Két antibiotikumot tartalmazó gyógypremix granulált formátumának előállítása = Preparation of Medicated Feed Premix with Two Active Ingredients in Granular Form

Tóth, Judit [Tóth, Judit (Részecsketechnoló...), szerző] Funkcionális Nanorészecskék Csoport (TTK / AKI); Gyetvai, Béla; Gyenis, János [Gyenis, János (Vegyipari művelet...), szerző] Műszaki Informatikai Kar (PE); Műszaki Kémiai Kutatóintézet (PE); Rózsa, László [Rózsa, László (takarmányélettan), szerző]

Magyar nyelvű Tudományos Szakcikk (Folyóiratcikk)
Megjelent: ÁLLATTENYÉSZTÉS ÉS TAKARMÁNYOZÁS 0230-1814 67 (1) pp. 1-11 2018
  • IV. Agrártudományok Osztálya: A
Azonosítók
  • MTMT: 3382415
  • REAL: 84360
The aim was to produce dust free granulated premix containing two antibiotics. Trierra A.U.V. veterinary premix was used as reference with 15 % of oxytetracycline and 7.5 % of bacitracin zinc (feed grade) content. Besides the elimination of fine particle content the preservation of the active ingredients content, the bioequivalence to the reference product and the stability during storage were the prescribed requirements during the development of a new formulation. Granulation was carried out in a laboratory size fluid granulator. The product active ingredient content was adjusted 15 w/w% for oxytetracycline dihydrate and 0.75 m/m% bacitracin zinc (pharma grade). The demonstrated GTRI1- 6 granules were prepared on wheat starch and isomalt matrix materials. For binder hydroxypropyl methylcellulose was used. The wettability of the binder was aided by isomalt, and for bacitracin zinc Tween 80 was used for the same propose during the binder solution preparation. The produced granules fine particle size fraction (<100 μm) were between 0.0 and 0.8 m/m%. The active ingredient content was preserved during the formulation, i. e. the decrease comparing to expected content was not exceed 5 %. The bioequivalence test showed similar dissolution profile for both antibiotics to Trierra A.U.V in case of granules were produced on isomalt carrier, that is GTRI2, 3 and 5. During six-month storage all the three granules showed eligible stability, i. e. the sixth moth highest value of active ingredient content decrease was 1.66 % for oxytetracycline and 4.9 % for bacitracin zinc.
Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
2021-10-20 22:27