https://m2.mtmt.hu/ hun 2026-09-22 10:13 JournalArticle 33741526 VALIDATED true Faculy of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Gh. Marinescu 38, Târgu Mureș, 540139, Romania Sz-Imfidum Ltd, nr. 504, Lunga, 525401, Romania University Pharmacy Department of Pharmaceutical Administration, Semmelweis University, Hőgyes E. 9, Budapest, 1085, Hungary Cyclolab Ltd, Illatos út 7, Budapest, H-1097, Hungary Department of Pharmaceutical Chemistry, Semmelweis University, Hőgyes E. 9, Budapest, 1085, Hungary Export Date: 15 May 2023 CODEN: MOLEF Correspondence Address: Tóth, G.; Department of Pharmaceutical Chemistry, Hőgyes E. 9, Hungary; email: toth.gergo@pharma.semmelweis-univ.hu 0 false 2026-09-16T08:39:42.215+0000 2025-02-28T11:12:35.957+0000 2023-04-09T07:19:25.839+0000 true 10080598 Benkő Beáta Mária /api/author/10080598 Author true 2025-03-17T19:08:07.144+0000 2025-03-17T19:08:07.144+0000 2025-02-28T11:12:36.240+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Szabó, Zoltán-István Chiral Separation of Apremilast by Capillary Electrophoresis Using Succinyl-β-Cyclodextrin—Reversal of Enantiomer Elution Order by Cationic Capillary Coating true true /api/journal/25013 REVIEWED true false 25013 false 25013 true 1431-5157 1420-3049 Journal FOREIGN 28 8 3310 3310 11 2023 A stereospecific capillary electrophoresis method was developed for the separation of the novel, antipsoriatic agent, apremilast (APR). Six anionic cyclodextrin (CD) derivatives were screened for their ability to discriminate between the uncharged enantiomers. Only succinyl-β-CD (Succ-β-CD) presented chiral interactions; however, the enantiomer migration order (EMO) was unfavorable, and the eutomer, S-APR, migrated faster. Despite the optimization of all possible parameters (pH, cyclodextrin concentration, temperature, and degree of substitution of CD), the method was unsuccessful for purity control due to the low resolution and the unfavorable enantiomer migration order. Changing the direction of electroosmotic flow (EOF) by the dynamic coating of the inner surface of the capillary with poly(diallyldimethylammonium) chloride or polybrene resulted in EMO reversal, and the developed method could be applied for the determination of R-APR as the enantiomeric purity. Thus, the application of the dynamic capillary coating offers a general opportunity for enantiomeric migration order reversal in particular cases when the chiral selector is a weak acid. true 2023 true true true false true false GOLD 2026-09-16 true https://doi.org/10.3390/molecules28083310 9 0 9 9 0 9 9 9 9 9 9 9 9 9 0 0 9 9 9 9 0 11 11 Folyóiratcikk Journal Article 24 9 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 1 1 1 1 2024 0 4 4 4 4 2025 0 2 2 2 2 2026 0 2 2 2 2 Q1 false 10080598,10028950 false false false 2023-05-14T09:51:58.094+0000 CycloLab Cyclodextrin Research and Development ...; Egyetemi Gyógyszertár Gyógyszerügyi Szervezési ... (SE / GYTK); Gyógyszerészi Kémiai Intézet (SE / GYTK) 5 16 3 7 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 107291947 /api/authorship/107291947 1 0.14285715 true false Szabó Zoltán-István true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107291948 /api/authorship/107291948 2 0.14285715 false false Author 10080598 /api/author/10080598 Benkő Beáta Mária true true Benkő Beáta-Mária true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107291949 /api/authorship/107291949 3 0.14285715 false false Bartalis-Fábián Ágnes true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107291950 /api/authorship/107291950 4 0.143 false false Author 10096763 /api/author/10096763 Iványi Róbert true true Iványi Róbert true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107291951 /api/authorship/107291951 5 0.143 false false Author 10044531 /api/author/10044531 Varga Erzsébet true 10044531 true Varga Erzsébet true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107291952 /api/authorship/107291952 6 0.143 false false Author 10032169 /api/author/10032169 Szőcs Levente true 10032169 true Szőcs Levente true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107291953 /api/authorship/107291953 7 0.143 false true true Author 10028950 /api/author/10028950 Tóth Gergő true 10028950 true Tóth Gergő true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 23349799 /api/publicationidentifier/23349799 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/molecules28083310 https://doi.org/10.3390/molecules28083310 false true PublicationIdentifier 23720009 /api/publicationidentifier/23720009 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000978945700001 https://www.webofscience.com/wos/woscc/full-record/000978945700001 false true PublicationIdentifier 