https://m2.mtmt.hu/ eng 2026-09-23 06:35 JournalArticle 3390405 APPROVED true Neuroscience Research Center, Charité Universitätsmedizin Berlin, Berlin, Germany Laboratory of 3D Functional Network and Dendritic Imaging, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Faculty of Information Technology and Bionics, Pázmány Péter University, Budapest, Hungary Einstein Center for Neuroscience, Berlin, Germany Bernstein Center for Computational Neuroscience, Berlin, Germany Cluster of Excellence “Neurocure”, Berlin, Germany DZNE-German Center for Neurodegenerative Disease, Berlin, Germany Berlin Institute of Health (BIH), Berlin, Germany Cited By :2 Export Date: 17 March 2021 Correspondence Address: Johenning, F.W.; Neuroscience Research Center, Germany; email: friedrich.johenning@charite.de Chemicals/CAS: alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid, 77521-29-0; calcium, 7440-70-2, 14092-94-5 Funding details: 3Faculty Funding details: Horizon 2020 Framework Programme, H2020, 682426 Funding details: Deutsche Forschungsgemeinschaft, JO1079/1-1, JO1079/3-1, SFB665, SFB958 Funding text 1: 1Neuroscience Research Center, Charité Universitätsmedizin Berlin, Berlin, Germany, 2Laboratory of 3D Functional Network and Dendritic Imaging, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary, 3Faculty of Information Technology and Bionics, Pázmány Péter University, Budapest, Hungary, 4Einstein Center for Neuroscience, Berlin, Germany, 5Bernstein Center for Computational Neuroscience, Berlin, Germany, 6Cluster of Excellence “Neurocure”, Berlin, Germany, 7DZNE-German Center for Neurodegenerative Disease, Berlin, Germany, 8Berlin Institute of Health (BIH), Berlin, Germany Funding text 2: This work was supported by the German Research Foundation (DFG), Grant No. JO1079/1-1, JO1079/3-1 and SFB665 to FWJ, Exc 257, SFB665 and SFB958 to DS. Neuroscience Research Center, Charité Universitätsmedizin Berlin, Berlin, Germany Laboratory of 3D Functional Network and Dendritic Imaging, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Faculty of Information Technology and Bionics, Pázmány Péter University, Budapest, Hungary Einstein Center for Neuroscience, Berlin, Germany Bernstein Center for Computational Neuroscience, Berlin, Germany Cluster of Excellence “Neurocure”, Berlin, Germany DZNE-German Center for Neurodegenerative Disease, Berlin, Germany Berlin Institute of Health (BIH), Berlin, Germany Cited By :2 Export Date: 19 March 2021 Correspondence Address: Johenning, F.W.; Neuroscience Research Center, Germany; email: friedrich.johenning@charite.de Chemicals/CAS: alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid, 77521-29-0; calcium, 7440-70-2, 14092-94-5 Funding details: 3Faculty Funding details: Horizon 2020 Framework Programme, H2020, 682426 Funding details: Deutsche Forschungsgemeinschaft, JO1079/1-1, JO1079/3-1, SFB665, SFB958 Funding text 1: 1Neuroscience Research Center, Charité Universitätsmedizin Berlin, Berlin, Germany, 2Laboratory of 3D Functional Network and Dendritic Imaging, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary, 3Faculty of Information Technology and Bionics, Pázmány Péter University, Budapest, Hungary, 4Einstein Center for Neuroscience, Berlin, Germany, 5Bernstein Center for Computational Neuroscience, Berlin, Germany, 6Cluster of Excellence “Neurocure”, Berlin, Germany, 7DZNE-German Center for Neurodegenerative Disease, Berlin, Germany, 8Berlin Institute of Health (BIH), Berlin, Germany Funding text 2: This work was supported by the German Research Foundation (DFG), Grant No. JO1079/1-1, JO1079/3-1 and SFB665 to FWJ, Exc 257, SFB665 and SFB958 to DS. Neuroscience Research Center, Charité Universitätsmedizin Berlin, Berlin, Germany Laboratory of 3D Functional Network and Dendritic Imaging, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Faculty of Information Technology and Bionics, Pázmány Péter University, Budapest, Hungary Einstein Center for Neuroscience, Berlin, Germany Bernstein Center for Computational Neuroscience, Berlin, Germany Cluster of Excellence “Neurocure”, Berlin, Germany DZNE-German Center for Neurodegenerative Disease, Berlin, Germany Berlin Institute of Health (BIH), Berlin, Germany Cited By :2 Export Date: 30 March 2021 Correspondence Address: Johenning, F.W.; Neuroscience Research Center, Germany; email: friedrich.johenning@charite.de Chemicals/CAS: alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid, 77521-29-0; calcium, 7440-70-2, 14092-94-5 Funding details: 3Faculty Funding details: Horizon 2020 Framework Programme, H2020, 682426 Funding details: Deutsche Forschungsgemeinschaft, JO1079/1-1, JO1079/3-1, SFB665, SFB958 Funding text 1: 1Neuroscience Research Center, Charité Universitätsmedizin Berlin, Berlin, Germany, 2Laboratory of 3D Functional Network and Dendritic Imaging, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary, 3Faculty of Information Technology and Bionics, Pázmány Péter University, Budapest, Hungary, 4Einstein Center for Neuroscience, Berlin, Germany, 5Bernstein Center for Computational Neuroscience, Berlin, Germany, 6Cluster of Excellence “Neurocure”, Berlin, Germany, 7DZNE-German Center for Neurodegenerative Disease, Berlin, Germany, 