https://m2.mtmt.hu/ hun 2026-09-21 16:49 JournalArticle 33814839 VALIDATED true 0 false 2026-08-13T10:49:47.726+0000 2024-11-15T11:51:19.728+0000 2023-05-14T15:20:26.803+0000 true 10060440 Pipek Orsolya Anna /api/author/10060440 Author Pipek Orsolya Anna (bioinformatika, big data, onkológia) true 10060440 2026-02-08T20:23:34.993+0000 2026-02-08T20:23:34.993+0000 2024-11-15T11:51:19.927+0000 true 10080073 Bolgár Andrea /api/admin/10080073 Admin Bolgár Andrea (MTMT ellenőrzés admin5) true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv (MTMT API user, admin) Ladányi Gusztáv true true Admin 10080073 /api/admin/10080073 Bolgár Andrea (MTMT ellenőrzés admin5) Bolgár Andrea true true 2024-10-17T17:10:18.585+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Pipek, Orsolya true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 24 10 8553 8553 19 2023 A limited number of studies have focused on the mutational landscape of breast cancer in different ethnic populations within Europe and compared the data with other ethnic groups and databases. We performed whole-genome sequencing of 63 samples from 29 Hungarian breast cancer patients. We validated a subset of the identified variants at the DNA level using the Illumina TruSight Oncology (TSO) 500 assay. Canonical breast-cancer-associated genes with pathogenic germline mutations were CHEK2 and ATM. Nearly all the observed germline mutations were as frequent in the Hungarian breast cancer cohort as in independent European populations. The majority of the detected somatic short variants were single-nucleotide polymorphisms (SNPs), and only 8% and 6% of them were deletions or insertions, respectively. The genes most frequently affected by somatic mutations were KMT2C (31%), MUC4 (34%), PIK3CA (18%), and TP53 (34%). Copy number alterations were most common in the NBN, RAD51C, BRIP1, and CDH1 genes. For many samples, the somatic mutational landscape was dominated by mutational processes associated with homologous recombination deficiency (HRD). Our study, as the first breast tumor/normal sequencing study in Hungary, revealed several aspects of the significantly mutated genes and mutational signatures, and some of the copy number variations and somatic fusion events. Multiple signs of HRD were detected, highlighting the value of the comprehensive genomic characterization of breast cancer patient populations. Funding 2027382 /api/funding/2027382 (FK20_134253) false true Funding 2027383 /api/funding/2027383 (K21-137948) false true Funding 2027384 /api/funding/2027384 (TKP2021-EGA-24) false true Funding 2027385 /api/funding/2027385 János Bolyai Research Scholarship of the Hungarian Academy of Sciences(TKP2021-NVA-15) false true Funding 2027386 /api/funding/2027386 (NVKP-16-1-2016-0004) false true Funding 2027387 /api/funding/2027387 (739593) Támogató: Horizon 2020 false true Funding 2027388 /api/funding/2027388 (BO/00125/22) false true Funding 2027389 /api/funding/2027389 (ÚNKP-22-5-SE-7) false true Funding 2027390 /api/funding/2027390 Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Támogató: EFOP-VEKOP false true true 2023 true true true false true false GOLD 2026-08-13 true https://doi.org/10.3390/ijms24108553 4 0 4 4 0 4 4 4 4 4 4 4 4 4 0 0 4 4 4 4 0 2 2 Folyóiratcikk Journal Article 24 4 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 1 1 1 1 2025 0 1 1 1 1 2026 0 2 2 2 2 D1 false 10000119,10070051,10013805,10018054 false false false 2023-06-04T11:20:41.518+0000 Fizika Doktori Iskola (ELTE / TTK); HCEMM-SE Molekuláris Onkohematológiai Kutatócso... (SE / AOK / I / PKRI); Komplex Rendszerek Fizikája Tanszék (ELTE / TTK / FizCsill_I); Onkoterápiás Klinika (SZTE / SZAOK); Pathologiai Intézet (SZTE / SZAOK); Patológiai, Igazságügyi és Biztosítási Orvostan... (SE / AOK / I) 14 49 6 14 0 true 10080073 10067876 Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 107700831 /api/authorship/107700831 Pipek, Orsolya [Pipek, Orsolya Anna (bioinformatika, b...), szerző] Komplex Rendszerek Fizikája Tanszék (ELTE / TTK / FizCsill_I) 1 0.071 true false false Author 10060440 /api/author/10060440 Pipek Orsolya Anna (bioinformatika, big data, onkológia) Pipek Orsolya Anna true 10060440 true Pipek Orsolya true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107700832 /api/authorship/107700832 Alpár, Donát [Alpár, Donát (Molekuláris patho...), szerző] HCEMM-SE Molekuláris Onkohematológiai Kutatócso... 