https://m2.mtmt.hu/ eng 2026-09-21 19:42 JournalArticle 33757727 VALIDATED true 0 false 2026-08-27T12:47:10.820+0000 2026-02-06T20:32:02.510+0000 2023-04-18T13:40:33.749+0000 true 10067763 Juriga-Tóth Krisztina /api/author/10067763 Author true 2026-03-16T10:53:55.804+0000 2025-06-17T06:00:31.223+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 Admin 10096252 /api/admin/10096252 Kósa Ilona true true 2026-01-27T08:00:10.801+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Tóth, Krisztina Different implantable electrospun meshes for simultaneous application of prednisone and doxorubicin true true /api/journal/2674 REVIEWED true false 2674 false 2674 true 0167-7322 1873-3166 Journal FOREIGN 381 121854 121854 14 2023 Electrospinning is widely applied to prepare nanofibers that provide high specific surfaces, enhanced bioavailability of poorly water-soluble drugs, moreover, enable several administration routes such as implantation. In this perspective, biocompatible poly(vinyl alcohol) (PVA), polysuccinimide (PSI), and ε-polycaprolactone (PCL) based implantable scaffolds were developed by electrospinning to improve the bioavailability of incorporated or conjugated prednisone (Pred) and doxorubicin (Dox). Besides physicochemical characterization, the effect of the loaded amount of Prednisone on the mechanical properties of the fibers as well as their drug release profile were investigated. The drug release measurement revealed that the release profile highly depends on the polarity of the applied polymer as well as the environmental pH. Concerning electrospun meshes incorporating prednisone, the anti-inflammatory effect was monitored by measuring the release of a wide spectrum of cytokines by MDA-MB-231 cells. Besides the loading of doxorubicin, the chemical conjugation to polysuccinimide was successfully carried out which provided prolonged release as well as increased cellular uptake. Based on the different drug release profiles, poly(vinyl alcohol), polysuccinimide, and ε-polycaprolactone fibrous meshes can be used to prepare a potential multi-layered drug-containing implantable scaffold, which can provide both burst and prolonged release of prednisone and doxorubicin. The anti-inflammatory effect of prednisone could be beneficial to avoid rejection after implantation while incorporation or conjugation of doxorubicin into polysuccinimide fibers provides sufficient cytotoxicity and enhanced cellular uptake of MDA-MB-231 cells. Funding 2027238 /api/funding/2027238 false true Funding 2027239 /api/funding/2027239 false true Funding 2027240 /api/funding/2027240 false true true 2023 true true true false true false NONE 2026-08-27 false 8 0 8 4 4 8 8 7 8 8 8 4 4 4 4 0 8 4 8 4 0 16 16 Folyóiratcikk Journal Article 24 8 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 3 2 3 2 2024 0 4 2 4 2 2025 0 1 0 1 0 Q1 false 10021907,10015589,10018916 false false false 2023-05-01T11:12:53.135+0000 Biofizikai és Sugárbiológiai Intézet (SE / AOK / I); Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I); Gyermekgyógyászati Klinika (SE / AOK / K); Gyógyszerészeti Intézet (SE / GYTK) 11 31 4 11 0 true 10096252 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 107376730 /api/authorship/107376730 1 0.091 true false Author 10067763 /api/author/10067763 Juriga-Tóth Krisztina true true Tóth Krisztina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107376731 /api/authorship/107376731 2 0.091 false false Author 10079998 /api/author/10079998 Fekete Nóra true true Fekete Nóra true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107376732 /api/authorship/107376732 3 0.091 false false Author 10100704 /api/author/10100704 Simon Vivien Klaudia true true Simon Vivien Klaudia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107376733 /api/authorship/107376733 4 0.091 false false Author 10096413 /api/author/10096413 Tóth Bence true true Tóth Bence true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107376734 /api/authorship/107376734 5 0.091 false false Author 10053336 /api/author/10053336 Kovács Árpád Ferenc true 10053336 true Kovács Árpád Ferenc true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107376735 /api/authorship/107376735 6 0.091 false false Author 10015589 /api/author/10015589 Pállinger Éva true 10015589 true Pállinger Éva true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107376736 /api/authorship/107376736 7 0.091 false false Author 10020626 /api/author/10020626 Antal István true 10020626 true Antal István true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107376737 /api/authorship/107376737 8 0.091 false false Author 10000509 /api/author/10000509 Kőhidai László true 10000509 true Kőhidai László true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107376738 /api/authorship/107376738 9 0.091 false true true Author 10018916 /api/author/10018916 Jedlovszky-Hajdú Angéla true 10018916 true Jedlovszky-Hajdú Angéla true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107376739 /api/authorship/107376739 10 0.091 false true true Author 10040625 /api/author/10040625 Juriga Dávid true 10040625 true Juriga Dávid true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107376740 /api/authorship/107376740 11 0.091 false true true Author 10021907 /api/author/10021907 S. Nagy Krisztina true 10021907 true S. Nagy Krisztina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 23390986 /api/publicationidentifier/23390986 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1016/j.molliq.2023.121854 https://doi.org/10.1016/j.molliq.2023.121854 false true PublicationIdentifier 23740999 /api/publicationidentifier/23740999 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000984229300001 https://www.webofscience.com/wos/woscc/full-record/000984229300001 false true PublicationIdentifier 23466007 /api/publicationidentifier/23466007 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85152915668 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85152915668 false true SjrRating 11357290 /api/sjrrating/11357290 43 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 3107 /api/classificationexternal/3107 true 3107 true Q1 DIRECT true true /api/publication/33757727 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10067763"><a href="/gui2/?type=authors&mode=browse&sel=10067763" target="_blank">Tóth Krisztina (<span class="authorship-author-name">Juriga-Tóth Krisztina</span> <span class="authorAux-mtmt"> biofizika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Departmnet of Biophysics and Radiation Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10079998"><a href="/gui2/?type=authors&mode=browse&sel=10079998" target="_blank">Fekete Nóra (<span class="authorship-author-name">Fekete Nóra</span> <span class="authorAux-mtmt"> áramlási citometriás módszerfejlesztések, extra...