https://m2.mtmt.hu/ hun 2026-04-17 03:13 JournalArticle 3379754 VALIDATED true 0 2018-09-28T22:21:31.000+0000 false 3379754 2026-04-02T08:47:26.735+0000 2024-11-29T08:57:11.777+0000 2018-05-31T13:04:07.000+0000 true 10023829 Keltai Katalin /api/author/10023829 Author true 10023829 2026-04-01T12:40:24.894+0000 2026-04-01T12:40:24.894+0000 2024-11-29T08:57:12.282+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 Admin 10013962 /api/admin/10013962 Vasvari Lilian true 10013962 true 2025-01-23T17:25:20.589+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Connolly, SJ Rivaroxaban with or without aspirin in patients with stable coronary artery disease: an international, randomised, double-blind, placebo-controlled trial true true /api/journal/3012 REVIEWED true false 3012 false 3012 true 0140-6736 1474-547X Journal FOREIGN 391 10117 205 218 205 14 2018 Background Coronary artery disease is a major cause of morbidity and mortality worldwide, and is a consequence of acute thrombotic events involving activation of platelets and coagulation proteins. Factor Xa inhibitors and aspirin each reduce thrombotic events but have not yet been tested in combination or against each other in patients with stable coronary artery disease. Methods In this multicentre, double-blind, randomised, placebo-controlled, outpatient trial, patients with stable coronary artery disease or peripheral artery disease were recruited at 602 hospitals, clinics, or community centres in 33 countries. This paper reports on patients with coronary artery disease. Eligible patients with coronary artery disease had to have had a myocardial infarction in the past 20 years, multi-vessel coronary artery disease, history of stable or unstable angina, previous multi-vessel percutaneous coronary intervention, or previous multi-vessel coronary artery bypass graft surgery. After a 30-day run in period, patients were randomly assigned (1: 1: 1) to receive rivaroxaban (2.5 mg orally twice a day) plus aspirin (100 mg once a day), rivaroxaban alone (5 mg orally twice a day), or aspirin alone (100 mg orally once a day). Randomisation was computer generated. Each treatment group was double dummy, and the patients, investigators, and central study staff were masked to treatment allocation. The primary outcome of the COMPASS trial was the occurrence of myocardial infarction, stroke, or cardiovascular death. This trial is registered with ClinicalTrials.gov, number NCT01776424, and is closed to new participants. Findings Between March 12, 2013, and May 10, 2016, 27 395 patients were enrolled to the COMPASS trial, of whom 24 824 patients had stable coronary artery disease from 558 centres. The combination of rivaroxaban plus aspirin reduced the primary outcome more than aspirin alone (347 [4%] of 8313 vs 460 [6%] of 8261; hazard ratio [HR] 0.74, 95% CI 0.65-0.86, p<0.0001). By comparison, treatment with rivaroxaban alone did not significantly improve the primary outcome when compared with treatment with aspirin alone (411 [5%] of 8250 vs 460 [6%] of 8261; HR 0.89, 95% CI 0.78-1.02, p=0.094). Combined rivaroxaban plus aspirin treatment resulted in more major bleeds than treatment with aspirin alone (263 [3%] of 8313 vs 158 [2%] of 8261; HR 1.66, 95% CI 1.37-2.03, p<0.0001), and similarly, more bleeds were seen in the rivaroxaban alone group than in the aspirin alone group (236 [3%] of 8250 vs 158 [2%] of 8261; HR 1.51, 95% CI 1.23-1.84, p<0.0001). The most common site of major bleeding was gastrointestinal, occurring in 130 [2%] patients who received combined rivaroxaban plus aspirin, in 84 [1%] patients who received rivaroxaban alone, and in 61 [1%] patients who received aspirin alone. Rivaroxaban plus aspirin reduced mortality when compared with aspirin alone (262 [3%] of 8313 vs 339 [4%] of 8261; HR 0.77, 95% CI 0.65-0.90, p=0.0012). Interpretation In patients with stable coronary artery disease, addition of rivaroxaban to aspirin lowered major vascular events, but increased major bleeding. There was no significant increase in intracranial bleeding or other critical organ bleeding. There was also a significant net benefit in favour of rivaroxaban plus aspirin and deaths were reduced by 23%. Thus, addition of rivaroxaban to aspirin has the potential to substantially reduce morbidity and mortality from coronary artery disease worldwide. true true INTERNATIONAL 2018 735881 true true true false true false NONE 2026-04-02 false 386 0 386 331 8 382 370 324 377 386 386 331 331 331 55 0 386 331 386 331 0 8 8 Folyóiratcikk Journal Article 24 383 Könyvrészlet Chapter in Book 25 2 Könyv Book 23 1 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat 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<span class="author-name" >Eikelboom JW </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bosch J </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dagenais G </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dyal L </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lanas F </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Metsarinne K </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >O'Donnell M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dans AL </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ha JW </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Parkhomenko AN </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Avezum AA </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lonn E </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Liu LS </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Torp-Pedersen C </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Widimsky P </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Maggioni AP </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Felix C </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023829"><a href="/gui2/?type=authors&mode=browse&sel=10023829" target="_blank">Keltai K (<span class="authorship-author-name">Keltai Katalin</span> <span class="authorAux-mtmt"> Kardiológia, belgyógyászat</span>) </a> </span> <span class="author-affil">Semmelweis Egyetem</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hori M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Yusoff K </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Guzik