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(SE / AOK / I) 8 0.071 false false false Author 10068108 /api/author/10068108 Szállási Zoltán (Onkológia, daganatkutatás) Szállási Zoltán true true Szállási Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107700839 /api/authorship/107700839 Madaras, Lilla [Madaras, Lilla (patologia), szerző] Patológiai, Igazságügyi és Biztosítási Orvostan... (SE / AOK / I) 9 0.071 false false false Author 10023809 /api/author/10023809 Madaras Lilla (patologia) Madaras Lilla true 10023809 true Madaras Lilla true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107700840 /api/authorship/107700840 Kahán, Zsuzsanna [Kahán, Zsuzsanna (Elméleti orvostud...), szerző] Onkoterápiás Klinika (SZTE / SZAOK) 10 0.071 false false Author 10013805 /api/author/10013805 Kahán Zsuzsanna (Elméleti orvostudomány) Kahán Zsuzsanna true 10013805 true Kahán Zsuzsanna true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107700841 /api/authorship/107700841 Cserni, Gábor [Cserni, Gábor (Patológia), szerző] Pathologiai Intézet (SZTE / SZAOK) 11 0.071428575 false false false Author 10000549 /api/author/10000549 Cserni Gábor (Patológia) Cserni Gábor true 10000549 true Cserni Gábor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107700842 /api/authorship/107700842 Kővári, Bence [Kővári, Bence (Patológia), szerző] Pathologiai Intézet (SZTE / SZAOK) 12 0.071 false false false Author 10028893 /api/author/10028893 Kővári Bence (Patológia) Kővári Bence true 10028893 true Kővári Bence true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107700843 /api/authorship/107700843 Kulka, Janina [Kulka, Janina (Emlőpathológia), szerző] Patológiai, Igazságügyi és Biztosítási Orvostan... 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(SE / AOK / I) 14 0.071 false true true Author 10000119 /api/author/10000119 Tőkés Anna-Mária (Emlőpathológia és biológia) Tőkés Anna-Mária true 10000119 true Tőkés Anna Mária true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 23543157 /api/publicationidentifier/23543157 DOI: 10.3390/ijms24108553 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms24108553 https://doi.org/10.3390/ijms24108553 false true PublicationIdentifier 24185037 /api/publicationidentifier/24185037 WoS: 000996944400001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000996944400001 https://www.webofscience.com/wos/woscc/full-record/000996944400001 false true PublicationIdentifier 23973688 /api/publicationidentifier/23973688 Scopus: 85160378669 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85160378669 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85160378669 false true PublicationIdentifier 23973689 /api/publicationidentifier/23973689 PubMed: 37239898 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37239898 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37239898&dopt=Abstract false true PublicationIdentifier 23917636 /api/publicationidentifier/23917636 SZTE Publicatio: 27348 SwordSource 90 /api/publicationsource/90 SZTE Publicatio PublicationSourceType 10007 /api/publicationsourcetype/10007 Repozitórium true true true SZTE Publicatio SZTE Publicatio http://publicatio.bibl.u-szeged.hu/@@@ true true 90 true GREEN true IDENTICAL 27348 http://publicatio.bibl.u-szeged.hu/27348 false true Classification 12211 /api/classification/12211 Patológia true true SjrRating 11388415 /api/sjrrating/11388415 sjr:D1 (2023) Scopus - Inorganic Chemistry INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 7 