; Vaclavik, D [Collaborator]; Vasko, P [Collaborator]; Veverka, T [Collaborator]; Vitkova, E [Collaborator]; Volna, J [Collaborator]; Andersen, G [Collaborator]; Christensen, H [Collaborator]; Christensen, T [Collaborator]; Damgaard, D [Collaborator]; Iversen, H [Collaborator]; Krarup, Hansen C [Collaborator]; Kruuse, C [Collaborator]; Martinussen, M [Collaborator]; Modrau, B [Collaborator]; Murtuzova, A [Collaborator]; Ovesen, C [Collaborator]; Papina, M [Collaborator]; Svaneborg, N [Collaborator]; Von Weitzel-Mudersbach, P [Collaborator]; Curtze, S [Collaborator]; Fanta, S [Collaborator]; Huhtakangas, J [Collaborator]; Keskinarkaus, I [Collaborator]; Kivioja, R [Collaborator]; Koivu, M [Collaborator]; Korpela, J [Collaborator]; Larjo, T [Collaborator]; Linna, M [Collaborator]; Marinkovic, I [Collaborator]; Martinez-Majander, N [Collaborator]; Nieminen, T [Collaborator]; Nikkanen, M [Collaborator]; Numminen, H [Collaborator]; Ortiz, R [Collaborator]; Österlund-Tauriala, E [Collaborator]; Roine, R [Collaborator]; Roine, S [Collaborator]; Ruuskanen, J [Collaborator]; Saarinen, J [Collaborator]; Shulga, A [Collaborator]; Sibolt, G [Collaborator]; Tapanainen, A [Collaborator]; Tapiola, T [Collaborator]; Tiainen, M [Collaborator]; Tomppo, L [Collaborator]; Tumpula, O [Collaborator]; Tuomainen, P [Collaborator]; Tynkkynen, J [Collaborator]; Vainikka, S [Collaborator]; Valpas, J [Collaborator]; Virta, J [Collaborator]; Ylikallio, E [Collaborator]; Ylikotila, P [Collaborator]; Accassat, S [Collaborator]; Aniculaesei, A [Collaborator]; Baronnet, F [Collaborator]; Bejot, Y [Collaborator]; Bindila, D [Collaborator]; Birchenall, J [Collaborator]; Blanc-Labarre, C [Collaborator]; Bodiguel, E [Collaborator]; Bouly, S [Collaborator]; Cabrejo, L [Collaborator]; Calvet, D [Collaborator]; Corlobe, A [Collaborator]; Crozier, S [Collaborator]; Delpont, B [Collaborator]; Deltour, S [Collaborator]; Diaconu, M [Collaborator]; Domigo, V [Collaborator]; Epinat, M [Collaborator]; Ferreira, A [Collaborator]; Fisselier, M [Collaborator]; Garnier, P [Collaborator]; Gimenez, L [Collaborator]; Gueguen, A [Collaborator]; Guidoux, C [Collaborator]; Guillon, B [Collaborator]; Guiraudg, V [Collaborator]; Hervieu-Begue, M [Collaborator]; Hobeanu, M [Collaborator]; Khoumri, C [Collaborator]; Lamy, C [Collaborator]; Lauer, V [Collaborator]; Le Bouc, R [Collaborator]; Lecouturier, K [Collaborator]; Leder, S [Collaborator]; Leger, A [Collaborator]; Macian-Montoro, F [Collaborator]; Meseguer, E [Collaborator]; Morar-Precup, D [Collaborator]; Morvan, T [Collaborator]; Morvan, E [Collaborator]; Obadia, M [Collaborator]; Osseby, G [Collaborator]; Philippi, S [Collaborator]; Pico, F [Collaborator]; Quenardelle, V [Collaborator]; Reiner, P [Collaborator]; Rigual, R [Collaborator]; Rosso, C [Collaborator]; Sabben, C [Collaborator]; Samson, Y [Collaborator]; Sevin, M [Collaborator]; Sibon, I [Collaborator]; Thouvenot, E [Collaborator]; Timsit, S [Collaborator]; Touze, E [Collaborator]; Turc, G [Collaborator]; Vahedi, K [Collaborator]; Varvat, J [Collaborator]; Wacongne, A [Collaborator]; Wolff, V [Collaborator]; Yalo, B [Collaborator]; Zinchenko, I [Collaborator]; Bagelmann, H [Collaborator]; Bardutzky, J [Collaborator]; Barlinn, J [Collaborator]; Bathe-Peters, R [Collaborator]; Berrouschot, J [Collaborator]; Dietzel, J [Collaborator]; Ehrlich, S [Collaborator]; Fatar, M [Collaborator]; Filipov, A [Collaborator]; Fluri, F [Collaborator]; Gabriel, M [Collaborator]; Geran, R [Collaborator]; Gliem, M [Collaborator]; Graf, S [Collaborator]; Griebe, M [Collaborator]; Grosse, G [Collaborator]; Haeusler, K [Collaborator]; Harmel, P [Collaborator]; Held, V [Collaborator]; Hellwig, S [Collaborator]; Henkner, J [Collaborator]; Hieber, M [Collaborator]; Hoyer, C [Collaborator]; Jander, S [Collaborator]; Keilitz, J [Collaborator]; Kellner, J [Collaborator]; Knecht, S [Collaborator]; Koch, M [Collaborator]; Koehler, L [Collaborator]; Kucken, D [Collaborator]; Kusnick, G [Collaborator]; Lambeck, J [Collaborator]; Lee, J [Collaborator]; Leisse, I [Collaborator]; Lubke-Detring, S [Collaborator]; Machetanz, J [Collaborator]; Mensch, A [Collaborator]; Meyer, N [Collaborator]; Molis, A [Collaborator]; Mueller, T [Collaborator]; Muhl, C [Collaborator]; Nave, A [Collaborator]; Radtke, A [Collaborator]; Roth, Y [Collaborator]; Roukens, R [Collaborator]; Schlachetzki, F [Collaborator]; Schneider, I [Collaborator]; Schuppner, R [Collaborator]; Schurig, J [Collaborator]; Schwarzbach, C [Collaborator]; Seidel, G [Collaborator]; Sonntag, N [Collaborator]; Steinert, S [Collaborator]; Stoll, A [Collaborator]; Stumpp, A [Collaborator]; Taggeselle, J [Collaborator]; Trommer, A [Collaborator]; Tuetuencue, S [Collaborator]; Wartenberg, K [Collaborator]; Weissenborn, K [Collaborator]; Wittayer, M [Collaborator]; Wolf, M [Collaborator]; Wolter, C [Collaborator]; Worthmann, H [Collaborator]; Wunderlich, S [Collaborator]; Zitzmann, A [Collaborator]; Anagnostou, E [Collaborator]; Brokalaki, C [Collaborator]; Hatzitolios, A [Collaborator]; Kakaletsis, N [Collaborator]; Kanellos, I [Collaborator]; Kei, A [Collaborator]; Korompoki, E [Collaborator]; Koutroubi, A [Collaborator]; Liamis, G [Collaborator]; Makaritsis, K [Collaborator]; Manios, E [Collaborator]; Michas, F [Collaborator]; Milionis, H [Collaborator]; Papadopoulos, G [Collaborator]; Papadopoulou, E [Collaborator]; Papagiannis, A [Collaborator]; Polychronopoulou, E [Collaborator]; Sagris, D [Collaborator]; Satsoglou, S [Collaborator]; Savopoulos, C [Collaborator]; Solganov, I [Collaborator]; Spengos, K [Collaborator]; Stamatelopoulos, K [Collaborator]; Terentiou, A [Collaborator]; Tountopoulou, A [Collaborator]; Vassilopoulou, S [Collaborator]; Amjad, A [Collaborator]; Balazs, A [Collaborator]; Bankuti, Z [Collaborator]; Bicsak, T [Collaborator]; Borcsik, L [Collaborator]; Csanyi, A [Collaborator]; Csiba, L [Collaborator]; Csontos, K [Collaborator]; Csuha, R [Collaborator]; Czurko, M [Collaborator]; Danku, V [Collaborator]; Dioszeghy, P [Collaborator]; Faust, K [Collaborator]; Fazekas, F [Collaborator]; Gerocs, Z [Collaborator]; Gottschal, M [Collaborator]; Gyuker, N [Collaborator]; Hajas, A [Collaborator]; Horvath, L [Collaborator]; Horvath, M [Collaborator]; Iljicsov, A [Collaborator]; Jakab, K [Collaborator]; Javor, L [Collaborator]; Kakuk, I [Collaborator]; Karasz, O [Collaborator]; Kasa, K [Collaborator]; Kasza, J [Collaborator]; Kerekgyarto, M [Collaborator]; Klivenyi, P [Klivényi, Péter (Neurológia), Collaborator] Department of Neurology (SZTE
/ ASZMS); Kovacs, K [Collaborator]; Kovacs, T [Kovács, Tibor (Dementia, Dystoni...), Collaborator]; Kovacs, H [Collaborator]; Lajos, B [Collaborator]; Lovasz, R [Collaborator]; Magyar, T [Collaborator]; Matoltsy, A [Collaborator]; May, Z [Collaborator]; Molnar, S [Collaborator]; Monosi, C [Collaborator]; Motko, T [Collaborator]; Nemeth, R [Collaborator]; Nemeth, L [Collaborator]; Nikl, J [Collaborator]; Olah, L [Collaborator]; Orosz, V [Collaborator]; Panczel, G [Collaborator]; Pentek, S [Collaborator]; Prendl, B [Collaborator]; Rozsa, C [Rózsa, Csilla (neurológia), Collaborator] Jahn Ferenc Dél-pesti Kórház;
