https://m2.mtmt.hu/ eng 2026-05-31 01:50 JournalArticle 33720677 VALIDATED true Department of Measurement and Information Systems, Budapest University of Technology and Economics, Muegyetem Rkp. 3., Budapest, 1111, Hungary Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Nagyvarad ter 4., Budapest, 1089, Hungary NAP3.0-SE Neuropsychopharmacology Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, Hungary Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto, Japan SE-NAP2 Genetic Brain Imaging Migraine Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, Hungary Department of Psychiatry and Psychotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary School of Health Sciences, University of Manchester, Manchester, United Kingdom Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom Export Date: 30 June 2023 Correspondence Address: Juhasz, G.; Department of Pharmacodynamics, Nagyvarad ter 4., Hungary; email: juhasz.gabriella@pharma.semmelweis-univ.hu 0 false 2026-05-28T09:53:30.620+0000 2026-02-23T13:26:00.732+0000 2023-03-28T11:15:18.235+0000 true 10030040 Ruzsits Ágnes /api/admin/10030040 Admin true 10030040 2026-02-23T13:26:01.369+0000 2026-02-23T13:26:01.369+0000 2024-03-04T10:44:04.490+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Bruncsics, Bence Genetic risk of depression is different in subgroups of dietary ratio of tryptophan to large neutral amino acids true true /api/journal/10019966 REVIEWED true false 10019966 false 10019966 true 2045-2322 Journal FOREIGN 13 1 4976 4976 14 2023 Manipulation of intake of serotonin precursor tryptophan has been exploited to rapidly induce and alleviate depression symptoms. While studies show that this latter effect is dependent on genetic vulnerability to depression, the effect of habitual tryptophan intake in the context of predisposing genetic factors has not been explored. Our aim was to investigate the effect of habitual tryptophan intake on mood symptoms and to determine the effect of risk variants on depression in those with high and low tryptophan intake in the whole genome and specifically in serotonin and kynurenine pathways. 63,277 individuals in the UK Biobank with data on depressive symptoms and tryptophan intake were included. We compared two subpopulations defined by their habitual diet of a low versus a high ratio of tryptophan to other large amino acids (TLR). A modest protective effect of high dietary TLR against depression was found. NPBWR1 among serotonin genes and POLI in kynurenine pathway genes were significantly associated with depression in the low but not in the high TLR group. Pathway-level analyses identified significant associations for both serotonin and kynurenine pathways only in the low TLR group. In addition, significant association was found in the low TLR group between depressive symptoms and biological process related to adult neurogenesis. Our findings demonstrate a markedly distinct genetic risk profile for depression in groups with low and high dietary TLR, with association with serotonin and kynurenine pathway variants only in case of habitual food intake leading to low TLR. Our results confirm the relevance of the serotonin hypothesis in understanding the neurobiological background of depression and highlight the importance of understanding its differential role in the context of environmental variables such as complexity of diet in influencing mental health, pointing towards emerging possibilities of personalised prevention and intervention in mood disorders in those who are genetically vulnerable. Funding 2025174 /api/funding/2025174 false true Funding 2027880 /api/funding/2027880 false true Funding 2027881 /api/funding/2027881 false true Funding 2027882 /api/funding/2027882 false true Funding 2027883 /api/funding/2027883 false true Funding 2027884 /api/funding/2027884 false true Funding 2027885 /api/funding/2027885 false true Funding 2027886 /api/funding/2027886 false true Funding 2027887 /api/funding/2027887 false true Funding 2064422 /api/funding/2064422 false true true 2023 true true true false true false GOLD 2026-05-28 true https://doi.org/10.1038/s41598-023-31495-x 6 0 6 6 0 6 6 4 3 4 4 4 4 6 0 0 6 6 6 6 0 5 5 Folyóiratcikk Journal Article 24 5 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 3 3 3 3 2025 0 2 2 2 2 2026 0 1 1 1 1 D1 A nemzetközi false 10003491,10068445,10041077,10062733 false false false 2023-04-03T07:50:57.311+0000 Gyógyszerhatástani Intézet (SE / GYTK); Méréstechnika és Információs Rendszerek Tanszék (BME / VIK); NAP3.0-SE Neuropszichofarmakológiai Kutatócsoport (SE / GYTK / GYHATAS); Pszichiátriai és Pszichoterápiás Klinika (SE / AOK / K); SE-NAP 2 Genetikai Agyi Képalkotó Migrén Kutató... 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10.1186/s12859-018-2475-9 false true Reference 39650860 /api/reference/39650860 74 10.1038/ng.3211 false true /api/publication/33720677 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10062733"><a href="/gui2/?type=authors&mode=browse&sel=10062733" target="_blank">Bruncsics Bence (<span class="authorship-author-name">Bruncsics Bence</span> <span class="authorAux-mtmt"> Informatika</span>) </a> </span> <span class="author-affil"><span title="Budapest University of Technology and Economics">BUTE</span>/<span title="Faculty of Electrical Engineering and Informatics">FEEI</span>/Department of Measurement and Information Systems</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10041077"><a href="/gui2/?type=authors&mode=browse&sel=10041077" target="_blank">Hullam Gabor<sup>*</sup> (<span class="authorship-author-name">Hullám Gábor István</span> <span class="authorAux-mtmt"> informatika</span>) </a> </span> <span class="author-affil"><span title="Budapest University of Technology and Economics">BUTE</span>/<span title="Faculty of Electrical Engineering and Informatics">FEEI</span>/Department of Measurement and Information Systems; <span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10042817"><a href="/gui2/?type=authors&mode=browse&sel=10042817" target="_blank">Bolgar Bence<sup>*</sup> (<span class="authorship-author-name">Bolgár Bence Márton</span> <span class="authorAux-mtmt"> bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Budapest University of Technology and Economics">BUTE</span>/<span title="Faculty of Electrical Engineering and Informatics">FEEI</span>/Department of Measurement and Information Systems</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024138"><a href="/gui2/?type=authors&mode=browse&sel=10024138" target="_blank">Petschner Peter (<span class="authorship-author-name">Petschner Péter</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics; <span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/<span title="Department of