Proteome alterations in human autopsy tissues in relation to time after death

https://m2.mtmt.hu/ hun 2026-09-22 16:40 JournalArticle 33738852 VALIDATED true 0 false 2026-07-31T14:57:22.382+0000 2025-12-02T11:32:44.782+0000 2023-04-06T11:46:31.731+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin Gere Tamásné (SE_KK_Admin5_GT, admin) true 10062062 2026-05-19T08:48:57.130+0000 2026-05-19T08:48:57.130+0000 2023-05-02T07:02:15.819+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) true true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Kocsmár, Éva Proteome alterations in human autopsy tissues in relation to time after death true true /api/journal/11507 REVIEWED CELLULAR AND MOLECULAR LIFE SCIENCES 1420-682X 1420-9071 true false 11507 false 11507 true 1420-682X 1420-9071 Journal FOREIGN 80 5 117 117 15 2023 Protein expression is a primary area of interest for routine histological diagnostics and tissue-based research projects, but the limitations of its post-mortem applicability remain largely unclear. On the other hand, tissue specimens obtained during autopsies can provide unique insight into advanced disease states, especially in cancer research. Therefore, we aimed to identify the maximum post-mortem interval (PMI) which is still suitable for characterizing protein expression patterns, to explore organ-specific differences in protein degradation, and to investigate whether certain proteins follow specific degradation kinetics. Therefore, the proteome of human tissue samples obtained during routine autopsies of deceased patients with accurate PMI (6, 12, 18, 24, 48, 72, 96 h) and without specific diseases that significantly affect tissue preservation, from lungs, kidneys and livers, was analyzed by liquid chromatography–tandem mass spectrometry (LC–MS/MS). For the kidney and liver, significant protein degradation became apparent at 48 h. For the lung, the proteome composition was rather static for up to 48 h and substantial protein degradation was detected only at 72 h suggesting that degradation kinetics appear to be organ specific. More detailed analyses suggested that proteins with similar post-mortem kinetics are not primarily shared in their biological functions. The overrepresentation of protein families with analogous structural motifs in the kidney indicates that structural features may be a common factor in determining similar postmortem stability. Our study demonstrates that a longer post-mortem period may have a significant impact on proteome composition, but sampling within 24 h may be appropriate, as degradation is within acceptable limits even in organs with faster autolysis. Funding 2025423 /api/funding/2025423 Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Támogató: EFOP-VEKOP false true Funding 2025424 /api/funding/2025424 (K128881) Támogató: OTKA false true Funding 2025425 /api/funding/2025425 (K_22 142604) Támogató: Hungarian National Research, Development and Innovation Office false true Funding 2025426 /api/funding/2025426 (UNKP-20-3-II-SE-36) Támogató: Innovációs és Technológiai Minisztérium false true Funding 2025427 /api/funding/2025427 (ÚNKP-21-4-I-SE-32) false true true true 2023 true true true false true false NONE 2026-07-31 false 30 0 29 29 0 28 26 26 24 26 26 26 26 30 0 0 30 30 29 29 0 0 0 Folyóiratcikk Journal Article 24 28 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 1 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 1 1 1 1 2024 0 10 10 10 10 2025 0 10 10 10 10 2026 0 9 9 9 9 D1 false 10023602,10016981,10061496 false false false 2023-04-11T07:16:46.106+0000 Patológiai és Kísérleti Rákkutató Intézet (SE / AOK / I); Patológiai, Igazságügyi és Biztosítási Orvostan... (SE / AOK / I); Urológiai Klinika (SE / AOK / K) 6 15 3 13 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 107276134 /api/authorship/107276134 Kocsmár, Éva [Kocsmár, Éva (patológia), szerző] Patológiai, Igazságügyi és Biztosítási Orvostan... (SE / AOK / I) 1 0.077 true false false Author 10061496 /api/author/10061496 Kocsmár Éva (patológia) Kocsmár Éva true 10061496 true Kocsmár Éva true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107276135 /api/authorship/107276135 Schmid, Marlene* 2 0.077 true false false Schmid Marlene true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107276136 /api/authorship/107276136 Cosenza-Contreras, Miguel 3 0.07692308 false false false Cosenza-Contreras Miguel true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107276137 /api/authorship/107276137 Kocsmár, Ildikó [Kocsmár, Ildikó (patológia), szerző] Urológiai Klinika (SE / AOK / K); Patológiai, Igazságügyi és Biztosítási Orvostan... (SE / AOK / I) 4 0.077 false false false Author 10061659 /api/author/10061659 Kocsmár Ildikó (patológia) Kocsmár Ildikó true 10061659 true Kocsmár Ildikó true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107276138 /api/authorship/107276138 Föll, Melanie 5 0.07692308 false false false Föll Melanie true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107276139 /api/authorship/107276139 Krey, Leah 6 0.07692308 false false false Krey Leah true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107276140 /api/authorship/107276140 Barta, Bálint András [Barta, Bálint András (Experimentális ka...), szerző] 7 0.077 false false false Author 10072454 /api/author/10072454 Barta Bálint András (Experimentális kardiológia, Proteomika) Barta Bálint András true true Barta Bálint András true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107276141 /api/authorship/107276141 Rácz, Gergely [Rácz, Gergely (Patológia), szerző] Patológiai és Kísérleti Rákkutató Intézet (SE / AOK / I) 8 0.077 false false false Author 10023602 /api/author/10023602 Rácz Gergely (Patológia) Rácz Gergely true 10023602 true Rácz Gergely true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107276142 /api/authorship/107276142 Kiss, András [Kiss, András (Pathológia, hepat...), szerző] Patológiai, Igazságügyi és Biztosítási Orvostan... (SE / AOK / I) 9 0.077 false false false Author 10000554 /api/author/10000554 Kiss András (Pathológia, hepatocarcinogenesis) Kiss András true 10000554 true Kiss András true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107276143 /api/authorship/107276143 Werner, Martin 10 0.07692308 false false false Werner Martin