https://m2.mtmt.hu/ hun 2026-09-22 14:38 JournalArticle 33753546 VALIDATED true Funding Agency and Grant Number: Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [268555672, SFB 1213, B05]; Hungarian National Scientific Research Fund [OTKA-138223]; National Research, Development and Innovation Office; Janos Bolyai Research Scholarships of the Hungarian Academy of Sciences; New National Excellence Program of the Ministry of Human Capacities [UNKP-22-5-SZTE-542]; Cooperative Doctoral Programme for Doctoral Scholarships [KDP-2020]; European Union [RRF-2.3.1-21-2022-00003]; Ministry of Culture and Innovation of Hungary [2020-1.1.5-GYORSITOSAV-2021-00011]; National Research, Development and Innovation Fund [2020-1.1.5-GYORSITOSAV] Funding text: This work was funded by Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) (Project number 268555672-SFB 1213, Project B05). The project was supported by the Hungarian National Scientific Research Fund (OTKA-138223) of the National Research, Development and Innovation Office. P.B. (Peter Bencsik) was supported by the Janos Bolyai Research Scholarships of the Hungarian Academy of Sciences and by the New National Excellence Program of the Ministry of Human Capacities (UNKP-22-5-SZTE-542). T.S. was supported by the Cooperative Doctoral Programme for Doctoral Scholarships (KDP-2020) of the National Research, Development and Innovation Office. Project no. RRF-2.3.1-21-2022-00003 has been implemented with the support provided by the European Union. Project no. 2020-1.1.5-GYORSITOSAV-2021-00011 has been implemented with the support provided by the Ministry of Culture and Innovation of Hungary from the National Research, Development and Innovation Fund, financed under the 2020-1.1.5-GYORSITOSAV funding scheme. 0 false 2026-08-12T07:57:41.249+0000 2026-06-26T08:06:19.236+0000 2023-04-16T13:43:55.702+0000 true 10026589 Tichy Rita /api/admin/10026589 Admin true 10026589 2026-08-12T07:56:20.919+0000 2023-04-20T08:47:52.568+0000 true 10028537 Baczkó Gabriella /api/admin/10028537 Admin true 10028537 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Heger, Jacqueline Sex Difference in Cardioprotection against Acute Myocardial Infarction in MAO-B Knockout Mice In Vivo true true /api/journal/10003252 REVIEWED true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 24 7 6443 6443 13 2023 The cardiomyocyte-specific knockout (KO) of monoamine oxidase (MAO)-B, an enzyme involved in the formation of reactive oxygen species (ROS), reduced myocardial ischemia/reperfusion (I/R) injury in vitro. Because sex hormones have a strong impact on MAO metabolic pathways, we analyzed the myocardial infarct size (IS) following I/R in female and male MAO-B KO mice in vivo. Method and Results: To induce the deletion of MAO-B, MAO-B KO mice (Myh6 Cre+/MAO-Bfl/fl) and wild-type (WT, Cre-negative MAO-Bfl/fl littermates) were fed with tamoxifen for 2 weeks followed by 10 weeks of normal mice chow. Myocardial infarction (assessed by TTC staining and expressed as a percentage of the area at risk as determined by Evans blue staining)) was induced by 45 min coronary occlusion followed by 120 min of reperfusion. Results: The mortality following I/R was higher in male compared to female mice, with the lowest mortality found in MAO-B KO female mice. IS was significantly higher in male WT mice compared to female WT mice. MAO-B KO reduced IS in male mice but had no further impact on IS in female MAO-B KO mice. Interestingly, there was no difference in the plasma estradiol levels among the groups. Conclusion: The cardiomyocyte-specific knockout of MAO-B protects male mice against acute myocardial infarction but had no effect on the infarct size in female mice. 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10.1161/CIRCRESAHA.121.319546 false true Reference 40187616 /api/reference/40187616 60 10.1007/s12576-017-0546-8 false true Reference 40187617 /api/reference/40187617 61 10.1016/j.vascn.2010.02.014 false true /api/publication/33753546 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Heger Jacqueline ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10067988"><a href="/gui2/?type=authors&mode=browse&sel=10067988" target="_blank">Szabados Tamara<sup>*</sup> (<span class="authorship-author-name">Szabados Tamara</span> <span class="authorAux-mtmt"> experimentális kardiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Farmakológiai és Farmakoterápiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Brosinsky Paulin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10022542"><a href="/gui2/?type=authors&mode=browse&sel=10022542" target="_blank">Bencsik Péter (<span class="authorship-author-name">Bencsik Péter</span> <span class="authorAux-mtmt"> Experimentális kardiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Farmakológiai és Farmakoterápiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010125"><a href="/gui2/?type=authors&mode=browse&sel=10010125" target="_blank">Ferdinandy Péter (<span class="authorship-author-name">Ferdinandy Péter</span> <span class="authorAux-mtmt"> Farmakológia, molekuláris medicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schulz Rainer </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33753546" target="_blank">Sex Difference in Cardioprotection against Acute Myocardial Infarction in MAO-B Knockout Mice In Vivo</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">24</span> <span class="journal-issue">7</span> <span class="page"> Paper 6443. 13 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms24076443" target="_blank" href="https://doi.org/10.3390/ijms24076443"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000969927900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000969927900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85152302806" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85152302806"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37047416" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37047416&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://www.mdpi.com/1422-0067/24/7/6443" target="_blank" href="https://www.mdpi.com/1422-0067/24/7/6443"> Egyéb URL </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="27024" target="_blank" href="http://publicatio.bibl.u-szeged.hu/27024"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR 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class="long-pub-mtid">Közlemény: 33753546</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (OTKA-138223), Kooperatív Doktori Program(KDP-2020) Támogató: NKFIH, (RRF-2.3.1-21-2022-00003), (2020-1.1.5-GYORSÍTÓSÁV-2021-00011) </div> <div class="lastModified">Utolsó módosítás: 2026.06.26. 10:06 Baczkó Gabriella (SZTE SZAOK admin5 Szemészeti Klinika) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [268555672, SFB 1213, B05]; Hungarian National Scientific Research Fund [OTKA-138223]; National Research, Development and Innovation Office; Janos Bolyai Research Scholarships of the Hungarian Academy of Sciences; New National Excellence Program of the Ministry of Human Capacities [UNKP-22-5-SZTE-...</pre> </div></div>