https://m2.mtmt.hu/ hun 2026-09-21 05:40 JournalArticle 33736950 VALIDATED true Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, United Kingdom Department of Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom Research Group for Immunology and Haematology, Semmelweis University - Eötvös Loránd Research Network (Office for Supported Research Groups), Budapest, Hungary Department of Haematology and Stem Cell Transplantation, Central Hospital of Southern Pest - Institute of Haematology and Infectious Diseases, Budapest, Hungary Department of Pulmonology, Semmelweis University, Budapest, Hungary Department of Anaesthesiology and Intensive Therapy, Semmelweis University, Budapest, Hungary Department of Infectology, Central Hospital of Southern Pest - Institute of Haematology and Infectious Diseases, Budapest, Hungary Department of Anaesthesiology and Intensive Therapy, Central Hospital of Southern Pest - Institute of Haematology and Infectious Diseases, Budapest, Hungary Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria Research and Development Department, Hycult Biotech, Uden, Netherlands Cited By :1 Export Date: 26 October 2023 Correspondence Address: Prohászka, Z.; Department of Internal Medicine and Haematology, Hungary; email: prohaszka.zoltan@med.semmelweis-univ.hu Chemicals/CAS: C reactive protein, 9007-41-4; complement component C4d, 80295-52-9; complement component C5b, 80295-55-2; Lectins; Mannose-Binding Lectin; MBL2 protein, human Tradenames: 3130xl, Life Technologies; Rotor-Gene Q, Qiagen, Germany; TaqMan, Life Technologies Manufacturers: Affymetrix, United Kingdom; Hycultec; Life Technologies; Qiagen, Germany Funding details: 12/20A Funding details: 860044 Funding details: 2020–1.1.6-JOVO-2021–00013 Funding details: UK Research and Innovation, UKRI Funding details: National Institute for Health and Care Research, NIHR Funding details: Semmelweis Egyetem, TKP2021-EGA-24 Funding details: Austrian Science Fund, FWF, HOROS W-1253 Funding details: Evelyn Trust, 20/75 Funding details: Emberi Eroforrások Minisztériuma, EMMI Funding details: NIHR Cambridge Biomedical Research Centre Funding details: UK Coronavirus Immunology Consortium, UK-CIC Funding text 1: The research was financed by the Higher Education Institutional Excellence Programme of the Ministry of Human Capacities in Hungary, within the framework of the molecular biology thematic program of the Semmelweis University, “MOLORKIV” (TKP2021-EGA-24) to ZP, and by the National Office for Innovation and Research (2020–1.1.6-JOVO-2021–00013 to ZP). ZP, RW and LH are supported by funds of the EU MSCA project CORVOS 860044. The research was further funded by the Austrian Science Fund (FWF), HOROS W-1253 (RW and LH). We are grateful to the Evelyn Trust (20/75), Addenbrooke’s Charitable Trust, Cambridge University Hospitals (12/20A), the NIHR Cambridge Biomedical Research Centre, and the UKRI/NIHR through the UK Coronavirus Immunology Consortium (UK-CIC) for their financial support. The authors declare that this study also received funding from CVC Capital Partners. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article, or the decision to submit it for publication. 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Reference 39925665 /api/reference/39925665 66 10.1007/s10875-005-4702-1 false true Reference 39925666 /api/reference/39925666 67 10.1016/S0140-6736(01)05776-2 false true Reference 39925667 /api/reference/39925667 68 10.1093/OXFORDJOURNALS.QJMED.A068848 false true /api/publication/33736950 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10077893"><a href="/gui2/?type=authors&mode=browse&sel=10077893" target="_blank">Hurler Lisa (<span class="authorship-author-name">Hurler Lisa</span> <span class="authorAux-mtmt"> Medical Biology</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Hematológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017487"><a href="/gui2/?type=authors&mode=browse&sel=10017487" target="_blank">Szilágyi Ágnes (<span class="authorship-author-name">Szilágyi Ágnes</span> <span class="authorAux-mtmt"> Humán molekuláris genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Hematológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mescia Federica </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bergamaschi Laura </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048389"><a href="/gui2/?type=authors&mode=browse&sel=10048389" target="_blank">Mező Blanka (<span class="authorship-author-name">Mező Blanka</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Hematológiai Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Belgyógyászati és Hematológiai Klinika">BHK</span>/ELKH-SE Immunológiai és Hematológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060721"><a href="/gui2/?type=authors&mode=browse&sel=10060721" target="_blank">Sinkovits György (<span class="authorship-author-name">Sinkovits György</span> <span class="authorAux-mtmt"> orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Hematológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10059803"><a href="/gui2/?type=authors&mode=browse&sel=10059803" target="_blank">Réti Marienn (<span class="authorship-author-name">Réti Marienn Györgyi</span> <span class="authorAux-mtmt"> Hematológia, transzfuziológia, belgyógyászat</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012282"><a href="/gui2/?type=authors&mode=browse&sel=10012282" target="_blank">Müller Veronika (<span class="authorship-author-name">Müller Veronika</span> <span class="authorAux-mtmt"> Pulmonológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pulmonológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024639"><a href="/gui2/?type=authors&mode=browse&sel=10024639" target="_blank">Iványi Zsolt (<span class="authorship-author-name">Iványi Zsolt</span> <span class="authorAux-mtmt"> Aneszteziológia intenzív terápia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Aneszteziológiai és Intenzív Terápiás Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024202"><a href="/gui2/?type=authors&mode=browse&sel=10024202" target="_blank">Gál János (<span class="authorship-author-name">Gál János</span> <span class="authorAux-mtmt"> Aneszteziológia és intenzív terápia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Aneszteziológiai és Intenzív Terápiás Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10066903"><a