https://m2.mtmt.hu/ eng 2026-06-24 21:24 JournalArticle 33742453 VALIDATED true 0 false 2026-05-28T09:45:45.431+0000 2024-02-26T08:20:58.171+0000 2023-04-11T05:31:16.965+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2025-05-28T10:38:16.835+0000 2025-05-28T10:38:16.835+0000 2023-09-02T14:12:05.205+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin true 10025544 true 2023-11-27T10:38:16.255+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Papp, Tímea Mortality on DOACs Versus on Vitamin K Antagonists in Atrial Fibrillation: Analysis of the Hungarian Health Insurance Fund Database true true /api/journal/1089 REVIEWED true false 1089 false 1089 true 0149-2918 1879-114X Journal FOREIGN 45 4 333 346 333 14 2023 Limited real-world data are available on the survival of patients treated with vitamin K antagonists (VKAs) versus with direct oral anticoagulants (DOACs) for nonvalvular atrial fibrillation (AF). In this nationwide registry, we analyzed the mortality risk of patients with nonvalvular AF taking DOACs versus VKAs, with a special attention to the early treatment period.The Hungarian National Health Insurance Fund (NHIF) database was searched to identify patients treated with VKA or DOAC as a thromboembolic prophylaxis for nonvalvular AF between 2011 and 2016. The overall and the early (0-3, 4-6, and 7-12 months) mortality risks with the 2 types of anticoagulation were compared. A total of 144,394 patients with AF treated with either a VKA (n = 129,925) or a DOAC (n = 14,469) were enrolled.A 28% improvement in 3-year survival with DOAC treatment compared with VKA treatment was shown. Mortality reduction with DOACs was consistent across different subgroups. However, younger patients (30-59 years old) initiated on DOAC therapy had the greatest RRR (53%) in mortality. Furthermore, DOAC treatment also yielded a benefit of greater magnitude (HR = 0.55; 95% CI, 0.40-0.77, P = 0.001) in the lower (0-1) CHA2DS2-VASc score segment and in those with fewer (0-1) bleeding risk factors (HR = 0.50, CI 0.34-0.73, P = 0.001). The RRR in mortality with DOACs was 33% within the first 3 months, and 6% in the second year.Thromboembolic prophylaxis with DOACs in this study yielded significantly lower mortality compared with VKA treatment in patients with nonvalvular AF. The largest benefit was shown in the early period after treatment initiation, as well as in younger patients, those with a lower CHA2DS2-VASc score, and those with fewer bleeding risk factors. Funding 2025782 /api/funding/2025782 false true true 2023 true true true false true false GOLD 2026-05-28 true https://doi.org/10.1016/j.clinthera.2023.03.008 6 0 6 6 2 5 6 5 5 6 6 6 6 6 0 0 6 6 6 6 0 2 2 Folyóiratcikk Journal Article 24 6 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 2 2 2 2 2025 0 2 2 2 2 2026 0 2 2 2 2 Q1 false 10047613,10029271 false false false 2023-04-17T11:56:27.218+0000 Angiológiai Tanszéki Csoport (SE / AOK / K / ÉET); Biomatematikai és számítástechnikai tanszék (ÁTE / GBI); Békés Megyei Képviselő-testület Pándy Kálmán Kó...; Egészség- és Ápolástudományi Tanszék (SZE / ESK); II. sz. Belgyógyászati Klinika és Nephrológiai,... (PTE / ÁOK); Kardiológia Központ - Kardiológiai Tanszék (SE / AOK / K); Kardiológiai Tanszék (DE / ÁOK / KardI); Klinikai Laboratóriumi Kutató Tanszék (DE / ÁOK / LMI); Repülõ- és Űrorvostani Tanszék (SE / AOK / K); Sportorvostan Tanszék (SE / AOK / K); Városmajori Szív- és Érgyógyászati Klinika (SE / AOK / K) 12 81 11 12 0 true 10025544 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 107297201 /api/authorship/107297201 1 0.083 true false true Author 10073632 /api/author/10073632 Papp Tímea Bianka true true Papp Tímea true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107297202 /api/authorship/107297202 2 0.083333336 false false false Author 10077079 /api/author/10077079 Kiss Zoltán true true Kiss Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107297203 /api/authorship/107297203 3 0.083333336 false false false Author 10080246 /api/author/10080246 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Zoltán true 10014929 true Járai Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107297212 /api/authorship/107297212 12 0.083 false true false Author 10029271 /api/author/10029271 Csanádi Zoltán true 10029271 true Csanádi Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 23350261 /api/publicationidentifier/23350261 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1016/j.clinthera.2023.03.008 https://doi.org/10.1016/j.clinthera.2023.03.008 false true PublicationIdentifier 24085487 /api/publicationidentifier/24085487 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001004703600001 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/api/keyword/1020053 true 1020053 true Keyword 1101336 /api/keyword/1101336 true 1101336 true Keyword 1495457 /api/keyword/1495457 true true Keyword 1525032 /api/keyword/1525032 true true Keyword 2994945 /api/keyword/2994945 true true SjrRating 11406515 /api/sjrrating/11406515 69 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2736 /api/classificationexternal/2736 true 2736 true Q1 DIRECT true true /api/publication/33742453 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10073632"><a href="/gui2/?type=authors&mode=browse&sel=10073632" target="_blank">Papp Tímea ✉ (<span class="authorship-author-name">Papp Tímea Bianka</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/<span title="Institute of Cardiology">KardI</span>/Department of Cardiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10077079"><a href="/gui2/?type=authors&mode=browse&sel=10077079" target="_blank">Kiss Zoltán (<span class="authorship-author-name">Kiss Zoltán</span> <span class="authorAux-mtmt"> A főbb mortalitásért felelős betegségek epidemi...