https://m2.mtmt.hu/ eng 2026-06-27 08:30 JournalArticle 33728442 VALIDATED true 0 false 2026-06-19T11:02:35.051+0000 2026-04-27T10:33:28.025+0000 2023-04-03T07:12:34.297+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 2026-04-27T10:33:28.251+0000 2026-04-27T10:33:28.251+0000 2026-04-27T10:32:05.909+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Visolyi, Gergely Á Comparison of Efficacy and Safety of Commercially Available Fixed-Ratio Combinations of Insulin Degludec/Liraglutide and Insulin Glargine/Lixisenatide: A Network Meta-analysis true true /api/journal/10015535 REVIEWED true false 10015535 false 10015535 true 1499-2671 1499-2671 Journal FOREIGN 47 4 368 377 368 10 2023 To compare the efficacy and safety of commercially available fixed ratio combinations (FRC) of glucagon-like peptide 1 receptor agonists (GLP-1RA) and basal insulins by a network meta-analysis (NMA) of randomised controlled trials (RCT) of type 2 diabetes patients.We report a systematic review and network meta-analyses of RCTs of type 2 diabetes patients randomized to FRCs or to their components for ≥24-weeks reported in PubMed or ClinicalTrials.gov until 28/FEB/2022. Primary outcome was attained HbA1c. Secondary outcomes included fasting plasma glucose, change in body weight, and incident hypoglycaemia. Treatment effects were estimated as mean differences and standard errors (MD; [SE]) or odds ratios (OR) with 95% confidence intervals (95%CI) using iGlarLixi as reference.We included 29 RCTs of the 1404 papers identified. No direct comparison between FRCs were found. After excluding some insulin capped trials to reach model consistency, both FRCs were more efficacious regarding HbA1c than their components, however no difference between FRCs were found (MD: -0.10 [SE: 0.10]%). The effect of IDegLira (-0.47 [0.24] mmol/l) and basal insulins was similar to that of iGlarLixi (ref.) on fasting glucose, while GLP-1RA had lower efficacy than iGlarLixi. Weight gain was lower with GLP-1RAs and IDegLira (-0.72 [0.32] kg) than iGlarLixi (ref.) and higher with basal insulins. Incident hypoglycemia (based on different definitions) was least frequent with GLP-1RAs followed by IDegLira (OR 0.78 95%CI 0.39-1.57), iGlarLixi (ref.) and basal insulins.Regarding HbA1c, both FRCs were more efficacious over their individual components with similar efficacies of the two FRCs. 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false false 2023-06-22T10:04:47.283+0000 Belgyógyászati és Onkológiai Klinika (SE / AOK / K); Doktori Iskola (SE); Népegészségtani Intézet (SE / AOK / I) 8 22 3 8 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 107220053 /api/authorship/107220053 1 0.125 true false true Author 10070314 /api/author/10070314 Visolyi Gergely true true Visolyi Gergely Á true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107220054 /api/authorship/107220054 2 0.125 false false false Author 10061261 /api/author/10061261 Domján Beatrix Annamária true 10061261 true Domján Beatrix A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107220055 /api/authorship/107220055 3 0.125 false false false Author 10027628 /api/author/10027628 Svébis Márk Márton true 10027628 true Svébis Márk M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107220056 /api/authorship/107220056 4 0.125 false false false Author 10084061 /api/author/10084061 Péterfi Anna true true Péterfi Anna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107220057 /api/authorship/107220057 5 0.125 false false false Author 10032100 /api/author/10032100 Lovász Barbara Dorottya true 10032100 true Lovász Barbara D true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107220058 /api/authorship/107220058 6 0.125 false false false Author 10024020 /api/author/10024020 Mészáros Szilvia true 10024020 true Mészáros Szilvia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107220059 /api/authorship/107220059 7 0.125 false false false Author 10035737 /api/author/10035737 Horváth Viktor József true 10035737 true Horváth Viktor J true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107220060 /api/authorship/107220060 8 0.125 false true false Author 10024030 /api/author/10024030 Tabák Ádám true 10024030 true Tabák Ádám G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 23312192 /api/publicationidentifier/23312192 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GREEN true IDENTICAL 10.1016/j.jcjd.2023.03.002 https://doi.org/10.1016/j.jcjd.2023.03.002 false true PublicationIdentifier 24202689 /api/publicationidentifier/24202689 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001024438100001 https://www.webofscience.com/wos/woscc/full-record/001024438100001 false true PublicationIdentifier 23558863 /api/publicationidentifier/23558863 PlainSource 3 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/api/keyword/1414857 true 1414857 true Keyword 1527284 /api/keyword/1527284 true true Keyword 1527858 /api/keyword/1527858 true true Keyword 2517402 /api/keyword/2517402 true