https://m2.mtmt.hu/ hun 2026-09-21 20:56 JournalArticle 33915025 VALIDATED true 0 false 2026-09-17T14:22:45.966+0000 2024-02-28T11:42:51.622+0000 2023-05-30T06:45:40.325+0000 true 10075334 Gerszi Dóra /api/author/10075334 Author true 2024-10-21T07:34:39.687+0000 2024-10-21T07:34:39.687+0000 2024-02-28T11:42:51.948+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Gerszi, Dóra Risk estimation of gestational diabetes mellitus in the first trimester true true /api/journal/10030700 REVIEWED true false 10030700 false 10030700 true 0021-972X 1945-7197 Journal FOREIGN 108 11 e1214 e1223 e1214 29 2023 There is no early - first trimester- risk estimation available to predict later (gestational week 24-28) gestational diabetes mellitus (GDM) - however it would be beneficial to start an early treatment to prevent the development of complications.We aimed to identify early, first trimester prediction markers for GDM.The present case-control study is based on the study cohort of a Hungarian biobank containing the biological samples and follow-up data from 2545 pregnant women. Oxidative-nitrative stress-related parameters, steroid hormone, and metabolite levels were measured in the serum/plasma samples collected at the end of the first trimester from 55-55 randomly selected control and later GDM women.Pregnant women, who developed GDM later during the pregnancy were older and had higher body mass indexes (BMI). The following parameters showed higher concentration in their serum/plasma samples: fructosamine, total antioxidant capacity (TAC), testosterone, cortisone, 21-deoxycortisol; while soluble urokinase plasminogen activator receptor (SuPAR), dehydroepiandrosterone sulfate (DHEAS), dihydrotestosterone (DHT), cortisol and 11-deoxycorticosterone levels were lower. Analyzing these variables using a forward stepwise multivariate logistic regression model we established a GDM prediction model with a specificity of 96.6% and sensitivity of 97.5% (included variables: fructosamine, cortisol, cortisone, 11-deoxycorticosterone, SuPAR).Based on these measurements we accurately predict the development of later onset GDM (24th-28th weeks of pregnancy). Early risk estimation provides the opportunity for targeted prevention and the timely treatment of GDM. Prevention and slowing the progression of GDM result in a lower lifelong metabolic risk for both mother and offspring. Funding 2028393 /api/funding/2028393 false true Funding 2028394 /api/funding/2028394 false true Funding 2028395 /api/funding/2028395 false true Funding 2028396 /api/funding/2028396 false true Funding 2028397 /api/funding/2028397 false true true true 2023 true true true false true false NONE 2026-09-17 false 19 0 19 19 0 19 19 16 15 18 18 18 18 19 0 0 19 19 19 19 0 2 2 Folyóiratcikk Journal Article 24 19 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 2 2 2 2 2024 0 4 4 4 4 2025 0 9 9 9 9 2026 0 4 4 4 4 D1 false 10011316,10075334,10049015,10020503 false false false 2023-08-28T06:45:41.116+0000 Doktori Iskola (SE); Laboratóriumi Medicina Intézet (SE / AOK / I); Szülészeti és Nőgyógyászati Intézet (DE / ÁOK); Szülészeti és Nőgyógyászati Klinika (SE / AOK / K); Élettani Intézet (SE / AOK / I) 11 58 5 11 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 108308271 /api/authorship/108308271 1 0.091 true false true Author 10075334 /api/author/10075334 Gerszi Dóra true true Gerszi Dóra true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108308272 /api/authorship/108308272 2 0.091 false false false Author 10059724 /api/author/10059724 Orosz Gergő Balázs true 10059724 true Orosz Gergő true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108308273 /api/authorship/108308273 3 0.091 false false false Author 10056811 /api/author/10056811 Török Marianna true 10056811 true Török Marianna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108308274 /api/authorship/108308274 4 0.091 false false false Author 10020763 /api/author/10020763 Szalay Balázs true 10020763 true Szalay Balázs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108308275 /api/authorship/108308275 5 0.091 false false false Author 10049015 /api/author/10049015 Karvaly Gellért Balázs true 10049015 true Karvaly Gellért true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108308276 /api/authorship/108308276 6 0.091 false false false Author 10032549 /api/author/10032549 Orosz László true 10032549 true Orosz László true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108308277 /api/authorship/108308277 7 0.091 false false false Author 10053136 /api/author/10053136 Hetthéssy Judit true 10053136 true Hetthéssy Judit true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108308278 /api/authorship/108308278 8 0.091 false false false Author 10003195 /api/author/10003195 Vásárhelyi Barna true 10003195 true Vásárhelyi Barna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108308279 /api/authorship/108308279 9 0.091 false false false Author 10039073 /api/author/10039073 Török Olga true 10039073 true Török Olga true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108308280 /api/authorship/108308280 10 0.091 false true false Author 10020503 /api/author/10020503 Horvath Eszter Mária true 10020503 true Horváth Eszter M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108308281 /api/authorship/108308281 11 0.091 false true false Author 10011316 /api/author/10011316 Várbíró Szabolcs true 10011316 true Várbíró Szabolcs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 23791837 /api/publicationidentifier/23791837 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1210/clinem/dgad301 https://doi.org/10.1210/clinem/dgad301 false true PublicationIdentifier 24096059 /api/publicationidentifier/24096059 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001004122600001 