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1604 /api/classificationexternal/1604 Scopus - Inorganic Chemistry true 1604 true D1 DIRECT true true Reference 41331074 /api/reference/41331074 1. Ferlay 2018: Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018., Eur. J. Cancer, 103, p. 356, DOI: 10.1016/j.ejca.2018.07.005 1 10.1016/j.ejca.2018.07.005 false true Reference 41331075 /api/reference/41331075 2. Dafni 2019: Breast Cancer Statistics in the European Union: Incidence and Survival across European Countries., Breast Care, 14, p. 344, DOI: 10.1159/000503219 2 10.1159/000503219 false true Reference 41331076 /api/reference/41331076 3. Dyba 2021: The European cancer burden in 2020: Incidence and mortality estimates for 40 countries and 25 major cancers., Eur. J. Cancer, 157, p. 308, DOI: 10.1016/j.ejca.2021.07.039 3 10.1016/j.ejca.2021.07.039 false true Reference 41331077 /api/reference/41331077 4. Sung 2021: Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries., CA Cancer J. Clin., 71, p. 209, DOI: 10.3322/caac.21660 4 10.3322/caac.21660 false true Reference 41331078 /api/reference/41331078 5. Weinstein 2013: The Cancer Genome Atlas Pan-Cancer analysis project., Nat. Genet., 45, p. 1113, DOI: 10.1038/ng.2764 5 10.1038/ng.2764 false true Reference 41331079 /api/reference/41331079 6. Hudson 2010: International network of cancer genome projects., Nature, 464, p. 993, DOI: 10.1038/nature08987 6 10.1038/nature08987 false true Reference 41331080 /api/reference/41331080 7. Davies 2016: Landscape of somatic mutations in 560 breast cancer whole-genome sequences., Nature, 534, p. 47, DOI: 10.1038/nature17676 7 10.1038/nature17676 false true Reference 41331081 /api/reference/41331081 8. Wijewardhane 2021: Normal Somatic Mutations in Cancer Transformation., Cancer Cell, 39, p. 125, DOI: 10.1016/j.ccell.2020.11.002 8 10.1016/j.ccell.2020.11.002 false true Reference 41331082 /api/reference/41331082 9. Alexandrov 2020: The repertoire of mutational signatures in human cancer., Nature, 578, p. 94, DOI: 10.1038/s41586-020-1943-3 9 10.1038/s41586-020-1943-3 false true Reference 41331083 /api/reference/41331083 10. Liu 2022: Somatic mutational profiles and germline polygenic risk scores in human cancer., Genome Med., 14, p. 14, DOI: 10.1186/s13073-022-01016-y 10 10.1186/s13073-022-01016-y false true Reference 41331084 /api/reference/41331084 11. Sokolova 2023: Hereditary breast cancer: Syndromes, tumour pathology and molecular testing., Histopathology, 82, p. 70, DOI: 10.1111/his.14808 11 10.1111/his.14808 false true Reference 41331085 /api/reference/41331085 12. Nones 2019: Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers., Ann. Oncol., 30, p. 1071, DOI: 10.1093/annonc/mdz132 12 10.1093/annonc/mdz132 false true Reference 41331086 /api/reference/41331086 13. Loveday 2022: Analysis of rare disruptive germline mutations in 2135 enriched BRCA-negative breast cancers excludes additional high-impact susceptibility genes., Ann. Oncol., 33, p. 1318, DOI: 10.1016/j.annonc.2022.09.152 13 10.1016/j.annonc.2022.09.152 false true Reference 41331087 /api/reference/41331087 14. Pan 2020: The molecular landscape of Asian breast cancers reveals clinically relevant population-specific differences., Nat. Commun., 11, p. 6433, DOI: 10.1038/s41467-020-20173-5 14 10.1038/s41467-020-20173-5 false true Reference 41331088 /api/reference/41331088 15. Yap 2019: Insights Into Breast Cancer in the East vs the West: A Review., JAMA Oncol., 5, p. 1489, DOI: 10.1001/jamaoncol.2019.0620 15 10.1001/jamaoncol.2019.0620 false true Reference 41331089 /api/reference/41331089 16. Mathioudaki 2020: Targeted sequencing reveals the somatic mutation landscape in a Swedish breast cancer cohort., Sci. Rep., 10, p. 19304, DOI: 10.1038/s41598-020-74580-1 16 10.1038/s41598-020-74580-1 false true Reference 41331090 /api/reference/41331090 17. Helgadottir 2021: Sequencing for germline mutations in Swedish breast cancer families reveals novel breast cancer risk genes., Sci. Rep., 