https://m2.mtmt.hu/ hun 2026-09-23 02:37 JournalArticle 33709059 VALIDATED true Journal Article; Review 0 false 2026-07-20T12:06:20.312+0000 2025-03-06T12:23:11.125+0000 2023-03-21T12:11:05.729+0000 true 10078148 Havas Petra /api/admin/10078148 Admin true 2026-07-20T12:01:16.556+0000 2025-03-06T12:23:11.401+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Gonda, Xenia How to save a life: From neurobiological underpinnings to psychopharmacotherapies in the prevention of suicide. true true /api/journal/3624 REVIEWED true false 3624 false 3624 true 0163-7258 1879-016X Journal FOREIGN 244 108390 108390 15 2023 The impact of suicide on our societies, mental healthcare, and public health is beyond questionable. Every year approximately 700 000 lives are lost due to suicide around the world (WHO, 2021); more people die by suicide than by homicide and war. Although suicide is a key issue and reducing suicide mortality is a global imperative, suicide is a highly complex biopsychosocial phenomenon, and in spite of several suicidal models developed in recent years and a high number of suicide risk factors identified, we still have neither a sufficient understanding of underpinnings of suicide nor adequate management strategies to reduce its prevalence. The present paper first overviews the background of suicidal behavior including its epidemiology, prevalence, age and gender correlations and its association with neuropsychiatric disorders as well as its clinical assessment. Then we give an overview of the etiological background, including its biopsychosocial contexts, genetics and neurobiology. Based on the above, we then provide a critical overview of the currently available intervention options to manage and reduce risk of suicide, including psychotherapeutic modalities, traditional medication classes also providing an up-to-date overview on the antisuicidal effects of lithium, as well as novel molecules such as esketamine and emerging medications and further molecules in development. Finally we give a critical overview on our current knowledge on using neuromodulatory and biological therapies, such as ECT, rTMS, tDCS and other options. Funding 2026306 /api/funding/2026306 false true Funding 2026307 /api/funding/2026307 false true true true 2023 true true true false true false NONE 2026-07-20 false 8 0 8 6 2 8 8 7 8 8 8 6 6 6 2 0 8 6 8 6 0 7 7 Folyóiratcikk Journal Article 24 8 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 1 0 1 0 2024 0 5 4 5 4 2025 0 2 2 2 2 D1 false 10003491 false false false 2023-04-27T08:01:50.716+0000 NAP3.0-SE Neuropszichofarmakológiai Kutatócsoport (SE / GYTK / GYHATAS); Nyírő Gyula Kórház (OMIII); Országos Mentális, Ideggyógyászati és Idegsebés...; Pszichiátriai és Pszichoterápiás Klinika (SE / AOK / K) 2 27 4 4 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 107083197 /api/authorship/107083197 1 0.25 true false true Author 10003491 /api/author/10003491 Gonda Xénia true 10003491 true Gonda Xenia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107083198 /api/authorship/107083198 2 0.25 false false false Author 10023468 /api/author/10023468 Döme Péter true 10023468 true Dome Peter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107083199 /api/authorship/107083199 3 0.25 false false false Serafini Gianluca true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107083200 /api/authorship/107083200 4 0.25 false true false Pompili Maurizio true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 23260811 /api/publicationidentifier/23260811 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1016/j.pharmthera.2023.108390 https://doi.org/10.1016/j.pharmthera.2023.108390 false true PublicationIdentifier 23453602 /api/publicationidentifier/23453602 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000961430200001 https://www.webofscience.com/wos/woscc/full-record/000961430200001 true true PublicationIdentifier 23367444 /api/publicationidentifier/23367444 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85150500582 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85150500582 false true PublicationIdentifier 23260810 /api/publicationidentifier/23260810 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 36940791 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36940791&dopt=Abstract false true Classification 12317 /api/classification/12317 true true Keyword 3185 /api/keyword/3185 true 3185 true Keyword 17621 /api/keyword/17621 true 17621 true Keyword 20800 /api/keyword/20800 true 20800 true Keyword 1009523 /api/keyword/1009523 true 1009523 true Keyword 1029659 /api/keyword/1029659 true 1029659 true Keyword 1696159 /api/keyword/1696159 true true SjrRating 11406445 /api/sjrrating/11406445 2 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2736 /api/classificationexternal/2736 true 2736 true D1 DIRECT true true /api/publication/33709059 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10003491"><a href="/gui2/?type=authors&mode=browse&sel=10003491" target="_blank">Gonda Xenia ✉ (<span class="authorship-author-name">Gonda Xénia</span> <span class="authorAux-mtmt"> Pszichiátria, pszichiátriai genetika, farmakoló...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pszichiátriai és Pszichoterápiás Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/<span title="Gyógyszerhatástani Intézet">GYHATAS</span>/NAP3.0-SE Neuropszichofarmakológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023468"><a href="/gui2/?type=authors&mode=browse&sel=10023468" target="_blank">Dome Peter (<span class="authorship-author-name">Döme Péter</span> <span class="authorAux-mtmt"> pszichiátria</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pszichiátriai és Pszichoterápiás Klinika; Országos Mentális, Ideggyógyászati és Idegsebészeti Intézet; <span title="Országos Mentális, Ideggyógyászati és Idegsebészeti Intézet">OMIII</span>/Nyírő Gyula Kórház</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Serafini Gianluca </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pompili Maurizio </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33709059" target="_blank">How to save a life: From neurobiological underpinnings to psychopharmacotherapies in the prevention of suicide.</a></div> <div> <span class="journal-title">PHARMACOLOGY & THERAPEUTICS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0163-7258">0163-7258</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1879-016X">1879-016X</a>)</span>: <span class="journal-volume">244</span> <span class="page"> Paper 108390. 15 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.pharmthera.2023.108390" target="_blank" href="https://doi.org/10.1016/j.pharmthera.2023.108390"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000961430200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000961430200001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85150500582" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85150500582"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36940791" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36940791&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmacology (medical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmacology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 8</span> | Független: 6 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 7 | Scopus jelölt:&nbsp;8 | WoS/Scopus jelölt:&nbsp;8 | DOI jelölt:&nbsp;8 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33709059&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33709059</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (Hungarian Brain Research Program 3.0 (NAP 3.0) 2022–2025), (TKP2021-EGA-25) </div> <div class="lastModified">Utolsó módosítás: 2025.03.06. 13:23 Molnár-Taga Márta (SE 4-es admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Journal Article; Review</pre> </div></div>