https://m2.mtmt.hu/ eng 2026-10-24 11:39 JournalArticle 33736965 VALIDATED true 0 false 2026-10-23T10:57:57.071+0000 2024-04-17T09:39:31.234+0000 2023-04-06T08:19:31.713+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-05-21T09:12:37.653+0000 2026-05-21T09:12:37.653+0000 2024-04-17T09:39:31.475+0000 true 10025544 Lévayné Deseő Katalin /api/admin/10025544 Admin true 10025544 Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin true 10025544 true 2024-04-17T09:39:42.247+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Szocsics, Peter Interhemispheric differences of pyramidal cells in the primary motor cortices of schizophrenia patients investigated postmortem true true /api/journal/960 REVIEWED true false 960 false 960 true 1047-3211 1460-2199 Journal FOREIGN 33 13 8179 8193 8179 15 2023 Motor disturbances are observed in schizophrenia patients, but the neuroanatomical background is unknown. Our aim was to investigate the pyramidal cells of the primary motor cortex (BA 4) in both hemispheres of postmortem control and schizophrenia subjects-8 subjects in each group-with 2.5-5.5 h postmortem interval. The density and size of the Sternberger monoclonal incorporated antibody 32 (SMI32)-immunostained pyramidal cells in layer 3 and 5 showed no change; however, the proportion of larger pyramidal cells is decreased in layer 5. Giant pyramidal neurons (Betz cells) were investigated distinctively with SMI32- and parvalbumin (PV) immunostainings. In the right hemisphere of schizophrenia subjects, the density of Betz cells was decreased and their PV-immunopositive perisomatic input showed impairment. Part of the Betz cells contained PV in both groups, but the proportion of PV-positive cells has declined with age. The rat model of antipsychotic treatment with haloperidol and olanzapine showed no differences in size and density of SMI32-immunopositive pyramidal cells. Our results suggest that motor impairment of schizophrenia patients may have a morphological basis involving the Betz cells in the right hemisphere. These alterations can have neurodevelopmental and neurodegenerative explanations, but antipsychotic treatment does not explain them. 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Humán Agyszövet Laboratórium (HRN KOKI); Kísérleti Orvostudományi Kutatóintézet 3 21 3 5 0 true 10025544 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 107265740 /api/authorship/107265740 1 0.2 true false false Author 10064391 /api/author/10064391 Szocsics Péter true 10064391 true Szocsics Peter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107265741 /api/authorship/107265741 2 0.2 false false false Author 10043524 /api/author/10043524 Papp Péter true 10043524 true Papp Peter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107265742 /api/authorship/107265742 3 0.2 false false false Havas Laszlo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107265743 /api/authorship/107265743 4 0.2 false false false Loke Janos true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107265744 /api/authorship/107265744 5 0.2 false true true Author 10009112 /api/author/10009112 Maglóczky Zsófia true 10009112 true Magloczky Zsofia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 23334034 /api/publicationidentifier/23334034 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1093/cercor/bhad107 https://doi.org/10.1093/cercor/bhad107 false true PublicationIdentifier 23334035 /api/publicationidentifier/23334035 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000952419600001 https://www.webofscience.com/wos/woscc/full-record/000952419600001 false true PublicationIdentifier 24175917 /api/publicationidentifier/24175917 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GOLD true IDENTICAL 169952 https://real.mtak.hu/169952 false true PublicationIdentifier 24201382 /api/publicationidentifier/24201382 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85164241304 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85164241304 true true PublicationIdentifier 23334036 /api/publicationidentifier/23334036 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 36967112 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36967112&dopt=Abstract false true Keyword 169 /api/keyword/169 true 169 true Keyword 181 /api/keyword/181 true 181 true Keyword 298 /api/keyword/298 true 298 true Keyword 601 /api/keyword/601 true 601 true Keyword 684 /api/keyword/684 true 684 true Keyword 962 /api/keyword/962 true 962 true Keyword 1223 /api/keyword/1223 true 1223 true Keyword 4675 /api/keyword/4675 true 4675 true Keyword 4719 /api/keyword/4719 true 4719 true Keyword 1009479 /api/keyword/1009479 true 1009479 true Keyword 1030818 /api/keyword/1030818 true 1030818 true Keyword 1041543 /api/keyword/1041543 true 1041543 true Keyword 1044605 /api/keyword/1044605 true 1044605 true SjrRating 11361627 /api/sjrrating/11361627 18 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2804 /api/classificationexternal/2804 true 2804 true Q1 DIRECT true true /api/publication/33736965 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10064391"><a href="/gui2/?type=authors&mode=browse&sel=10064391" target="_blank">Szocsics Peter (<span class="authorship-author-name">Szocsics Péter</span> <span class="authorAux-mtmt"> idegtudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/School of PhD Studies; Institute of Experimental Medicine; <span title="Institute of Experimental Medicine">IEM</span>/Human Brain Research Laboratory</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043524"><a href="/gui2/?type=authors&mode=browse&sel=10043524" target="_blank">Papp Peter (<span class="authorship-author-name">Papp Péter</span> <span class="authorAux-mtmt"> Pszichológia, neurobiológia</span>) </a> </span> <span class="author-affil">Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Havas Laszlo </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Loke Janos </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009112"><a href="/gui2/?type=authors&mode=browse&sel=10009112" target="_blank">Magloczky Zsofia ✉ (<span class="authorship-author-name">Maglóczky Zsófia</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil">Institute of Experimental Medicine; <span title="Institute of Experimental Medicine">IEM</span>/Human Brain Research Laboratory</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33736965" target="_blank">Interhemispheric differences of pyramidal cells in the primary motor cortices of schizophrenia patients investigated postmortem</a></div> <div> <span class="journal-title">CEREBRAL CORTEX</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1047-3211">1047-3211</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1460-2199">1460-2199</a>)</span>: <span class="journal-volume">33</span> <span class="journal-issue">13</span> <span class="page"> pp 8179-8193 </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1093/cercor/bhad107" target="_blank" href="https://doi.org/10.1093/cercor/bhad107"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000952419600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000952419600001"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="169952" target="_blank" href="https://real.mtak.hu/169952"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85164241304" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85164241304"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36967112" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36967112&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Cellular and Molecular Neuroscience&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Cognitive Neuroscience&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 2</span> | Independent citation: 2 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 2 | Number of citations in Scopus:&nbsp;2 | WoS/Scopus assigned:&nbsp;2 | Number of citations with DOI:&nbsp;2 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33736965&sort=publishedYear,desc&sort=title"> Number of cited publications: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33736965</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="funder"> (K 125436) Funder: NKFI, Hungarian National Brain Research Program(2017-1.2.1-NKP-2017-00002) </div> <div class="lastModified">Last Modified: 2024.04.17. 11:39 Katalin Lévayné Deseő (MTMT Központi admin) </div> <div class="lockedBy">Centrally managed 2024.04.17. 11:39 Katalin Lévayné Deseő (MTMT Központi admin) </div> </div></div>