https://m2.mtmt.hu/ eng 2026-10-25 14:54 JournalArticle 33917113 VALIDATED true 0 false 2026-10-23T13:44:02.375+0000 2024-04-17T12:15:14.654+0000 2023-05-30T11:03:58.190+0000 true 10023751 Haltrich Irén /api/author/10023751 Author true 10023751 2026-09-16T11:03:53.692+0000 2024-04-17T12:15:15.143+0000 true 10025544 Lévayné Deseő Katalin /api/admin/10025544 Admin true 10025544 Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin true 10025544 true 2024-04-17T12:15:22.218+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Salas-Lucia, Federico Axonal T3 uptake and transport can trigger thyroid hormone signaling in the brain true true /api/journal/10031024 REVIEWED true false 10031024 false 10031024 true 2050-084X Journal FOREIGN 12 e82683 e82683 18 2023 The development of the brain, as well as mood and cognitive functions, are affected by thyroid hormone (TH) signaling. Neurons are the critical cellular target for TH action, with T3 regulating the expression of important neuronal gene sets. However, the steps involved in T3 signaling remain poorly known given that neurons express high levels of type 3 deiodinase (D3), which inactivates both T4 and T3. To investigate this mechanism, we used a compartmentalized microfluid device and identified a novel neuronal pathway of T3 transport and action that involves axonal T3 uptake into clathrin-dependent, endosomal/non-degradative lysosomes (NDLs). NDLs-containing T3 are retrogradely transported via microtubules, delivering T3 to the cell nucleus, and doubling the expression of a T3-responsive reporter gene. The NDLs also contain the monocarboxylate transporter 8 (Mct8) and D3, which transport and inactivate T3, respectively. Notwithstanding, T3 gets away from degradation because D3's active center is in the cytosol. Moreover, we used a unique mouse system to show that T3 implanted in specific brain areas can trigger selective signaling in distant locations, as far as the contralateral hemisphere. These findings provide a pathway for L-T3 to reach neurons and resolve the paradox of T3 signaling in the brain amid high D3 activity. Funding 2027944 /api/funding/2027944 false true Funding 2027945 /api/funding/2027945 false true Funding 2027946 /api/funding/2027946 false true true 2023 true true true false true false GOLD 2026-10-23 true https://doi.org/10.7554/eLife.82683 36 0 36 26 3 36 36 35 32 36 36 26 26 26 10 0 36 26 36 26 0 15 15 Folyóiratcikk Journal Article 24 35 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 1 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 3 2 3 2 2024 0 13 9 13 9 2025 0 14 10 14 10 2026 0 6 5 6 5 D1 false 10052876,10012354,10011473 false false false 2023-06-18T10:58:56.977+0000 Doktori Iskola (SE); Integratív Neuroendokrinológiai Kutatócsoport (HRN KOKI); Kísérleti Orvostudományi Kutatóintézet; Molekuláris Sejt Metabolizmus Kutatócsoport (HRN KOKI) 6 34 4 8 0 true 10025544 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 108319529 /api/authorship/108319529 1 0.125 true false false Salas-Lucia Federico true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108319530 /api/authorship/108319530 2 0.125 true false false Author 10012354 /api/author/10012354 Fekete Csaba true 10012354 true Fekete Csaba true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108319531 /api/authorship/108319531 3 0.125 false false false Author 10052876 /api/author/10052876 Sinkó Richárd true 10052876 true Sinko Richárd true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108319532 /api/authorship/108319532 4 0.125 false false false Author 206 /api/author/206 Egri Péter true 206 true Egri Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108319533 /api/authorship/108319533 5 0.125 false false false Author 10053189 /api/author/10053189 Rada Kristóf Róbert true 10053189 true Rada Kristóf true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108319534 /api/authorship/108319534 6 0.125 false false false Author 10076858 /api/author/10076858 Szilágyi Yvette Magdolna true true Ruska Yvette true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108319535 /api/authorship/108319535 7 0.125 false false true Author 10011473 /api/author/10011473 Gereben Balázs true 10011473 true Gereben Balázs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108319536 /api/authorship/108319536 8 0.125 false true true Bianco Antonio true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 23796553 /api/publicationidentifier/23796553 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.7554/eLife.82683 https://doi.org/10.7554/eLife.82683 false true PublicationIdentifier 24061622 /api/publicationidentifier/24061622 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GOLD true IDENTICAL 168206 https://real.mtak.hu/168206 false true PublicationIdentifier 24097052 /api/publicationidentifier/24097052 