https://m2.mtmt.hu/ hun 2026-09-23 04:47 JournalArticle 33701053 VALIDATED true Heart Institute, Medical School and Szentágothai Research Centre, University of Pecs, Pecs, 7624, Hungary Department of Morphology and Physiology, Faculty of Health Sciences, Semmelweis University, Budapest, 1088, Hungary Eötvös Loránd Research Network, Semmelweis University (ELRN-SU), Cerebrovascular and Neurocognitive Disorders Research Group, Department of Translational Medicine, Faculty of Medicine, Semmelweis University, Budapest, 1094, Hungary Department of Laboratory Medicine, Medical School, University of Pecs, Pecs, 7624, Hungary Research Center for Sports Physiology, Hungarian University of Sports Science, Budapest, 1123, Hungary Department of Physiology, New York Medical College, Valhalla, 10595, NY, United States Export Date: 22 April 2025; Cited By: 2; Correspondence Address: A. Koller; Department of Morphology and Physiology, Faculty of Health Sciences, Semmelweis University, Budapest, 1088, Hungary; email: akos.koller@gmail.com 0 false 2026-07-10T15:40:23.998+0000 2025-07-18T11:04:58.182+0000 2023-03-15T12:17:04.338+0000 true 10015206 Áncsán Gizella /api/admin/10015206 Admin Áncsán Gizella (SE admin) true 10015206 2026-07-10T15:39:17.080+0000 2025-06-06T16:13:45.300+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin Milánkovics Róbert (PTE ÁOK admin 4) true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Cziraki, Attila true true /api/journal/10053785 REVIEWED JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE 2308-3425 true false 10053785 false 10053785 true 2308-3425 Journal FOREIGN 10 3 122 122 13 2023 Background: Homocysteine (Hcy) is involved in various methylation processes, and its plasma level is increased in cardiac ischemia. Thus, we hypothesized that levels of homocysteine correlate with the morphological and functional remodeling of ischemic hearts. Thus, we aimed to measure the Hcy levels in the plasma and pericardial fluid (PF) and correlate them with morphological and functional changes in the ischemic hearts of humans. Methods: Concentration of total homocysteine (tHcy) and cardiac troponin-I (cTn-I) of plasma and PF were measured in patients undergoing coronary artery bypass graft (CABG) surgery (n = 14). Left-ventricular (LV) end-diastolic diameter (LVED), LV end-systolic diameter (LVES), right atrial, left atrial (LA) area, thickness of interventricular septum (IVS) and posterior wall, LV ejection fraction (LVEF), and right ventricular outflow tract end-diastolic area (RVOT EDA) of CABG and non-cardiac patients (NCP; n = 10) were determined by echocardiography, and LV mass was calculated (cLVM). Results: Positive correlations were found between Hcy levels of plasma and PF, tHcy levels and LVED, LVES and LA, and an inverse correlation was found between tHcy levels and LVEF. cLVM, IVS, and RVOT EDA were higher in CABG with elevated tHcy (>12 µM/L) compared to NCP. In addition, we found a higher cTn-I level in the PF compared to the plasma of CABG patients (0.08 ± 0.02 vs. 0.01 ± 0.003 ng/mL, p < 0.001), which was ~10 fold higher than the normal level. Conclusions: We propose that homocysteine is an important cardiac biomarker and may have an important role in the development of cardiac remodeling and dysfunction in chronic myocardial ischemia in humans. Funding 2025520 /api/funding/2025520 (National Bionics Programme ED_17-1-2017-0009) Támogató: NKFIH false true Funding 2025521 /api/funding/2025521 (K132596) Támogató: OTKA false true Funding 2025522 /api/funding/2025522 (TKP2020-NKA17) false true Funding 2025523 /api/funding/2025523 TKP2021-EGA-37(TKP2021-EGA-37) false true Funding 2025524 /api/funding/2025524 (Post-Covid 2021–34.) Támogató: MTA false true Funding 2025525 /api/funding/2025525 (TKP-2021-EGA-10) false true Funding 2025526 /api/funding/2025526 (K120536) false true true 2023 true true true false true false GOLD 2026-07-10 true https://doi.org/10.3390/jcdd10030122 4 0 4 4 0 4 4 4 4 4 4 4 4 4 0 0 4 4 4 4 0 9 9 Folyóiratcikk Journal Article 24 4 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 1 1 1 1 2024 0 2 2 2 2 2025 0 0 0 0 0 2026 0 1 1 1 1 Q1 false 10013007,10016439 false false false 2023-03-14T12:18:19.093+0000 Laboratóriumi Medicina Intézet (PTE / ÁOK); Molekuláris Edzésélettani Kutató Központ (MTSE / SETI); Molekuláris Kardiológiai Kutatócsoport (PTE / SZKK); Morfológiai és Fiziológiai Tanszék (SE / ETK2007); Sport- és Egészségtudományi Intézet (MTSE); Sport- és egészségtudományi Kutatócsoport (EKKE / KUTE); Szentágothai János Kutatóközpont (PTE); Szívgyógyászati Klinika (PTE / ÁOK); Transzlációs Medicina Intézet (SE / AOK / I) 6 50 9 7 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 107035571 /api/authorship/107035571 Cziraki, Attila [Cziráki, Attila (Az endotél diszfu...), szerző] Szívgyógyászati