Pharmacodynamics">DP</span>/NAP3.0-SE Neuropsychopharmacology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10041129"><a href="/gui2/?type=authors&mode=browse&sel=10041129" target="_blank">Millinghoffer Andras (<span class="authorship-author-name">Millinghoffer András Dániel</span> <span class="authorAux-mtmt"> információs rendszerek</span>) </a> </span> <span class="author-affil"><span title="Budapest University of Technology and Economics">BUTE</span>/<span title="Faculty of Electrical Engineering and Informatics">FEEI</span>/Department of Measurement and Information Systems; <span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/<span title="Department of Pharmacodynamics">DP</span>/NAP3.0-SE Neuropsychopharmacology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10068445"><a href="/gui2/?type=authors&mode=browse&sel=10068445" target="_blank">Gecse Kinga (<span class="authorship-author-name">Gecse Kinga</span> <span class="authorAux-mtmt"> Farmakológia és Idegtudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics; <span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/<span title="Department of Pharmacodynamics">DP</span>/SE-NAP 2 Genetic Brain Imaging Migraine Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10045710"><a href="/gui2/?type=authors&mode=browse&sel=10045710" target="_blank">Eszlari Nora (<span class="authorship-author-name">Eszlári Nóra</span> <span class="authorAux-mtmt"> Pszichiátriai genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics; <span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/<span title="Department of Pharmacodynamics">DP</span>/NAP3.0-SE Neuropsychopharmacology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003491"><a href="/gui2/?type=authors&mode=browse&sel=10003491" target="_blank">Gonda Xenia (<span class="authorship-author-name">Gonda Xénia</span> <span class="authorAux-mtmt"> Pszichiátria, pszichiátriai genetika, farmakoló...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Pszichiátriai és Pszichoterápiás Klinika; <span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/<span title="Department of Pharmacodynamics">DP</span>/NAP3.0-SE Neuropsychopharmacology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jones Debra J. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Burden Sorrel T. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10041166"><a href="/gui2/?type=authors&mode=browse&sel=10041166" target="_blank">Antal Peter (<span class="authorship-author-name">Antal Péter</span> <span class="authorAux-mtmt"> bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Budapest University of Technology and Economics">BUTE</span>/<span title="Faculty of Electrical Engineering and Informatics">FEEI</span>/Department of Measurement and Information Systems</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Deakin Bill </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001318"><a href="/gui2/?type=authors&mode=browse&sel=10001318" target="_blank">Bagdy Gyorgy (<span class="authorship-author-name">Bagdy György</span> <span class="authorAux-mtmt"> Neuropszichofarmakológia, gyógyszertan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics; <span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/<span title="Department of Pharmacodynamics">DP</span>/NAP3.0-SE Neuropsychopharmacology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017483"><a href="/gui2/?type=authors&mode=browse&sel=10017483" target="_blank">Juhasz Gabriella ✉ (<span class="authorship-author-name">Juhász Gabriella</span> <span class="authorAux-mtmt"> Neurológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics; <span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/<span title="Department of Pharmacodynamics">DP</span>/SE-NAP 2 Genetic Brain Imaging Migraine Research Group; <span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/<span title="Department of Pharmacodynamics">DP</span>/NAP3.0-SE Neuropsychopharmacology Research Group</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33720677" target="_blank">Genetic risk of depression is different in subgroups of dietary ratio of tryptophan to large neutral amino acids</a></div> <div> <span class="journal-title">SCIENTIFIC REPORTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2045-2322">2045-2322</a>)</span>: <span class="journal-volume">13</span> <span class="journal-issue">1</span> <span class="page"> Paper 4976. 14 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1038/s41598-023-31495-x" target="_blank" href="https://doi.org/10.1038/s41598-023-31495-x"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000984110600050" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000984110600050"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85150991779" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85150991779"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36973313" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36973313&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="8963237766119218219" target="_blank" href="http://scholar.Google.com/scholar?hl=en&lr=&cluster=8963237766119218219"> Google scholar </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Committee on Sociology HASSELIX SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Committee on Regional Studies HASSELIX RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 6</span> | Independent citation: 6 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 4 | Number of citations in Scopus:&nbsp;3 | WoS/Scopus assigned:&nbsp;4 | Number of citations with DOI:&nbsp;6 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33720677&sort=publishedYear,desc&sort=title"> Number of cited publications: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33720677</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (Open access funding provided by Semmelweis University), Hungarian National Brain Research Program(2017-1.2.1-NKP-2017-00002), National Brain Programme(NAP2022-I-4/2022 3.0), (2019-2.1.7-ERA-NET-2020-00005) Funder: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal, (ÚNKP-22-3-II-SE-27), (ÚNKP-22-4-II-SE-1), Tématerületi Kiválósági Program(2020-4.1.1.-TKP2020), (TKP2021-EGA-25), (139330), (Artificial Intelligence National Laboratory Programme) Funder: NRDIO </div> <div class="lastModified">Last Modified: 2026.02.23. 14:26 Katalin Andódy (BME admin4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Department of Measurement and Information Systems, Budapest University of Technology and Economics, Muegyetem Rkp. 3., Budapest, 1111, Hungary Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Nagyvarad ter 4., Budapest, 1089, Hungary NAP3.0-SE Neuropsychopharmacology Research Group, Hungarian Brain Research Program, Semm...</pre> </div></div>