https://m2.mtmt.hu/ hun 2026-09-22 16:40 JournalArticle 33827888 VALIDATED true 0 false 2026-07-29T07:42:05.087+0000 2026-01-21T16:34:53.875+0000 2023-05-16T09:25:11.655+0000 true 10050820 Buglyó Gergely /api/author/10050820 Author Buglyó Gergely (humángenetika) true 10050820 2026-07-29T07:40:52.197+0000 2024-11-28T06:05:48.234+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin Milánkovics Róbert (PTE ÁOK admin 4) true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Csók, Ádám true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 24 10 8793 8793 16 2023 Wilms’ tumor (WT) is the most common renal malignancy in children. In diffuse hyperplastic perilobar nephroblastomatosis (DHPLN), nephrogenic rests result in a bulky enlargement of the kidney, a condition considered as a premalignant state before WT. Despite relevant clinical differences between WT and DHPLN, they are often challenging to distinguish based on histology. Molecular markers would improve differential diagnosis, but none are available at present. In our study, we investigated the potential of microRNAs (miRNAs) as such biomarkers, also aiming to shed light on the chronological order of expression changes. Formalin-fixed, paraffin-embedded (FFPE) samples from four DHPLN cases and adjacent healthy tissues were tested using a PCR array containing primers for 84 miRNAs implicated in genitourinary cancer. Expression in DHPLN was compared to WT data available in dbDEMC. Let-7, miR-135, miR-146a-5p, miR-182-5p, miR-183-5p, miR-20b-3p, miR-29b-3p, miR-195-5p and miR-17-5p showed potential to be used as biomarkers to distinguish WT and DHPLN in cases when traditional differential diagnosis is inconclusive. Our study also revealed miRNAs which may play a role in the initial steps of the pathogenesis (at a precancerous stage) and ones which become deregulated later in WT. More experiments are needed to confirm our observations and find new candidate markers. true 2023 true true true false true false GOLD 2026-07-29 true https://doi.org/10.3390/ijms24108793 6 0 6 5 1 6 6 6 6 6 6 5 5 5 1 0 6 5 6 5 0 3 3 Folyóiratcikk Journal Article 24 6 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 2 2 2 2 2025 0 3 3 3 3 2026 0 1 0 1 0 D1 false 10044751,10050820 false false false 2023-05-15T11:08:39.729+0000 Gyermekgyógyászati Klinika (PTE / ÁOK); Gyermekgyógyászati Klinika (SE / AOK / K); Humángenetikai Tanszék (DE / ÁOK); Klinikai Genetikai Tanszék (DE / ÁOK / LMI); Pathologiai Intézet (PTE / ÁOK); Pathologiai Intézet (SZTE / SZAOK); Patológiai és Kísérleti Rákkutató Intézet (SE / AOK / I); Szülészeti és Nőgyógyászati Klinika Baross utca... (SE / AOK / K / SZSZNK) 11 54 8 12 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 107763627 /api/authorship/107763627 Csók, Ádám [Csók, Ádám (Biológiai tudományok), szerző] Humángenetikai Tanszék (DE / ÁOK) 1 0.083 true false false Author 10082925 /api/author/10082925 Csók Ádám (Biológiai tudományok) Csók Ádám true true Csók Ádám true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107763628 /api/authorship/107763628 Micsik, Tamás [Micsik, Tamás (Patológia), szerző] Patológiai és Kísérleti Rákkutató Intézet (SE / AOK / I) 2 0.083 false false false Author 10025105 /api/author/10025105 Micsik Tamás (Patológia) Micsik Tamás true 10025105 true Micsik Tamás true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107763629 /api/authorship/107763629 Magyar, Zsófia [Magyar, Zsófia (Csecsemő és gyerm...), szerző] Szülészeti és Nőgyógyászati Klinika Baross utca... (SE / AOK / K / SZSZNK) 3 0.083 false false false Author 10064410 /api/author/10064410 Magyar Zsófia (Csecsemő és gyermekgyógyászat) Magyar Zsófia true 10064410 true Magyar Zsófia true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107763630 /api/authorship/107763630 Tornóczky, Tamás [Tornóczky, Tamás (Pathológia), szerző] Pathologiai Intézet (PTE / ÁOK) 4 0.083 false false false Author 10015871 /api/author/10015871 Tornóczky Tamás (Pathológia) Tornóczky Tamás true 10015871 true Tornóczky Tamás true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107763631 /api/authorship/107763631 Kuthi, Levente [Kuthi, Levente (Patológia), szerző] Pathologiai Intézet (SZTE / SZAOK) 5 0.083 false false false Author 10028829 /api/author/10028829 Kuthi Levente (Patológia) Kuthi Levente true 10028829 true Kuthi