https://m2.mtmt.hu/ eng 2026-10-23 01:39 JournalArticle 33841048 VALIDATED true 0 false 2026-10-19T10:28:49.007+0000 2024-04-17T14:36:36.750+0000 2023-05-21T23:21:04.988+0000 true 10003491 Gonda Xénia /api/author/10003491 Author true 10003491 2026-07-07T10:45:08.963+0000 2024-04-17T14:36:37.158+0000 true 10025544 Lévayné Deseő Katalin /api/admin/10025544 Admin true 10025544 Admin 10066925 /api/admin/10066925 Nemec Évi true true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true 2024-10-17T16:20:19.023+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Kristof, Zsuliet Variation along P2RX7 interacts with early traumas on severity of anxiety suggesting a role for neuroinflammation true true /api/journal/10019966 REVIEWED true false 10019966 false 10019966 true 2045-2322 Journal FOREIGN 13 1 7757 7757 13 2023 Emotional stress is a leading risk factor in the development of neuropsychiatric disorders possibly via immune activation. P2X7 receptors promote neuroinflammation, and research suggests a relationship between chromosome region 12q2431, in which the P2X7R gene is located, and development of mood disorders, however, few studies concentrate on its association with anxiety. Our aim was to investigate the effects of P2RX7 variation in interaction with early childhood traumas and recent stressors on anxiety. 1752 participants completed questionnaires assessing childhood adversities and recent negative life events, provided data on anxiety using the Brief Symptom Inventory, and were genotyped for 681 SNPs in the P2RX7 gene, 335 of which passed quality control and were entered into linear regression models followed by a linkage disequilibrium-based clumping procedure to identify clumps of SNPs with a significant main or interaction effect. We identified a significant clump with top SNP rs67881993 and containing a set of 29SNPs that are in high LD, which significantly interacted with early childhood traumas but not with recent stress conveying a protective effect against increased anxiety in those exposed to early adversities. Our study demonstrated that P2RX7 variants interact with distal and more etiological stressors in influencing the severity of anxiety symptoms, supporting previous scarce results and demonstrating its role in moderating the effects of stress. 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proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 3 2 3 2 2025 0 2 1 2 1 2026 0 4 4 4 4 D1 A nemzetközi false 10003491 false false false 2023-05-29T11:11:20.015+0000 Doktori Iskola (SE); Gyógyszerhatástani Intézet (SE / GYTK); Molekuláris Farmakológia Kutatócsoport (HRN KOKI); NAP3.0-SE Neuropszichofarmakológiai Kutatócsoport (SE / GYTK / GYHATAS); Pszichiátriai és Pszichoterápiás Klinika (SE / AOK / K) 11 48 5 13 0 true 10066925 10067876 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 107841289 /api/authorship/107841289 1 0.077 true false false Author 10067777 /api/author/10067777 Kristóf Zsüliet true true Kristof Zsuliet true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107841290 /api/authorship/107841290 2 0.077 false false false Author 10067900 /api/author/10067900 Gál Zsófia true true Gal Zsofia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107841291 /api/authorship/107841291 3 0.077 false false false Author 10075294 /api/author/10075294 Török Dóra true true Torok Dora true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107841292 /api/authorship/107841292 4 0.077 false false false Author 10045710 /api/author/10045710 Eszlári Nóra true 10045710 true Eszlari Nora true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107841293 /api/authorship/107841293 5 0.077 false false false Author 10067899 /api/author/10067899 Sütöri Sára true true Sutori Sara true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107841294 /api/authorship/107841294 6 0.077 false false false Author 10048201 /api/author/10048201 Erdélyi-Hamza Berta true 10048201 true Erdelyi-Hamza Berta true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107841295 /api/authorship/107841295 7 0.077 false false false Author 10024138 /api/author/10024138 Petschner Péter true 10024138 true Petschner Peter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107841296 /api/authorship/107841296 8 0.077 false false false Author 10008942 /api/author/10008942 Sperlágh Beáta true 10008942 true Sperlagh Beata true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107841297 /api/authorship/107841297 9 0.07692308 false false false Anderson Ian M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107841298 /api/authorship/107841298 10 0.07692308 false false false Deakin John Francis William true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107841299 /api/authorship/107841299 11 0.077 false false false Author 10001318 /api/author/10001318 Bagdy György true 10001318 true Bagdy Gyorgy true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107841300 /api/authorship/107841300 12 0.077 false false false Author 10017483 /api/author/10017483 Juhász Gabriella true 10017483 true Juhasz Gabriella true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107841301 /api/authorship/107841301 13 0.077 false true true Author 10003491 /api/author/10003491 Gonda Xénia true 10003491 true Gonda Xenia true false false AuthorshipType 1 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/api/institute/14102 0 false true false Szociológiai Tudományos Bizottság Committee on Sociology true 14102 true true true A nemzetközi true 19359 true MtaRating 11551161 /api/mtarating/11551161 RatingType 10010 /api/ratingtype/10010 RegTB Institute 14100 /api/institute/14100 0 false true false Regionális Tudományok Bizottsága Committee on Regional Studies true 14100 true true true B nemzetközi true true SjrRating 11400906 /api/sjrrating/11400906 15 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1000 /api/classificationexternal/1000 true 1000 true D1 DIRECT true true /api/publication/33841048 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10067777"><a href="/gui2/?type=authors&mode=browse&sel=10067777" target="_blank">Kristof Zsuliet (<span class="authorship-author-name">Kristóf Zsüliet</span> <span class="authorAux-mtmt"> pszichológia, pszichiátria</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Pszichiátriai és Pszichoterápiás Klinika; <span title="Semmelweis University">SU</span>/School of PhD Studies; <span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Molecular Pharmacology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10067900"><a href="/gui2/?type=authors&mode=browse&sel=10067900" target="_blank">Gal Zsofia (<span class="authorship-author-name">Gál Zsófia</span> <span class="authorAux-mtmt"> neurobiológia, pszichiátriai genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics; <span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/<span