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Genetics, Cell- and Immunology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10100704"><a href="/gui2/?type=authors&mode=browse&sel=10100704" target="_blank">Simon Vivien Klaudia (<span class="authorship-author-name">Simon Vivien Klaudia</span> <span class="authorAux-mtmt"> orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Departmnet of Biophysics and Radiation Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10096413"><a href="/gui2/?type=authors&mode=browse&sel=10096413" target="_blank">Tóth Bence (<span class="authorship-author-name">Tóth Bence</span> <span class="authorAux-mtmt"> gyógyszertechnológia - porröntgen (XRD); szilár...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmaceutics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10053336"><a href="/gui2/?type=authors&mode=browse&sel=10053336" target="_blank">Kovács Árpád Ferenc (<span class="authorship-author-name">Kovács Árpád Ferenc</span> <span class="authorAux-mtmt"> genetika, immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Pediatrics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015589"><a href="/gui2/?type=authors&mode=browse&sel=10015589" target="_blank">Pállinger Éva (<span class="authorship-author-name">Pállinger Éva</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Genetics, Cell- and Immunology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020626"><a href="/gui2/?type=authors&mode=browse&sel=10020626" target="_blank">Antal István (<span class="authorship-author-name">Antal István</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmaceutics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000509"><a href="/gui2/?type=authors&mode=browse&sel=10000509" target="_blank">Kőhidai László (<span class="authorship-author-name">Kőhidai László</span> <span class="authorAux-mtmt"> Elméleti orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Genetics, Cell- and Immunology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10018916"><a href="/gui2/?type=authors&mode=browse&sel=10018916" target="_blank">Jedlovszky-Hajdú Angéla<sup>**</sup> ✉ (<span class="authorship-author-name">Jedlovszky-Hajdú Angéla</span> <span class="authorAux-mtmt"> Kolloidkémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Departmnet of Biophysics and Radiation Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040625"><a href="/gui2/?type=authors&mode=browse&sel=10040625" target="_blank">Juriga Dávid<sup>**</sup> ✉ (<span class="authorship-author-name">Juriga Dávid</span> <span class="authorAux-mtmt"> Kémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Departmnet of Biophysics and Radiation Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021907"><a href="/gui2/?type=authors&mode=browse&sel=10021907" target="_blank">S. Nagy Krisztina ✉ (<span class="authorship-author-name">S. Nagy Krisztina</span> <span class="authorAux-mtmt"> Sejtbiológia, őssejtek, tumorsejtek</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Departmnet of Biophysics and Radiation Biology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33757727" target="_blank">Different implantable electrospun meshes for simultaneous application of prednisone and doxorubicin</a></div> <div> <span class="journal-title">JOURNAL OF MOLECULAR LIQUIDS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0167-7322">0167-7322</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1873-3166">1873-3166</a>)</span>: <span class="journal-volume">381</span> <span class="page"> Paper 121854. 14 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.molliq.2023.121854" target="_blank" href="https://doi.org/10.1016/j.molliq.2023.121854"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000984229300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000984229300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85152915668" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85152915668"> Scopus </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Atomic and Molecular Physics, and Optics&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Condensed Matter Physics&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Electronic, Optical and Magnetic Materials&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Materials Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 8</span> | Independent citation: 4 | Self citation: 4 | Unknown citation: 0 | Number of citations in WoS: 7 | Number of citations in Scopus:&nbsp;8 | WoS/Scopus assigned:&nbsp;8 | Number of citations with DOI:&nbsp;8 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33757727&sort=publishedYear,desc&sort=title"> Number of cited publications: 16 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33757727</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (137749) Funder: NRDIO, Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Funder: EFOP-VEKOP, (TKP2021-EGA-23) Funder: Ministry for Innovation and Technology </div> <div class="lastModified">Last Modified: 2026.02.06. 21:32 András Balázs (MTMT Központ, admin) </div> <div class="lockedBy">Centrally managed 2026.01.27. 09:00 Ilona Kósa (MTMT központi Admin, admin) </div> </div></div>