TJ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bhatt DL </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Branch KRH </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bruns NC </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Berkowitz SD </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Anand SS </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Varigos JD </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Fox KAA </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Yusuf S<sup>**</sup> </span> </div> <div class="autype autype-11"> Kollaborációs közreműködő: <span class="author-name" mtid="10002738"><a href="/gui2/?type=authors&mode=browse&sel=10002738" target="_blank">M. Keltai (<span class="authorship-author-name">Keltai Mátyás</span> <span class="authorAux-mtmt"> Klinikai kardiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10004436"><a href="/gui2/?type=authors&mode=browse&sel=10004436" target="_blank">A. Hargitai (<span class="authorship-author-name">Hargitainé Tóth Ágnes</span> <span class="authorAux-mtmt"> Fizikai kémia</span>) </a> </span> <span class="author-affil"><span title="Nyíregyházi Egyetem">NYE</span>/<span title="Környezettudományi Intézet">KI</span>/Kémia Intézeti Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10016411"><a href="/gui2/?type=authors&mode=browse&sel=10016411" target="_blank">L. Bajnok (<span class="authorship-author-name">Bajnok László Zoltán</span> <span class="authorAux-mtmt"> Belgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/Általános Orvostudományi Kar</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Z. Marton </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032482"><a href="/gui2/?type=authors&mode=browse&sel=10032482" target="_blank">Z. Laszlo (<span class="authorship-author-name">László Zoltán</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028344"><a href="/gui2/?type=authors&mode=browse&sel=10028344" target="_blank">D. Aradi (<span class="authorship-author-name">Aradi Dániel</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >A. Vertes </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023788"><a href="/gui2/?type=authors&mode=browse&sel=10023788" target="_blank">A. Zsary (<span class="authorship-author-name">Zsáry András</span> <span class="authorAux-mtmt"> Kardiológia, belgyógyászat, intenzív</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008869"><a href="/gui2/?type=authors&mode=browse&sel=10008869" target="_blank">L. Koranyi (<span class="authorship-author-name">Korányi László</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >I. Agardi </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Z. Boda </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052973"><a href="/gui2/?type=authors&mode=browse&sel=10052973" target="_blank">K. Razso (<span class="authorship-author-name">Rázsó Katalin</span> <span class="authorAux-mtmt"> belgyógyászat, kardiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009056"><a href="/gui2/?type=authors&mode=browse&sel=10009056" target="_blank">F. Poor (<span class="authorship-author-name">Poór Zoltán Ferenc</span> <span class="authorAux-mtmt"> Nyelvpedagógia, tanárképzés, pedagógiai technol...</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014929"><a href="/gui2/?type=authors&mode=browse&sel=10014929" target="_blank">Z. Jarai (<span class="authorship-author-name">Járai Zoltán</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024040"><a href="/gui2/?type=authors&mode=browse&sel=10024040" target="_blank">L. Sallai (<span class="authorship-author-name">Sallai László</span> <span class="authorAux-mtmt"> belgyógyászat, kardiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10077102"><a href="/gui2/?type=authors&mode=browse&sel=10077102" target="_blank">Benedek Imre (<span class="authorship-author-name">Benedek Imre-Sándor</span> <span class="authorAux-mtmt"> Invazív kardiológia, Elektrofiziológia, Kardiol...</span>) </a> </span> </div> <div class="autype autype-29"> Kollaborációs szervezet: <span class="author-affil">COMPASS Investigators</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3379754" target="_blank">Rivaroxaban with or without aspirin in patients with stable coronary artery disease: an international, randomised, double-blind, placebo-controlled trial</a></div> <div> <span class="journal-title">LANCET</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0140-6736">0140-6736</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1474-547X">1474-547X</a>)</span>: <span class="journal-volume">391</span> <span class="journal-issue">10117</span> <span class="page"> pp 205-218 </span> <span class="year">(2018)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/S0140-6736(17)32458-3" target="_blank" href="https://doi.org/10.1016/S0140-6736%2817%2932458-3"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000423867000023" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000423867000023"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85033557607" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85033557607"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="29132879" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=29132879&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://linkinghub.elsevier.com/retrieve/pii/S0140673617324583" target="_blank" href="https://linkinghub.elsevier.com/retrieve/pii/S0140673617324583"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Demográfiai Osztályközi Állandó Bizottság IXGJO DEM [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Szociológiai Tudományos Bizottság IXGJO SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 386</span> | Független: 331 | Függő: 55 | Nem jelölt: 0 | WoS jelölt: 324 | Scopus jelölt:&nbsp;377 | WoS/Scopus jelölt:&nbsp;386 | DOI jelölt:&nbsp;370 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3379754&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 3379754</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 3379754</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS</span> </div> <div class="lastModified">Utolsó módosítás: 2024.11.29. 09:57 Milánkovics Róbert (PTE ÁOK admin 4) </div> <div class="lockedBy">Központi kezelésű 2025.01.23. 18:25 Vasvari Lilian (MTMT Központ, admin) </div> </div></div>