https://m2.mtmt.hu/ hun 2026-08-24 01:17 JournalArticle 33811668 VALIDATED true 0 false 2026-06-01T13:30:20.215+0000 2024-12-06T18:04:23.197+0000 2023-05-11T17:35:44.702+0000 true 10068237 Molnár Szilárd /api/author/10068237 Author Molnár Szilárd (Analitikai kémia) true 2026-04-29T13:05:00.034+0000 2024-12-06T18:04:23.591+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin Milánkovics Róbert (PTE ÁOK admin 4) true 10039043 Admin 10096252 /api/admin/10096252 Kósa Ilona (MTMT központi Admin, admin) Kósa Ilona true true 2025-09-10T08:35:57.369+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Kenari, Fatemeh true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 24 10 8557 8557 17 2023 Non-enzymatic thiol addition into the α,β-unsaturated carbonyl system is associated with several biological effects. In vivo, the reactions can form small-molecule thiol (e.g., glutathione) or protein thiol adducts. The reaction of two synthetic (4′-methyl- and 4′-methoxy substituted) cyclic chalcone analogs with reduced glutathione (GSH) and N-acetylcysteine (NAC) was studied by (high-pressure liquid chromatography-ultraviolet spectroscopy) HPLC-UV method. The selected compounds displayed in vitro cancer cell cytotoxicity (IC50) of different orders of magnitude. The structure of the formed adducts was confirmed by (high-pressure liquid chromatography-mass spectrometry) HPLC-MS. The incubations were performed under three different pH conditions (pH 3.2/3.7, 6.3/6.8, and 8.0/7.4). The chalcones intrinsically reacted with both thiols under all incubation conditions. The initial rates and compositions of the final mixtures depended on the substitution and the pH. The frontier molecular orbitals and the Fukui function were carried out to investigate the effects on open-chain and seven-membered cyclic analogs. Furthermore, machine learning protocols were used to provide more insights into physicochemical properties and to support the different thiol-reactivity. HPLC analysis indicated diastereoselectivity of the reactions. The observed reactivities do not directly relate to the different in vitro cancer cell cytotoxicity of the compounds. Funding 2027628 /api/funding/2027628 (EFOP-3.6.1.-16-2016-00004) Támogató: EFOP false true true 2023 true true true false false GOLD 2026-06-01 true https://doi.org/10.3390/ijms24108557 4 0 4 1 0 4 4 4 4 4 4 1 1 1 3 0 4 1 4 1 0 14 14 Folyóiratcikk Journal Article 24 4 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 1 1 1 1 2024 0 2 0 2 0 2025 0 1 0 1 0 D1 false 10008303 false false false 2023-05-11T07:20:57.150+0000 Gyógyszerészi Kémiai Intézet (PTE / GYTK); Szőlészeti és Borászati Kutatóintézet (PTE) 3 10 2 5 0 true 10096252 Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 107674405 /api/authorship/107674405 Kenari, Fatemeh [Kenari, Fatemeh (Gyógyszerészet), szerző] Gyógyszerészi Kémiai Intézet (PTE / GYTK) 1 0.2 true false false Author 10065758 /api/author/10065758 Kenari Fatemeh (Gyógyszerészet) Kenari Fatemeh true true Kenari Fatemeh true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107674406 /api/authorship/107674406 Molnár, Szilárd [Molnár, Szilárd (Analitikai kémia), szerző] Szőlészeti és Borászati Kutatóintézet (PTE); Gyógyszerészi Kémiai Intézet (PTE / GYTK) 2 0.2 false false false Author 10068237 /api/author/10068237 Molnár Szilárd (Analitikai kémia) Molnár Szilárd true true Molnár Szilárd true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107674407 /api/authorship/107674407 Borges, Igor D. 3 0.2 false false false Borges Igor D. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107674408 /api/authorship/107674408 Napolitano, Hamilton B. 4 0.2 false false false Napolitano Hamilton B. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107674409 /api/authorship/107674409 Perjési, Pál ✉ [Perjési, Pál (Bioorganikus kémia), szerző] Gyógyszerészi Kémiai Intézet (PTE / GYTK) 5 0.2 false true true Author 10008303 /api/author/10008303 Perjési Pál (Bioorganikus kémia) Perjési Pál true 10008303 true Perjési Pál true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 23537187 /api/publicationidentifier/23537187 DOI: 10.3390/ijms24108557 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms24108557 https://doi.org/10.3390/ijms24108557 false true PublicationIdentifier 24111174 /api/publicationidentifier/24111174 WoS: 000996520800001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000996520800001 https://www.webofscience.com/wos/woscc/full-record/000996520800001 true true PublicationIdentifier 23967928 /api/publicationidentifier/23967928 Scopus: 85160379293 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85160379293 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85160379293 false true PublicationIdentifier 23858782 /api/publicationidentifier/23858782 PubMed: 37239911 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37239911 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37239911&dopt=Abstract false true SjrRating 11388415 /api/sjrrating/11388415 sjr:D1 (2023) Scopus - Inorganic Chemistry INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 7 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1604 /api/classificationexternal/1604 Scopus - Inorganic Chemistry true 1604 true D1 DIRECT true true Reference 41272567 /api/reference/41272567 1. 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(2023) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 24 10<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10065758"><a href="/gui2/?type=authors&mode=browse&sel=10065758" target="_blank">Kenari Fatemeh (<span class="authorship-author-name">Kenari Fatemeh</span> <span class="authorAux-mtmt"> Gyógyszerészet</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészi Kémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10068237"><a href="/gui2/?type=authors&mode=browse&sel=10068237" target="_blank">Molnár Szilárd (<span class="authorship-author-name">Molnár Szilárd</span> <span class="authorAux-mtmt"> Analitikai kémia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/Szőlészeti és Borászati Kutatóintézet; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészi Kémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Borges Igor D. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Napolitano Hamilton B. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008303"><a href="/gui2/?type=authors&mode=browse&sel=10008303" target="_blank">Perjési Pál ✉ (<span class="authorship-author-name">Perjési Pál</span> <span class="authorAux-mtmt"> Bioorganikus kémia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészi Kémiai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33811668" target="_blank">(E)-2-Benzylidenecyclanones: Part XVIII Study the Possible Link between Glutathione Reactivity and Cancer Cell Cytotoxic Effects of Some Cyclic Chalcone Analogs A Comparison of the Reactivity of the Open-Chain and the Seven-Membered Homologs</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">24</span> <span class="journal-issue">10</span> <span class="page"> Paper 8557. 17 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms24108557" target="_blank" href="https://doi.org/10.3390/ijms24108557"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000996520800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000996520800001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85160379293" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85160379293"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37239911" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37239911&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 4</span> | Független: 1 | Függő: 3 | Nem jelölt: 0 | WoS jelölt: 4 | Scopus jelölt:&nbsp;4 | WoS/Scopus jelölt:&nbsp;4 | DOI jelölt:&nbsp;4 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33811668&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 14 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33811668</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (EFOP-3.6.1.-16-2016-00004) Támogató: EFOP </div> <div class="lastModified">Utolsó módosítás: 2024.12.06. 19:04 Milánkovics Róbert (PTE ÁOK admin 4) </div> <div class="lockedBy">Központi kezelésű 2025.09.10. 10:35 Kósa Ilona (MTMT központi Admin, admin) </div> </div></div>