Department of Neurology; Rum, G [Collaborator]; Sas, K [Collaborator]; Sas, A [Collaborator]; Semjen, J [Collaborator]; Simony, Z [Collaborator]; Sipos, I [Collaborator]; Szabo, K [Collaborator]; Szasz, G [Collaborator]; Szegedi, N [Collaborator]; Szekely, A [Collaborator]; Szilagyi, G [Collaborator]; Szoboszlai, K [Collaborator]; Szpisjak, L [Collaborator]; Toth, G [Collaborator]; Uhrinyakova, L [Collaborator]; Valikovics, A [Collaborator]; Varga, Z [Collaborator]; Vass, L [Collaborator]; Vastagh, I [Vastagh, Ildikó (Dystonia, Cerebro...), Collaborator]; Vecsei, L [Vécsei, László (Neurológia), Collaborator] Department of Neurology (SZTE
/ ASZMS); Zboznovits, D [Collaborator]; Coveney, S [Collaborator]; Horgan, G [Collaborator]; Kelly, P [Collaborator]; Murphy, S [Collaborator]; Smyth, A [Collaborator]; Waters, R [Collaborator]; Abu, Ahmad F [Collaborator]; Bloch, S [Collaborator]; Dorodnicov, E [Collaborator]; Hallevi, H [Collaborator]; Haratz, S [Collaborator]; Horev, A [Collaborator]; Kolianov, V [Collaborator]; Leker, R [Collaborator]; Mahagney, A [Collaborator]; Marzelik, O [Collaborator]; Rephaeli, G [Collaborator]; Tanne, D [Collaborator]; Weller, B [Collaborator]; Acciaresi, M [Collaborator]; Adami, A [Collaborator]; Agostoni, E [Collaborator]; Alemseged, F [Collaborator]; Altavilla, R [Collaborator]; Angelocola, S [Collaborator]; Anticoli, S [Collaborator]; Berardi, V [Collaborator]; Bravi, M [Collaborator]; Candeloro, E [Collaborator]; Cappellari, M [Collaborator]; Carletti, M [Collaborator]; Caruso, P [Collaborator]; Castellini, P [Collaborator]; Cavallini, A [Collaborator]; Cenciarelli, S [Collaborator]; Cerrone, P [Collaborator]; Condurso, R [Collaborator]; Consoli, D [Collaborator]; Danese, A [Collaborator]; Della Marca, G [Collaborator]; Denaro, M [Collaborator]; Di Mascio, M [Collaborator]; Diomedi, M [Collaborator]; Distefano, M [Collaborator]; Frisullo, G [Collaborator]; Furlanis, G [Collaborator]; Galati, F [Collaborator]; Gallina, A [Collaborator]; Gallinella, E [Collaborator]; Giannandrea, D [Collaborator]; Giatsidis, F [Collaborator]; Greco, L [Collaborator]; Impellizzeri, M [Collaborator]; Landolfi, A [Collaborator]; Lanfranconi, S [Collaborator]; Latte, L [Collaborator]; Lembo, G [Collaborator]; Longoni, M [Collaborator]; Marando, C [Collaborator]; Marini, C [Collaborator]; Marsili, E [Collaborator]; Mastrocola, S [Collaborator]; Mazzoli, T [Collaborator]; Melis, M [Collaborator]; Micheletti, N [Collaborator]; Moller, J [Collaborator]; Monzani, V [Collaborator]; Naccarato, M [Collaborator]; Paciaroni, M [Collaborator]; Padiglioni, C [Collaborator]; Persico, A [Collaborator]; Pezzella, F [Collaborator]; Pieroni, A [Collaborator]; Piras, V [Collaborator]; Postorino, P [Collaborator]; Pozzerese, C [Collaborator]; Profice, P [Collaborator]; Ricci, S [Collaborator]; Rinaldi, C [Collaborator]; Rizzato, B [Collaborator]; Rocco, A [Collaborator]; Roveri, L [Collaborator]; Santalucia, P [Collaborator]; Semerano, A [Collaborator]; Sicilia, I [Collaborator]; Silvestrini, M [Collaborator]; Sucapane, P [Collaborator]; Tomelleri, G [Collaborator]; Tropepi, D [Collaborator]; Venti, M [Collaborator]; Amino, T [Collaborator]; Chin, M [Collaborator]; Deguchi, I [Collaborator]; Fujigasaki, H [Collaborator]; Fukuyama, K [Collaborator]; Haraguchi, K [Collaborator]; Hasegawa, Y [Collaborator]; Hattori, M [Collaborator]; Hayashi, T [Collaborator]; Hirose, M [Collaborator]; Honma, Y [Collaborator]; Igarashi, S [Collaborator]; Irie, S [Collaborator]; Itabashi, R [Collaborator]; Ito, Y [Collaborator]; Kamata, T [Collaborator]; Kaneko, C [Collaborator]; Kawanishi, M [Collaborator]; Kimura, R [Collaborator]; Kitagawa, K [Collaborator]; Kobayashi, Y [Collaborator]; Kondo, T [Collaborator]; Kuwashiro, T [Collaborator]; Matsumoto, S [Collaborator]; Miyake, H [Collaborator]; Nagakane, Y [Collaborator]; Nishino, S [Collaborator]; Nishiyama, Y [Collaborator]; Nogawa, S [Collaborator]; Ochiai, J [Collaborator]; Ohira, M [Collaborator]; Okamoto, Y [Collaborator]; Okubo, S [Collaborator]; Okuda, S [Collaborator]; Ooyama, K [Collaborator]; Sakai, N [Collaborator]; Suenaga, T [Collaborator]; Suzuki, H [Collaborator]; Takamatsu, K [Collaborator]; Takao, M [Collaborator]; Taki, W [Collaborator]; Takizawa, S [Collaborator]; Tokunaga, K [Collaborator]; Toyoda, K [Collaborator]; Urui, S [Collaborator]; Yamada, T [Collaborator]; Yamasaki, M [Collaborator]; Yoshida, Y [Collaborator]; Yuasa, H [Collaborator]; Bae, H [Collaborator]; Cha, J [Collaborator]; Chang, D [Collaborator]; Chung, C [Collaborator]; Heo, J [Collaborator]; Hong, K [Collaborator]; Kim, J [Collaborator]; Lee, B [Collaborator]; Lee, J [Collaborator]; Nah, H [Collaborator]; Oh, K [Collaborator]; Park, M [Collaborator]; Park, J [Collaborator]; Rha, J [Collaborator]; Sohn, S [Collaborator]; Amaya, Sanchez L [Collaborator]; Arauz, Gongora A [Collaborator]; Cantu, Brito C [Collaborator]; Chiquete, Anaya E [Collaborator]; Felipe, Amaya P [Collaborator]; Fernandez, Vera J [Collaborator]; Garcia, Lopez R [Collaborator]; Gien, Lopez J [Collaborator]; Gongora-Rivera, J [Collaborator]; Hernandez, J [Collaborator]; Leal, Cantu R [Collaborator]; Lopez, Garza N [Collaborator]; Medina, Pech C [Collaborator]; Mendez, B [Collaborator]; Pena, Sedna L [Collaborator]; Reyes, Morales S [Collaborator]; Ruiz, Franco A [Collaborator]; Serrano, F [Collaborator]; Tovar, M [Collaborator]; Uribe, R [Collaborator]; Bak, Z [Collaborator]; Baranowska, A [Collaborator]; Bilik, M [Collaborator]; Blazejewska-Hyzorek, B [Collaborator]; Brola, W [Collaborator]; Brzoska-Mizgalska, J [Collaborator]; Buksinska-Lisik, M [Collaborator]; Chorazy, M [Collaborator]; Czerska, M [Collaborator]; Czuryszkiewicz, M [Collaborator]; Dalek, G [Collaborator]; Dylewicz, L [Collaborator]; Fiszer, U [Collaborator]; Fraczek, A [Collaborator]; Friedman, A [Collaborator]; Fryze, W [Collaborator]; Gasecki, D [Collaborator]; Gębura, K [Collaborator]; Geremek, M [Collaborator]; Glabinski, A [Collaborator]; Gluszkiewicz, M [Collaborator]; Goździk, I [Collaborator]; Grzesik, M [Collaborator]; Jasek, L [Collaborator]; Kaczorowska, B [Collaborator]; Kalinowska, K [Collaborator]; Kaminska, K [Collaborator]; Kapica-Topczewska, K [Collaborator]; Karlinski, M [Collaborator]; Kobayashi, A [Collaborator]; Kosarz-Lanczek, K [Collaborator]; Kowalczyk, K [Collaborator]; Kowalska, M [Collaborator]; Kraska, J [Collaborator]; Krzyzanowska, M [Collaborator]; Kulakowska, A [Collaborator]; Kurkowska-Jastrzebska, I [Collaborator]; Lasek-Bal, A [Collaborator]; Litwin, T [Collaborator]; Morton, M [Collaborator]; Myśliwy, W [Collaborator]; Nosek, K [Collaborator]; Nowak, B [Collaborator]; Nowakowska-Śledź, E [Collaborator]; Odyniec, A [Collaborator]; Oleszek, J [Collaborator]; Ozdoba-Rot, J [Collaborator]; Palasik, W [Collaborator]; Pawelczyk, M [Collaborator]; Rozanski, D [Collaborator]; Rozniecki, J [Collaborator]; Sawicka, M [Collaborator]; Sieczkowska, E [Collaborator]; Skowron, P [Collaborator]; Skowronska, M [Collaborator]; Sliwinska, B [Collaborator]; Sobolewski, P [Collaborator]; Sobota, A [Collaborator]; Stoiński, J [Collaborator]; Szczuchniak, W [Collaborator]; Szczyrba, S [Collaborator]; Szewczyk, Z [Collaborator]; Szlufik, S [Collaborator]; Tarasiuk, J [Collaborator]; Tutaj, A [Collaborator]; Uchwat, U [Collaborator]; Wach-Klink, A [Collaborator]; Winska-Tereszkiewicz, A [Collaborator]; Wisniewska, A [Collaborator]; Włodek, A [Collaborator]; Wojnarowska-Arendt, A [Collaborator]; Zalewska, J [Collaborator]; Zielinska-Turek, J [Collaborator]; Ziomek, M [Collaborator]; Zwiernik, J [Collaborator]; Abreu, P [Collaborator]; Amaral, E Silva A [Collaborator]; Azevedo, E [Collaborator]; Barroso, C [Collaborator]; Calejo, M [Collaborator]; Campillo, J [Collaborator]; Campos, Costa E [Collaborator]; Coelho, J [Collaborator]; Correia, M [Collaborator]; Correia, C [Collaborator]; Gregorio, T [Collaborator]; Lopes, D [Collaborator]; Machado, C [Collaborator]; Mendonca, T [Collaborator]; Pereira, L [Collaborator]; Pidal, A [Collaborator]; Pineiro, S [Collaborator]; Pinto, A [Collaborator]; Ribeiro, J [Collaborator]; Rodrigues, M [Collaborator]; Salgado, P [Collaborator]; Salgado, A [Collaborator]; Santo, G [Collaborator]; Sargento, J [Collaborator]; Varela, R [Collaborator]; Abroskina, M [Collaborator]; Badalyan, K [Collaborator]; Balueva, T [Collaborator]; Barulin, A [Collaborator]; Bazhenova, O [Collaborator]; Belkin, A [Collaborator]; Bogdanov, E [Collaborator]; Daineko, A [Collaborator]; Druzenko, I [Collaborator]; Fedin, A [Collaborator]; Fidler, M [Collaborator]; Gogoleva, E [Collaborator]; Golikov, K [Collaborator]; Gonysheva, Y [Collaborator]; Greshnova, I [Collaborator]; Guryanova, N [Collaborator]; Gusev, V [Collaborator]; Kashaeva, E [Collaborator]; Kaygorodtseva, S [Collaborator]; Khairutdinova, D [Collaborator]; Kholopov, M [Collaborator]; Kirpicheva, S [Collaborator]; Koltsov, I [Collaborator]; Konkov, I [Collaborator]; Kurenkova, N [Collaborator]; Kurtenkova, N [Collaborator]; Kurushina, O [Collaborator]; Kustova, M [Collaborator]; Lagutenko, M [Collaborator]; Lenskaya, L [Collaborator]; Lupinogina, L [Collaborator]; Lvova, A [Collaborator]; Melnikova, E [Collaborator]; Meshkova, K [Collaborator]; Morozova, E [Collaborator]; Mozhejko, E [Collaborator]; Nikoforova, M [Collaborator]; Obrezan, A [Collaborator]; Ondar, V [Collaborator]; Pizova, N [Collaborator]; Polyakov, A [Collaborator]; Popov, D [Collaborator]; Prazdnichkova, E [Collaborator]; Prokopenko, S [Collaborator]; Pudov, E [Collaborator]; Salnikov, M [Collaborator]; Samoshkina, O [Collaborator]; Semushina, D [Collaborator]; Shchukin, I [Collaborator]; Shepeleva, E [Collaborator]; Shmonin, A [Collaborator]; Smolkin, A [Collaborator]; Soldatov, M [Collaborator]; Soloveva, L [Collaborator]; Solovyeva, E [Collaborator]; Stakhovskaya, L [Collaborator]; Tcvetkova, S [Collaborator]; Varvyanskaya, N [Collaborator]; Voznyuk, I [Collaborator]; Zhirnova, O [Collaborator]; Ahmed, F [Collaborator]; Basson, M [Collaborator]; Engelbrecht, J [Collaborator]; Hobson, B [Collaborator]; Jansen, J [Collaborator]; Nel, J [Collaborator]; Nell, H [Collaborator]; Njovane, X [Collaborator]; Pretorius, M [Collaborator]; Roos, J [Collaborator]; Salig, S [Collaborator]; Siebert, M [Collaborator]; Amaro, S [Collaborator]; Arenillas, Lara J [Collaborator]; Arias, Rivas S [Collaborator]; Baez, Martinez E [Collaborator]; Bas, M [Collaborator]; Bashir, S [Collaborator]; Bragado, I [Collaborator]; Cajaraville, S [Collaborator]; Camps, P [Collaborator]; Cardona, Portela P [Collaborator]; Casado-Naranjo, I [Collaborator]; Castellanos, M [Collaborator]; Cayuela, Caudevilla N [Collaborator]; Chamorro, A [Collaborator]; Constantino, Silva A [Collaborator]; Cortijo, Garcia E [Collaborator]; De La Torre, J [Collaborator]; De Torres, R [Collaborator]; Diaz, Otero F [Collaborator]; Diez-Tejedor, E [Collaborator]; Escribano, B [Collaborator]; Escudero, I [Collaborator]; Fernandez, M [Collaborator]; Font, M [Collaborator]; Fortea, G [Collaborator]; Freijo, M [Collaborator]; Fuentes, Gimeno B [Collaborator]; Gamero, M [Collaborator]; Garcia, J [Collaborator]; Garcia, Pastor A [Collaborator]; Garcia, Sanchez S [Collaborator]; Geniz, Clavijo M [Collaborator]; Gil, Nunez A [Collaborator]; Giralt, E [Collaborator]; Gomez-Choco, M [Collaborator]; Gomis, M [Collaborator]; Gutiérrez, R [Collaborator]; Iglesias, Mohedano A [Collaborator]; Lago, A [Collaborator]; Lara, Lezama L [Collaborator]; Lara, Rodriguez B [Collaborator]; Llull, L [Collaborator]; Lopez, Fernandez M [Collaborator]; Lorenzo, A [Collaborator]; Maestre-Moreno, J [Collaborator]; Marta, Moreno J [Collaborator]; Marti-Fabregas, J [Collaborator]; Martínez, Sánchez P [Collaborator]; Mauri, Cabdevila G [Collaborator]; Mengual, Chirifie J [Collaborator]; Molina, C [Collaborator]; Molina, J [Collaborator]; Moniche, F [Collaborator]; Morales, L [Collaborator]; Morales, A [Collaborator]; Nombela, F [Collaborator]; Núñez, F [Collaborator]; Pagola, J [Collaborator]; Perez, S [Collaborator]; Portilla, J [Collaborator]; Prats, L [Collaborator]; Purroy, F [Collaborator]; Quesada, Garcia H [Collaborator]; Ramirez, Moreno J [Collaborator]; Redondo, Robles L [Collaborator]; Renu, A [Collaborator]; Riveira, Rodriguez C [Collaborator]; Roa, A [Collaborator]; Rodriguez, Campello A [Collaborator]; Rodriguez, Pardo De Donlebun J [Collaborator]; Rodriguez, Yanez M [Collaborator]; Rudilosso, S [Collaborator]; Ruiz, Ares G [Collaborator]; Sànchez, Cerón M [Collaborator]; Santamaria, Cadavid M [Collaborator]; Sanz, Cuesta B [Collaborator]; Serena, J [Collaborator]; Silva, Y [Collaborator]; Soriano, Soriano C [Collaborator]; Tejada, Garcia J [Collaborator]; Tejada, Meza H [Collaborator]; Tembl, J [Collaborator]; Terceno, M [Collaborator]; Trillo, S [Collaborator]; Urra, X [Collaborator]; Usero, Ruiz M [Collaborator]; Vazquez, P [Collaborator]; Vilar, C [Collaborator]; Villanueva, Osorio J [Collaborator]; Ximenez-Carrillo, A [Collaborator]; Zapata, E [Collaborator]; Esbjornsson, M [Collaborator]; Karlsson, J [Collaborator]; Kremer, C [Collaborator]; Kuris, A [Collaborator]; Staaf, G [Collaborator]; Stiehm, M [Collaborator]; Timberg, I [Collaborator]; Tossavainen, C [Collaborator]; Wester, P [Collaborator]; Arnold, M [Collaborator]; Baumgartner, P [Collaborator]; Beer, J [Collaborator]; Bicker, H [Collaborator]; Boos, L [Collaborator]; Cereda, C [Collaborator]; Chaloulos-Iakovidis, P [Collaborator]; Christian, L [Collaborator]; Engelter, S [Collaborator]; Fisch, L [Collaborator]; Fischer, U [Collaborator]; Frey, S [Collaborator]; Frick, M [Collaborator]; Hauk, M [Collaborator]; Hoffmann, M [Collaborator]; Kahles, T [Collaborator]; Manno, C [Collaborator]; Medlin, F [Collaborator]; Mircea, D [Collaborator]; Nedeltchev, K [Collaborator]; Panos, L [Collaborator]; Polymeris, A [Collaborator]; Schillinger, N [Collaborator]; Stocker, R [Collaborator]; Sztajzel, R [Collaborator]; Alaydin, H [Collaborator]; Batur, Caglayan H [Collaborator]; Colakoglu, S [Collaborator]; Demirci, N [Collaborator]; Duman, T [Collaborator]; Eren, F [Collaborator]; Gokce, M [Collaborator]; Inanc, Y [Collaborator]; Nazliel, B [Collaborator]; Ongun, G [Collaborator]; Ozcekic, Demirhan S [Collaborator]; Ozyurt, E [Collaborator]; Selcuk, D [Collaborator]; Sorgun, M [Collaborator]; Tezcan, S [Collaborator]; Togay, Isikay C [Collaborator]; Tokgoz, O [Collaborator]; Ulku, Acar R [Collaborator]; Uluduz, Ugurlu D [Collaborator]; Abdul-Saheb, M [Collaborator]; Ahmad, N [Collaborator]; Ali, A [Collaborator]; Alwis, L [Collaborator]; Balogun, I [Collaborator]; Bathula, R [Collaborator]; Behnam, Y [Collaborator]; Bhandari, M [Collaborator]; Bhargavah, M [Collaborator]; Black, T [Collaborator]; Blank, C [Collaborator]; Bruce, D [Collaborator]; Burn, M [Collaborator]; Canepa, C [Collaborator]; Chakrabarti, A [Collaborator]; Chandrasena, D [Collaborator]; Chembala, J [Collaborator]; Cheripelli, B [Collaborator]; Clarke, R [Collaborator]; Cohen, D [Collaborator]; Collas, D [Collaborator]; Constantin, C [Collaborator]; Dani, K [Collaborator]; Del Giudice, A [Collaborator]; Dennis, M [Collaborator]; Devine, J [Collaborator]; Dima, S [Collaborator]; Doubal, F [Collaborator]; Duodu, Y [Collaborator]; Dutta, D [Collaborator]; El, Ta Wil S [Collaborator]; Elyas, S [Collaborator]; Evans, N [Collaborator]; Eveson, D [Collaborator]; Fotherby, K [Collaborator]; France, E [Collaborator]; Furnace, J [Collaborator]; Grabowski, S [Collaborator]; Gunathilagan, G [Collaborator]; Gutierrez, R [Collaborator]; Guyler, P [Collaborator]; Hargroves, D [Collaborator]; Harkness, K [Collaborator]; Harvey, M [Collaborator]; Hassan, A [Collaborator]; Hayhoe, H [Collaborator]; Hicken, L [Collaborator]; Hussain, M [Collaborator]; Kelly, S [Collaborator]; Lam, M [Collaborator]; Lindert, R [Collaborator]; Louw, S [Collaborator]; Luder, R [Collaborator]; Macleod, M [Collaborator]; Majid, A [Collaborator]; Mangion, D [Collaborator]; Markova, S [Collaborator]; Markus, H [Collaborator]; Marsh, R [Collaborator]; Mcarthur, K [Collaborator]; Menon, N [Collaborator]; Metcalf, K [Collaborator]; Minhas, J [Collaborator]; Minns, M [Collaborator]; Mistri, A [Collaborator]; Moreton, F [Collaborator]; Mpelembue, M [Collaborator]; Muddegowda, G [Collaborator]; Mudhar, O [Collaborator]; Musarrat, K [Collaborator]; Myint, M [Collaborator]; Natarajan, I [Collaborator]; Naylor, D [Collaborator]; Ngeh, J [Collaborator]; Papavasileiou, V [Collaborator]; Perry, R [Collaborator]; Piechowski-Jozwiak, B [Collaborator]; Pradhan, M [Collaborator]; Rani, A [Collaborator]; Rashed, K [Collaborator]; Robinson, T [Collaborator]; Roffe, C [Collaborator]; Saksena, R [Collaborator]; Sattar, N [Collaborator]; Sekaran, L [Collaborator]; Selvarajah, J [Collaborator]; Shah, S [Collaborator]; Sinha, D [Collaborator]; Sivakumar, R [Collaborator]; Sztriha, L [Collaborator]; Walters, D [Collaborator]; Webb, T [Collaborator]; Werring, D [Collaborator]; Whiteley, W [Collaborator]; Whiting, R [Collaborator]; Abdelhamid, N [Collaborator]; Abdul, Rahman D [Collaborator]; Amin, H [Collaborator]; Androulakis, M [Collaborator]; Babikian, V [Collaborator]; Baker, M [Collaborator]; Barker, Trejo S [Collaborator]; Benjamin, A [Collaborator]; Birnbaum, L [Collaborator]; Burke, J [Collaborator]; Chen, S [Collaborator]; Clark, W [Collaborator]; Coull, B [Collaborator]; De Havenon, A [Collaborator]; Dearborn, J [Collaborator]; Degeorgia, M [Collaborator]; Essa, B [Collaborator]; Fares, M [Collaborator]; Favate, A [Collaborator]; Furlan, A [Collaborator]; Gebreyohanns, M [Collaborator]; Goddeau, R [Collaborator]; Green, D [Collaborator]; Greer, D [Collaborator]; Haralur, Sreekantaiah Y [Collaborator]; Hasan, R [Collaborator]; Hedna, V [Collaborator]; Henninger, N [Collaborator]; Holmstedt, C [Collaborator]; Hussain, M [Collaborator]; Ishida, K [Collaborator]; Jagolino, A [Collaborator]; Johnson, M [Collaborator]; Jun-Oconnell, A [Collaborator]; Kaur, S [Collaborator]; Khanna, A [Collaborator]; Kirshner, H [Collaborator]; Kittner, S [Collaborator]; Kleindorfer, D [Collaborator]; Leira, E [Collaborator]; Loomis, C [Collaborator]; Lord, A [Collaborator]; Lowenkopf, T [Collaborator]; Lutsep, H [Collaborator]; Magadan, A [Collaborator]; Majjhoo, A [Collaborator]; Maud, A [Collaborator]; Mayasi, Y [Collaborator]; Mccullough, L [Collaborator]; Mckinney, J [Collaborator]; Mehta, S [Collaborator]; Mehta, D [Collaborator]; Mehta, B [Collaborator]; Messe, S [Collaborator]; Miller, B [Collaborator]; Milling, T [Collaborator]; Moonis, M [Collaborator]; Navaratnam, D [Collaborator]; Okpala, M [Collaborator]; Patel, N [Collaborator]; Pettigrew, L [Collaborator]; Phinney, T [Collaborator]; Ramos-Estebanez, C [Collaborator]; Rasmussen, J [Collaborator]; Rodriguez, G [Collaborator]; Rybinnik, I [Collaborator]; Santiago, P [Collaborator]; Sarraj, A [Collaborator]; Savitz, S [Collaborator]; Sawyer, R [Collaborator]; Scandura, T [Collaborator]; Schindler, J [Collaborator]; Sen, S [Collaborator]; Shang, T [Collaborator]; Sharrief, A [Collaborator]; Sila, C [Collaborator]; Simpkins, A [Collaborator]; Sundararajan, S [Collaborator]; Talahma, M [Collaborator]; Tayal, A [Collaborator]; Thaler, D [Collaborator]; Tirschwell, D [Collaborator]; Torres, J [Collaborator]; Vora, N [Collaborator]; Warnack, W [Collaborator]; Waters, M [Collaborator]; Wilson, C [Collaborator]; Xiong, W [Collaborator]; Zhang, C [Collaborator]; Zweifler, R [Collaborator]; Zanferrari, C [Collaborator]
BACKGROUND Embolic strokes of undetermined source represent 20% of ischemic strokes
and are associated with a high rate of recurrence. Anticoagulant treatment with rivaroxaban,
an oral factor Xa inhibitor, may result in a lower risk of recurrent stroke than aspirin.
METHODS We compared the efficacy and safety of rivaroxaban (at a daily dose of 15
mg) with aspirin (at a daily dose of 100 mg) for the prevention of recurrent stroke
in patients with recent ischemic stroke that was presumed to be from cerebral embolism
but without arterial stenosis, lacune, or an identified cardioembolic source. The
primary efficacy outcome was the first recurrence of ischemic or hemorrhagic stroke
or systemic embolism in a time-to-event analysis; the primary safety outcome was the
rate of major bleeding. RESULTS A total of 7213 participants were enrolled at 459
sites; 3609 patients were randomly assigned to receive rivaroxaban and 3604 to receive
aspirin. Patients had been followed for a median of 11 months when the trial was terminated
early because of a lack of benefit with regard to stroke risk and because of bleeding
associated with rivaroxaban. The primary efficacy outcome occurred in 172 patients
in the rivaroxaban group (annualized rate, 5.1%) and in 160 in the aspirin group (annualized
rate, 4.8%) (hazard ratio, 1.07; 95% confidence interval [CI], 0.87 to 1.33; P=0.52).
Recurrent ischemic stroke occurred in 158 patients in the rivaroxaban group (annualized
rate, 4.7%) and in 156 in the aspirin group (annualized rate, 4.7%). Major bleeding
occurred in 62 patients in the rivaroxaban group (annualized rate, 1.8%) and in 23
in the aspirin group (annualized rate, 0.7%) (hazard ratio, 2.72; 95% CI, 1.68 to
4.39; P<0.001). CONCLUSIONS Rivaroxaban was not superior to aspirin with regard to
the prevention of recurrent stroke after an initial embolic stroke of undetermined
source and was associated with a higher risk of bleeding.