https://m2.mtmt.hu/ hun 2026-09-20 16:05 JournalArticle 33784924 VALIDATED true 0 false 2026-09-08T08:22:52.980+0000 2024-02-06T06:40:23.402+0000 2023-05-01T14:02:57.646+0000 true 10074690 Áncsán Gizella /api/admin/10074690 Admin true 2026-09-08T08:21:46.984+0000 2026-09-08T08:21:46.984+0000 2024-02-06T06:40:23.696+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2024-04-03T13:49:16.111+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Karádi, David Á. Telmisartan Is a Promising Agent for Managing Neuropathic Pain and Delaying Opioid Analgesic Tolerance in Rats true true /api/journal/10003252 REVIEWED true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 24 9 7970 7970 18 2023 Despite the large arsenal of analgesic medications, neuropathic pain (NP) management is not solved yet. Angiotensin II receptor type 1 (AT1) has been identified as a potential target in NP therapy. Here, we investigate the antiallodynic effect of AT1 blockers telmisartan and losartan, and particularly their combination with morphine on rat mononeuropathic pain following acute or chronic oral administration. The impact of telmisartan on morphine analgesic tolerance was also assessed using the rat tail-flick assay. Morphine potency and efficacy in spinal cord samples of treated neuropathic animals were assessed by [35S]GTPγS-binding assay. Finally, the glutamate content of the cerebrospinal fluid (CSF) was measured by capillary electrophoresis. Oral telmisartan or losartan in higher doses showed an acute antiallodynic effect. In the chronic treatment study, the combination of subanalgesic doses of telmisartan and morphine ameliorated allodynia and resulted in a leftward shift in the dose–response curve of morphine in the [35S]GTPγS binding assay and increased CSF glutamate content. Telmisartan delayed morphine analgesic-tolerance development. Our study has identified a promising combination therapy composed of telmisartan and morphine for NP and opioid tolerance. Since telmisartan is an inhibitor of AT1 and activator of PPAR-γ, future studies are needed to analyze the effect of each component. Funding 2027204 /api/funding/2027204 false true Funding 2027205 /api/funding/2027205 false true Funding 2027206 /api/funding/2027206 false true true 2023 true true true false true false GOLD 2026-09-08 true https://doi.org/10.3390/ijms24097970 9 0 9 8 1 9 8 8 7 8 8 7 7 8 1 0 9 8 9 8 0 11 11 Folyóiratcikk Journal Article 24 9 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 2 2 2 2 2024 0 4 3 4 3 2025 0 2 2 2 2 2026 0 1 1 1 1 D1 false 10008920,10015484 false false false 2023-05-07T10:57:59.291+0000 Biokémiai Intézet (HRN SZBK); Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I); Gyógyszerhatástani Intézet (SE / GYTK) 14 33 3 15 0 true 10014568 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 107534016 /api/authorship/107534016 1 0.067 true false false Author 10076883 /api/author/10076883 Karádi Dávid Árpád true true Karádi David Á. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107534017 /api/authorship/107534017 2 0.067 false false false Author 10080867 /api/author/10080867 Galambos Anna Rita true true Galambos Anna Rita true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107534018 /api/authorship/107534018 3 0.067 false false false Author 10067520 /api/author/10067520 Lakatos Péter Pál true true Lakatos Péter P. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107534019 /api/authorship/107534019 4 0.06666667 false false false Apenberg Joost true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107534020 /api/authorship/107534020 5 0.067 false false false Author 10090125 /api/author/10090125 Abbood Sarah Kadhim true true Abbood Sarah K. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107534021 /api/authorship/107534021 6 0.067 false false false Author 10051360 /api/author/10051360 Balogh Mihály true 10051360 true Balogh Mihály true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107534022 /api/authorship/107534022 7 0.067 false false false Author 10015480 /api/author/10015480 Király Kornél P true 10015480 true Király Kornél true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107534023 /api/authorship/107534023 8 0.067 false false false Author 10000721 /api/author/10000721 Riba Pál true 10000721 true Riba Pál true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107534024 /api/authorship/107534024 9 0.067 false false false Author 10090082 /api/author/10090082 Gomaa Nariman Essmat Mohamed Abdeltawab true true Essmat Nariman true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107534025 /api/authorship/107534025 10 0.067 false false false Author 10056809 /api/author/10056809 Szűcs Edina true 10056809 true Szűcs Edina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107534026 /api/authorship/107534026 11 0.06666667 false false false Author 10008920 /api/author/10008920 Benyhe Sándor true 10008920 true Benyhe Sándor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107534027 /api/authorship/107534027 12 0.06666667 false false false Author 10028393 /api/author/10028393 Varga Zoltán true 10028393 true Varga Zoltán V. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107534028 /api/authorship/107534028 13 0.067 false false false Author 10003174 /api/author/10003174 Szökő Éva true 10003174 true Szökő Éva true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107534029 /api/authorship/107534029 14 0.067 false false false Author 10012548 /api/author/10012548 Tábi Tamás true 10012548 true Tábi Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107534030 /api/authorship/107534030 15 0.067 false true true Author 10015484 /api/author/10015484 Al-Khrasani Mahmoud true 10015484 true Al-Khrasani Mahmoud true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 23465634 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DIRECT true true /api/publication/33784924 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10076883"><a href="/gui2/?type=authors&mode=browse&sel=10076883" target="_blank">Karádi David Á. (<span class="authorship-author-name">Karádi Dávid Árpád</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10080867"><a href="/gui2/?type=authors&mode=browse&sel=10080867" target="_blank">Galambos Anna Rita (<span class="authorship-author-name">Galambos Anna Rita</span> <span class="authorAux-mtmt"> fájdalomkutatás, neuropátia, farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10067520"><a href="/gui2/?type=authors&mode=browse&sel=10067520" target="_blank">Lakatos Péter P. (<span class="authorship-author-name">Lakatos Péter Pál</span> <span class="authorAux-mtmt"> Gyógyszerészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerhatástani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Apenberg Joost </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10090125"><a href="/gui2/?type=authors&mode=browse&sel=10090125" target="_blank">Abbood Sarah K. (<span class="authorship-author-name">Abbood Sarah Kadhim</span> <span class="authorAux-mtmt"> In vivo AND In vitro pain assessment</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10051360"><a href="/gui2/?type=authors&mode=browse&sel=10051360" target="_blank">Balogh Mihály (<span class="authorship-author-name">Balogh Mihály</span> <span class="authorAux-mtmt"> gyógyszerészeti tudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015480"><a href="/gui2/?type=authors&mode=browse&sel=10015480" target="_blank">Király Kornél (<span class="authorship-author-name">Király Kornél P</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000721"><a href="/gui2/?type=authors&mode=browse&sel=10000721" target="_blank">Riba Pál (<span class="authorship-author-name">Riba Pál</span> <span class="authorAux-mtmt"> Farmakológia, opioid fájdalomcsillapítás</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10090082"><a href="/gui2/?type=authors&mode=browse&sel=10090082" target="_blank">Essmat Nariman (<span class="authorship-author-name">Gomaa Nariman Essmat Mohamed Abdeltawab</span> <span class="authorAux-mtmt"> In vivo and in vitro pain assessment</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10056809"><a href="/gui2/?type=authors&mode=browse&sel=10056809" target="_blank">Szűcs Edina (<span class="authorship-author-name">Szűcs Edina</span> <span class="authorAux-mtmt"> idegtudomány</span>) </a> </span> <span class="author-affil"><span title="Szegedi Biológiai Kutatóközpont">SZBK</span>/Biokémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008920"><a href="/gui2/?type=authors&mode=browse&sel=10008920" target="_blank">Benyhe Sándor (<span class="authorship-author-name">Benyhe Sándor</span> <span class="authorAux-mtmt"> Biokémia, neurokémia, receptorok</span>) </a> </span> <span class="author-affil"><span title="Szegedi Biológiai Kutatóközpont">SZBK</span>/Biokémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028393"><a href="/gui2/?type=authors&mode=browse&sel=10028393" target="_blank">Varga Zoltán V. (<span class="authorship-author-name">Varga Zoltán</span> <span class="authorAux-mtmt"> kardiovaszkuláris kutatás</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003174"><a href="/gui2/?type=authors&mode=browse&sel=10003174" target="_blank">Szökő Éva (<span class="authorship-author-name">Szökő Éva</span> <span class="authorAux-mtmt"> Farmakológia, gyógyszeranalitika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerhatástani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012548"><a href="/gui2/?type=authors&mode=browse&sel=10012548" target="_blank">Tábi Tamás (<span class="authorship-author-name">Tábi Tamás</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerhatástani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015484"><a href="/gui2/?type=authors&mode=browse&sel=10015484" target="_blank">Al-Khrasani Mahmoud ✉ (<span class="authorship-author-name">Al-Khrasani Mahmoud</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33784924" target="_blank">Telmisartan Is a Promising Agent for Managing Neuropathic Pain and Delaying Opioid Analgesic Tolerance in Rats</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">24</span> <span class="journal-issue">9</span> <span class="page"> Paper 7970. 18 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms24097970" target="_blank" href="https://doi.org/10.3390/ijms24097970"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000987494900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000987494900001"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="174966" target="_blank" href="https://real.mtak.hu/174966"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85159326774" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85159326774"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37175678" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37175678&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 9</span> | Független: 8 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 8 | Scopus jelölt:&nbsp;7 | WoS/Scopus jelölt:&nbsp;8 | DOI jelölt:&nbsp;8 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33784924&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 11 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33784924</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (ÚNKP-22-3-II-SE-31), Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Támogató: EFOP-VEKOP, (TKP2021-EGA-25) </div> <div class="lastModified">Utolsó módosítás: 2024.02.06. 07:40 Csajbók Edit (SE_KK_Admin5_CSE, admin) </div> <div class="lockedBy">Központi kezelésű 2024.04.03. 15:49 Vándor Andrea (VA, admin) </div> </div></div>