https://m2.mtmt.hu/ hun 2026-05-01 12:21 JournalArticle 33775569 VALIDATED true 0 false 2026-04-10T07:31:41.513+0000 2025-11-21T12:48:58.462+0000 2023-04-26T11:48:55.627+0000 true 10088107 Pinto Amorim das Virgens Isabel /api/author/10088107 Author Pinto Amorim das Virgens Isabel (Translational Medicine) true 2025-11-21T12:48:58.824+0000 2025-11-21T12:48:58.824+0000 2024-11-28T06:05:22.550+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin Milánkovics Róbert (PTE ÁOK admin 4) true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType Összefoglaló cikk (Folyóiratcikk) 102 true 1134514 true 1 /api/category/1 Category Tudományos true 1 Kubik, András true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 24 9 7859 7859 16 2023 Lymph node (LN) status is the most significant prognostic factor for invasive urothelial bladder cancer (UBC); however, the optimal extent of LN dissection (LND) is debated. We assessed circulating matrix metalloproteinase-7 (MMP-7) as a prognostic factor and decision-making marker for the extent of LND. Preoperative serum MMP-7 levels were determined in two independent UBC cohorts (n = 188; n = 68) and in one control cohort (n = 97) by using the ELISA method. A systematic review and meta-analysis on the prognostic role of circulating pretreatment MMP-7 levels were performed. Serum MMP-7 levels were higher in patients compared to controls (p < 0.001) with the highest levels in LN-positive cases. Half of LN-positive UBC patients had low MMP-7 levels, whereas the survival of LN-negative patients with high serum MMP-7 findings was poor. MMP-7 levels were independently associated with poor survival in both cohorts (p = 0.006, p < 0.001). Accordingly, our systematic review of six eligible publications revealed a 2.5-fold higher mortality risk in patients with high MMP-7 levels. In conclusion, preoperative MMP-7 level is a validated and independent prognostic factor in urothelial cancer. It cannot be used to decide between regional or extended LND but may be useful in identifying LN-negative high-risk patients with potentially undetected metastases. Funding 2026960 /api/funding/2026960 (K139059) false true Funding 2026961 /api/funding/2026961 (BO/00451/20/5) false true Funding 2026962 /api/funding/2026962 (ÚNKP-21-5-SE-3) false true Funding 2026963 /api/funding/2026963 (ÚNKP-21-3-II-SE-13) false true true 2023 true true true false true false GOLD 2026-04-10 true https://doi.org/10.3390/ijms24097859 8 0 8 8 0 8 8 6 7 8 8 8 8 8 0 0 8 8 8 8 0 5 5 Folyóiratcikk Journal Article 24 6 Könyvrészlet Chapter in Book 25 2 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 1 1 1 1 2024 0 5 5 5 5 2025 0 2 2 2 2 D1 false false false false 2023-05-15T08:34:38.643+0000 Biostatisztika tanszék (ÁTE / GBI); Pankreász Betegségek Részlege (SE / AOK / K); Szülészeti és Nőgyógyászati Klinika Üllői úti r... (SE / AOK / K / SZSZNK); Transzlációs Medicina Intézet (PTE / ÁOK); Transzlációs Medicina Központ (SE / KSZE); Urológiai Klinika (SE / AOK / K) 12 54 6 12 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 107483163 /api/authorship/107483163 Kubik, András [Kubik, András (Urológia), szerző] Urológiai Klinika (SE / AOK / K); Transzlációs Medicina Központ (SE / KSZE) 1 0.083 true false false Author 10035288 /api/author/10035288 Kubik András (Urológia) Kubik András true 10035288 true Kubik András true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107483164 /api/authorship/107483164 das Virgens, Isabel Pinto Amorim [Pinto Amorim das Virgens, Isabel (Translational Med...), szerző] Transzlációs Medicina Központ (SE / KSZE) 2 0.083 false false false Author 10088107 /api/author/10088107 Pinto Amorim das Virgens Isabel (Translational Medicine) Pinto Amorim das Virgens Isabel true true das Virgens Isabel Pinto Amorim true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107483165 /api/authorship/107483165 Szabó, Anett [Szabó, Anett (urológia, andrológia), szerző] Urológiai Klinika (SE / AOK / K); Transzlációs Medicina Központ (SE / KSZE) 3 0.083 false false false Author 10086438 /api/author/10086438 Szabó Anett (urológia, andrológia) Szabó Anett true true Szabó Anett true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107483166 /api/authorship/107483166 Váradi, Melinda [Váradi, Melinda (Urológia), szerző] Urológiai Klinika (SE / AOK / K) 4 0.083 false false false Author 10074880 /api/author/10074880 Váradi Melinda (Urológia) Váradi Melinda true true Váradi Melinda true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107483167 /api/authorship/107483167 Csizmarik, Anita [Pásztor-Csizmarik, Anita (Urológia), szerző] Urológiai Klinika (SE / AOK / K) 5 0.083 false false false Author 10064212 /api/author/10064212 Pásztor-Csizmarik Anita (Urológia) Pásztor-Csizmarik Anita true 10064212 true Csizmarik Anita true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107483168 /api/authorship/107483168 Keszthelyi, Attila [Keszthelyi, Attila (urológia), szerző] Urológiai Klinika (SE / AOK / K) 6 0.083 false false false Author 10024659 /api/author/10024659 Keszthelyi Attila (urológia) Keszthelyi Attila true 10024659 true Keszthelyi Attila true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107483169 /api/authorship/107483169 Majoros, Attila [Majoros, Attila (urológia), szerző] Urológiai Klinika (SE / AOK / K) 7 0.083 false false false Author 10024664 /api/author/10024664 Majoros Attila (urológia) Majoros Attila true 10024664 true Majoros Attila true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107483170 /api/authorship/107483170 Fehérvári, Péter [Fehérvári, Péter (Biomatematika), szerző] Transzlációs Medicina Központ (SE / KSZE); Biostatisztika tanszék (ÁTE / GBI) 8 0.083 false false false Author 10023284 /api/author/10023284 Fehérvári Péter (Biomatematika) Fehérvári Péter true 10023284 true Fehérvári Péter true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107483171 /api/authorship/107483171 Hegyi, Péter [Hegyi, Péter (Gasztroenterológia), szerző] Transzlációs Medicina Intézet (PTE / ÁOK); Transzlációs Medicina Központ (SE / KSZE); Pankreász Betegségek Részlege (SE / AOK / K) 9 0.083 false false false Author 10002629 /api/author/10002629 Hegyi Péter (Gasztroenterológia) Hegyi Péter true 10002629 true Hegyi Péter true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107483172 /api/authorship/107483172 Ács, Nándor [Ács, Nándor (Szülészet-nőgyógy...), szerző] Transzlációs Medicina Központ (SE / KSZE); Szülészeti és Nőgyógyászati Klinika Üllői úti r... (SE / AOK / K / SZSZNK) 10 0.083 false false false Author 10013998 /api/author/10013998 Ács Nándor (Szülészet-nőgyógyászat) Ács Nándor true 10013998 true Ács Nándor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107483173 /api/authorship/107483173 Nyirády, Péter [Nyirády, Péter (Urológia), szerző] Urológiai Klinika (SE / AOK / K) 11 0.083 false false false Author 10013343 /api/author/10013343 Nyirády Péter (Urológia) Nyirády Péter true 10013343 true Nyirády Péter true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107483174 /api/authorship/107483174 Szarvas, Tibor ✉ [Szarvas, Tibor (urológia), szerző] Urológiai Klinika (SE / AOK / K) 12 0.083 false true true Author 10052466 /api/author/10052466 Szarvas Tibor (urológia) Szarvas Tibor true 10052466 true Szarvas Tibor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 23438176 /api/publicationidentifier/23438176 DOI: 10.3390/ijms24097859 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms24097859 https://doi.org/10.3390/ijms24097859 false true PublicationIdentifier 24042875 /api/publicationidentifier/24042875 WoS: 000987359100001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000987359100001 https://www.webofscience.com/wos/woscc/full-record/000987359100001 false true PublicationIdentifier 23817144 /api/publicationidentifier/23817144 Scopus: 85159347998 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85159347998 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85159347998 true true PublicationIdentifier 23564311 /api/publicationidentifier/23564311 PubMed: 37175566 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37175566 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37175566&dopt=Abstract false true Classification 12305 /api/classification/12305 Urológia true true Keyword 3375201 /api/keyword/3375201 [Meta-analysis] true true SjrRating 11388415 /api/sjrrating/11388415 sjr:D1 (2023) Scopus - Inorganic Chemistry INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 7 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1604 /api/classificationexternal/1604 Scopus - Inorganic Chemistry true 1604 true D1 DIRECT true true Reference 40607471 /api/reference/40607471 1. 