Levente true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107763632 /api/authorship/107763632 Nishi, Yumika 6 0.083333336 false false false Nishi Yumika true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107763633 /api/authorship/107763633 Szirák, Krisztina [Szentesiné Szirák, Krisztina (molekuláris biológia), szerző] Humángenetikai Tanszék (DE / ÁOK) 7 0.083 false false false Author 10040202 /api/author/10040202 Szentesiné Szirák Krisztina (molekuláris biológia) Szentesiné Szirák Krisztina true 10040202 true Szirák Krisztina true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107763634 /api/authorship/107763634 Csóka, Monika [Csóka, Monika (Gyermekgyógyászat...), szerző] Gyermekgyógyászati Klinika (SE / AOK / K) 8 0.083 false false false Author 10022998 /api/author/10022998 Csóka Monika (Gyermekgyógyászat hematológia) Csóka Monika true 10022998 true Csóka Monika true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107763635 /api/authorship/107763635 Ottóffy, Gábor [Ottóffy, Gábor (Gyermekonkológia), szerző] Gyermekgyógyászati Klinika (PTE / ÁOK) 9 0.083 false false false Author 10020332 /api/author/10020332 Ottóffy Gábor (Gyermekonkológia) Ottóffy Gábor true 10020332 true Ottóffy Gábor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107763636 /api/authorship/107763636 Soltész, Beáta [Soltész, Beáta (molekuláris biológus), szerző] Humángenetikai Tanszék (DE / ÁOK) 10 0.083 false false false Author 10044751 /api/author/10044751 Soltész Beáta (molekuláris biológus) Soltész Beáta true 10044751 true Soltész Beáta true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107763637 /api/authorship/107763637 Balogh, István ✉ [Balogh, István (Klinikai laborató...), szerző] Humángenetikai Tanszék (DE / ÁOK); Klinikai Genetikai Tanszék (DE / ÁOK / LMI) 11 0.083 false false true Author 10003267 /api/author/10003267 Balogh István (Klinikai laboratóriumi genetika) Balogh István true 10003267 true Balogh István true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107763638 /api/authorship/107763638 Buglyó, Gergely [Buglyó, Gergely (humángenetika), szerző] Humángenetikai Tanszék (DE / ÁOK) 12 0.083 false true false Author 10050820 /api/author/10050820 Buglyó Gergely (humángenetika) Buglyó Gergely true 10050820 true Buglyó Gergely true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 23566661 /api/publicationidentifier/23566661 DOI: 10.3390/ijms24108793 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms24108793 https://doi.org/10.3390/ijms24108793 false true PublicationIdentifier 24078412 /api/publicationidentifier/24078412 WoS: 000996948500001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000996948500001 https://www.webofscience.com/wos/woscc/full-record/000996948500001 true true PublicationIdentifier 23967934 /api/publicationidentifier/23967934 Scopus: 85160377221 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85160377221 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85160377221 false true PublicationIdentifier 23858770 /api/publicationidentifier/23858770 PubMed: 37240139 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37240139 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37240139&dopt=Abstract false true SjrRating 11388415 /api/sjrrating/11388415 sjr:D1 (2023) Scopus - Inorganic Chemistry INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 7 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1604 /api/classificationexternal/1604 Scopus - Inorganic Chemistry true 1604 true D1 DIRECT true true Reference 41400315 /api/reference/41400315 1. 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(2023) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 24 10<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10082925"><a href="/gui2/?type=authors&mode=browse&sel=10082925" target="_blank">Csók Ádám (<span class="authorship-author-name">Csók Ádám</span> <span class="authorAux-mtmt"> Biológiai tudományok</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Humángenetikai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025105"><a href="/gui2/?type=authors&mode=browse&sel=10025105" target="_blank">Micsik Tamás (<span class="authorship-author-name">Micsik Tamás</span> <span class="authorAux-mtmt"> Patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai és Kísérleti