https://m2.mtmt.hu/ hun 2026-09-21 14:46 JournalArticle 33728647 VALIDATED true Department of Neurobiology, Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, Nijenborgh 7, Groningen, 9747 AG, Netherlands Research Center for Molecular Exercise Science, Hungarian University of Sports Science, Budapest, Hungary Department of Morphology and Physiology, Health Science Faculty, Semmelweis Univesity, Budapest, Hungary Department of Human Movement Sciences, University of Groningen, University Medical Center Groningen, Groningen, Netherlands Export Date: 11 April 2023 Correspondence Address: Oroszi, T.; Department of Neurobiology, Nijenborgh 7, Netherlands; email: oroszitomi91@gmail.com 0 false 2026-06-18T13:00:25.896+0000 2025-07-18T11:29:31.766+0000 2023-04-03T08:12:36.992+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-06-18T12:58:56.606+0000 2023-04-03T17:49:55.580+0000 true 10071714 Lukácsné Varga Judit /api/admin/10071714 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Oroszi, Tamas Whole-body vibration ameliorates glial pathological changes in the hippocampus of hAPP transgenic mice, but does not affect plaque load true true /api/journal/10009896 REVIEWED true false 10009896 false 10009896 true 1744-9081 1744-9081 Journal FOREIGN 19 1 5 5 12 2023 Background Alzheimer's disease (AD) is the core cause of dementia in elderly populations. One of the main hallmarks of AD is extracellular amyloid beta (A beta) accumulation (APP-pathology) associated with glial-mediated neuroinflammation. Whole-Body Vibration (WBV) is a passive form of exercise, but its effects on AD pathology are still unknown. Methods Five months old male J20 mice (n = 26) and their wild type (WT) littermates (n = 24) were used to investigate the effect of WBV on amyloid pathology and the healthy brain. Both J20 and WT mice underwent WBV on a vibration platform or pseudo vibration treatment. The vibration intervention consisted of 2 WBV sessions of 10 min per day, five days per week for five consecutive weeks. After five weeks of WBV, the balance beam test was used to assess motor performance. Brain tissue was collected to quantify A beta deposition and immunomarkers of astrocytes and microglia. Results J20 mice have a limited number of plaques at this relatively young age. Amyloid plaque load was not affected by WBV. Microglia activation based on IBA1-immunostaining was significantly increased in the J20 animals compared to the WT littermates, whereas CD68 expression was not significantly altered. WBV treatment was effective to ameliorate microglia activation based on morphology in both J20 and WT animals in the Dentate Gyrus, but not so in the other subregions. Furthermore, GFAP expression based on coverage was reduced in J20 pseudo-treated mice compared to the WT littermates and it was significantly reserved in the J20 WBV vs. pseudo-treated animals. Further, only for the WT animals a tendency of improved motor performance was observed in the WBV group compared to the pseudo vibration group. Conclusion In accordance with the literature, we detected an early plaque load, reduced GFAP expression and increased microglia activity in J20 mice at the age of similar to 6 months. Our findings indicate that WBV has beneficial effects on the early progression of brain pathology. WBV restored, above all, the morphology of GFAP positive astrocytes to the WT level that could be considered the non-pathological and hence "healthy" level. Next experiments need to be performed to determine whether WBV is also affective in J20 mice of older age or other AD mouse models. true 2023 true true true false true false GOLD 2026-06-18 true https://doi.org/10.1186/s12993-023-00208-9 8 0 8 5 2 8 7 7 8 8 8 5 5 5 3 0 8 5 8 5 0 7 7 Folyóiratcikk Journal Article 24 7 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 1 1 1 1 2024 0 4 1 4 1 2025 0 2 2 2 2 2026 0 1 1 1 1 Q1 false false false false 2023-04-02T08:17:54.934+0000 Molekuláris Edzésélettani Kutató Központ (MTSE / SETI); Morfológiai és Fiziológiai Tanszék (SE / ETK2007); Sport- és egészségtudományi Kutatócsoport (EKKE / KUTE) 2 25 3 6 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 107221149 /api/authorship/107221149 1 0.167 true false true Author 10063588 /api/author/10063588 Oroszi Tamás true 10063588 true Oroszi Tamas true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107221150 /api/authorship/107221150 2 0.16666667 false false false Geerts Eva true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107221151 /api/authorship/107221151 3 0.16666667 false false false Rajadhyaksha Reuben true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107221152 /api/authorship/107221152 4 0.167 false false false Author 10010173 /api/author/10010173 Nyakas Csaba true 10010173 true Nyakas Csaba true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107221153 /api/authorship/107221153 5 0.16666667 false false false van Heuvelen Marieke J. 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G. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >van der Zee Eddy A. </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33728647" target="_blank">Whole-body vibration ameliorates glial pathological changes in the hippocampus of hAPP transgenic mice, but does not affect plaque load</a></div> <div> <span class="journal-title">BEHAVIORAL AND BRAIN FUNCTIONS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1744-9081">1744-9081</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1744-9081">1744-9081</a>)</span>: <span class="journal-volume">19</span> <span class="journal-issue">1</span> <span class="page"> Paper 5. 12 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1186/s12993-023-00208-9" target="_blank" href="https://doi.org/10.1186/s12993-023-00208-9"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000950761000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000950761000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85150752405" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85150752405"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36941713" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36941713&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Behavioral Neuroscience&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cognitive Neuroscience&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biological Psychiatry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 8</span> | Független: 5 | Függő: 3 | Nem jelölt: 0 | WoS jelölt: 7 | Scopus jelölt:&nbsp;8 | WoS/Scopus jelölt:&nbsp;8 | DOI jelölt:&nbsp;7 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33728647&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33728647</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2025.07.18. 13:29 Oszlánczi Krisztina (EKKE admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Neurobiology, Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, Nijenborgh 7, Groningen, 9747 AG, Netherlands Research Center for Molecular Exercise Science, Hungarian University of Sports Science, Budapest, Hungary Department of Morphology and Physiology, Health Science Faculty, Semmelweis Unives...</pre> </div></div>