title="Department of Pharmacodynamics">DP</span>/NAP3.0-SE Neuropsychopharmacology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10075294"><a href="/gui2/?type=authors&mode=browse&sel=10075294" target="_blank">Torok Dora (<span class="authorship-author-name">Török Dóra</span> <span class="authorAux-mtmt"> pszichiátriai genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics; <span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/<span title="Department of Pharmacodynamics">DP</span>/NAP3.0-SE Neuropsychopharmacology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10045710"><a href="/gui2/?type=authors&mode=browse&sel=10045710" target="_blank">Eszlari Nora (<span class="authorship-author-name">Eszlári Nóra</span> <span class="authorAux-mtmt"> Pszichiátriai genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics; <span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/<span title="Department of Pharmacodynamics">DP</span>/NAP3.0-SE Neuropsychopharmacology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10067899"><a href="/gui2/?type=authors&mode=browse&sel=10067899" target="_blank">Sutori Sara (<span class="authorship-author-name">Sütöri Sára</span> <span class="authorAux-mtmt"> pszichológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048201"><a href="/gui2/?type=authors&mode=browse&sel=10048201" target="_blank">Erdelyi-Hamza Berta (<span class="authorship-author-name">Erdélyi-Hamza Berta</span> <span class="authorAux-mtmt"> klinikai szakpszichológus</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Pszichiátriai és Pszichoterápiás Klinika; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024138"><a href="/gui2/?type=authors&mode=browse&sel=10024138" target="_blank">Petschner Peter (<span class="authorship-author-name">Petschner Péter</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics; <span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/<span title="Department of Pharmacodynamics">DP</span>/NAP3.0-SE Neuropsychopharmacology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008942"><a href="/gui2/?type=authors&mode=browse&sel=10008942" target="_blank">Sperlagh Beata (<span class="authorship-author-name">Sperlágh Beáta</span> <span class="authorAux-mtmt"> Neurofarmakológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Molecular Pharmacology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Anderson Ian M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Deakin John Francis William </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001318"><a href="/gui2/?type=authors&mode=browse&sel=10001318" target="_blank">Bagdy Gyorgy (<span class="authorship-author-name">Bagdy György</span> <span class="authorAux-mtmt"> Neuropszichofarmakológia, gyógyszertan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics; <span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/<span title="Department of Pharmacodynamics">DP</span>/NAP3.0-SE Neuropsychopharmacology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017483"><a href="/gui2/?type=authors&mode=browse&sel=10017483" target="_blank">Juhasz Gabriella (<span class="authorship-author-name">Juhász Gabriella</span> <span class="authorAux-mtmt"> Neurológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics; <span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/<span title="Department of Pharmacodynamics">DP</span>/NAP3.0-SE Neuropsychopharmacology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003491"><a href="/gui2/?type=authors&mode=browse&sel=10003491" target="_blank">Gonda Xenia ✉ (<span class="authorship-author-name">Gonda Xénia</span> <span class="authorAux-mtmt"> Pszichiátria, pszichiátriai genetika, farmakoló...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Pszichiátriai és Pszichoterápiás Klinika; <span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/<span title="Department of Pharmacodynamics">DP</span>/NAP3.0-SE Neuropsychopharmacology Research Group</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33841048" target="_blank">Variation along P2RX7 interacts with early traumas on severity of anxiety suggesting a role for neuroinflammation</a></div> <div> <span class="journal-title">SCIENTIFIC REPORTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2045-2322">2045-2322</a>)</span>: <span class="journal-volume">13</span> <span class="journal-issue">1</span> <span class="page"> Paper 7757. 13 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1038/s41598-023-34781-w" target="_blank" href="https://doi.org/10.1038/s41598-023-34781-w"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000992578000005" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000992578000005"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="184492" target="_blank" href="https://real.mtak.hu/184492"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85159225709" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85159225709"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37173368" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37173368&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Committee on Sociology HASSELIX SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Committee on Regional Studies HASSELIX RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 9</span> | Independent citation: 7 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 7 | Number of citations in Scopus:&nbsp;8 | WoS/Scopus assigned:&nbsp;9 | Number of citations with DOI:&nbsp;8 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33841048&sort=publishedYear,desc&sort=title"> Number of cited publications: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33841048</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Recovery and Resilience Facility of the European Union within the framework of Programme Szécheny...(RRF-2.3.1-21-2022-00011), National Laboratory of Translational Neuroscience (TINL)(RRF-2.3.1-21-2022-00011), (ÚNKP-20-4-II-SE-9) Funder: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal, (ÚNKP-21-4-II-SE-1) Funder: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal, National Brain Programme(NAP2022-I-4/2022 3.0), (K 143391) Funder: NRDIO, Nemzeti Agykutatási Program = National Brain Research Program(2017-1.2.1-NKP-2017-00002 NAP VI/4.), Hungarian Brain Research Program(KTIA_NAP_13-2-2015-0001), (2019-2.1.7-ERA-NET-2020-00005) Funder: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal, ERA PerMed(ERAPERMED2019-108), (TKP2021-EGA-25), (TKP2021-EGA), Hungarian Research and Development Fund(131629), Postdoctoral Fellowships for Research(P20809) </div> <div class="lastModified">Last Modified: 2024.04.17. 16:36 Katalin Lévayné Deseő (MTMT Központi admin) </div> <div class="lockedBy">Centrally managed 2024.10.17. 18:20 Évi Nemec (MTMT Központi 3, admin) Gusztáv Ladányi (MTMT API user, admin) </div> </div></div>