</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Second Department of Medicine and Nephrology-Diabetes Centre</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10080246"><a href="/gui2/?type=authors&mode=browse&sel=10080246" target="_blank">Rokszin György (<span class="authorship-author-name">Rokszin György Aurél</span> <span class="authorAux-mtmt"> Orvosi tudományok</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023209"><a href="/gui2/?type=authors&mode=browse&sel=10023209" target="_blank">Fábián Ibolya (<span class="authorship-author-name">Bajcsayné Fábián Ibolya</span> <span class="authorAux-mtmt"> Biomatematika</span>) </a> </span> <span class="author-affil"><span title="University of Veterinary Medicine Budapest">UVMB</span>/<span title="Élelmiszerlánc-biztonsági és Járványvédelmi Intézet">ÉBJI</span>/<span title="Institute of Economics and Biostatistics">IEB</span>/Department of Biomathematics and Informatics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10047613"><a href="/gui2/?type=authors&mode=browse&sel=10047613" target="_blank">Márk László (<span class="authorship-author-name">Márk László</span> <span class="authorAux-mtmt"> Belgyógyászat, kardiológia</span>) </a> </span> <span class="author-affil">Békés Megyei Képviselő-testület Pándy Kálmán Kórház</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10037330"><a href="/gui2/?type=authors&mode=browse&sel=10037330" target="_blank">Bagoly Zsuzsa (<span class="authorship-author-name">Bagoly Zsuzsa</span> <span class="authorAux-mtmt"> Klinikai orvostudományok</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/<span title="Department of Laboratory Medicine">DLM</span>/Klinikai Laboratóriumi Kutató Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013967"><a href="/gui2/?type=authors&mode=browse&sel=10013967" target="_blank">Becker Dávid (<span class="authorship-author-name">Becker Dávid</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Department of Cardiology – Heart and Vascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002691"><a href="/gui2/?type=authors&mode=browse&sel=10002691" target="_blank">Merkely Béla (<span class="authorship-author-name">Merkely Béla Péter</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Department of Cardiology – Heart and Vascular Center; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Faculty of Sports Medicine; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Aerospace Medicine Department</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028344"><a href="/gui2/?type=authors&mode=browse&sel=10028344" target="_blank">Aradi Dániel (<span class="authorship-author-name">Aradi Dániel</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10050815"><a href="/gui2/?type=authors&mode=browse&sel=10050815" target="_blank">Dézsi Csaba András (<span class="authorship-author-name">Dézsi Csaba András</span> <span class="authorAux-mtmt"> Belgyógyászat, kardiológia</span>) </a> </span> <span class="author-affil"><span title="Széchenyi István University">Széchenyi István University</span>/<span title="Faculty of Health and Sport Sciences">FHSS</span>/Department of Health and Nursing Sciences</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014929"><a href="/gui2/?type=authors&mode=browse&sel=10014929" target="_blank">Járai Zoltán (<span class="authorship-author-name">Járai Zoltán</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/<span title="Érsebészeti és Endovaszkuláris Tanszék">ÉET</span>/Section of Angiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10029271"><a href="/gui2/?type=authors&mode=browse&sel=10029271" target="_blank">Csanádi Zoltán (<span class="authorship-author-name">Csanádi Zoltán</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/<span title="Institute of Cardiology">KardI</span>/Department of Cardiology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33742453" target="_blank">Mortality on DOACs Versus on Vitamin K Antagonists in Atrial Fibrillation: Analysis of the Hungarian Health Insurance Fund Database</a></div> <div> <span class="journal-title">CLINICAL THERAPEUTICS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0149-2918">0149-2918</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1879-114X">1879-114X</a>)</span>: <span class="journal-volume">45</span> <span class="journal-issue">4</span> <span class="page"> pp 333-346 </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1016/j.clinthera.2023.03.008" target="_blank" href="https://doi.org/10.1016/j.clinthera.2023.03.008"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001004703600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001004703600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85151758723" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85151758723"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37028991" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37028991&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Pharmacology (medical)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Pharmacology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 6</span> | Independent citation: 6 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 5 | Number of citations in Scopus:&nbsp;5 | WoS/Scopus assigned:&nbsp;6 | Number of citations with DOI:&nbsp;6 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33742453&sort=publishedYear,desc&sort=title"> Number of cited publications: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33742453</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (GINOP-2.3.2-15-2016-00043) </div> <div class="lastModified">Last Modified: 2024.02.26. 09:20 xAnikó xHegedűs (INAKTÍV_SE_AOK_AITK és Érseb_Admin5_HA, admin) </div> <div class="lockedBy">Centrally managed 2023.11.27. 11:38 Katalin Lévayné Deseő (MTMT Központi admin) </div> </div></div>