Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high
cardiovascular risk
Fitchett, David; Zinman, Bernard; Wanner, Christoph; Lachin, John M; Hantel, Stefan; Salsali, Afshin; Johansen, Odd Erik; Woerle, Hans J; Broedl, Uli C; Inzucchi, Silvio E; Aizenberg, D [Collaborator]; EMPA-REG OUTCOME® trial investigators [Collaborative Organization]; Ulla, M [Collaborator]; Waitman, J [Collaborator]; De Loredo, L [Collaborator]; Farias, J [Collaborator]; Fideleff, H [Collaborator]; Lagrutta, M [Collaborator]; Maldonado, N [Collaborator]; Colombo, H [Collaborator]; Pacora, FF [Collaborator]; Wasserman, A [Collaborator]; Maffei, L [Collaborator]; Lehman, R [Collaborator]; Selvanayagam, J [Collaborator]; d'Emden, M [Collaborator]; Fasching, P [Collaborator]; Paulweber, B [Collaborator]; Toplak, H [Collaborator]; Luger, A [Collaborator]; Drexel, H [Collaborator]; Prager, R [Collaborator]; Schnack, C [Collaborator]; Schernthaner, G [Collaborator]; Fliesser-Gorzer, E [Collaborator]; Kaser, S [Collaborator]; Scheen, A [Collaborator]; Van, Gaal L [Collaborator]; Hollanders, G [Collaborator]; Kockaerts, Y [Collaborator]; Capiau, L [Collaborator]; Chachati, A [Collaborator]; Persu, A [Collaborator]; Hermans, M [Collaborator]; Vantroyen, D [Collaborator]; Vercammen, C [Collaborator]; Van, de Borne P [Collaborator]; Mathieu, C [Collaborator]; Benhalima, K [Collaborator]; Lienart, F [Collaborator]; Mortelmans, J [Collaborator]; Strivay, M [Collaborator]; Vereecken, G [Collaborator]; Keymeulen, B [Collaborator]; Lamkanfi, F [Collaborator]; Chacra, A [Collaborator]; Eliaschewitz, F [Collaborator]; Zanella, M [Collaborator]; Faludi, A [Collaborator]; Bertolami, M [Collaborator]; Hayashida, C [Collaborator]; Salles, JN [Collaborator]; Monte, O [Collaborator]; Dinato, M [Collaborator]; Manenti, E [Collaborator]; Rassi, N [Collaborator]; Halpern, A [Collaborator]; Lima, M [Collaborator]; Ayoub, J [Collaborator]; Felicio, J [Collaborator]; Borges, J [Collaborator]; Gross, J [Collaborator]; Sgarbi, J [Collaborator]; Betti, R [Collaborator]; Tiburcio, A [Collaborator]; Purisch, S [Collaborator]; Schmid, H [Collaborator]; Takahashi, M [Collaborator]; Castro, M [Collaborator]; Rea, R [Collaborator]; Hissa, M [Collaborator]; Neto, BG [Collaborator]; Saraiva, J [Collaborator]; Henein, S [Collaborator]; Lochnan, H [Collaborator]; Imran, SA [Collaborator]; Clayton, D [Collaborator]; Bayly, K [Collaborator]; Berlingieri, J [Collaborator]; Boucher, P [Collaborator]; Chan, Y [Collaborator]; Gupta, M [Collaborator]; Chehayeb, R [Collaborator]; Ouellett, A [Collaborator]; Ur, E [Collaborator]; Woo, V [Collaborator]; Zinman, B [Collaborator]; St, Amour E [Collaborator]; Lozano, MT [Collaborator]; Lozno, HY [Collaborator]; Urina, M [Collaborator]; Jaramillo, PL [Collaborator]; Jaramillo, N [Collaborator]; Sanchez, G [Collaborator]; Perez, G [Collaborator]; Tusek, S [Collaborator]; Mirosevic, G [Collaborator]; Goldoni, V [Collaborator]; Jurisic-Erzen, D [Collaborator]; Balasko, A [Collaborator]; Balic, S [Collaborator]; Drvodelic-Sunic, E [Collaborator]; Varzic, SC [Canecki-Varzic, Silvija (Endocrinology), Collaborator]; Machkova, M [Collaborator]; Weiner, P [Collaborator]; Lastuvka, J [Collaborator]; Olsovsky, J [Collaborator]; Krarup, T [Collaborator]; Ridderstrale, M [Collaborator]; Tarnow, L [Collaborator]; Boesgaard, TW [Collaborator]; Lihn, AS [Collaborator]; Christensen, P [Collaborator]; Juhl, H [Collaborator]; Urhammer, S [Collaborator]; Lund, P [Collaborator]; Adojaan, B [Collaborator]; Jakovlev, U [Collaborator]; Lanno, R [Collaborator]; Lubi, M [Collaborator]; Marandi, T [Collaborator]; Gouet, D [Collaborator]; Courreges, J [Collaborator]; Zaoui, P [Collaborator]; Choukroun, G [Collaborator]; Petit, C [Collaborator]; Formagne, L [Collaborator]; Estour, B [Collaborator]; Mabire, P [Collaborator]; Daugenet, C [Collaborator]; Lemarie, B [Collaborator]; Clavel, S [Collaborator]; Aure, P [Collaborator]; Remaud, P [Collaborator]; Halimi, J [Collaborator]; Hadjadj, S [Collaborator]; Couffinhal, T [Collaborator]; Glonti, S [Collaborator]; Metreveli, D [Collaborator]; Lominadze, Z [Collaborator]; Giorgadze, E [Collaborator]; Burtchuladze, T [Collaborator]; Javashvili, L [Collaborator]; Kurashvili, G [Collaborator]; Kurashvili, R [Collaborator]; Virsaladze, D [Collaborator]; Nadareishvili, L [Collaborator]; Khomasuridze, A [Collaborator]; Cahill, T [Collaborator]; Green, F [Collaborator]; MacRury, S [Collaborator]; Waldron, M [Collaborator]; Middleton, A [Collaborator]; McKnight, J [Collaborator]; Pearson, E [Collaborator]; Butler, M [Collaborator]; Choksi, M [Collaborator]; Caldwell, I [Collaborator]; Farmer, I [Collaborator]; Wyatt, N [Collaborator]; Patrick, J [Collaborator]; O'Brien, I [Collaborator]; Devers, M [Collaborator]; Bousboulas, S [Collaborator]; Pappas, S [Collaborator]; Piaditis, G [Collaborator]; Vryonidou, A [Collaborator]; Tentolouris, N [Collaborator]; Karamitsos, K [Collaborator]; Manes, C [Collaborator]; Benroubi, M [Collaborator]; Avramidis, I [Collaborator]; Ozaki, R [Collaborator]; Tan, K [Collaborator]; Siu, S [Collaborator]; Tsang, C [Collaborator]; Dudas, M [Collaborator]; Nagy, K [Collaborator]; Salamon, C [Collaborator]; Ip, T [Collaborator]; Gero, L [Gerő, László (Endokrinológia, a...), Collaborator] Department of Internal
Medicine and Oncology (SU / FM / C); Patkay, J [Collaborator]; Tabak, A [Tabák, Ádám (belgyógyászat, di...), Collaborator] Department of Internal
Medicine and Oncology (SU / FM / C); Juhasz, F [Collaborator]; Szentpeteri, I [Collaborator]; Tamas, G [Collaborator]; Ghaisas, N [Collaborator]; Bantwal, G [Collaborator]; Mohan, V [Collaborator]; Gupta, J [Collaborator]; Sadhu, N [Collaborator]; Kulkarni, A [Collaborator]; Garg, N [Collaborator]; Reddy, S [Collaborator]; Deshpande, N [Collaborator]; Gutlapalli, K [Collaborator]; Pillai, M [Collaborator]; Premchand, R [Collaborator]; Badgandi, M [Collaborator]; Jain, S [Collaborator]; Aravind, S [Collaborator]; Shamanna, P [Collaborator]; Pandey, A [Collaborator]; Gupta, S [Collaborator]; Pramono, B [Collaborator]; Saksono, HD [Collaborator]; Agung, P [Collaborator]; Wahono, SD [Collaborator]; Suastika, K [Collaborator]; Tanggo, Y [Collaborator]; Juwana, Y [Collaborator]; Siswanto, B [Collaborator]; Adawi, F [Collaborator]; Efrati, S [Collaborator]; Mazen, E [Collaborator]; Bashkin, A [Collaborator]; Herskovits, T [Collaborator]; Jaffe, A [Collaborator]; Schiff, E [Collaborator]; Wainstein, J [Collaborator]; Taddei, S [Collaborator]; Aiello, A [Collaborator]; Arca, M [Collaborator]; Calabro, P [Collaborator]; Cignarelli, M [Collaborator]; Fioretto, P [Collaborator]; Reggiani, GM [Collaborator]; Gnasso, A [Collaborator]; Marchionni, N [Collaborator]; Marsilii, A [Collaborator]; Bucci, M [Collaborator]; Mezzetti, A [Collaborator]; Pozzilli, P [Collaborator]; Colivicchi, F [Collaborator]; Santini, M [Collaborator]; Moro, E [Collaborator]; Toscano, V [Collaborator]; Fucili, A [Collaborator]; Semplicini, A [Collaborator]; Monno, S [Collaborator]; Furui, K [Collaborator]; Higashiue, S [Collaborator]; Hiramatsu, N [Collaborator]; Kawamitsu, K [Collaborator]; Takenaka, T [Collaborator]; Takahashi, H [Collaborator]; Hojo, F [Collaborator]; Onishi, Y [Collaborator]; Izumino, K [Collaborator]; Okubo, M [Collaborator]; Wakida, Y [Collaborator]; Kondo, Y [Collaborator]; Hieshima, K [Collaborator]; Jinnouchi, H [Collaborator]; Suzuki, A [Collaborator]; Ito, M [Collaborator]; Park, S [Collaborator]; Kim, Y [Collaborator]; Hong, T [Collaborator]; Park, H [Collaborator]; Gwon, H [Collaborator]; Kim, H [Collaborator]; Kang, K [Collaborator]; Jeong, M [Collaborator]; Seung, K [Collaborator]; Lim, D [Collaborator]; Rha, S [Collaborator]; Tahk, S [Collaborator]; Yang, J [Collaborator]; Yoon, J [Collaborator]; Shin, M [Collaborator]; Kim, D [Collaborator]; Jeong, J [Collaborator]; Ahmad, NN [Collaborator]; Mustafa, N [Collaborator]; Mohamed, WW [Collaborator]; Fung, Y [Collaborator]; Ghani, RA [Collaborator]; Chandramouli, A [Collaborator]; Chee, K [Collaborator]; Kadir, KA [Collaborator]; Ling, K [Collaborator]; Abu, Hassan M [Collaborator]; Foo, S [Collaborator]; Lee, S [Collaborator]; Hernandez, PG [Collaborator]; Aguilar-Salinas, C [Collaborator]; Velazquez, MV [Collaborator]; Flores, F [Collaborator]; Salazar, MA [Collaborator]; Escalante, DM [Collaborator]; Soria, MG [Collaborator]; Munoz, EC [Collaborator]; Storms, G [Collaborator]; Schaper, N [Collaborator]; Kooy, A [Collaborator]; Krekels, M [Collaborator]; van Bemmel, T [Collaborator]; Verhoeven, R [Collaborator]; Mulder, H [Collaborator]; Oldenburg-Ligtenberg, P [Collaborator]; Gonkel, F [Collaborator]; de Jong, A [Collaborator]; van Soest, J [Collaborator]; Viergever, P [Collaborator]; Mevissen, H [Collaborator]; Lochorn, G [Collaborator]; Zwiers, G [Collaborator]; Hoogslag, P [Collaborator]; Ronner, E [Collaborator]; Nierop, P [Collaborator]; Al-Windy, N [Collaborator]; Kragten, J [Collaborator]; Dekelver, P [Collaborator]; Benatar, J [Collaborator]; Krebs, J [Collaborator]; Scott, R [Collaborator]; Heggen, E [Collaborator]; Berz, A [Collaborator]; Fossum, C [Collaborator]; Hurtig, U [Collaborator]; Langslet, G [Collaborator]; Baranowski, M [Collaborator]; Sparby, J [Collaborator]; Karlsson, T [Collaborator]; Karlsson, T [Collaborator]; Torres, CD [Collaborator]; Escudero, AR [Collaborator]; Lisson, R [Collaborator]; Maldonado, AA [Collaborator]; Rojas, WG [Collaborator]; Bravo, LG [Collaborator]; Osores, JL [Collaborator]; Farfan, J [Collaborator]; Zapata, L [Collaborator]; Junchaya, JG [Collaborator]; Concha, YR [Collaborator]; Calderon, JU [Collaborator]; Sy, R [Collaborator]; Tan, G [Collaborator]; Aquitania, G [Collaborator]; De Los, Santos G [Collaborator]; Panelo, A [Collaborator]; Roderos, O [Collaborator]; Rosales, R [Collaborator]; Toledo, R [Collaborator]; Liwag, A [Collaborator]; Ramoncito, H [Collaborator]; Skokowska, E [Collaborator]; Krzyzagorska, E [Collaborator]; Ogorek, M [Collaborator]; Wojnowski, L [Collaborator]; Spyra, J [Collaborator]; Konieczny, M [Collaborator]; Piesiewicz, W [Collaborator]; Kus, W [Collaborator]; Ocicka-Kozakiewicz, A [Collaborator]; Orlowska-Kunikowska, E [Collaborator]; Zmuda, W [Collaborator]; Duarte, S [Collaborator]; Leitao, A [Collaborator]; Monteiro, P [Collaborator]; Rita, H [Collaborator]; Salgado, V [Collaborator]; Pinto, L [Collaborator]; Queiros, J [Collaborator]; Teixeira, J [Collaborator]; Rogado, C [Collaborator]; Duarte, R [Collaborator]; do, Rosario FS [Collaborator]; Silva, A [Collaborator]; Andrade, L [Collaborator]; Velez, M [Collaborator]; Brazao, M [Collaborator]; Istratoaie, O [Collaborator]; Lichiardopol, R [Collaborator]; Catrinoiu, D [Collaborator]; Militaru, C [Collaborator]; Zetu, C [Collaborator]; Barbonta, D [Collaborator]; Cosma, D [Collaborator]; Crisan, C [Collaborator]; Pop, L [Collaborator]; Esip, V [Collaborator]; Khetagurova, F [Collaborator]; Petrov, A [Collaborator]; Arutyunov, G [Collaborator]; Boyarkin, M [Collaborator]; Agafyina, A [Collaborator]; Vorokhobina, N [Collaborator]; Petunina, N [Collaborator]; Libov, I [Collaborator]; Zalevskaya, A [Collaborator]; Nikolaev, K [Collaborator]; Barbarash, O [Collaborator]; Potemkin, V [Collaborator]; Bystrova, A [Collaborator]; Krasilnikova, E [Collaborator]; Barbarich, V [Collaborator]; Chumakova, G [Collaborator]; Tarasov, N [Collaborator]; Meleshkevich, T [Collaborator]; Zateyshchikov, D [Collaborator]; Lantseva, O [Collaborator]; Belenkiy, D [Collaborator]; Obrezan, A [Collaborator]; Rossolko, L [Collaborator]; Fillipova, E [Collaborator]; Yakhontova, P [Collaborator]; Khokhlov, A [Collaborator]; Tan, R [Collaborator]; Sum, C [Collaborator]; Chang, H [Collaborator]; Distiller, L [Collaborator]; Pretorius, M [Collaborator]; Nortje, H [Collaborator]; Mitha, E [Collaborator]; Burgess, L [Collaborator]; Blignaut, S [Collaborator]; Venter, T [Collaborator]; Moodley, R [Collaborator]; Lombaard, J [Collaborator]; Govind, U [Collaborator]; Naidoo, V [Collaborator]; Mookadam, M [Collaborator]; Engelbrecht, J [Collaborator]; Omar, M [Collaborator]; Jurgens, J [Collaborator]; Podgorski, G [Collaborator]; Vawda, H [Collaborator]; Naidoo, D [Collaborator]; Emanuel, S [Collaborator]; Roodt, A [Collaborator]; Amod, A [Collaborator]; Van, Zyl L [Collaborator]; Segura, J [Collaborator]; Brito, M [Collaborator]; Fernandez-Cruz, A [Collaborator]; Artola, S [Collaborator]; Iglesias, R [Collaborator]; Toural, E [Collaborator]; Garcia-Ortiz, L [Collaborator]; Saban, J [Collaborator]; Mesa, J [Collaborator]; Vidal, J [Collaborator]; Linares, J [Collaborator]; del, Canizo F [Collaborator]; Rigla, M [Collaborator]; Suarez, C [Collaborator]; Llorente, I [Collaborator]; Moreno, B [Collaborator]; Antoli, A [Collaborator]; Peralta, FG [Collaborator]; Iglesias, M [Collaborator]; Pereg, V [Collaborator]; de Teresa, L [Collaborator]; Camafort, M [Collaborator]; Trescoli, C [Collaborator]; Satarasinghe, R [Collaborator]; Somasundaram, N [Collaborator]; Siyambalapitiya, S [Collaborator]; Antonypillai, C [Collaborator]; Bulugahapitiya, D [Collaborator]; Medagama, U [Collaborator]; Huang, C [Collaborator]; Lu, Y [Collaborator]; Hwang, J [Collaborator]; Chiang, C [Collaborator]; Wen, M [Collaborator]; Chen, J [Collaborator]; Lai, W [Collaborator]; Chang, K [Collaborator]; Wang, J [Collaborator]; Yeh, H [Collaborator]; Kriangsak, P [Collaborator]; Deerochanawong, C [Collaborator]; Suwanwalaikorn, S [Collaborator]; Mangklabruks, A [Collaborator]; Kaewsuwanna, P [Collaborator]; Piyayotai, D [Collaborator]; Iabluchanskyi, M [Collaborator]; Samoylov, O [Collaborator]; Godlevska, O [Collaborator]; Kovalyova, O [Collaborator]; Voloshyna, O [Collaborator]; Tseluyko, V [Collaborator]; Zotov, S [Collaborator]; Vykhovanyuk, I [Collaborator]; Dulgeroff, A [Collaborator]; Mayfield, R [Collaborator]; Zaniewski-Singh, M [Collaborator]; Ullal, J [Collaborator]; Aloi, J [Collaborator]; De La Rosa, R [Collaborator]; Mosely, J [Collaborator]; Wittmer, B [Collaborator]; Aronoff, S [Collaborator]; Rosenfeld, J [Collaborator]; Seidner, M [Collaborator]; Warren, M [Collaborator]; Fishman, N [Collaborator]; Weiss, R [Collaborator]; Arif, A [Collaborator]; Sandberg, M [Collaborator]; Lewis, D [Collaborator]; Ball, E [Collaborator]; Graf, R [Collaborator]; Breton, C [Collaborator]; Tamayo, R [Collaborator]; Richards, R [Collaborator]; Cefalu, W [Collaborator]; Uwaifo, G [Collaborator]; Zayour, D [Collaborator]; Hoffman, J [Collaborator]; Fitz-Patrick, D [Collaborator]; Khan, B [Collaborator]; Blaze, K [Collaborator]; Bressler, P [Collaborator]; Halpern, S [Collaborator]; Chappell, D [Collaborator]; Bergenstal, R [Collaborator]; Cuddihy, R [Collaborator]; Matfin, G [Collaborator]; Freedman, Z [Collaborator]; Gonzalez-Campoy, J [Collaborator]; Lerman, S [Collaborator]; Rendell, M [Collaborator]; Sitar, S [Collaborator]; Reeves, M [Collaborator]; Howard, T [Collaborator]; Soufer, J [Collaborator]; Miranda-Palma, B [Collaborator]; Laliotis, A [Collaborator]; Shomali, M [Collaborator]; Teltser, M [Collaborator]; Hurley, D [Collaborator]; Morawski, E [Collaborator]; Cherlin, R [Collaborator]; Houchin, V [Collaborator]; Welch, M [Collaborator]; Goytia-Leos, D [Collaborator]; Syed, M [Collaborator]; Kowaloff, E [Collaborator]; Weinrauch, L [Collaborator]; Peniston, J [Collaborator]; Brockmyre, A [Collaborator]; First, B [Collaborator]; Feld, L [Collaborator]; Huffman, D [Collaborator]; Nassim, O [Collaborator]; Gottschlich, G [Collaborator]; Patel, A [Collaborator]; Knopke, C [Collaborator]; Hernandez, M [Collaborator]; Diaz, J [Collaborator]; Giugliano, G [Collaborator]; Nicasio, J [Collaborator]; Eagerton, D [Collaborator]; Huntley, R [Collaborator]; Reed, J [Collaborator]; Magee, M [Collaborator]; Hippert, R [Collaborator]; Sofley, C [Collaborator]; Alzohaili, O [Collaborator]; Levins, P [Collaborator]; Anspach, R [Collaborator]; Shah, S [Collaborator]; Brusco, O [Collaborator]; Naidu, J [Collaborator]; Lindenbaum, J [Collaborator]; Jacks, R [Collaborator]; Hammond, G [Collaborator]; Arena, C [Collaborator]; Saxman, K [Collaborator]; Mach, M [Collaborator]; Kerstein, H [Collaborator]; Kereiakes, D [Collaborator]; Wahlen, J [Collaborator]; Wehmeier, K [Collaborator]; Chaykin, L [Collaborator]; Rothman, J [Collaborator]; Fogelfeld, L [Collaborator]; Stroger, JH [Collaborator]; Bittar, N [Collaborator]; Rosenstock, J [Collaborator]; Kayne, D [Collaborator]; Navarro, J [Collaborator]; Colfer, H [Collaborator]; Mokshagundam, S [Collaborator]; Shandilya, L [Collaborator]; Connery, L [Collaborator]; Wysham, C [Collaborator]; Dela, Llana A [Collaborator]; Jardula, M [Collaborator]; MacAdams, M [Collaborator]; Flippo, G [Collaborator]; Heurich, E [Collaborator]; Curtis, C [Collaborator]; Sanders, D [Collaborator]; Rawls, R [Collaborator]; Velazquez, F [Collaborator]; Osea, E [Collaborator]; Mahood, K [Collaborator]; Feldman, G [Collaborator]; Eder, F [Collaborator]; Riley, E [Collaborator]; Fowler, W [Collaborator]; Jain, M [Collaborator]; Shepard, M [Collaborator]; Schear, M [Collaborator]; Barker, B [Collaborator]; Strout, C [Collaborator]; Obiekwe, O [Collaborator]; Shanik, M [Collaborator]; Green, C [Collaborator]; Blakney, E [Collaborator]; Roberson, K [Collaborator]; Bretton, E [Collaborator]; Pish, R [Collaborator]; Kaveh, K [Collaborator]; Maynard, B [Collaborator]; Barager, W [Collaborator]; Soldyshev, R [Collaborator]; Austin, B [Collaborator]; Parmar, P [Collaborator]; Simpson, R [Collaborator]; Chauhan, A [Collaborator]; Kasper, J [Collaborator]; Burr, R [Collaborator]; Patel, N [Collaborator]; Mariano, H [Collaborator]; Pluto, T [Collaborator]; Bratcher, C [Collaborator]; Juarez, M [Collaborator]; Levinson, L [Collaborator]; Awad, A [Collaborator]; Longshaw, K [Collaborator]; Hoffman, K [Collaborator]; Richwine, R [Collaborator]; Molter, D [Collaborator]; Boscia, J [Collaborator]; Kowalyk, S [Collaborator]; Lemis, P [Collaborator]; Liss, J [Collaborator]; Orr, R [Collaborator]; Riser, J [Collaborator]; Wood, J [Collaborator]; Ubani, A [Collaborator]; Paine, W [Collaborator]; Hassani, F [Collaborator]; Miranda, F [Collaborator]; Hansen, V [Collaborator]; Hansen, VR [Collaborator]; Farris, N [Collaborator]; Bowden, R [Collaborator]; Ajani, D [Collaborator]; Maw, K [Collaborator]; Andersen, J [Collaborator]; Bergman, B [Collaborator]; Dunmyer, S [Collaborator]; Brandon, D [Collaborator]; Anderson, M [Collaborator]; Bononi, P [Collaborator]; Prawer, J [Collaborator]; Seidman, B [Collaborator]; Cruz, H [Collaborator]; Wilks, K [Collaborator]; DiSanto, L [Collaborator]; Buynak, R [Collaborator]; Christensen, T [Collaborator]; Denker, P [Collaborator]; Koppel, W [Collaborator]; Stedman, M [Collaborator]; Lewy-Alterbaum, L [Collaborator]; Karim, S [Collaborator]; Shapiro, J [Collaborator]; Gardner, T [Collaborator]; Oskin, T [Collaborator]; Gabra, N [Collaborator]; Malano, J [Collaborator]
We previously reported that in the EMPA-REG OUTCOME(®) trial, empagliflozin added
to standard of care reduced the risk of 3-point major adverse cardiovascular events,
cardiovascular and all-cause death, and hospitalization for heart failure in patients
with type 2 diabetes and high cardiovascular risk. We have now further investigated
heart failure outcomes in all patients and in subgroups, including patients with or
without baseline heart failure.Patients were randomized to receive empagliflozin 10
mg, empagliflozin 25 mg, or placebo. Seven thousand and twenty patients were treated;
706 (10.1%) had heart failure at baseline. Heart failure hospitalization or cardiovascular
death occurred in a significantly lower percentage of patients treated with empagliflozin
[265/4687 patients (5.7%)] than with placebo [198/2333 patients (8.5%)] [hazard ratio,
HR: 0.66 (95% confidence interval: 0.55-0.79); P < 0.001], corresponding to a number
needed to treat to prevent one heart failure hospitalization or cardiovascular death
of 35 over 3 years. Consistent effects of empagliflozin were observed across subgroups
defined by baseline characteristics, including patients with vs. without heart failure,
and across categories of medications to treat diabetes and/or heart failure. Empagliflozin
improved other heart failure outcomes, including hospitalization for or death from
heart failure [2.8 vs. 4.5%; HR: 0.61 (0.47-0.79); P < 0.001] and was associated with
a reduction in all-cause hospitalization [36.8 vs. 39.6%; HR: 0.89 (0.82-0.96); P
= 0.003]. Serious adverse events and adverse events leading to discontinuation were
reported by a higher proportion of patients with vs. without heart failure at baseline
in both treatment groups, but were no more common with empagliflozin than with placebo.In
patients with type 2 diabetes and high cardiovascular risk, empagliflozin reduced
heart failure hospitalization and cardiovascular death, with a consistent benefit
in patients with and without baseline heart failure.