Rákkutató Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064410"><a href="/gui2/?type=authors&mode=browse&sel=10064410" target="_blank">Magyar Zsófia (<span class="authorship-author-name">Magyar Zsófia</span> <span class="authorAux-mtmt"> Csecsemő és gyermekgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Szülészeti és Nőgyógyászati Klinika">SZSZNK</span>/Szülészeti és Nőgyógyászati Klinika Baross utcai részleg</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015871"><a href="/gui2/?type=authors&mode=browse&sel=10015871" target="_blank">Tornóczky Tamás (<span class="authorship-author-name">Tornóczky Tamás</span> <span class="authorAux-mtmt"> Pathológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Pathologiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028829"><a href="/gui2/?type=authors&mode=browse&sel=10028829" target="_blank">Kuthi Levente (<span class="authorship-author-name">Kuthi Levente</span> <span class="authorAux-mtmt"> Patológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Pathologiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nishi Yumika </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040202"><a href="/gui2/?type=authors&mode=browse&sel=10040202" target="_blank">Szirák Krisztina (<span class="authorship-author-name">Szentesiné Szirák Krisztina</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Humángenetikai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10022998"><a href="/gui2/?type=authors&mode=browse&sel=10022998" target="_blank">Csóka Monika (<span class="authorship-author-name">Csóka Monika</span> <span class="authorAux-mtmt"> Gyermekgyógyászat hematológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020332"><a href="/gui2/?type=authors&mode=browse&sel=10020332" target="_blank">Ottóffy Gábor (<span class="authorship-author-name">Ottóffy Gábor</span> <span class="authorAux-mtmt"> Gyermekonkológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10044751"><a href="/gui2/?type=authors&mode=browse&sel=10044751" target="_blank">Soltész Beáta (<span class="authorship-author-name">Soltész Beáta</span> <span class="authorAux-mtmt"> molekuláris biológus</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Humángenetikai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003267"><a href="/gui2/?type=authors&mode=browse&sel=10003267" target="_blank">Balogh István ✉ (<span class="authorship-author-name">Balogh István</span> <span class="authorAux-mtmt"> Klinikai laboratóriumi genetika</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Humángenetikai Tanszék; <span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Laboratóriumi Medicina Intézet">LMI</span>/Klinikai Genetikai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10050820"><a href="/gui2/?type=authors&mode=browse&sel=10050820" target="_blank">Buglyó Gergely (<span class="authorship-author-name">Buglyó Gergely</span> <span class="authorAux-mtmt"> humángenetika</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Humángenetikai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33827888" target="_blank">Alterations of miRNA Expression in Diffuse Hyperplastic Perilobar Nephroblastomatosis: Mapping the Way to Understanding Wilms’ Tumor Development and Differential Diagnosis</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">24</span> <span class="journal-issue">10</span> <span class="page"> Paper 8793. 16 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms24108793" target="_blank" href="https://doi.org/10.3390/ijms24108793"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000996948500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000996948500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85160377221" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85160377221"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37240139" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37240139&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 6</span> | Független: 5 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 6 | Scopus jelölt:&nbsp;6 | WoS/Scopus jelölt:&nbsp;6 | DOI jelölt:&nbsp;6 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33827888&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33827888</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2026.01.21. 17:34 Milánkovics Róbert (PTE ÁOK admin 4) </div> </div></div>