https://m2.mtmt.hu/ hun 2026-05-26 10:51 JournalArticle 3375975 APPROVED true Export Date: 30 April 2026; Cited By: 1047; Correspondence Address: B. Gyorffy; MTA TTK Lendület Cancer Biomarker Research Group, Institute of Enzymology, Budapest, Magyar Tudósok körútja 2, 1117, Hungary; email: gyorffy.balazs@ttk.mta.hu; 0 2018-09-18T22:20:07.000+0000 false 3375975 2026-05-21T13:14:55.383+0000 2026-04-30T12:01:36.265+0000 2018-05-24T07:39:29.000+0000 true 10047679 Nagy Ádám /api/author/10047679 Author true 10047679 2026-04-30T12:01:36.185+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Nagy, Ádám Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets true true /api/journal/10019966 REVIEWED true false 10019966 false 10019966 true 2045-2322 Journal FOREIGN 8 1 9227 9227 9 2018 Multiple studies suggested using different miRNAs as biomarkers for prognosis of hepatocellular carcinoma (HCC). We aimed to assemble a miRNA expression database from independent datasets to enable an independent validation of previously published prognostic biomarkers of HCC. A miRNA expression database was established by searching the TCGA (RNA-seq) and GEO (microarray) repositories to identify miRNA datasets with available expression and clinical data. A PubMed search was performed to identify prognostic miRNAs for HCC. We performed a uni- and multivariate Cox regression analysis to validate the prognostic significance of these miRNAs. The Limma R package was applied to compare the expression of miRNAs between tumor and normal tissues. We uncovered 214 publications containing 223 miRNAs identified as potential prognostic biomarkers for HCC. In the survival analysis, the expression levels of 55 and 84 miRNAs were significantly correlated with overall survival in RNA-seq and gene chip datasets, respectively. The most significant miRNAs were hsa-miR-149, hsa-miR-139, and hsa-miR-3677 in the RNA-seq and hsa-miR-146b-3p, hsa-miR-584, and hsa-miR-31 in the microarray dataset. Of the 223 miRNAs studied, the expression was significantly altered in 102 miRNAs in tumors compared to normal liver tissues. In summary, we set up an integrated miRNA expression database and validated prognostic miRNAs in HCC. Funding 2065124 /api/funding/2065124 false true Funding 2065125 /api/funding/2065125 false true true 2018 true true true false true false GOLD 2026-05-21 true https://doi.org/10.1038/s41598-018-27521-y 1119 0 1119 1109 10 1117 1095 1082 1074 1118 1118 1108 1108 1109 10 0 1119 1109 1119 1109 0 5 5 Folyóiratcikk Journal Article 24 1110 Könyvrészlet Chapter in Book 25 8 Könyv Book 23 1 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2018 0 3 1 3 1 2019 0 62 61 62 61 2020 0 338 338 338 338 2021 0 369 364 369 364 2022 0 189 187 189 187 2023 0 74 74 74 74 2024 0 46 46 46 46 2025 0 31 31 31 31 2026 0 7 7 7 7 D1 A nemzetközi false false false false 2018-06-19T11:59:06.000+0000 2018-06-14T08:29:37.000+0000 Enzimológiai Intézet (TTK); II. Sz. Gyermekgyógyászati Klinika (SE / AOK / K); Onkológiai Biomarker Kutatócsoport (Lendület) (HRN TTK / MÉI) 4 27 3 4 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 10138434 /api/authorship/10138434 1 0.25 true false Author 10047679 /api/author/10047679 Nagy Ádám true 10047679 true Nagy Ádám true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28302930 true PersonAuthorship 10138435 /api/authorship/10138435 2 0.25 false false Author 10073052 /api/author/10073052 Lánczky András true true Lánczky András true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28302929 true PersonAuthorship 10138436 /api/authorship/10138436 3 0.25 false false Author 10045338 /api/author/10045338 Menyhart Otilia true 10045338 true Menyhárt Otília true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28302928 true PersonAuthorship 10138437 /api/authorship/10138437 4 0.25 false true true Author 10000109 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mtid="10047679"><a href="/gui2/?type=authors&mode=browse&sel=10047679" target="_blank">Nagy Ádám (<span class="authorship-author-name">Nagy Ádám</span> <span class="authorAux-mtmt"> biológia</span>) </a> </span> <span class="author-affil"><span title="MTA Természettudományi Kutatóközpont">MTA TTK</span>/Enzimológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/II. Sz. Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10073052"><a href="/gui2/?type=authors&mode=browse&sel=10073052" target="_blank">Lánczky András (<span class="authorship-author-name">Lánczky András</span> <span class="authorAux-mtmt"> bioinformatika</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10045338"><a href="/gui2/?type=authors&mode=browse&sel=10045338" target="_blank">Menyhárt Otília (<span class="authorship-author-name">Menyhart Otilia</span> <span class="authorAux-mtmt"> onkologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/II. Sz. Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000109"><a href="/gui2/?type=authors&mode=browse&sel=10000109" target="_blank">Győrffy Balázs ✉ (<span class="authorship-author-name">Győrffy Balázs</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/II. Sz. Gyermekgyógyászati Klinika; <span title="MTA Természettudományi Kutatóközpont">MTA TTK</span>/<span title="Enzimológiai Intézet">EI</span>/Onkológiai Biomarker Kutatócsoport (Lendület)</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3375975" target="_blank">Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets</a></div> <div> <span class="journal-title">SCIENTIFIC REPORTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2045-2322">2045-2322</a>)</span>: <span class="journal-volume">8</span> <span class="journal-issue">1</span> <span class="page"> Paper 9227. 9 p. </span> <span class="year">(2018)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1038/s41598-018-27521-y" target="_blank" href="https://doi.org/10.1038/s41598-018-27521-y"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="6001" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/6001"> SE Repozitórium </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="91781" target="_blank" href="http://real.mtak.hu/91781"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000435338900067" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000435338900067"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85048731494" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85048731494"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="29907753" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=29907753&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://www.scopus.com/pages/publications/85048731494?origin=resultslist" target="_blank" href="https://www.scopus.com/pages/publications/85048731494?origin=resultslist"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Szociológiai Tudományos Bizottság IXGJO SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Regionális Tudományok Bizottsága IXGJO RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1,119</span> | Független: 1,109 | Függő: 10 | Nem jelölt: 0 | WoS jelölt: 1,082 | Scopus jelölt:&nbsp;1,074 | WoS/Scopus jelölt:&nbsp;1,118 | DOI jelölt:&nbsp;1,095 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3375975&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 3375975</span> | <span class="status-data status-APPROVED"> Nyilvános </span> <span class="oldId">Régi azonosító: 3375975</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (NVKP_16-1-2016-0037), (FIEK_16-1-2016-0005) </div> <div class="lastModified">Utolsó módosítás: 2026.04.30. 14:01 Kondor Zóra (SE_KK_Admin5_KZ, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Export Date: 30 April 2026; Cited By: 1047; Correspondence Address: B. Gyorffy; MTA TTK Lendület Cancer Biomarker Research Group, Institute of Enzymology, Budapest, Magyar Tudósok körútja 2, 1117, Hungary; email: gyorffy.balazs@ttk.mta.hu;</pre> </div></div>