https://m2.mtmt.hu/ hun 2026-09-23 04:45 JournalArticle 33810371 VALIDATED true Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, 1085, Hungary HCEMM-SE Cardiometabolic Immunology Research Group, Semmelweis University, Budapest, 1085, Hungary MTA-SE Momentum Cardio-Oncology and Cardioimmunology Research Group, Semmelweis University, Budapest, 1085, Hungary Ludwig Boltzmann Institute for Cardiovascular Research, Center for Biomedical Research and Translational Surgery, Medical University of Vienna, Vienna, 1090, Austria Department of Neurophysiology & Neuropharmacology, Center for Physiology & Pharmacology, Medical University of Vienna, Vienna, 1090, Austria Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, AB T6G 2R3, Canada Pharmahungary Group, Szeged, 6728, Hungary Cited By :1 Export Date: 3 January 2024 Correspondence Address: Varga, Z.V.; Department of Pharmacology and Pharmacotherapy, Hungary; email: varga.zoltan@med.semmelweis-univ.hu Chemicals/CAS: caspase 11, 216503-96-7; interleukin 18, 189304-55-0; interleukin 1beta converting enzyme, 122191-40-6, 187414-12-6 0 false 2026-09-02T16:34:27.300+0000 2023-11-30T09:19:09.906+0000 2023-05-11T11:21:46.434+0000 true 10061054 Onódi Zsófia /api/author/10061054 Author true 10061054 2026-08-10T13:35:30.622+0000 2026-08-10T13:35:30.622+0000 2023-11-30T09:19:10.191+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Onódi, Zsófia Inflammasome Activity in the Skeletal Muscle and Heart of Rodent Models for Duchenne Muscular Dystrophy true true /api/journal/10003252 REVIEWED true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 24 10 8497 8497 14 2023 Duchenne muscular dystrophy (DMD) is characterized by wasting of muscles that leads to difficulty moving and premature death, mainly from heart failure. Glucocorticoids are applied in the management of the disease, supporting the hypothesis that inflammation may be driver as well as target. However, the inflammatory mechanisms during progression of cardiac and skeletal muscle dysfunction are still not well characterized. Our objective was to characterize the inflammasomes in myocardial and skeletal muscle in rodent models of DMD. Gastrocnemius and heart samples were collected from mdx mice and DMDmdx rats (3 and 9–10 months). Inflammasome sensors and effectors were assessed by immunoblotting. Histology was used to assess leukocyte infiltration and fibrosis. In gastrocnemius, a tendency towards elevation of gasdermin D irrespective of the age of the animal was observed. The adaptor protein was elevated in the mdx mouse skeletal muscle and heart. Increased cleavage of the cytokines was observed in the skeletal muscle of the DMDmdx rats. Sensor or cytokine expression was not changed in the tissue samples of the mdx mice. In conclusion, inflammatory responses are distinct between the skeletal muscle and heart in relevant models of DMD. Inflammation tends to decrease over time, supporting the clinical observations that the efficacy of anti-inflammatory therapies might be more prominent in the early stage. 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(SE / AOK / I / FFI) 5 25 2 11 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 107666817 /api/authorship/107666817 1 0.091 true false Author 10061054 /api/author/10061054 Onódi Zsófia true 10061054 true Onódi Zsófia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107666818 /api/authorship/107666818 2 0.091 true false false Szabó Petra Lujza true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107666819 /api/authorship/107666819 3 0.091 false false false Author 10069243 /api/author/10069243 Kucsera Dániel true true Kucsera Dániel true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107666820 /api/authorship/107666820 4 0.09090909 false false false Author 10062024 /api/author/10062024 Pokreisz Peter true 10062024 true Pokreisz Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true 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107666826 /api/authorship/107666826 10 0.091 false true true Author 10028393 /api/author/10028393 Varga Zoltán true 10028393 true Varga Zoltán V. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107666827 /api/authorship/107666827 11 0.09090909 false true false Kiss Attila true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 23534251 /api/publicationidentifier/23534251 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms24108497 https://doi.org/10.3390/ijms24108497 false true PublicationIdentifier 24046844 /api/publicationidentifier/24046844 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 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<img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10061054"><a href="/gui2/?type=authors&mode=browse&sel=10061054" target="_blank">Onódi Zsófia (<span class="authorship-author-name">Onódi Zsófia</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/HCEMM-SE Kardiometabolikus Immunológia Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Szabó Petra Lujza<sup>*</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10069243"><a href="/gui2/?type=authors&mode=browse&sel=10069243" target="_blank">Kucsera Dániel (<span class="authorship-author-name">Kucsera Dániel</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/HCEMM-SE Kardiometabolikus Immunológia Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10062024"><a href="/gui2/?type=authors&mode=browse&sel=10062024" target="_blank">Pokreisz Péter (<span class="authorship-author-name">Pokreisz Peter</span> <span class="authorAux-mtmt"> Kísérleti kardiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dostal Christopher </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hilber Karlheinz </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Oudit Gavin Y. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Podesser Bruno K. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010125"><a href="/gui2/?type=authors&mode=browse&sel=10010125" target="_blank">Ferdinandy Péter (<span class="authorship-author-name">Ferdinandy Péter</span> <span class="authorAux-mtmt"> Farmakológia, molekuláris medicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028393"><a href="/gui2/?type=authors&mode=browse&sel=10028393" target="_blank">Varga Zoltán V.<sup>**</sup> ✉ (<span class="authorship-author-name">Varga Zoltán</span> <span class="authorAux-mtmt"> kardiovaszkuláris kutatás</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/HCEMM-SE Kardiometabolikus Immunológia Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kiss Attila </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33810371" target="_blank">Inflammasome Activity in the Skeletal Muscle and Heart of Rodent Models for Duchenne Muscular Dystrophy</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">24</span> <span class="journal-issue">10</span> <span class="page"> Paper 8497. 14 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms24108497" target="_blank" href="https://doi.org/10.3390/ijms24108497"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000997941200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000997941200001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85160411388" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85160411388"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37239853" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37239853&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 9</span> | Független: 6 | Függő: 3 | Nem jelölt: 0 | WoS jelölt: 8 | Scopus jelölt:&nbsp;9 | WoS/Scopus jelölt:&nbsp;9 | DOI jelölt:&nbsp;9 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33810371&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33810371</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> HCEMM(739593) Támogató: Horizon 2020, Tématerületi Kiválósági Program(2020-4.1.1.-TKP2020), (Therapeutic Development and Bioimaging thematic programmes of the Semmelweis University), (2020-1.1.6-JOVO-2021-00013), National Research, Development and Innovation Office (NKFIH) of Hungary(FK134751), (ÚNKP-22-4-II-SE-3), Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Támogató: EFOP-VEKOP </div> <div class="lastModified">Utolsó módosítás: 2023.11.30. 10:19 Molnár-Taga Márta (SE 4-es admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, 1085, Hungary HCEMM-SE Cardiometabolic Immunology Research Group, Semmelweis University, Budapest, 1085, Hungary MTA-SE Momentum Cardio-Oncology and Cardioimmunology Research Group, Semmelweis University, Budapest, 1085, Hungary Ludwig Boltzman...</pre> </div></div>