true SjrRating 11376624 /api/sjrrating/11376624 57 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1310 /api/classificationexternal/1310 true 1310 true Q2 DIRECT true true /api/publication/33728442 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10070314"><a href="/gui2/?type=authors&mode=browse&sel=10070314" target="_blank">Visolyi Gergely Á ✉ (<span class="authorship-author-name">Visolyi Gergely</span> <span class="authorAux-mtmt"> klinikai</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Internal Medicine and Oncology; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061261"><a href="/gui2/?type=authors&mode=browse&sel=10061261" target="_blank">Domján Beatrix A (<span class="authorship-author-name">Domján Beatrix Annamária</span> <span class="authorAux-mtmt"> belgyógyászat, diabetológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Internal Medicine and Oncology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027628"><a href="/gui2/?type=authors&mode=browse&sel=10027628" target="_blank">Svébis Márk M (<span class="authorship-author-name">Svébis Márk Márton</span> <span class="authorAux-mtmt"> belgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Internal Medicine and Oncology; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10084061"><a href="/gui2/?type=authors&mode=browse&sel=10084061" target="_blank">Péterfi Anna (<span class="authorship-author-name">Péterfi Anna</span> <span class="authorAux-mtmt"> Megelőző orvostan és népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Public Health</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032100"><a href="/gui2/?type=authors&mode=browse&sel=10032100" target="_blank">Lovász Barbara D (<span class="authorship-author-name">Lovász Barbara Dorottya</span> <span class="authorAux-mtmt"> gastroenterologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Internal Medicine and Oncology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024020"><a href="/gui2/?type=authors&mode=browse&sel=10024020" target="_blank">Mészáros Szilvia (<span class="authorship-author-name">Mészáros Szilvia</span> <span class="authorAux-mtmt"> belgyógyászat, endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Internal Medicine and Oncology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10035737"><a href="/gui2/?type=authors&mode=browse&sel=10035737" target="_blank">Horváth Viktor J (<span class="authorship-author-name">Horváth Viktor József</span> <span class="authorAux-mtmt"> belgyógyászat, diabetológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Internal Medicine and Oncology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024030"><a href="/gui2/?type=authors&mode=browse&sel=10024030" target="_blank">Tabák Ádám G (<span class="authorship-author-name">Tabák Ádám</span> <span class="authorAux-mtmt"> belgyógyászat, diabetológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Public Health; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Internal Medicine and Oncology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33728442" target="_blank">Comparison of Efficacy and Safety of Commercially Available Fixed-Ratio Combinations of Insulin Degludec/Liraglutide and Insulin Glargine/Lixisenatide: A Network Meta-analysis</a></div> <div> <span class="journal-title">CANADIAN JOURNAL OF DIABETES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1499-2671">1499-2671</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1499-2671">1499-2671</a>)</span>: <span class="journal-volume">47</span> <span class="journal-issue">4</span> <span class="page"> pp 368-377 </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="10.1016/j.jcjd.2023.03.002" target="_blank" href="https://doi.org/10.1016/j.jcjd.2023.03.002"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001024438100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001024438100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85156112970" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85156112970"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36963632" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36963632&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Endocrinology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Endocrinology, Diabetes and Metabolism&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Internal Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 15</span> | Independent citation: 15 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 12 | Number of citations in Scopus:&nbsp;15 | WoS/Scopus assigned:&nbsp;15 | Number of citations with DOI:&nbsp;15 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33728442&sort=publishedYear,desc&sort=title"> Number of cited publications: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33728442</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (TKP2021-NKTA-47) </div> <div class="lastModified">Last Modified: 2026.04.27. 12:33 Edit Csajbók (SE_KK_Admin5_CSE, admin) </div> </div></div>