https://www.webofscience.com/wos/woscc/full-record/001004122600001 true true PublicationIdentifier 25360926 /api/publicationidentifier/25360926 PlainSource 3 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true SjrRating 11358438 /api/sjrrating/11358438 7 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2704 /api/classificationexternal/2704 true 2704 true D1 DIRECT true true /api/publication/33915025 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10075334"><a href="/gui2/?type=authors&mode=browse&sel=10075334" target="_blank">Gerszi Dóra ✉ (<span class="authorship-author-name">Gerszi Dóra</span> <span class="authorAux-mtmt"> szülészet - nőgyógyászat, élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Szülészeti és Nőgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10059724"><a href="/gui2/?type=authors&mode=browse&sel=10059724" target="_blank">Orosz Gergő (<span class="authorship-author-name">Orosz Gergő Balázs</span> <span class="authorAux-mtmt"> Szülészet Nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Szülészeti és Nőgyógyászati Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10056811"><a href="/gui2/?type=authors&mode=browse&sel=10056811" target="_blank">Török Marianna (<span class="authorship-author-name">Török Marianna</span> <span class="authorAux-mtmt"> élettan, szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Szülészeti és Nőgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020763"><a href="/gui2/?type=authors&mode=browse&sel=10020763" target="_blank">Szalay Balázs (<span class="authorship-author-name">Szalay Balázs</span> <span class="authorAux-mtmt"> Laboratóriumi diagnosztika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Laboratóriumi Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10049015"><a href="/gui2/?type=authors&mode=browse&sel=10049015" target="_blank">Karvaly Gellért (<span class="authorship-author-name">Karvaly Gellért Balázs</span> <span class="authorAux-mtmt"> klinikai kémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Laboratóriumi Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032549"><a href="/gui2/?type=authors&mode=browse&sel=10032549" target="_blank">Orosz László (<span class="authorship-author-name">Orosz László</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Szülészeti és Nőgyógyászati Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10053136"><a href="/gui2/?type=authors&mode=browse&sel=10053136" target="_blank">Hetthéssy Judit (<span class="authorship-author-name">Hetthéssy Judit</span> <span class="authorAux-mtmt"> Ortopédia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003195"><a href="/gui2/?type=authors&mode=browse&sel=10003195" target="_blank">Vásárhelyi Barna (<span class="authorship-author-name">Vásárhelyi Barna</span> <span class="authorAux-mtmt"> gyermekgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Laboratóriumi Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10039073"><a href="/gui2/?type=authors&mode=browse&sel=10039073" target="_blank">Török Olga (<span class="authorship-author-name">Török Olga</span> <span class="authorAux-mtmt"> szülészet-nőgyógyászat, klinikai genetika</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Szülészeti és Nőgyógyászati Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020503"><a href="/gui2/?type=authors&mode=browse&sel=10020503" target="_blank">Horváth Eszter M<sup>**</sup> (<span class="authorship-author-name">Horvath Eszter Mária</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011316"><a href="/gui2/?type=authors&mode=browse&sel=10011316" target="_blank">Várbíró Szabolcs (<span class="authorship-author-name">Várbíró Szabolcs</span> <span class="authorAux-mtmt"> Keringésélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Szülészeti és Nőgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33915025" target="_blank">Risk estimation of gestational diabetes mellitus in the first trimester</a></div> <div> <span class="journal-title">JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0021-972X">0021-972X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1945-7197">1945-7197</a>)</span>: <span class="journal-volume">108</span> <span class="journal-issue">11</span> <span class="page"> pp e1214-e1223 </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1210/clinem/dgad301" target="_blank" href="https://doi.org/10.1210/clinem/dgad301"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001004122600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001004122600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85168485988" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85168485988"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37247379" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37247379&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry (medical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Clinical Biochemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Endocrinology, Diabetes and Metabolism&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Endocrinology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 19</span> | Független: 19 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 16 | Scopus jelölt:&nbsp;15 | WoS/Scopus jelölt:&nbsp;18 | DOI jelölt:&nbsp;19 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33915025&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33915025</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Hungarian Hypertension Society, Dean of the Medical Faculty, Semmelweis University, (STIA-OTKA-2021), (PD 113022) Támogató: OTKA, (FK129206) </div> <div class="lastModified">Utolsó módosítás: 2024.02.28. 12:42 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> </div></div>