https://m2.mtmt.hu/ eng 2026-09-21 13:29 JournalArticle 33768622 VALIDATED true 0 false 2026-09-21T07:37:29.608+0000 2025-07-30T10:14:51.714+0000 2023-04-24T11:37:55.722+0000 true 10065463 Turek Márta /api/admin/10065463 Admin Márta Turek (KOKI admin 4) true 2026-09-21T07:34:53.940+0000 2025-07-30T10:14:53.066+0000 true 10003134 Wolf György /api/admin/10003134 Admin György Wolf (MTMT Központi admin) true 10003134 Admin 10025544 /api/admin/10025544 Katalin Lévayné Deseő (MTMT Központi admin) Lévayné Deseő Katalin true 10025544 true 2024-04-17T09:39:03.825+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Kim, Young Joon true true /api/journal/10022692 REVIEWED CELL REPORTS 2639-1856 2211-1247 true false 10022692 false 10022692 true 2639-1856 2211-1247 Journal FOREIGN 42 4 112386 112386 23 2023 The input-output transformation of individual neurons is a key building block of neural circuit dynamics. While previous models of this transformation vary widely in their complexity, they all describe the underlying functional architecture as unitary, such that each synaptic input makes a single contribution to the neuronal response. Here, we show that the input-output transformation of CA1 pyramidal cells is instead best captured by two distinct functional architectures operating in parallel. We used statistically principled methods to fit flexible, yet interpretable, models of the transformation of input spikes into the somatic ‘‘output’’ voltage and to automatically select among alternative functional architectures. With dendritic Na + channels blocked, responses are accurately captured by a single static and global nonlinearity. In contrast, dendritic Na+ -dependent integration requires a functional architecture with multiple dynamic nonlinearities and clustered connectivity. These two architectures incorporate distinct morphological and biophysical properties of the neuron and its synaptic organization. Funding 2025988 /api/funding/2025988 Wellcome Trust(212262/Z/18/Z) false true Funding 2025989 /api/funding/2025989 NKFIH(FK-125324) false true Funding 2025990 /api/funding/2025990 Human Frontiers Science Programme(RGP0044/2018) false true true true 2023 true true true false true false GOLD 2026-09-21 true https://doi.org/10.1016/j.celrep.2023.112386 4 0 4 3 0 4 4 4 3 4 4 3 3 3 1 0 4 3 4 3 0 13 13 Folyóiratcikk Journal Article 24 4 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 1 1 1 1 2024 0 2 1 2 1 2025 0 1 1 1 1 D1 false 10017153 false false false 2023-05-22T16:02:37.662+0000 Biológiai Számítások Laboratórium (HRN KOKI); Kísérleti Orvostudományi Kutatóintézet 1 19 2 3 0 true 10025544 Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 107448180 /api/authorship/107448180 Kim, Young Joon ✉ 1 0.333 true false true Kim Young Joon true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 107448181 /api/authorship/107448181 Ujfalussy, Balázs B.** [Ujfalussy, Balázs Benedek (Idegtudományok), author] Laboratory of Biological Computatio; Institute of Experimental Medicine 2 0.333 false true false Author 10017153 /api/author/10017153 Balázs Benedek Ujfalussy (Idegtudományok) Ujfalussy Balázs Benedek true 10017153 true Ujfalussy Balázs B. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 107448182 /api/authorship/107448182 Lengyel, Máté 3 0.33333334 false true false Lengyel Máté true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 23418297 /api/publicationidentifier/23418297 DOI: 10.1016/j.celrep.2023.112386 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1016/j.celrep.2023.112386 https://doi.org/10.1016/j.celrep.2023.112386 false true PublicationIdentifier 23418311 /api/publicationidentifier/23418311 REAL: 164173 SwordSource 36 /api/publicationsource/36 REAL PublicationSourceType 10007 /api/publicationsourcetype/10007 Repozitórium true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GOLD true IDENTICAL 164173 https://real.mtak.hu/164173 false true PublicationIdentifier 23592874 /api/publicationidentifier/23592874 WoS: 000983803300001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000983803300001 https://www.webofscience.com/wos/woscc/full-record/000983803300001 false true PublicationIdentifier 23449939 /api/publicationidentifier/23449939 Scopus: 85152438808 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85152438808 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85152438808 false true PublicationIdentifier 23649183 /api/publicationidentifier/23649183 PubMed: 37060564 