https://m2.mtmt.hu/ hun 2026-05-30 13:51 JournalArticle 33810076 VALIDATED true 0 false 2026-05-22T22:40:06.860+0000 2026-03-23T21:13:55.288+0000 2023-05-11T10:10:27.849+0000 true 10080212 Kocsis Dorottya /api/author/10080212 Author Kocsis Dorottya (biológia) true 2026-03-25T17:16:20.125+0000 2026-03-25T17:16:20.125+0000 2023-06-23T07:07:42.615+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) true Admin 10065569 /api/admin/10065569 Pécsi Éva (MTMT Közp 2,3, admin) Pécsi Éva true true 2026-04-14T13:01:34.757+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Kocsis, Dorottya true true /api/journal/10022148 REVIEWED PHARMACEUTICS 1999-4923 true false 10022148 false 10022148 true 1999-4923 Journal FOREIGN 15 5 1464 1464 13 2023 α-Aminophosphonates are organophosphorus compounds with an obvious similarity with α-amino acids. Owing to their biological and pharmacological characteristics, they have attracted the attention of many medicinal chemists. α-Aminophosphonates are known to exhibit antiviral, antitumor, antimicrobial, antioxidant and antibacterial activities, which can all be important in pathological dermatological conditions. However, their ADMET properties are not well studied. The aim of the current study was to provide preliminary information about the skin penetration of three preselected α-aminophosphonates when applying them as topical cream formulations in static and dynamic diffusion chambers. The results indicate that aminophosphonate 1a, without any substituent in the para position, shows the best release from the formulation and the highest absorption through the excised skin. However, based on our previous study, the in vitro pharmacological potency was higher in the case of para-substituted molecules 1b and 1c. The particle size and rheological studies revealed that the 2% cream of aminophosphonate 1a was the most homogenous formulation. In conclusion, the most promising molecule was 1a, but further experiments are proposed to uncover the possible transporter interactions in the skin, optimize the topical formulations and improve PK/PD profiles in case of transdermal delivery. Funding 2027370 /api/funding/2027370 Thematic Excellence Program(TKP2021-EGA-42) false true Funding 2027371 /api/funding/2027371 (ÚNKP-22-3) false true Funding 2027372 /api/funding/2027372 (K134318) false true true 2023 true true true false true false GOLD 2026-05-23 true https://doi.org/10.3390/pharmaceutics15051464 8 0 8 5 2 7 7 7 7 7 7 5 5 5 3 0 8 5 8 5 0 13 13 Folyóiratcikk Journal Article 24 8 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 2 1 2 1 2024 0 4 2 4 2 2025 0 0 0 0 0 2026 0 2 2 2 2 Q1 false 10080212 false false false 2023-06-04T11:54:34.131+0000 Gyógyszerészeti Intézet (SE / GYTK); Információs Technológiai és Bionikai Kar (PPKE); Műszercentrum (TTK); Roska Tamás Műszaki és Természettudományi Dokto... (PPKE / ITK); Szerves Kémia és Technológia Tanszék (BME / VBK) 8 39 5 10 0 true 10065569 Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 107665544 /api/authorship/107665544 Kocsis, Dorottya [Kocsis, Dorottya (biológia), szerző] Roska Tamás Műszaki és Természettudományi Dokto... (PPKE / ITK) 1 0.1 true false false Author 10080212 /api/author/10080212 Kocsis Dorottya (biológia) Kocsis Dorottya true true Kocsis Dorottya true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107665545 /api/authorship/107665545 Varga, Petra Regina [Varga, Petra Regina (szerves kémia), szerző] Szerves Kémia és Technológia Tanszék (BME / VBK) 2 0.1 false false false Author 10071640 /api/author/10071640 Varga Petra Regina (szerves kémia) Varga Petra Regina true true Varga Petra Regina true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107665546 /api/authorship/107665546 Keshwan, Rusul 3 0.1 false false false Keshwan Rusul true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107665547 /api/authorship/107665547 Nader, Mina 4 0.1 false false false Nader Mina true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107665548 /api/authorship/107665548 Lengyel, Miléna [Lengyel, Miléna (Gyógyszertechnológia), szerző] Gyógyszerészeti Intézet (SE / GYTK) 5 0.1 false false false Author 10020628 /api/author/10020628 Lengyel Miléna (Gyógyszertechnológia) Lengyel Miléna true 10020628 true Lengyel Miléna true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107665549 /api/authorship/107665549 Szabó, Pál [Szabó, Pál Tamás (Tömegspektrometria), szerző] Műszercentrum (TTK) 6 0.1 false false false Author 10014589 /api/author/10014589 Szabó Pál Tamás (Tömegspektrometria) Szabó Pál Tamás true 10014589 true Szabó Pál true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107665550 /api/authorship/107665550 Antal, István [Antal, István (Gyógyszertechnológia), szerző] Gyógyszerészeti Intézet (SE / GYTK) 7 0.1 false false false Author 10020626 /api/author/10020626 Antal István (Gyógyszertechnológia) Antal István true 10020626 true Antal István true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107665551 /api/authorship/107665551 Kánai, Károly [Kánai, Károly (Szerves kémia, gy...), szerző] Szerves Kémia és Technológia Tanszék (BME / VBK) 8 0.1 false false false Author 10008298 /api/author/10008298 Kánai Károly (Szerves kémia, gyógyszerkémia) Kánai Károly true 10008298 true Kánai Károly true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107665552 /api/authorship/107665552 Keglevich, György [Keglevich, György (Szerves kémia, fo...), szerző] Szerves Kémia és Technológia Tanszék (BME / VBK) 9 0.1 false false false Author 1272454 /api/author/1272454 Keglevich György (Szerves kémia, foszfororganikus környezetbarát kémia) Keglevich György true 1272454 true Keglevich György true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107665553 /api/authorship/107665553 Erdő, Franciska ✉ [Erdő, Franciska (biológia, neurode...), szerző] Információs Technológiai és Bionikai Kar (PPKE) 10 0.1 false true true Author 10044620 /api/author/10044620 Erdő Franciska (biológia, neurodegenerativ betegségek, gyógyszerkutatás, mikrodialízis, in vivo állatmodellek, innovatív gyógyszerformák, gyógyszerpenetráció) Erdő Franciska DUPLUM true 10044620 true Erdő Franciska true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 23533480 /api/publicationidentifier/23533480 DOI: 10.3390/pharmaceutics15051464 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/pharmaceutics15051464 https://doi.org/10.3390/pharmaceutics15051464 false true PublicationIdentifier 24134166 /api/publicationidentifier/24134166 WoS: 000997201900001 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PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37242706 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37242706&dopt=Abstract true true SjrRating 11405944 /api/sjrrating/11405944 sjr:Q1 (2023) Scopus - Pharmaceutical Science PHARMACEUTICS 1999-4923 1999-4923 26 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 3003 /api/classificationexternal/3003 Scopus - Pharmaceutical Science true 3003 true Q1 DIRECT true true Reference 41243791 /api/reference/41243791 1. 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(2023) PHARMACEUTICS 1999-4923 15 5<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10080212"><a href="/gui2/?type=authors&mode=browse&sel=10080212" target="_blank">Kocsis Dorottya (<span class="authorship-author-name">Kocsis Dorottya</span> <span class="authorAux-mtmt"> biológia</span>) </a> </span> <span class="author-affil"><span title="Pázmány Péter Katolikus Egyetem">PPKE</span>/<span title="Információs Technológiai és Bionikai Kar">ITK</span>/Roska Tamás Műszaki és Természettudományi Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071640"><a href="/gui2/?type=authors&mode=browse&sel=10071640" target="_blank">Varga Petra Regina (<span class="authorship-author-name">Varga Petra Regina</span> <span class="authorAux-mtmt"> szerves kémia</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Vegyészmérnöki és Biomérnöki Kar">VBK</span>/Szerves Kémia és Technológia Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Keshwan Rusul </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nader Mina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020628"><a href="/gui2/?type=authors&mode=browse&sel=10020628" target="_blank">Lengyel Miléna (<span class="authorship-author-name">Lengyel Miléna</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészeti Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014589"><a href="/gui2/?type=authors&mode=browse&sel=10014589" target="_blank">Szabó Pál (<span class="authorship-author-name">Szabó Pál Tamás</span> <span class="authorAux-mtmt"> Tömegspektrometria</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Műszercentrum</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020626"><a href="/gui2/?type=authors&mode=browse&sel=10020626" target="_blank">Antal István (<span class="authorship-author-name">Antal István</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészeti Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008298"><a href="/gui2/?type=authors&mode=browse&sel=10008298" target="_blank">Kánai Károly (<span class="authorship-author-name">Kánai Károly</span> <span class="authorAux-mtmt"> Szerves kémia, gyógyszerkémia</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Vegyészmérnöki és Biomérnöki Kar">VBK</span>/Szerves Kémia és Technológia Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1272454"><a href="/gui2/?type=authors&mode=browse&sel=1272454" target="_blank">Keglevich György (<span class="authorship-author-name">Keglevich György</span> <span class="authorAux-mtmt"> Szerves kémia, foszfororganikus környezetbarát ...</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Vegyészmérnöki és Biomérnöki Kar">VBK</span>/Szerves Kémia és Technológia Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10044620"><a href="/gui2/?type=authors&mode=browse&sel=10044620" target="_blank">Erdő Franciska ✉ (<span class="authorship-author-name">Erdő Franciska</span> <span class="authorAux-mtmt"> biológia, neurodegenerativ betegségek, gyógysze...</span>) </a> </span> <span class="author-affil"><span title="Pázmány Péter Katolikus Egyetem">PPKE</span>/Információs Technológiai és Bionikai Kar</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33810076" target="_blank">Transdermal Delivery of α-Aminophosphonates as Semisolid Formulations—An In Vitro-Ex Vivo Study</a></div> <div> <span class="journal-title">PHARMACEUTICS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1999-4923">1999-4923</a>)</span>: <span class="journal-volume">15</span> <span class="journal-issue">5</span> <span class="page"> Paper 1464. 13 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/pharmaceutics15051464" target="_blank" href="https://doi.org/10.3390/pharmaceutics15051464"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000997201900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000997201900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85160434432" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85160434432"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37242706" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37242706&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmaceutical Science&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 8</span> | Független: 5 | Függő: 3 | Nem jelölt: 0 | WoS jelölt: 7 | Scopus jelölt:&nbsp;7 | WoS/Scopus jelölt:&nbsp;7 | DOI jelölt:&nbsp;7 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33810076&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 13 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33810076</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Thematic Excellence Program(TKP2021-EGA-42), (ÚNKP-22-3), (K134318) </div> <div class="lastModified">Utolsó módosítás: 2026.03.23. 22:13 Pécsi Éva (MTMT Közp 2,3, admin) </div> <div class="lockedBy">Központi kezelésű 2026.04.14. 15:01 Pécsi Éva (MTMT Közp 2,3, admin) </div> </div></div>