href="/gui2/?type=authors&mode=browse&sel=10066903" target="_blank">Gopcsa László (<span class="authorship-author-name">Gopcsa László</span> <span class="authorAux-mtmt"> Belgyógyászat, hematológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10059885"><a href="/gui2/?type=authors&mode=browse&sel=10059885" target="_blank">Reményi Péter (<span class="authorship-author-name">Reményi Péter</span> <span class="authorAux-mtmt"> Belgyógyászat, hematológia, infektológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Szathmáry Beáta </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10036670"><a href="/gui2/?type=authors&mode=browse&sel=10036670" target="_blank">Lakatos Botond (<span class="authorship-author-name">Lakatos Botond</span> <span class="authorAux-mtmt"> Orvostudomány, infektologia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Szlávik János </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bobek Ilona </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10083743"><a href="/gui2/?type=authors&mode=browse&sel=10083743" target="_blank">Prohászka Zita Z. (<span class="authorship-author-name">Prohászka Z. Zita</span> <span class="authorAux-mtmt"> klinikai orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Hematológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023872"><a href="/gui2/?type=authors&mode=browse&sel=10023872" target="_blank">Förhécz Zsolt (<span class="authorship-author-name">Förhécz Zsolt</span> <span class="authorAux-mtmt"> Kardiológia, belgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Hematológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023983"><a href="/gui2/?type=authors&mode=browse&sel=10023983" target="_blank">Csuka Dorottya (<span class="authorship-author-name">Csuka Dorottya</span> <span class="authorAux-mtmt"> Humán molekuláris genetika és immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Hematológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040542"><a href="/gui2/?type=authors&mode=browse&sel=10040542" target="_blank">Kajdácsi Erika (<span class="authorship-author-name">Kajdácsi Erika</span> <span class="authorAux-mtmt"> immunológia, sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Hematológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000203"><a href="/gui2/?type=authors&mode=browse&sel=10000203" target="_blank">Cervenak László (<span class="authorship-author-name">Cervenak László</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Hematológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10076443"><a href="/gui2/?type=authors&mode=browse&sel=10076443" target="_blank">Kiszel Petra (<span class="authorship-author-name">Kiszel Petra</span> <span class="authorAux-mtmt"> biológus</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Belgyógyászati és Hematológiai Klinika">BHK</span>/ELKH-SE Immunológiai és Hematológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015319"><a href="/gui2/?type=authors&mode=browse&sel=10015319" target="_blank">Masszi Tamás (<span class="authorship-author-name">Masszi Tamás</span> <span class="authorAux-mtmt"> belgyógyászat, hematológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Hematológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10034838"><a href="/gui2/?type=authors&mode=browse&sel=10034838" target="_blank">Vályi-Nagy István (<span class="authorship-author-name">Vályi-Nagy István</span> <span class="authorAux-mtmt"> Hematológia, belgyógyászat, onkológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Würzner Reinhard </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lyons Paul A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Toonen Erik J. M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000530"><a href="/gui2/?type=authors&mode=browse&sel=10000530" target="_blank">Prohászka Zoltán ✉ (<span class="authorship-author-name">Prohászka Zoltán</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Hematológiai Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Belgyógyászati és Hematológiai Klinika">BHK</span>/ELKH-SE Immunológiai és Hematológiai Kutatócsoport</span> </div> <div class="autype autype-29"> Kollaborációs szervezet: <span class="author-affil">Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33736950" target="_blank">Complement lectin pathway activation is associated with COVID-19 disease severity, independent of MBL2 genotype subgroups</a></div> <div> <span class="journal-title">FRONTIERS IN IMMUNOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1664-3224">1664-3224</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1664-3224">1664-3224</a>)</span>: <span class="journal-volume">14</span> <span class="page"> Paper 1162171. 19 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3389/fimmu.2023.1162171" target="_blank" href="https://doi.org/10.3389/fimmu.2023.1162171"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000966884100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000966884100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85152344844" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85152344844"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37051252" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37051252&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://www.scopus.com/pages/publications/85152344844?origin=resultslist" target="_blank" href="https://www.scopus.com/pages/publications/85152344844?origin=resultslist"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology and Allergy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 20</span> | Független: 15 | Függő: 5 | Nem jelölt: 0 | WoS jelölt: 20 | Scopus jelölt:&nbsp;20 | WoS/Scopus jelölt:&nbsp;20 | DOI jelölt:&nbsp;20 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33736950&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33736950</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (TKP2021-EGA-24), (2020-1.1.6-JOVO-2021-00013), (EU MSCA-ITN 860044) </div> <div class="lastModified">Utolsó módosítás: 2023.09.22. 23:35 Réti Marienn Györgyi (Hematológia, transzfuziológia, belgyógyászat) </div> <div class="lockedBy">Központi kezelésű 2024.10.17. 18:18 Ladányi Gusztáv (MTMT API user, admin) Kériné Tornyi Katalin (MTMT ellenőrzés admin5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, United Kingdom Department of Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom ...</pre> </div></div>