https://m2.mtmt.hu/ eng 2026-04-16 01:55 JournalArticle 33834650 VALIDATED true National Laboratory for Drug Research and Development, Magyar Tudósok Körútja 2, Budapest, 1117, Hungary Oncology Biomarker Research Group, Research Centre for Natural Sciences, Institute of Enzymology, Magyar Tudósok Körútja 2, Budapest, 1117, Hungary Seagen, Dammstrasse 23, Zug, 6300, Switzerland Department of Bioinformatics, Semmelweis University, Tűzoltó u. 5-7, Budapest, 1094, Hungary Department of Pediatrics, Semmelweis University, Tűzoltó u. 5-7, Budapest, 1094, Hungary Export Date: 23 August 2023 Correspondence Address: Győrffy, B.; Department of Bioinformatics, Tűzoltó u. 5-7, Hungary; email: gyorffy.balazs@med.semmelweis-univ.hu Chemicals/CAS: Receptors, Estrogen 0 false 2026-01-01T21:02:48.590+0000 2023-07-10T08:01:45.466+0000 2023-05-19T10:24:02.060+0000 true 10035718 Sonnevend Kinga /api/admin/10035718 Admin Kinga Sonnevend (SE_AOK_Adm5_Élet_kutcsop, admin) true 10035718 2024-11-19T14:58:35.037+0000 2023-05-22T09:27:05.378+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Ágnes Szalóky-Siki (SE_KK_Admin5_SZSA, admin) true Admin 10014568 /api/admin/10014568 Andrea Vándor (VA, admin) Vándor Andrea true 10014568 true 2024-04-04T10:41:23.960+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType Survey paper (Journal Article) 102 true 1134514 true 1 /api/category/1 Category Scientific true 1 Munkácsy, G. true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 24 8 6945 6945 21 2023 Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, with clinical features of high metastatic potential, susceptibility to relapse, and poor prognosis. TNBC lacks the expression of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). It is characterized by genomic and transcriptional heterogeneity and a tumor microenvironment (TME) with the presence of high levels of stromal tumor-infiltrating lymphocytes (TILs), immunogenicity, and an important immunosuppressive landscape. Recent evidence suggests that metabolic changes in the TME play a key role in molding tumor development by impacting the stromal and immune cell fractions, TME composition, and activation. Hence, a complex inter-talk between metabolic and TME signaling in TNBC exists, highlighting the possibility of uncovering and investigating novel therapeutic targets. A better understanding of the interaction between the TME and tumor cells, and the underlying molecular mechanisms of cell–cell communication signaling, may uncover additional targets for better therapeutic strategies in TNBC treatment. In this review, we aim to discuss the mechanisms in tumor metabolic reprogramming, linking these changes to potential targetable molecular mechanisms to generate new, physical science-inspired clinical translational insights for the cure of TNBC. © 2023 by the authors. Funding 2028837 /api/funding/2028837 Nemzeti Gyógyszerkutatási és Fejlesztési Laboratórium(PharmaLab) Funder: NRDIO false true true true 2023 true true true false true false GOLD 2026-01-01 true https://doi.org/10.3390/ijms24086945 24 0 24 24 0 24 24 24 17 24 24 24 24 24 0 0 24 24 24 24 0 3 3 Folyóiratcikk Journal Article 24 24 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 2 2 2 2 2024 0 9 9 9 9 2025 0 11 11 11 11 2026 0 2 2 2 2 D1 false 10024232 false false false 2023-05-21T09:27:05.078+0000 Bioinformatika Tanszék (SE / AOK / I); Gyermekgyógyászati Klinika (SE / AOK / K); Onkológiai Biomarker Kutatócsoport (Lendület) (HRN TTK / MÉI) 2 28 3 3 0 true 10014568 Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 107810580 /api/authorship/107810580 Munkácsy, G. [Munkácsy, Gyöngyi (onkológia), author] Enzim_417 (IMLS) 1 0.333 true false false Author 10024232 /api/author/10024232 Gyöngyi Munkácsy (onkológia) Munkácsy Gyöngyi true 10024232 true Munkácsy G. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 107810581 /api/authorship/107810581 Santarpia, L. 2 0.33333334 false false false Santarpia L. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 107810582 /api/authorship/107810582 Győrffy, B. ✉ [Győrffy, Balázs (Onkológia), author] Bioinformatika Tanszék (SU / FM / I); Department of Pediatrics (SU / FM / C) 3 0.333 false true true Author 10000109 /api/author/10000109 Balázs Győrffy (Onkológia) Győrffy Balázs true 10000109 true Győrffy B. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 23585752 /api/publicationidentifier/23585752 DOI: 10.3390/ijms24086945 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms24086945 https://doi.org/10.3390/ijms24086945 false true PublicationIdentifier 23694813 /api/publicationidentifier/23694813 WoS: 000977552100001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000977552100001 https://www.webofscience.com/wos/woscc/full-record/000977552100001 false true PublicationIdentifier 23585751 /api/publicationidentifier/23585751 Scopus: 85158047911 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85158047911 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85158047911 false true PublicationIdentifier 23615472 /api/publicationidentifier/23615472 PubMed: 37108109 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37108109 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37108109&dopt=Abstract true true Keyword 1037360 /api/keyword/1037360 SIGNALING PATHWAY true 1037360 true Keyword 1113033 /api/keyword/1113033 Tumor microenvironment true 1113033 true Keyword 1295807 /api/keyword/1295807 Reprogramming true 1295807 true Keyword 1500507 /api/keyword/1500507 Triple-negative breast cancer true true Keyword 1543492 /api/keyword/1543492 Cancer metabolism true true Keyword 3019063 /api/keyword/3019063 therapeutic signaling true true SjrRating 11388415 /api/sjrrating/11388415 sjr:D1 (2023) Scopus - Inorganic Chemistry INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 7 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1604 /api/classificationexternal/1604 Scopus - Inorganic Chemistry true 1604 true D1 DIRECT true true Reference 41550222 /api/reference/41550222 1. 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(2023) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 24 8<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10024232"><a href="/gui2/?type=authors&mode=browse&sel=10024232" target="_blank">Munkácsy G. (<span class="authorship-author-name">Munkácsy Gyöngyi</span> <span class="authorAux-mtmt"> onkológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/<span title="Institute of Molecular Life Sciences">IMLS</span>/Enzim_417</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Santarpia L. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000109"><a href="/gui2/?type=authors&mode=browse&sel=10000109" target="_blank">Győrffy B. ✉ (<span class="authorship-author-name">Győrffy Balázs</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Bioinformatika Tanszék; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Pediatrics</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33834650" target="_blank">Therapeutic Potential of Tumor Metabolic Reprogramming in Triple-Negative Breast Cancer</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">24</span> <span class="journal-issue">8</span> <span class="page"> Paper 6945. 21 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms24086945" target="_blank" href="https://doi.org/10.3390/ijms24086945"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000977552100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000977552100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85158047911" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85158047911"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37108109" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37108109&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Catalysis&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 24</span> | Independent citation: 24 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 24 | Number of citations in Scopus:&nbsp;17 | WoS/Scopus assigned:&nbsp;24 | Number of citations with DOI:&nbsp;24 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33834650&sort=publishedYear,desc&sort=title"> Number of cited publications: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33834650</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> Nemzeti Gyógyszerkutatási és Fejlesztési Laboratórium (PharmaLab)(RRF-2.3.1-21-2022-00015) Funder: NRDIO </div> <div class="lastModified">Last Modified: 2023.07.10. 10:01 Zsuzsa Makovsky (SE_AOK_Bioinformatika_Admin5_MZS, admin) </div> <div class="lockedBy">Centrally managed 2024.04.04. 12:41 Andrea Vándor (VA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: National Laboratory for Drug Research and Development, Magyar Tudósok Körútja 2, Budapest, 1117, Hungary Oncology Biomarker Research Group, Research Centre for Natural Sciences, Institute of Enzymology, Magyar Tudósok Körútja 2, Budapest, 1117, Hungary Seagen, Dammstrasse 23, Zug, 6300, Switzerland Department of Bioinformat...</pre> </div></div>