8Berlin Institute of Health (BIH), Berlin, Germany Funding text 2: This work was supported by the German Research Foundation (DFG), Grant No. JO1079/1-1, JO1079/3-1 and SFB665 to FWJ, Exc 257, SFB665 and SFB958 to DS. Neuroscience Research Center, Charité Universitätsmedizin Berlin, Berlin, Germany Laboratory of 3D Functional Network and Dendritic Imaging, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Faculty of Information Technology and Bionics, Pázmány Péter University, Budapest, Hungary Einstein Center for Neuroscience, Berlin, Germany Bernstein Center for Computational Neuroscience, Berlin, Germany Cluster of Excellence “Neurocure”, Berlin, Germany DZNE-German Center for Neurodegenerative Disease, Berlin, Germany Berlin Institute of Health (BIH), Berlin, Germany Cited By :2 Export Date: 20 April 2021 Correspondence Address: Johenning, F.W.; Neuroscience Research Center, Germany; email: friedrich.johenning@charite.de Chemicals/CAS: alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid, 77521-29-0; calcium, 7440-70-2, 14092-94-5 Funding details: 3Faculty Funding details: Horizon 2020 Framework Programme, H2020, 682426 Funding details: Deutsche Forschungsgemeinschaft, JO1079/1-1, JO1079/3-1, SFB665, SFB958 Funding text 1: 1Neuroscience Research Center, Charité Universitätsmedizin Berlin, Berlin, Germany, 2Laboratory of 3D Functional Network and Dendritic Imaging, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary, 3Faculty of Information Technology and Bionics, Pázmány Péter University, Budapest, Hungary, 4Einstein Center for Neuroscience, Berlin, Germany, 5Bernstein Center for Computational Neuroscience, Berlin, Germany, 6Cluster of Excellence “Neurocure”, Berlin, Germany, 7DZNE-German Center for Neurodegenerative Disease, Berlin, Germany, 8Berlin Institute of Health (BIH), Berlin, Germany Funding text 2: This work was supported by the German Research Foundation (DFG), Grant No. JO1079/1-1, JO1079/3-1 and SFB665 to FWJ, Exc 257, SFB665 and SFB958 to DS. 0 2018-07-25T22:20:08.000+0000 false 3390405 2026-08-30T22:31:20.673+0000 2024-05-03T11:12:09.845+0000 2018-06-27T09:43:04.000+0000 true 10012926 Rózsa J. Balázs /api/author/10012926 Author true 10012926 2025-03-22T18:51:01.246+0000 2025-03-22T18:51:01.246+0000 2019-10-17T10:38:21.915+0000 true 10058019 Serf András /api/admin/10058019 Admin true 10058019 2019-12-03T09:36:26.915+0000 true 565 WoS import /api/admin/565 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 AK, Theis Voltage Gated Calcium Channel Activation by Backpropagating Action Potentials Downregulates NMDAR Function. true true /api/journal/10015931 REVIEWED true false 10015931 false 10015931 true 1662-5102 Journal FOREIGN 12 109 109 14 2018 The majority of excitatory synapses are located on dendritic spines of cortical glutamatergic neurons. In spines, compartmentalized Ca(2+) signals transduce electrical activity into specific long-term biochemical and structural changes. Action potentials (APs) propagate back into the dendritic tree and activate voltage gated Ca(2+) channels (VGCCs). For spines, this global mode of spine Ca(2+) signaling is a direct biochemical feedback of suprathreshold neuronal activity. We previously demonstrated that backpropagating action potentials (bAPs) result in long-term enhancement of spine VGCCs. This activity-dependent VGCC plasticity results in a large interspine variability of VGCC Ca(2+) influx. Here, we investigate how spine VGCCs affect glutamatergic synaptic transmission. We combined electrophysiology, two-photon Ca(2+) imaging and two-photon glutamate uncaging in acute brain slices from rats. T- and R-type VGCCs were the dominant depolarization-associated Ca(2+)conductances in dendritic spines of excitatory layer 2 neurons and do not affect synaptic excitatory postsynaptic potentials (EPSPs) measured at the soma. Using two-photon glutamate uncaging, we compared the properties of glutamatergic synapses of single spines that express different levels of VGCCs. While VGCCs contributed to EPSP mediated Ca(2+) influx, the amount of EPSP mediated Ca(2+) influx is not determined by spine VGCC expression. On a longer timescale, the activation of VGCCs by bAP bursts results in downregulation of spine NMDAR function. 2018 803147 true true true false true false GOLD 2026-08-31 true https://doi.org/10.3389/fncel.2018.00109 11 0 10 10 0 10 10 9 9 10 10 10 10 11 0 0 11 11 10 10 0 7 7 Folyóiratcikk Journal Article 24 10 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 1 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2019 0 2 2 2 2 2020 0 0 0 0 0 2021 0 2 2 2 2 2022 0 2 2 2 2 2023 0 2 2 2 2 2024 0 2 2 2 2 2025 0 1 1 1 1 Q1 false false false false 2018-07-25T13:34:18.000+0000 2018-06-27T09:57:51.000+0000 Információs Technológiai és Bionikai Kar (PPKE); Neuronhálózat és Dendritikus Aktivitás Kutatócs... 