Klinika (PTE / ÁOK); Molekuláris Kardiológiai Kutatócsoport (PTE / SZKK) 1 0.14285715 true false false Author 10016439 /api/author/10016439 Cziráki Attila (Az endotél diszfunkció artériás stiffness és biokémiai paraméterek (PARP,ADMA,NO) vizsgálata) Cziráki Attila true 10016439 true Cziraki Attila true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107035572 /api/authorship/107035572 Nemeth, Zoltan [Németh, Zoltán (Kísérletes orvost...), szerző] Morfológiai és Fiziológiai Tanszék (SE / ETK2007); Transzlációs Medicina Intézet (SE / AOK / I) 2 0.143 false false false Author 10027596 /api/author/10027596 Németh Zoltán (Kísérletes orvostudományok) Németh Zoltán true 10027596 true Nemeth Zoltan true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107035573 /api/authorship/107035573 Szabados, Sandor [Szabados, Sándor (Szívsebészet), szerző] Szívgyógyászati Klinika (PTE / ÁOK); Szentágothai János Kutatóközpont (PTE) 3 0.14285715 false false false Author 10014564 /api/author/10014564 Szabados Sándor (Szívsebészet) Szabados Sándor true 10014564 true Szabados Sandor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107035574 /api/authorship/107035574 Nagy, Tamas [Nagy, Tamás (Laboratóriumi Med...), szerző] Laboratóriumi Medicina Intézet (PTE / ÁOK) 4 0.14285715 false false false Author 10013007 /api/author/10013007 Nagy Tamás (Laboratóriumi Medicina) Nagy Tamás true 10013007 true Nagy Tamas true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107035575 /api/authorship/107035575 Szántó, Márk 5 0.14285715 false false false Szántó Márk true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107035576 /api/authorship/107035576 Nyakas, Csaba [Nyakas, Csaba (Molekuláris neuro...), szerző] Morfológiai és Fiziológiai Tanszék (SE / ETK2007); Molekuláris Edzésélettani Kutató Központ (MTSE / SETI); Sport- és egészségtudományi Kutatócsoport (EKKE / KUTE) 6 0.143 false false false Author 10010173 /api/author/10010173 Nyakas Csaba (Molekuláris neurobiológia) Nyakas Csaba true 10010173 true Nyakas Csaba true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 107035577 /api/authorship/107035577 Koller, Akos ✉ [Koller, Ákos (Szív és vérkeringés), szerző] Morfológiai és Fiziológiai Tanszék (SE / ETK2007); Transzlációs Medicina Intézet (SE / AOK / I); Sport- és Egészségtudományi Intézet (MTSE) 7 0.143 false true true Author 10002221 /api/author/10002221 Koller Ákos (Szív és vérkeringés) Koller Ákos true 10002221 true Koller Akos true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 23240748 /api/publicationidentifier/23240748 DOI: 10.3390/jcdd10030122 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/jcdd10030122 https://doi.org/10.3390/jcdd10030122 false true PublicationIdentifier 23350257 /api/publicationidentifier/23350257 WoS: 000955076300001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000955076300001 https://www.webofscience.com/wos/woscc/full-record/000955076300001 false true PublicationIdentifier 23346974 /api/publicationidentifier/23346974 Scopus: 85151075417 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85151075417 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85151075417 false true PublicationIdentifier 23319314 /api/publicationidentifier/23319314 PubMed: 36975886 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 36975886 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36975886&dopt=Abstract true true SjrRating 11406718 /api/sjrrating/11406718 sjr:Q1 (2023) Scopus - Pharmacology, Toxicology and Pharmaceutics (miscellaneous) JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE 2308-3425 2308-3425 23 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 3001 /api/classificationexternal/3001 Scopus - Pharmacology, Toxicology and Pharmaceutics (miscellaneous) true 3001 true Q1 DIRECT true true Reference 39331174 /api/reference/39331174 1. 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Liao 2004: Statin therapy for cardiac hypertrophy and heart failure., J. Investig. Med., 52, p. 248, DOI: 10.1177/108155890405200433 53 10.1177/108155890405200433 false true Reference 39331227 /api/reference/39331227 54. Wile 2010: Association of Metformin, Elevated Homocysteine, and Methylmalonic Acid Levels and Clinically Wors-ened Diabetic Peripheral Neuropathy., Diabetes Care, 33, p. 156, DOI: 10.2337/dc09-0606 54 10.2337/dc09-0606 false true /api/publication/33701053 Cziraki Attila et al. Morphological and Functional Remodeling of the Ischemic Heart Correlates with Homocysteine Levels. (2023) JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE 2308-3425 10 3<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10016439"><a href="/gui2/?type=authors&mode=browse&sel=10016439" target="_blank">Cziraki Attila (<span class="authorship-author-name">Cziráki Attila</span> <span class="authorAux-mtmt"> Az endotél diszfunkció artériás stiffness és bi...