Therapeutic Potential of Tumor Metabolic Reprogramming in Triple-Negative Breast Cancer

Munkácsy, G. [Munkácsy, Gyöngyi (onkológia), szerző] Onkológiai Biomarker Kutatócsoport (Lendület) (HRN TTK / MÉI); Santarpia, L.; Győrffy, B. ✉ [Győrffy, Balázs (Onkológia), szerző] Bioinformatika Tanszék (SE / AOK / I); Gyermekgyógyászati Klinika (SE / AOK / K)

Angol nyelvű Összefoglaló cikk (Folyóiratcikk) Tudományos
Megjelent: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 24 (8) Paper: 6945 , 21 p. 2023
  • SJR Scopus - Inorganic Chemistry: D1
Azonosítók
Támogatások:
  • Nemzeti Gyógyszerkutatási és Fejlesztési Laboratórium(PharmaLab) Támogató: NKFIH
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, with clinical features of high metastatic potential, susceptibility to relapse, and poor prognosis. TNBC lacks the expression of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). It is characterized by genomic and transcriptional heterogeneity and a tumor microenvironment (TME) with the presence of high levels of stromal tumor-infiltrating lymphocytes (TILs), immunogenicity, and an important immunosuppressive landscape. Recent evidence suggests that metabolic changes in the TME play a key role in molding tumor development by impacting the stromal and immune cell fractions, TME composition, and activation. Hence, a complex inter-talk between metabolic and TME signaling in TNBC exists, highlighting the possibility of uncovering and investigating novel therapeutic targets. A better understanding of the interaction between the TME and tumor cells, and the underlying molecular mechanisms of cell–cell communication signaling, may uncover additional targets for better therapeutic strategies in TNBC treatment. In this review, we aim to discuss the mechanisms in tumor metabolic reprogramming, linking these changes to potential targetable molecular mechanisms to generate new, physical science-inspired clinical translational insights for the cure of TNBC. © 2023 by the authors.
Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
2024-12-11 07:03