11, p. 14737, DOI: 10.1038/s41598-021-94316-z 17 10.1038/s41598-021-94316-z false true Reference 41331091 /api/reference/41331091 18. Goldhirsch 2013: Personalizing the treatment of women with early breast cancer: Highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013., Ann. Oncol., 24, p. 2206, DOI: 10.1093/annonc/mdt303 18 10.1093/annonc/mdt303 false true Reference 41331092 /api/reference/41331092 19. Pinder 2007: Laboratory handling and histology reporting of breast specimens from patients who have received neoadjuvant chemotherapy., Histopathology, 50, p. 409, DOI: 10.1111/j.1365-2559.2006.02419.x 19 10.1111/j.1365-2559.2006.02419.x false true Reference 41331093 /api/reference/41331093 20. Daly 2020: NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 1.2020., J. Natl. Compr. Cancer Netw., 18, p. 380, DOI: 10.6004/jnccn.2020.0017 20 10.6004/jnccn.2020.0017 false true Reference 41331094 /api/reference/41331094 21. Mistry 2021: Pfam: The protein families database in 2021., Nucleic Acids Res., 49, p. D412, DOI: 10.1093/nar/gkaa913 21 10.1093/nar/gkaa913 false true Reference 41331095 /api/reference/41331095 22. Sammut 2019: The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer., Cell Rep., 27, p. 2690, DOI: 10.1016/j.celrep.2019.04.098 22 10.1016/j.celrep.2019.04.098 false true Reference 41331096 /api/reference/41331096 23. World Health Organization (2019). New WHO Classification for Breast Tumours, World Health Organization. [5th ed.]. 23 false true Reference 41331097 /api/reference/41331097 24. Abecasis 2012: An integrated map of genetic variation from 1,092 human genomes., Nature, 491, p. 56, DOI: 10.1038/nature11632 24 10.1038/nature11632 false true Reference 41331098 /api/reference/41331098 25. Belsare, S., Levy-Sakin, M., Mostovoy, Y., Durinck, S., Chaudhuri, S., Xiao, M., Peterson, A.S., Kwok, P.Y., Seshagiri, S., and Wall, J.D. (2019). Evaluating the quality of the 1000 genomes project data. BMC Genom., 20., DOI: 10.1186/s12864-019-5957-x 25 10.1186/s12864-019-5957-x false true Reference 41331099 /api/reference/41331099 26. Karczewski 2020: The mutational constraint spectrum quantified from variation in 141,456 humans., Nature, 581, p. 434, DOI: 10.1038/s41586-020-2308-7 26 10.1038/s41586-020-2308-7 false true Reference 41331100 /api/reference/41331100 27. Alexandrov 2013: Signatures of mutational processes in human cancer., Nature, 500, p. 415, DOI: 10.1038/nature12477 27 10.1038/nature12477 false true Reference 41331101 /api/reference/41331101 28. Auton 2015: A global reference for human genetic variation., Nature, 526, p. 68, DOI: 10.1038/nature15393 28 10.1038/nature15393 false true Reference 41331102 /api/reference/41331102 29. Adzhubei 2010: A method and server for predicting damaging missense mutations., Nat. Methods, 7, p. 248, DOI: 10.1038/nmeth0410-248 29 10.1038/nmeth0410-248 false true Reference 41331103 /api/reference/41331103 30. Ng 2003: SIFT: Predicting amino acid changes that affect protein function., Nucleic Acids Res., 31, p. 3812, DOI: 10.1093/nar/gkg509 30 10.1093/nar/gkg509 false true Reference 41331104 /api/reference/41331104 31. Thulin 2021: Discordance of PIK3CA and TP53 mutations between breast cancer brain metastases and matched primary tumors., Sci. Rep., 11, p. 23548, DOI: 10.1038/s41598-021-02903-x 31 10.1038/s41598-021-02903-x false true Reference 41331105 /api/reference/41331105 32. Fumagalli 2020: Inter-tumor genomic heterogeneity of breast cancers: Comprehensive genomic profile of primary early breast cancers and relapses., Breast Cancer Res., 22, p. 107, DOI: 10.1186/s13058-020-01345-z 32 10.1186/s13058-020-01345-z false true Reference 41331106 /api/reference/41331106 33. Chai, Y., Chen, Y., Zhang, D., Wei, Y., Li, Z., Li, Q., and Xu, B. (2022). Homologous Recombination Deficiency (HRD) and BRCA 1/2 Gene Mutation for Predicting the Effect of Platinum-Based Neoadjuvant Chemotherapy of Early-Stage Triple-Negative Breast Cancer (TNBC): A Systematic