https://m2.mtmt.hu/ eng 2026-04-15 16:26 JournalArticle 33780028 VALIDATED true Export Date: 29 August 2024 0 false 2026-04-14T11:20:53.639+0000 2024-10-27T20:03:11.114+0000 2023-04-27T15:58:02.027+0000 true 10039927 Ella Krisztina /api/author/10039927 Author true 10039927 2026-04-14T11:09:08.128+0000 2024-10-27T20:03:11.356+0000 true 10097590 Orbán Zsófia /api/admin/10097590 Admin true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true Admin 10097590 /api/admin/10097590 Orbán Zsófia true true 2024-10-17T16:10:53.532+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Czárán, Domonkos Lacking ARHGAP25 mitigates the symptoms of autoantibody-induced arthritis in mice true true /api/journal/10023324 REVIEWED true false 10023324 false 10023324 true 1664-3224 1664-3224 Journal FOREIGN 14 1182278 1182278 13 2023 Despite intensive research on rheumatoid arthritis, the pathomechanism of the disease is still not fully understood and the treatment has not been completely resolved. Previously we demonstrated that the GTPase-activating protein, ARHGAP25 has a crucial role in the regulation of basic phagocyte functions. Here we investigate the role of ARHGAP25 in the complex inflammatory process of autoantibody-induced arthritis.Wild-type and ARHGAP25 deficient (KO) mice on a C57BL/6 background, as well as bone marrow chimeric mice, were treated i.p. with the K/BxN arthritogenic or control serum, and the severity of inflammation and pain-related behavior was measured. Histology was prepared, leukocyte infiltration, cytokine production, myeloperoxidase activity, and superoxide production were determined, and comprehensive western blot analysis was conducted.In the absence of ARHGAP25, the severity of inflammation, joint destruction, and mechanical hyperalgesia significantly decreased, similarly to phagocyte infiltration, IL-1β, and MIP-2 levels in the tibiotarsal joint, whereas superoxide production or myeloperoxidase activity was unchanged. We observed a significantly mitigated phenotype in KO bone marrow chimeras as well. In addition, fibroblast-like synoviocytes showed comparable expression of ARHGAP25 to neutrophils. Significantly reduced ERK1/2, MAPK, and I-κB protein signals were detected in the arthritic KO mouse ankles.Our findings suggest that ARHGAP25 has a key role in the pathomechanism of autoantibody-induced arthritis in which it regulates inflammation via the I-κB/NF-κB/IL-1β axis with the involvement of both immune cells and fibroblast-like synoviocytes. 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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37234175 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37234175&dopt=Abstract false true SjrRating 11386651 /api/sjrrating/11386651 39 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2403 /api/classificationexternal/2403 true 2403 true Q1 DIRECT true true /api/publication/33780028 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10085536"><a href="/gui2/?type=authors&mode=browse&sel=10085536" target="_blank">Czárán Domonkos (<span class="authorship-author-name">Czárán Domonkos Tamás</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10085543"><a href="/gui2/?type=authors&mode=browse&sel=10085543" target="_blank">Sasvári Péter (<span class="authorship-author-name">Sasvári Péter</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10045471"><a href="/gui2/?type=authors&mode=browse&sel=10045471" target="_blank">Horváth Ádám István (<span class="authorship-author-name">Horváth Ádám István</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Pharmacology and Pharmacotherapy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10039927"><a href="/gui2/?type=authors&mode=browse&sel=10039927" target="_blank">Ella Krisztina (<span class="authorship-author-name">Ella Krisztina</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060610"><a href="/gui2/?type=authors&mode=browse&sel=10060610" target="_blank">Sűdy Ágnes Réka (<span class="authorship-author-name">Südy Ágnes</span> <span class="authorAux-mtmt"> Sejtélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021077"><a href="/gui2/?type=authors&mode=browse&sel=10021077" target="_blank">Borbely Eva (<span class="authorship-author-name">Borbély Éva</span> <span class="authorAux-mtmt"> Gyógyszertudomány</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Pharmacology and Pharmacotherapy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064018"><a href="/gui2/?type=authors&mode=browse&sel=10064018" target="_blank">Rusznák Kitti (<span class="authorship-author-name">Rusznák Kitti</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Laboratory Medicine; <span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Structural Neurobiology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020800"><a href="/gui2/?type=authors&mode=browse&sel=10020800" target="_blank">Czéh Boldizsár (<span class="authorship-author-name">Czéh Boldizsár</span> <span class="authorAux-mtmt"> Idegtudományok</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Laboratory Medicine; <span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Structural Neurobiology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011643"><a href="/gui2/?type=authors&mode=browse&sel=10011643" target="_blank">Mócsai Attila (<span class="authorship-author-name">Mócsai Attila</span> <span class="authorAux-mtmt"> Élettan, sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001426"><a href="/gui2/?type=authors&mode=browse&sel=10001426" target="_blank">Helyes Zsuzsanna (<span class="authorship-author-name">Helyes Zsuzsanna</span> <span class="authorAux-mtmt"> Neurofarmakológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Pharmacology and Pharmacotherapy; <span title="University of Pécs">UP</span>/<span title="Research Groups">RG</span>/ELKH-PTE Chronic Pain Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023793"><a href="/gui2/?type=authors&mode=browse&sel=10023793" target="_blank">Csépányi-Kömi Roland ✉ (<span class="authorship-author-name">Csépányi-Kömi Roland</span> <span class="authorAux-mtmt"> élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33780028" target="_blank">Lacking ARHGAP25 mitigates the symptoms of autoantibody-induced arthritis in mice</a></div> <div> <span class="journal-title">FRONTIERS IN IMMUNOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1664-3224">1664-3224</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1664-3224">1664-3224</a>)</span>: <span class="journal-volume">14</span> <span class="page"> Paper 1182278. 13 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3389/fimmu.2023.1182278" target="_blank" href="https://doi.org/10.3389/fimmu.2023.1182278"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000992196900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000992196900001"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="172812" target="_blank" href="http://real.mtak.hu/172812"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85159958492" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85159958492"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37234175" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37234175&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Immunology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Immunology and Allergy&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 5</span> | Independent citation: 3 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 5 | Number of citations in Scopus:&nbsp;4 | WoS/Scopus assigned:&nbsp;5 | Number of citations with DOI:&nbsp;5 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33780028&sort=publishedYear,desc&sort=title"> Number of cited publications: 10 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33780028</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (FK_18 128376), (TKP2021-EGA-24), (TKP2021-EGA-13), (K 138046) Funder: HSRF, Thematic Excellence Program 2021 Health Sub-program of the Ministry for Innovation and Technology...(TKP2021-EGA-16), (János Bolyai Research Scholarship), Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Funder: EFOP-VEKOP, Nemzeti Gyógyszerkutatási és Fejlesztési Laboratórium (PharmaLab)(RRF-2.3.1-21-2022-00015) Funder: NRDIO </div> <div class="lastModified">Last Modified: 2024.10.27. 21:03 Zsófia Orbán (MTMT ellenőrzés, admin) </div> <div class="lockedBy">Centrally managed 2024.10.17. 18:10 Gusztáv Ladányi (MTMT API user, admin) Zsófia Orbán (MTMT ellenőrzés, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Export Date: 29 August 2024</pre> </div></div>