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001002604600001 https://www.webofscience.com/wos/woscc/full-record/001002604600001 true true PublicationIdentifier 24053271 /api/publicationidentifier/24053271 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85161491080 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85161491080 false true PublicationIdentifier 24053722 /api/publicationidentifier/24053722 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37204837 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37204837&dopt=Abstract true true SjrRating 11358157 /api/sjrrating/11358157 16 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1301 /api/classificationexternal/1301 true 1301 true D1 DIRECT true true /api/publication/33917113 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Salas-Lucia Federico </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012354"><a href="/gui2/?type=authors&mode=browse&sel=10012354" target="_blank">Fekete Csaba<sup>*</sup> (<span class="authorship-author-name">Fekete Csaba</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Integratív Neuroendokrinológiai Kutatócsoport; Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052876"><a href="/gui2/?type=authors&mode=browse&sel=10052876" target="_blank">Sinko Richárd (<span class="authorship-author-name">Sinkó Richárd</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Molecular Cell Metabolism; <span title="Semmelweis University">SU</span>/School of PhD Studies; Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="206"><a href="/gui2/?type=authors&mode=browse&sel=206" target="_blank">Egri Péter (<span class="authorship-author-name">Egri Péter</span> <span class="authorAux-mtmt"> Endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Molecular Cell Metabolism</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10053189"><a href="/gui2/?type=authors&mode=browse&sel=10053189" target="_blank">Rada Kristóf (<span class="authorship-author-name">Rada Kristóf Róbert</span> <span class="authorAux-mtmt"> Tumorbiológia, redox biológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Molecular Cell Metabolism</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10076858"><a href="/gui2/?type=authors&mode=browse&sel=10076858" target="_blank">Ruska Yvette (<span class="authorship-author-name">Szilágyi Yvette Magdolna</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Integratív Neuroendokrinológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011473"><a href="/gui2/?type=authors&mode=browse&sel=10011473" target="_blank">Gereben Balázs ✉ (<span class="authorship-author-name">Gereben Balázs</span> <span class="authorAux-mtmt"> Pajzsmirigy endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Molecular Cell Metabolism; Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bianco Antonio ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33917113" target="_blank">Axonal T3 uptake and transport can trigger thyroid hormone signaling in the brain</a></div> <div> <span class="journal-title">ELIFE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2050-084X">2050-084X</a>)</span>: <span class="journal-volume">12</span> <span class="page"> Paper e82683. 18 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.7554/eLife.82683" target="_blank" href="https://doi.org/10.7554/eLife.82683"> DOI </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="168206" target="_blank" href="https://real.mtak.hu/168206"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001002604600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001002604600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85161491080" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85161491080"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37204837" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37204837&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Immunology and Microbiology (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 36</span> | Independent citation: 26 | Self citation: 10 | Unknown citation: 0 | Number of citations in WoS: 35 | Number of citations in Scopus:&nbsp;32 | WoS/Scopus assigned:&nbsp;36 | Number of citations with DOI:&nbsp;36 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33917113&sort=publishedYear,desc&sort=title"> Number of cited publications: 15 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33917113</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Hungarian National Brain Research Program(NAP2.0), National Institute of Diabetes and Digestive and Kidney Diseases(DK58538), National Institute of Diabetes and Digestive and Kidney Diseases(DK65055) </div> <div class="lastModified">Last Modified: 2024.04.17. 14:15 Katalin Lévayné Deseő (MTMT Központi admin) </div> <div class="lockedBy">Centrally managed 2024.04.17. 14:15 Katalin Lévayné Deseő (MTMT Központi admin) </div> </div></div>