23557224 /api/publicationidentifier/23557224 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85156176187 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85156176187 false true PublicationIdentifier 23557611 /api/publicationidentifier/23557611 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37110544 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37110544&dopt=Abstract true true SjrRating 11352629 /api/sjrrating/11352629 37 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1602 /api/classificationexternal/1602 true 1602 true Q1 DIRECT true true /api/publication/33741526 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Szabó Zoltán-István </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10080598"><a href="/gui2/?type=authors&mode=browse&sel=10080598" target="_blank">Benkő Beáta-Mária (<span class="authorship-author-name">Benkő Beáta Mária</span> <span class="authorAux-mtmt"> Gyógyszerészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Egyetemi Gyógyszertár Gyógyszerügyi Szervezési Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bartalis-Fábián Ágnes </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10096763"><a href="/gui2/?type=authors&mode=browse&sel=10096763" target="_blank">Iványi Róbert (<span class="authorship-author-name">Iványi Róbert</span> <span class="authorAux-mtmt"> ciklodextrin kémia</span>) </a> </span> <span class="author-affil">CycloLab Cyclodextrin Research and Development Laboratory Ltd.</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10044531"><a href="/gui2/?type=authors&mode=browse&sel=10044531" target="_blank">Varga Erzsébet (<span class="authorship-author-name">Varga Erzsébet</span> <span class="authorAux-mtmt"> analitika</span>) </a> </span> <span class="author-affil">CycloLab Cyclodextrin Research and Development Laboratory Ltd.</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032169"><a href="/gui2/?type=authors&mode=browse&sel=10032169" target="_blank">Szőcs Levente (<span class="authorship-author-name">Szőcs Levente</span> <span class="authorAux-mtmt"> gyógyszerészi kémia</span>) </a> </span> <span class="author-affil">CycloLab Cyclodextrin Research and Development Laboratory Ltd.</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028950"><a href="/gui2/?type=authors&mode=browse&sel=10028950" target="_blank">Tóth Gergő ✉ (<span class="authorship-author-name">Tóth Gergő</span> <span class="authorAux-mtmt"> gyógyszerkémia/analitika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészi Kémiai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33741526" target="_blank">Chiral Separation of Apremilast by Capillary Electrophoresis Using Succinyl-β-Cyclodextrin—Reversal of Enantiomer Elution Order by Cationic Capillary Coating</a></div> <div> <span class="journal-title">MOLECULES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1431-5157">1431-5157</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1420-3049">1420-3049</a>)</span>: <span class="journal-volume">28</span> <span class="journal-issue">8</span> <span class="page"> Paper 3310. 11 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/molecules28083310" target="_blank" href="https://doi.org/10.3390/molecules28083310"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000978945700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000978945700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85156176187" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85156176187"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37110544" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37110544&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Analytical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Chemistry (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmaceutical Science&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Drug Discovery&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 9</span> | Független: 9 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 9 | Scopus jelölt:&nbsp;9 | WoS/Scopus jelölt:&nbsp;9 | DOI jelölt:&nbsp;9 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33741526&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 11 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33741526</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2025.02.28. 12:12 Csajbók Edit (SE_KK_Admin5_CSE, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Faculy of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Gh. Marinescu 38, Târgu Mureș, 540139, Romania Sz-Imfidum Ltd, nr. 504, Lunga, 525401, Romania University Pharmacy Department of Pharmaceutical Administration, Semmelweis University, Hőgyes E. 9, Budapest, 1085, Hungary ...</pre> </div></div>