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(2023) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 24 9<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10035288"><a href="/gui2/?type=authors&mode=browse&sel=10035288" target="_blank">Kubik András (<span class="authorship-author-name">Kubik András</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Transzlációs Medicina Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10088107"><a href="/gui2/?type=authors&mode=browse&sel=10088107" target="_blank">das Virgens Isabel Pinto Amorim (<span class="authorship-author-name">Pinto Amorim das Virgens Isabel</span> <span class="authorAux-mtmt"> Translational Medicine</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Transzlációs Medicina Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10086438"><a href="/gui2/?type=authors&mode=browse&sel=10086438" target="_blank">Szabó Anett (<span class="authorship-author-name">Szabó Anett</span> <span class="authorAux-mtmt"> urológia, andrológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Transzlációs Medicina Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074880"><a href="/gui2/?type=authors&mode=browse&sel=10074880" target="_blank">Váradi Melinda (<span class="authorship-author-name">Váradi Melinda</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064212"><a href="/gui2/?type=authors&mode=browse&sel=10064212" target="_blank">Csizmarik Anita (<span class="authorship-author-name">Pásztor-Csizmarik Anita</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024659"><a href="/gui2/?type=authors&mode=browse&sel=10024659" target="_blank">Keszthelyi Attila (<span class="authorship-author-name">Keszthelyi Attila</span> <span class="authorAux-mtmt"> urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024664"><a href="/gui2/?type=authors&mode=browse&sel=10024664" target="_blank">Majoros Attila (<span class="authorship-author-name">Majoros Attila</span> <span class="authorAux-mtmt"> urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023284"><a href="/gui2/?type=authors&mode=browse&sel=10023284" target="_blank">Fehérvári Péter (<span class="authorship-author-name">Fehérvári Péter</span> <span class="authorAux-mtmt"> Biomatematika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Transzlációs Medicina Központ; <span title="Állatorvostudományi Egyetem">ÁTE</span>/<span title="Élelmiszerlánc-biztonsági és Járványvédelmi Intézet">ÉBJI</span>/<span title="Gazdaságtudományi és Biostatisztikai Intézet">GBI</span>/Biostatisztika tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002629"><a href="/gui2/?type=authors&mode=browse&sel=10002629" target="_blank">Hegyi Péter (<span class="authorship-author-name">Hegyi Péter</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Transzlációs Medicina Központ; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Pankreász Betegségek Részlege</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013998"><a href="/gui2/?type=authors&mode=browse&sel=10013998" target="_blank">Ács Nándor (<span class="authorship-author-name">Ács Nándor</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Transzlációs Medicina Központ; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Szülészeti és Nőgyógyászati Klinika">SZSZNK</span>/Szülészeti és Nőgyógyászati Klinika Üllői úti részleg</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013343"><a href="/gui2/?type=authors&mode=browse&sel=10013343" target="_blank">Nyirády Péter (<span class="authorship-author-name">Nyirády Péter</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052466"><a href="/gui2/?type=authors&mode=browse&sel=10052466" target="_blank">Szarvas Tibor ✉ (<span class="authorship-author-name">Szarvas Tibor</span> <span class="authorAux-mtmt"> urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33775569" target="_blank">Comprehensive Analysis of the Prognostic Value of Circulating MMP-7 Levels in Urothelial Carcinoma: A Combined Cohort Analysis, Systematic Review, and Meta-Analysis</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">24</span> <span class="journal-issue">9</span> <span class="page"> Paper 7859. 16 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" 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