true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107276144 /api/authorship/107276144 Schilling, Oliver** ✉ 11 0.077 false true true Schilling Oliver true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107276145 /api/authorship/107276145 Lotz, Gábor** [Lotz, Gábor (Hepatológia, path...), szerző] Patológiai, Igazságügyi és Biztosítási Orvostan... (SE / AOK / I) 12 0.077 false true Author 10016981 /api/author/10016981 Lotz Gábor (Hepatológia, pathológia) Lotz Gábor true 10016981 true Lotz Gábor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107276146 /api/authorship/107276146 Bronsert, Peter ✉ 13 0.077 false true true Bronsert Peter true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 23339675 /api/publicationidentifier/23339675 DOI: 10.1007/s00018-023-04754-3 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1007/s00018-023-04754-3 https://doi.org/10.1007/s00018-023-04754-3 false true PublicationIdentifier 23467192 /api/publicationidentifier/23467192 WoS: 000963360900001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000963360900001 https://www.webofscience.com/wos/woscc/full-record/000963360900001 true true PublicationIdentifier 23387039 /api/publicationidentifier/23387039 Scopus: 85151808333 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85151808333 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85151808333 true true PublicationIdentifier 23339677 /api/publicationidentifier/23339677 PubMed: 37020120 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37020120 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37020120&dopt=Abstract false true SjrRating 11400704 /api/sjrrating/11400704 sjr:D1 (2023) Scopus - Molecular Medicine CELLULAR AND MOLECULAR LIFE SCIENCES 1420-682X 1420-9071 16 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1313 /api/classificationexternal/1313 Scopus - Molecular Medicine true 1313 true D1 DIRECT true true Reference 39938867 /api/reference/39938867 1. 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(2023) CELLULAR AND MOLECULAR LIFE SCIENCES 1420-682X 1420-9071 80 5<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10061496"><a href="/gui2/?type=authors&mode=browse&sel=10061496" target="_blank">Kocsmár Éva (<span class="authorship-author-name">Kocsmár Éva</span> <span class="authorAux-mtmt"> patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;    <span class="author-name" >Schmid Marlene<sup>*</sup> </span> ;    <span class="author-name" >Cosenza-Contreras Miguel </span> ;    <span class="author-name" mtid="10061659"><a href="/gui2/?type=authors&mode=browse&sel=10061659" target="_blank">Kocsmár Ildikó (<span class="authorship-author-name">Kocsmár Ildikó</span> <span class="authorAux-mtmt"> patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;    <span class="author-name" >Föll Melanie </span> ;    <span class="author-name" >Krey Leah </span> ;    <span class="author-name" mtid="10072454"><a href="/gui2/?type=authors&mode=browse&sel=10072454" target="_blank">Barta Bálint András (<span class="authorship-author-name">Barta Bálint András</span> <span class="authorAux-mtmt"> Experimentális kardiológia, Proteomika</span>) </a> </span> ;    <span class="author-name" mtid="10023602"><a href="/gui2/?type=authors&mode=browse&sel=10023602" target="_blank">Rácz Gergely (<span class="authorship-author-name">Rácz Gergely</span> <span class="authorAux-mtmt"> Patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai és Kísérleti Rákkutató Intézet</span> ;    <span class="author-name" mtid="10000554"><a href="/gui2/?type=authors&mode=browse&sel=10000554" target="_blank">Kiss András (<span class="authorship-author-name">Kiss András</span> <span class="authorAux-mtmt"> Pathológia, hepatocarcinogenesis</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;    <span class="author-name" >Werner Martin </span> ;    <span class="author-name" >Schilling Oliver<sup>**</sup> ✉ </span> ;    <span class="author-name" mtid="10016981"><a href="/gui2/?type=authors&mode=browse&sel=10016981" target="_blank">Lotz Gábor<sup>**</sup> (<span class="authorship-author-name">Lotz Gábor</span> <span class="authorAux-mtmt"> Hepatológia, pathológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;    <span class="author-name" >Bronsert Peter ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33738852" target="_blank">Proteome alterations in human autopsy tissues in relation to time after death</a></div> <div> <span class="journal-title">CELLULAR AND MOLECULAR LIFE SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1420-682X">1420-682X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1420-9071">1420-9071</a>)</span>: <span class="journal-volume">80</span> <span class="journal-issue">5</span> <span class="page"> Paper 117. 15 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s00018-023-04754-3" target="_blank" href="https://doi.org/10.1007/s00018-023-04754-3"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000963360900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000963360900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85151808333" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85151808333"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37020120" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37020120&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Medicine   SJR indikátor: D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmacology   SJR indikátor: D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cell Biology   SJR indikátor: Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cellular and Molecular Neuroscience   SJR indikátor: Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology   SJR indikátor: Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 30</span> | Független: 30 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 26 | Scopus jelölt: 24 | WoS/Scopus jelölt: 26 | DOI jelölt: 26 </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33738852</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Támogató: EFOP-VEKOP, (K128881) Támogató: OTKA, (K_22 142604) Támogató: OTKA, (UNKP-20-3-II-SE-36) Támogató: Innovációs és Technológiai Minisztérium, (ÚNKP-21-4-I-SE-32) </div> <div class="lastModified">Utolsó módosítás: 2025.12.02. 12:32 Gere Tamásné (SE_KK_Admin5_GT, admin) </div> </div></div>