</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Szívgyógyászati Klinika; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Szentágothai János Kutatóközpont">SZKK</span>/Molekuláris Kardiológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027596"><a href="/gui2/?type=authors&mode=browse&sel=10027596" target="_blank">Nemeth Zoltan (<span class="authorship-author-name">Németh Zoltán</span> <span class="authorAux-mtmt"> Kísérletes orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Egészségtudományi Kar">ETK2007</span>/Morfológiai és Fiziológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014564"><a href="/gui2/?type=authors&mode=browse&sel=10014564" target="_blank">Szabados Sandor (<span class="authorship-author-name">Szabados Sándor</span> <span class="authorAux-mtmt"> Szívsebészet</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Szívgyógyászati Klinika; <span title="Pécsi Tudományegyetem">PTE</span>/Szentágothai János Kutatóközpont</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013007"><a href="/gui2/?type=authors&mode=browse&sel=10013007" target="_blank">Nagy Tamas (<span class="authorship-author-name">Nagy Tamás</span> <span class="authorAux-mtmt"> Laboratóriumi Medicina</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Laboratóriumi Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Szántó Márk </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010173"><a href="/gui2/?type=authors&mode=browse&sel=10010173" target="_blank">Nyakas Csaba (<span class="authorship-author-name">Nyakas Csaba</span> <span class="authorAux-mtmt"> Molekuláris neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Egészségtudományi Kar">ETK2007</span>/Morfológiai és Fiziológiai Tanszék; <span title="Magyar Testnevelési és Sporttudományi Egyetem">MTSE</span>/<span title="Sport- és Egészségtudományi Intézet">SETI</span>/Molekuláris Edzésélettani Kutató Központ; <span title="Eszterházy Károly Katolikus Egyetem">EKKE</span>/<span title="Kutatási egységek">KUTE</span>/Sport- és egészségtudományi Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002221"><a href="/gui2/?type=authors&mode=browse&sel=10002221" target="_blank">Koller Akos ✉ (<span class="authorship-author-name">Koller Ákos</span> <span class="authorAux-mtmt"> Szív és vérkeringés</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Egészségtudományi Kar">ETK2007</span>/Morfológiai és Fiziológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet; <span title="Magyar Testnevelési és Sporttudományi Egyetem">MTSE</span>/Sport- és Egészségtudományi Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33701053" target="_blank">Morphological and Functional Remodeling of the Ischemic Heart Correlates with Homocysteine Levels</a></div> <div> <span class="journal-title">JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2308-3425">2308-3425</a>)</span>: <span class="journal-volume">10</span> <span class="journal-issue">3</span> <span class="page"> Paper 122. 13 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/jcdd10030122" target="_blank" href="https://doi.org/10.3390/jcdd10030122"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000955076300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000955076300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85151075417" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85151075417"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36975886" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36975886&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmacology, Toxicology and Pharmaceutics (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmacology (medical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 4</span> | Független: 4 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 4 | Scopus jelölt:&nbsp;4 | WoS/Scopus jelölt:&nbsp;4 | DOI jelölt:&nbsp;4 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33701053&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 9 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33701053</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (National Bionics Programme ED_17-1-2017-0009) Támogató: NKFIH, (K132596) Támogató: OTKA, (TKP2020-NKA17), TKP2021-EGA-37(TKP2021-EGA-37), (Post-Covid 2021–34.) Támogató: MTA, (TKP-2021-EGA-10), (K120536) </div> <div class="lastModified">Utolsó módosítás: 2025.07.18. 13:04 Oszlánczi Krisztina (EKKE admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Heart Institute, Medical School and Szentágothai Research Centre, University of Pecs, Pecs, 7624, Hungary Department of Morphology and Physiology, Faculty of Health Sciences, Semmelweis University, Budapest, 1088, Hungary Eötvös Loránd Research Network, Semmelweis University (ELRN-SU), Cerebrovascular and Neurocognitive Disorders Research Group, D...</pre> </div></div>