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37060564 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37060564&dopt=Abstract false true PublicationIdentifier 23418298 /api/publicationidentifier/23418298 Other URL: https://linkinghub.elsevier.com/retrieve/pii/S2211124723003972 PlainSource 40 /api/publicationsource/40 Other URL PublicationSourceType 10006 /api/publicationsourcetype/10006 Link true true true Egyéb URL Other URL @@@ true true 40 true IDENTICAL https://linkinghub.elsevier.com/retrieve/pii/S2211124723003972 https://linkinghub.elsevier.com/retrieve/pii/S2211124723003972 false true Keyword 1141847 /api/keyword/1141847 dendritic spikes true 1141847 true Keyword 1343427 /api/keyword/1343427 deep neural network true 1343427 true Keyword 1502794 /api/keyword/1502794 dendritic integration true true Keyword 1519786 /api/keyword/1519786 NMDA channels true true Keyword 1590562 /api/keyword/1590562 cascade model true true Keyword 1596812 /api/keyword/1596812 biophysical model true true Keyword 2775895 /api/keyword/2775895 Cascaded models true true Keyword 3000925 /api/keyword/3000925 dendritic Na+ channels true true Keyword 3000929 /api/keyword/3000929 dynamic subunits true true Keyword 3000937 /api/keyword/3000937 action potential timing true true Keyword 3000938 /api/keyword/3000938 subthreshold fluctuations true true SjrRating 11358168 /api/sjrrating/11358168 sjr:D1 (2023) Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous) CELL REPORTS 2211-1247 2211-1247 14 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1301 /api/classificationexternal/1301 Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous) true 1301 true D1 DIRECT true true Reference 40446909 /api/reference/40446909 1. 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(2023) CELL REPORTS 2639-1856 2211-1247 42 4<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Kim Young Joon ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017153"><a href="/gui2/?type=authors&mode=browse&sel=10017153" target="_blank">Ujfalussy Balázs B.^** (<span class="authorship-author-name">Ujfalussy Balázs Benedek</span> <span class="authorAux-mtmt"> Idegtudományok</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/ Laboratory of Biological Computatio; Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lengyel Máté </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33768622" target="_blank">Parallel functional architectures within a single dendritic tree</a></div> <div> <span class="journal-title">CELL REPORTS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2639-1856">2639-1856</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2211-1247">2211-1247</a>)</span>: <span class="journal-volume">42</span> <span class="journal-issue">4</span> <span class="page"> Paper 112386. 23 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1016/j.celrep.2023.112386" target="_blank" href="https://doi.org/10.1016/j.celrep.2023.112386"> DOI </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="164173" target="_blank" href="https://real.mtak.hu/164173"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000983803300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000983803300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85152438808" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85152438808"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37060564" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37060564&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://linkinghub.elsevier.com/retrieve/pii/S2211124723003972" target="_blank" href="https://linkinghub.elsevier.com/retrieve/pii/S2211124723003972"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 4</span> | Independent citation: 3 | Self citation: 1 | Unknown citation: 0 | Number of citations in WoS: 4 | Number of citations in Scopus:&nbsp;3 | WoS/Scopus assigned:&nbsp;4 | Number of citations with DOI:&nbsp;4 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33768622&sort=publishedYear,desc&sort=title"> Number of cited publications: 13 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33768622</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Wellcome Trust(212262/Z/18/Z), NKFIH(FK-125324), Human Frontiers Science Programme(RGP0044/2018) </div> <div class="lastModified">Last Modified: 2025.07.30. 12:14 György Wolf (MTMT Központi admin) </div> <div class="lockedBy">Centrally managed 2024.04.17. 11:39 Katalin Lévayné Deseő (MTMT Központi admin) </div> </div></div>