Review and Meta-Analysis. J. Pers. Med., 12., DOI: 10.3390/jpm12020323 33 10.3390/jpm12020323 false true Reference 41331107 /api/reference/41331107 34. How, J.A., Jazaeri, A.A., Fellman, B., Daniels, M.S., Penn, S., Solimeno, C., Yuan, Y., Schmeler, K., Lanchbury, J.S., and Timms, K. (2021). Modification of Homologous Recombination Deficiency Score Threshold and Association with Long-Term Survival in Epithelial Ovarian Cancer. Cancers, 13., DOI: 10.3390/cancers13050946 34 10.3390/cancers13050946 false true Reference 41331108 /api/reference/41331108 35. Kalimutho 2019: Patterns of Genomic Instability in Breast Cancer., Trends Pharmacol. Sci., 40, p. 198, DOI: 10.1016/j.tips.2019.01.005 35 10.1016/j.tips.2019.01.005 false true Reference 41331109 /api/reference/41331109 36. Yoshida 2020: Genetic and clinical landscape of breast cancers with germline BRCA1/2 variants., Commun. Biol., 3, p. 578, DOI: 10.1038/s42003-020-01301-9 36 10.1038/s42003-020-01301-9 false true Reference 41331110 /api/reference/41331110 37. Helaers 2020: Tumor sequencing is useful to refine the analysis of germline variants in unexplained high-risk breast cancer families., Breast Cancer Res., 22, p. 36, DOI: 10.1186/s13058-020-01273-y 37 10.1186/s13058-020-01273-y false true Reference 41331111 /api/reference/41331111 38. Shahi, R.B., De Brakeleer, S., Caljon, B., Pauwels, I., Bonduelle, M., Joris, S., Fontaine, C., Vanhoeij, M., Van Dooren, S., and Teugels, E. (2019). Identification of candidate cancer predisposing variants by performing whole-exome sequencing on index patients from BRCA1 and BRCA2-negative breast cancer families. BMC Cancer, 19., DOI: 10.1186/s12885-019-5494-7 38 10.1186/s12885-019-5494-7 false true Reference 41331112 /api/reference/41331112 39. Hempel 2020: Real world data analysis of next generation sequencing and protein expression in metastatic breast cancer patients., Sci. Rep., 10, p. 10459, DOI: 10.1038/s41598-020-67393-9 39 10.1038/s41598-020-67393-9 false true Reference 41331113 /api/reference/41331113 40. Powles 2020: Analysis of Pre- and Posttreatment Tissues from the SWOG S0800 Trial Reveals an Effect of Neoadjuvant Chemotherapy on the Breast Cancer Genome., Clin. Cancer Res., 26, p. 1977, DOI: 10.1158/1078-0432.CCR-19-2405 40 10.1158/1078-0432.CCR-19-2405 false true Reference 41331114 /api/reference/41331114 41. Toy 2013: ESR1 ligand-binding domain mutations in hormone-resistant breast cancer., Nat. Genet., 45, p. 1439, DOI: 10.1038/ng.2822 41 10.1038/ng.2822 false true Reference 41331115 /api/reference/41331115 42. Carey 2016: Molecular Heterogeneity and Response to Neoadjuvant Human Epidermal Growth Factor Receptor 2 Targeting in CALGB 40601, a Randomized Phase III Trial of Paclitaxel Plus Trastuzumab With or Without Lapatinib., J. Clin. Oncol., 34, p. 542, DOI: 10.1200/JCO.2015.62.1268 42 10.1200/JCO.2015.62.1268 false true Reference 41331116 /api/reference/41331116 43. Dorling 2021: Breast Cancer Risk Genes—Association Analysis in More than 113,000 Women., N. Engl. J. Med., 384, p. 428, DOI: 10.1056/NEJMoa1913948 43 10.1056/NEJMoa1913948 false true Reference 41331117 /api/reference/41331117 44. Lee 2019: Clinical validity assessment of genes frequently tested on hereditary breast and ovarian cancer susceptibility sequencing panels., Genet. Med., 21, p. 1497, DOI: 10.1038/s41436-018-0361-5 44 10.1038/s41436-018-0361-5 false true Reference 41331118 /api/reference/41331118 45. Hu 2021: A Population-Based Study of Genes Previously Implicated in Breast Cancer., N. Engl. J. Med., 384, p. 440, DOI: 10.1056/NEJMoa2005936 45 10.1056/NEJMoa2005936 false true Reference 41331119 /api/reference/41331119 46. Maishman 2020: Pathogenic Variants in CHEK2 Are Associated With an Adverse Prognosis in Symptomatic Early-Onset Breast Cancer., JCO Precis. Oncol., 4, p. 472 46 false true Reference 41331120 /api/reference/41331120 47. Zacharakis 2018: Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer., Nat. Med., 24, p. 