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Balázs true 10012926 true B Rozsa true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28472986 true PersonAuthorship 10233102 /api/authorship/10233102 3 0.2 false false Author 191 /api/author/191 Katona Gergely true 191 true G Katona true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28472985 true PersonAuthorship 10233103 /api/authorship/10233103 4 0.2 false false D Schmitz true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28472984 true PersonAuthorship 10233104 /api/authorship/10233104 5 0.2 false true true FW Johenning true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28472983 true PublicationIdentifier 1307798 /api/publicationidentifier/1307798 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3389/fncel.2018.00109 https://doi.org/10.3389/fncel.2018.00109 false 1793196 true PublicationIdentifier 1307796 /api/publicationidentifier/1307796 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000430589800001 https://www.webofscience.com/wos/woscc/full-record/000430589800001 false 1806436 true PublicationIdentifier 1307797 /api/publicationidentifier/1307797 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 85046720358 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85046720358 false 1805063 true PublicationIdentifier 1307799 /api/publicationidentifier/1307799 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 29755321 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=29755321&dopt=Abstract false 1793198 true PublicationIdentifier 1307800 /api/publicationidentifier/1307800 PlainSource 137 /api/publicationsource/137 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true Pubmed Central http://www.ncbi.nlm.nih.gov/pmc/articles/@@@ true true 137 true false IDENTICAL PMC5932410 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932410 false 1793197 true Classification 12125 /api/classification/12125 true true SjrRating 10760957 /api/sjrrating/10760957 20 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2804 /api/classificationexternal/2804 true 2804 true Q1 DIRECT true true /api/publication/3390405 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >AK Theis </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012926"><a href="/gui2/?type=authors&mode=browse&sel=10012926" target="_blank">B Rozsa (<span class="authorship-author-name">Rózsa J. Balázs</span> <span class="authorAux-mtmt"> Idegtudomány, fizika</span>) </a> </span> <span class="author-affil"><span title="Pázmány Péter Catholic University">PPCU</span>/Információs Technológiai és Bionikai Kar; <span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Pharmacology">DP</span>/Neuronhálózat és Dendritikus Aktivitás Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="191"><a href="/gui2/?type=authors&mode=browse&sel=191" target="_blank">G Katona (<span class="authorship-author-name">Katona Gergely</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Pázmány Péter Catholic University">PPCU</span>/Információs Technológiai és Bionikai Kar; <span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Pharmacology">DP</span>/Neuronhálózat és Dendritikus Aktivitás Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >D Schmitz </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >FW Johenning ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3390405" target="_blank">Voltage Gated Calcium Channel Activation by Backpropagating Action Potentials Downregulates NMDAR Function.</a></div> <div> <span class="journal-title">FRONTIERS IN CELLULAR NEUROSCIENCE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1662-5102">1662-5102</a>)</span>: <span class="journal-volume">12</span> <span class="page"> Paper 109. 14 p. </span> <span class="year">(2018)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3389/fncel.2018.00109" target="_blank" href="https://doi.org/10.3389/fncel.2018.00109"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000430589800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000430589800001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85046720358" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85046720358"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="29755321" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=29755321&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="PMC5932410" target="_blank" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932410"> Pubmed Central </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Cellular and Molecular Neuroscience&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 11</span> | Independent citation: 11 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 9 | Number of citations in Scopus:&nbsp;9 | WoS/Scopus assigned:&nbsp;10 | Number of citations with DOI:&nbsp;10 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3390405&sort=publishedYear,desc&sort=title"> Number of cited publications: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 3390405</span> | <span class="status-data status-APPROVED"> Published </span> <span class="oldId">Old id: 3390405</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2024.05.03. 13:12 Viktória Sifter (PPKE ITK admin 5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Neuroscience Research Center, Charité Universitätsmedizin Berlin, Berlin, Germany Laboratory of 3D Functional Network and Dendritic Imaging, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Faculty of Information Technology and Bionics, Pázmány Péter University, Budapest, Hungary Einstein...</pre> </div></div>