https://m2.mtmt.hu/ eng 2026-04-04 20:50 JournalArticle 33828389 VALIDATED true Ningxia Key Laboratory of Craniocerebral Diseases, School of Clinical Medicine, Ningxia Medical University, Ningxia Hui Autonomous Region, Yinchuan, China Ningxia Key Laboratory of Craniocerebral Diseases, Ningxia Medical University, Ningxia Hui Autonomous Region, Yinchuan, China Export Date: 16 May 2023 Correspondence Address: Wang, P.; Ningxia Key Laboratory of Craniocerebral Diseases, Ningxia Hui Autonomous Region, China; email: pengwang@nxmu.edu.cn 0 false 2025-01-02T08:23:54.245+0000 2023-11-04T23:46:51.881+0000 2023-05-16T11:27:01.345+0000 true 10054097 Nicsinger Anita /api/admin/10054097 Admin Anita Nicsinger (PTE ETK admin 5) true 10054097 2025-01-02T08:21:36.320+0000 2023-11-04T23:46:46.393+0000 true 521 Szuper Admin /api/admin/521 Admin Admin Szuper (admin) true false false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType Survey paper (Journal Article) 102 true 1134514 true 1 /api/category/1 Category Scientific true 1 Wei, S.-S. true true /api/journal/10012890 REVIEWED NEURAL REGENERATION RESEARCH 1673-5374 1876-7958 true false 10012890 false 10012890 true 1673-5374 1876-7958 Journal FOREIGN 18 10 2147 2155 2147 9 2023 Remyelination failure is one of the main characteristics of multiple sclerosis and is potentially correlated with disease progression. Previous research has shown that the extracellular matrix is associated with remyelination failure because remodeling of the matrix often fails in both chronic and progressive multiple sclerosis. Fibronectin aggregates are assembled and persistently exist in chronic multiple sclerosis, thus inhibiting remyelination. Although many advances have been made in the mechanisms and treatment of multiple sclerosis, it remains very difficult for drugs to reach pathological brain tissues; this is due to the complexity of brain structure and function, especially the existence of the blood-brain barrier. Therefore, herein, we review the effects of fibronectin aggregates on multiple sclerosis and the efficacy of different forms of drug delivery across the blood-brain barrier in the treatment of this disease. © 2023 Authors. All rights reserved. 2023 true true true false false GOLD 2025-01-02 false http://www.nrronline.org/backissues.asp 0 0 0 0 0 0 0 0 0 0 0 0 1 1 Q2 false false false false 2023-08-14T11:27:58.834+0000 1 11 0 5 0 true Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 107765955 /api/authorship/107765955 Wei, S.-S. 1 0.2 true false false Wei S.-S. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 107765956 /api/authorship/107765956 Chen, L. 2 0.2 false false false Chen L. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 107765957 /api/authorship/107765957 Yang, F.-Y. 3 0.2 false false false Yang F.-Y. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 107765958 /api/authorship/107765958 Wang, S.-Q. 4 0.2 false false false Wang S.-Q. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 107765959 /api/authorship/107765959 Wang, P. ✉ 5 0.2 false true true Wang P. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 23568080 /api/publicationidentifier/23568080 DOI: 10.4103/1673-5374.369102 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.4103/1673-5374.369102 https://doi.org/10.4103/1673-5374.369102 false true PublicationIdentifier 24659819 /api/publicationidentifier/24659819 WoS: 001058059000008 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001058059000008 https://www.webofscience.com/wos/woscc/full-record/001058059000008 false true PublicationIdentifier 23568079 /api/publicationidentifier/23568079 Scopus: 85151904621 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85151904621 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85151904621 false true PublicationIdentifier 26813626 /api/publicationidentifier/26813626 PubMed: 37056122 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37056122 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37056122&dopt=Abstract false true Keyword 555 /api/keyword/555 FIBRONECTIN true 555 true Keyword 951 /api/keyword/951 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/api/keyword/14974 immune response true 14974 true Keyword 15108 /api/keyword/15108 Liposome true 15108 true Keyword 15306 /api/keyword/15306 autoimmune disease true 15306 true Keyword 17278 /api/keyword/17278 MULTIPLE SCLEROSIS true 17278 true Keyword 19903 /api/keyword/19903 immunopathology true 19903 true Keyword 20008 /api/keyword/20008 regulatory T lymphocyte true 20008 true Keyword 20009 /api/keyword/20009 CD8+ T lymphocyte true 20009 true Keyword 1001091 /api/keyword/1001091 demyelination true 1001091 true Keyword 1007980 /api/keyword/1007980 extracellular matrix true 1007980 true Keyword 1008597 /api/keyword/1008597 glycosaminoglycan true 1008597 true Keyword 1008743 /api/keyword/1008743 ADAPTIVE IMMUNITY true 1008743 true Keyword 1008826 /api/keyword/1008826 matrix metalloproteinase true 1008826 true Keyword 1010987 /api/keyword/1010987 blood brain barrier true 1010987 true Keyword 1011139 /api/keyword/1011139 transforming growth factor beta true 1011139 true Keyword 1011859 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true true /api/publication/33828389 Wei S.-S. et al. The role of fibronectin in multiple sclerosis and the effect of drug delivery across the blood-brain barrier. (2023) NEURAL REGENERATION RESEARCH 1673-5374 1876-7958 18 10 2147-2155<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Wei S.-S. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Chen L. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Yang F.-Y. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Wang S.-Q. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Wang P. ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33828389" target="_blank">The role of fibronectin in multiple sclerosis and the effect of drug delivery across the blood-brain barrier</a></div> <div> <span class="journal-title">NEURAL REGENERATION RESEARCH</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1673-5374">1673-5374</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1876-7958">1876-7958</a>)</span>: <span class="journal-volume">18</span> <span class="journal-issue">10</span> <span class="page"> pp 2147-2155 </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.4103/1673-5374.369102" target="_blank" href="https://doi.org/10.4103/1673-5374.369102"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001058059000008" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001058059000008"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85151904621" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85151904621"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37056122" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37056122&dopt=Abstract"> PubMed </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33828389&sort=publishedYear,desc&sort=title"> Number of cited publications: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33828389</span> | <span class="status-data status-VALIDATED"> Validated </span> Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="lastModified">Last Modified: 2023.11.05. 00:46 Admin Szuper (admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Ningxia Key Laboratory of Craniocerebral Diseases, School of Clinical Medicine, Ningxia Medical University, Ningxia Hui Autonomous Region, Yinchuan, China Ningxia Key Laboratory of Craniocerebral Diseases, Ningxia Medical University, Ningxia Hui Autonomous Region, Yinchuan, China Export Date: 16 May 2023 Correspondence Addr...</pre> </div></div>