724, DOI: 10.1038/s41591-018-0040-8 47 10.1038/s41591-018-0040-8 false true Reference 41331121 /api/reference/41331121 48. Zhang 2017: Breast Cancer Neoantigens Can Induce CD8(+) T-Cell Responses and Antitumor Immunity., Cancer Immunol. Res., 5, p. 516, DOI: 10.1158/2326-6066.CIR-16-0264 48 10.1158/2326-6066.CIR-16-0264 false true Reference 41331122 /api/reference/41331122 49. Denkert 2021: Reconstructing tumor history in breast cancer: Signatures of mutational processes and response to neoadjuvant chemotherapy (small star, filled)., Ann. Oncol., 32, p. 500, DOI: 10.1016/j.annonc.2020.12.016 49 10.1016/j.annonc.2020.12.016 false true Reference 41331123 /api/reference/41331123 50. Kostecka 2022: High prevalence of somatic PIK3CA and TP53 pathogenic variants in the normal mammary gland tissue of sporadic breast cancer patients revealed by duplex sequencing., NPJ Breast Cancer, 8, p. 76, DOI: 10.1038/s41523-022-00443-9 50 10.1038/s41523-022-00443-9 false true Reference 41331124 /api/reference/41331124 51. Chang 2019: Genomic analysis of racial differences in triple negative breast cancer., Genomics, 111, p. 1529, DOI: 10.1016/j.ygeno.2018.10.010 51 10.1016/j.ygeno.2018.10.010 false true Reference 41331125 /api/reference/41331125 52. Prasad 2020: The FDA approval of pembrolizumab for patients with TMB >10 mut/Mb: Was it a wise decision? No., Ann. Oncol., 31, p. 1112, DOI: 10.1016/j.annonc.2020.07.001 52 10.1016/j.annonc.2020.07.001 false true Reference 41331126 /api/reference/41331126 53. McGrail 2021: High tumor mutation burden fails to predict immune checkpoint blockade response across all cancer types., Ann. Oncol., 32, p. 661, DOI: 10.1016/j.annonc.2021.02.006 53 10.1016/j.annonc.2021.02.006 false true Reference 41331127 /api/reference/41331127 54. Narang, P., Chen, M., Sharma, A.A., Anderson, K.S., and Wilson, M.A. (2019). The neoepitope landscape of breast cancer: Implications for immunotherapy. BMC Cancer, 19., DOI: 10.1186/s12885-019-5402-1 54 10.1186/s12885-019-5402-1 false true Reference 41331128 /api/reference/41331128 55. Jain 2020: Prevalence and mutational determinants of high tumor mutation burden in breast cancer., Ann. Oncol., 31, p. 387, DOI: 10.1016/j.annonc.2019.11.010 55 10.1016/j.annonc.2019.11.010 false true Reference 41331129 /api/reference/41331129 56. Dennis 2022: Rare germline copy number variants (CNVs) and breast cancer risk., Commun. Biol., 5, p. 65, DOI: 10.1038/s42003-021-02990-6 56 10.1038/s42003-021-02990-6 false true Reference 41331130 /api/reference/41331130 57. Morisaki 2021: Neoantigens elicit T cell responses in breast cancer., Sci. Rep., 11, p. 13590, DOI: 10.1038/s41598-021-91358-1 57 10.1038/s41598-021-91358-1 false true Reference 41331131 /api/reference/41331131 58. Alexandrov 2012: Mutational processes molding the genomes of 21 breast cancers., Cell, 149, p. 979, DOI: 10.1016/j.cell.2012.04.024 58 10.1016/j.cell.2012.04.024 false true Reference 41331132 /api/reference/41331132 59. Davies 2017: Whole-Genome Sequencing Reveals Breast Cancers with Mismatch Repair Deficiency., Cancer Res., 77, p. 4755, DOI: 10.1158/0008-5472.CAN-17-1083 59 10.1158/0008-5472.CAN-17-1083 false true Reference 41331133 /api/reference/41331133 60. Li 2022: A functional genomic approach to actionable gene fusions for precision oncology., Sci. Adv., 8, p. eabm2382, DOI: 10.1126/sciadv.abm2382 60 10.1126/sciadv.abm2382 false true Reference 41331134 /api/reference/41331134 61. Landrum 2020: ClinVar: Improvements to accessing data., Nucleic Acids Res., 48, p. D835, DOI: 10.1093/nar/gkz972 61 10.1093/nar/gkz972 false true Reference 41331135 /api/reference/41331135 62. Sherry 1999: dbSNP-database for single nucleotide polymorphisms and other classes of minor genetic variation., Genome Res., 9, p. 677, DOI: 10.1101/gr.9.8.677 62 10.1101/gr.9.8.677 false true Reference 41331136 /api/reference/41331136 63. Tate 2019: COSMIC: The Catalogue Of Somatic Mutations In Cancer., Nucleic Acids Res., 47, p. D941, DOI: 10.1093/nar/gky1015 63 10.1093/nar/gky1015 false true Reference 41331137 /api/reference/41331137 64. Clarke 2017: The international Genome sample resource (IGSR): A worldwide collection of genome variation incorporating the 1000 Genomes Project data., Nucleic Acids Res., 45, p. D854, DOI: 10.1093/nar/gkw829 64 10.1093/nar/gkw829 false true Reference 41331138 /api/reference/41331138 65. Favero 2015: Sequenza: Allele-specific copy number and mutation profiles from tumor sequencing data., Ann. Oncol., 26, p. 64, DOI: 10.1093/annonc/mdu479 65 10.1093/annonc/mdu479 false true Reference 41331139 /api/reference/41331139 66. Abkevich 2012: Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer., Br. J. Cancer, 107, p. 1776, DOI: 10.1038/bjc.2012.451 66 10.1038/bjc.2012.451 false true Reference 41331140 /api/reference/41331140 67. Popova 2012: Ploidy and large-scale genomic instability consistently identify basal-like breast carcinomas with BRCA1/2 inactivation., Cancer Res., 72, p. 5454, DOI: 10.1158/0008-5472.CAN-12-1470 67 10.1158/0008-5472.CAN-12-1470 false true Reference 41331141 /api/reference/41331141 68. Sztupinszki 2018: Migrating the SNP array-based homologous recombination deficiency measures to next generation sequencing data of breast cancer., NPJ Breast Cancer, 4, p. 16, DOI: 10.1038/s41523-018-0066-6 68 10.1038/s41523-018-0066-6 false true /api/publication/33814839 Pipek Orsolya et al. Genomic Landscape of Normal and Breast Cancer Tissues in a Hungarian Pilot Cohort. (2023) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 24 10<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10060440"><a href="/gui2/?type=authors&mode=browse&sel=10060440" target="_blank">Pipek Orsolya (<span class="authorship-author-name">Pipek Orsolya Anna</span> <span class="authorAux-mtmt"> bioinformatika, big data, onkológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Fizikai és Csillagászati Intézet">FizCsill_I</span>/Komplex Rendszerek Fizikája Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10018054"><a href="/gui2/?type=authors&mode=browse&sel=10018054" target="_blank">Alpár Donát (<span class="authorship-author-name">Alpár Donát</span> <span class="authorAux-mtmt"> Molekuláris pathológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Patológiai és Kísérleti Rákkutató Intézet">PKRI</span>/HCEMM-SE Molekuláris Onkohematológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10036411"><a href="/gui2/?type=authors&mode=browse&sel=10036411" target="_blank">Rusz Orsolya (<span class="authorship-author-name">Rusz Orsolya</span> <span class="authorAux-mtmt"> onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025100"><a href="/gui2/?type=authors&mode=browse&sel=10025100" target="_blank">Bödör Csaba (<span class="authorship-author-name">Bödör Csaba</span> <span class="authorAux-mtmt"> Molekuláris Onkohematológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Patológiai és Kísérleti Rákkutató Intézet">PKRI</span>/HCEMM-SE Molekuláris Onkohematológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10070051"><a href="/gui2/?type=authors&mode=browse&sel=10070051" target="_blank">Udvarnoki Zoltán (<span class="authorship-author-name">Udvarnoki Zoltán András</span> <span class="authorAux-mtmt"> Fizika</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/Fizika Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10042851"><a href="/gui2/?type=authors&mode=browse&sel=10042851" target="_blank">Medgyes-Horváth Anna (<span class="authorship-author-name">Medgyes-Horváth Anna</span> <span class="authorAux-mtmt"> Sejtciklus</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Fizikai és Csillagászati Intézet">FizCsill_I</span>/Komplex Rendszerek Fizikája Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000521"><a href="/gui2/?type=authors&mode=browse&sel=10000521" target="_blank">Csabai István (<span class="authorship-author-name">Csabai István</span> <span class="authorAux-mtmt"> Statisztikus fizika</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Fizikai és Csillagászati Intézet">FizCsill_I</span>/Komplex Rendszerek Fizikája Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10068108"><a href="/gui2/?type=authors&mode=browse&sel=10068108" target="_blank">Szállási Zoltán (<span class="authorship-author-name">Szállási Zoltán</span> <span class="authorAux-mtmt"> Onkológia, daganatkutatás</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023809"><a href="/gui2/?type=authors&mode=browse&sel=10023809" target="_blank">Madaras Lilla (<span class="authorship-author-name">Madaras Lilla</span> <span class="authorAux-mtmt"> patologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013805"><a href="/gui2/?type=authors&mode=browse&sel=10013805" target="_blank">Kahán Zsuzsanna (<span class="authorship-author-name">Kahán Zsuzsanna</span> <span class="authorAux-mtmt"> Elméleti orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Onkoterápiás Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000549"><a href="/gui2/?type=authors&mode=browse&sel=10000549" target="_blank">Cserni Gábor (<span class="authorship-author-name">Cserni Gábor</span> <span class="authorAux-mtmt"> Patológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Pathologiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028893"><a href="/gui2/?type=authors&mode=browse&sel=10028893" target="_blank">Kővári Bence (<span class="authorship-author-name">Kővári Bence</span> <span class="authorAux-mtmt"> Patológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Pathologiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017900"><a href="/gui2/?type=authors&mode=browse&sel=10017900" target="_blank">Kulka Janina (<span class="authorship-author-name">Kulka Janina</span> <span class="authorAux-mtmt"> Emlőpathológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000119"><a href="/gui2/?type=authors&mode=browse&sel=10000119" target="_blank">Tőkés Anna Mária ✉ (<span class="authorship-author-name">Tőkés Anna-Mária</span> <span class="authorAux-mtmt"> Emlőpathológia és biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33814839" target="_blank">Genomic Landscape of Normal and Breast Cancer Tissues in a Hungarian Pilot Cohort</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">24</span> <span class="journal-issue">10</span> <span class="page"> Paper 8553. 19 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms24108553" target="_blank" href="https://doi.org/10.3390/ijms24108553"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000996944400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000996944400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85160378669" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85160378669"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37239898" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37239898&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="27348" target="_blank" href="http://publicatio.bibl.u-szeged.hu/27348"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 4</span> | Független: 4 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 4 | Scopus jelölt:&nbsp;4 | WoS/Scopus jelölt:&nbsp;4 | DOI jelölt:&nbsp;4 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33814839&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33814839</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (FK20_134253), (K21-137948), (TKP2021-EGA-24), János Bolyai Research Scholarship of the Hungarian Academy of Sciences(TKP2021-NVA-15), (NVKP_16-1-2016-0004) Támogató: NKFIH, HCEMM(739593) Támogató: Horizon 2020, (BO/00125/22), (ÚNKP-22-5-SE-7), Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Támogató: EFOP-VEKOP </div> <div class="lastModified">Utolsó módosítás: 2024.11.15. 12:51 Bolgár Andrea (MTMT ellenőrzés admin5) </div> <div class="lockedBy">Központi kezelésű 2024.10.17. 19:10 Ladányi Gusztáv (MTMT API user, admin) Bolgár Andrea (MTMT ellenőrzés admin5) </div> </div></div>